TY  - JOUR
AU  - Marković, Goran
AU  - Kostić, Aleksandar Ž
AU  - Pantelić, Nebojša Đ
AU  - Maletić, Radojka
AU  - Štrbački, Jana
AU  - Cakić, Jovan
AU  - Kaluđerović, Lazar
AU  - Dojčinović, Biljana P.
AU  - Giuffrè, Angelo Maria
AU  - Popović-Djordjević, Jelena B.
PY  - 2023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/37733141
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6433
AB  - Lakes and reservoirs are the main water resources for household, irrigation, and industrial use. Hence, it is necessary to control water pollution and have reliable information on water quality, which refers to its suitability for a particular purpose. The main objective of this study was to evaluate the suitability of water for drinking and irrigation purposes from ten artificial lakes on the territory of the Republic of Serbia. The physicochemical parameters were determined using standard analytical methods, whereas the optical emission spectrometry with inductively coupled plasma, ICP-OES, was used to determine the concentrations of 23 macro-, micro-, and trace elements in water. Health risk indices of drinking water and its suitability for irrigation purposes were evaluated. The results of physicochemical parameters, except for total organic matter, indicated that most samples were within the recommended values. Among analyzed elements, the concentration of Mg was elevated in the water of the lakes Srebrno and Prvonek. The results of health risk assessment clearly showed that there was no acute health risk (HQA < 1), whereas long-term risk (HQL) in the studied lakes was observed with respect to As (lakes Grlište and Srebrno), Mn (lakes Srebrno and Prvonek), Ni (Lake Vrutci), and Sr (Lake Grlište). The irrigation criteria indicated that the water from the examined lakes had satisfactory quality for this purpose, except for residual sodium carbonates (RSC). This criterion indicated low quality or unsuitability of the water in 7 lakes. The main outcomes provided valuable information on the suitability of water from the artificial lakes for intended uses.
T2  - Environmental Monitoring and Assessment
T2  - Environmental Monitoring and AssessmentEnviron Monit Assess
T1  - Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes
IS  - 10
SP  - 1237
VL  - 195
DO  - 10.1007/s10661-023-11740-6
ER  - 

@article{
author = "Marković, Goran and Kostić, Aleksandar Ž and Pantelić, Nebojša Đ and Maletić, Radojka and Štrbački, Jana and Cakić, Jovan and Kaluđerović, Lazar and Dojčinović, Biljana P. and Giuffrè, Angelo Maria and Popović-Djordjević, Jelena B.",
year = "2023",
abstract = "Lakes and reservoirs are the main water resources for household, irrigation, and industrial use. Hence, it is necessary to control water pollution and have reliable information on water quality, which refers to its suitability for a particular purpose. The main objective of this study was to evaluate the suitability of water for drinking and irrigation purposes from ten artificial lakes on the territory of the Republic of Serbia. The physicochemical parameters were determined using standard analytical methods, whereas the optical emission spectrometry with inductively coupled plasma, ICP-OES, was used to determine the concentrations of 23 macro-, micro-, and trace elements in water. Health risk indices of drinking water and its suitability for irrigation purposes were evaluated. The results of physicochemical parameters, except for total organic matter, indicated that most samples were within the recommended values. Among analyzed elements, the concentration of Mg was elevated in the water of the lakes Srebrno and Prvonek. The results of health risk assessment clearly showed that there was no acute health risk (HQA < 1), whereas long-term risk (HQL) in the studied lakes was observed with respect to As (lakes Grlište and Srebrno), Mn (lakes Srebrno and Prvonek), Ni (Lake Vrutci), and Sr (Lake Grlište). The irrigation criteria indicated that the water from the examined lakes had satisfactory quality for this purpose, except for residual sodium carbonates (RSC). This criterion indicated low quality or unsuitability of the water in 7 lakes. The main outcomes provided valuable information on the suitability of water from the artificial lakes for intended uses.",
journal = "Environmental Monitoring and Assessment, Environmental Monitoring and AssessmentEnviron Monit Assess",
title = "Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes",
number = "10",
pages = "1237",
volume = "195",
doi = "10.1007/s10661-023-11740-6"
}

Marković, G., Kostić, A. Ž., Pantelić, N. Đ., Maletić, R., Štrbački, J., Cakić, J., Kaluđerović, L., Dojčinović, B. P., Giuffrè, A. M.,& Popović-Djordjević, J. B.. (2023). Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes. in Environmental Monitoring and Assessment, 195(10), 1237.
https://doi.org/10.1007/s10661-023-11740-6

Marković G, Kostić AŽ, Pantelić NĐ, Maletić R, Štrbački J, Cakić J, Kaluđerović L, Dojčinović BP, Giuffrè AM, Popović-Djordjević JB. Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes. in Environmental Monitoring and Assessment. 2023;195(10):1237.
doi:10.1007/s10661-023-11740-6 .

Marković, Goran, Kostić, Aleksandar Ž, Pantelić, Nebojša Đ, Maletić, Radojka, Štrbački, Jana, Cakić, Jovan, Kaluđerović, Lazar, Dojčinović, Biljana P., Giuffrè, Angelo Maria, Popović-Djordjević, Jelena B., "Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes" in Environmental Monitoring and Assessment, 195, no. 10 (2023):1237,
https://doi.org/10.1007/s10661-023-11740-6 . .

TY  - JOUR
AU  - Marković, Goran
AU  - Kostić, Aleksandar Ž
AU  - Pantelić, Nebojša Đ
AU  - Maletić, Radojka
AU  - Štrbački, Jana
AU  - Cakić, Jovan
AU  - Kaluđerović, Lazar
AU  - Dojčinović, Biljana P.
AU  - Giuffrè, Angelo Maria
AU  - Popović-Djordjević, Jelena B.
PY  - 2023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/37733141
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6459
AB  - Lakes and reservoirs are the main water resources for household, irrigation, and industrial use. Hence, it is necessary to control water pollution and have reliable information on water quality, which refers to its suitability for a particular purpose. The main objective of this study was to evaluate the suitability of water for drinking and irrigation purposes from ten artificial lakes on the territory of the Republic of Serbia. The physicochemical parameters were determined using standard analytical methods, whereas the optical emission spectrometry with inductively coupled plasma, ICP-OES, was used to determine the concentrations of 23 macro-, micro-, and trace elements in water. Health risk indices of drinking water and its suitability for irrigation purposes were evaluated. The results of physicochemical parameters, except for total organic matter, indicated that most samples were within the recommended values. Among analyzed elements, the concentration of Mg was elevated in the water of the lakes Srebrno and Prvonek. The results of health risk assessment clearly showed that there was no acute health risk (HQA < 1), whereas long-term risk (HQL) in the studied lakes was observed with respect to As (lakes Grlište and Srebrno), Mn (lakes Srebrno and Prvonek), Ni (Lake Vrutci), and Sr (Lake Grlište). The irrigation criteria indicated that the water from the examined lakes had satisfactory quality for this purpose, except for residual sodium carbonates (RSC). This criterion indicated low quality or unsuitability of the water in 7 lakes. The main outcomes provided valuable information on the suitability of water from the artificial lakes for intended uses.
T2  - Environmental Monitoring and Assessment
T2  - Environmental Monitoring and AssessmentEnviron Monit Assess
T1  - Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes
IS  - 10
SP  - 1237
VL  - 195
DO  - 10.1007/s10661-023-11740-6
ER  - 

@article{
author = "Marković, Goran and Kostić, Aleksandar Ž and Pantelić, Nebojša Đ and Maletić, Radojka and Štrbački, Jana and Cakić, Jovan and Kaluđerović, Lazar and Dojčinović, Biljana P. and Giuffrè, Angelo Maria and Popović-Djordjević, Jelena B.",
year = "2023",
abstract = "Lakes and reservoirs are the main water resources for household, irrigation, and industrial use. Hence, it is necessary to control water pollution and have reliable information on water quality, which refers to its suitability for a particular purpose. The main objective of this study was to evaluate the suitability of water for drinking and irrigation purposes from ten artificial lakes on the territory of the Republic of Serbia. The physicochemical parameters were determined using standard analytical methods, whereas the optical emission spectrometry with inductively coupled plasma, ICP-OES, was used to determine the concentrations of 23 macro-, micro-, and trace elements in water. Health risk indices of drinking water and its suitability for irrigation purposes were evaluated. The results of physicochemical parameters, except for total organic matter, indicated that most samples were within the recommended values. Among analyzed elements, the concentration of Mg was elevated in the water of the lakes Srebrno and Prvonek. The results of health risk assessment clearly showed that there was no acute health risk (HQA < 1), whereas long-term risk (HQL) in the studied lakes was observed with respect to As (lakes Grlište and Srebrno), Mn (lakes Srebrno and Prvonek), Ni (Lake Vrutci), and Sr (Lake Grlište). The irrigation criteria indicated that the water from the examined lakes had satisfactory quality for this purpose, except for residual sodium carbonates (RSC). This criterion indicated low quality or unsuitability of the water in 7 lakes. The main outcomes provided valuable information on the suitability of water from the artificial lakes for intended uses.",
journal = "Environmental Monitoring and Assessment, Environmental Monitoring and AssessmentEnviron Monit Assess",
title = "Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes",
number = "10",
pages = "1237",
volume = "195",
doi = "10.1007/s10661-023-11740-6"
}

Marković, G., Kostić, A. Ž., Pantelić, N. Đ., Maletić, R., Štrbački, J., Cakić, J., Kaluđerović, L., Dojčinović, B. P., Giuffrè, A. M.,& Popović-Djordjević, J. B.. (2023). Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes. in Environmental Monitoring and Assessment, 195(10), 1237.
https://doi.org/10.1007/s10661-023-11740-6

Marković G, Kostić AŽ, Pantelić NĐ, Maletić R, Štrbački J, Cakić J, Kaluđerović L, Dojčinović BP, Giuffrè AM, Popović-Djordjević JB. Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes. in Environmental Monitoring and Assessment. 2023;195(10):1237.
doi:10.1007/s10661-023-11740-6 .

Marković, Goran, Kostić, Aleksandar Ž, Pantelić, Nebojša Đ, Maletić, Radojka, Štrbački, Jana, Cakić, Jovan, Kaluđerović, Lazar, Dojčinović, Biljana P., Giuffrè, Angelo Maria, Popović-Djordjević, Jelena B., "Spatial distribution of major and trace elements in artificial lakes in Serbia: health risk indices and suitability of water for drinking and irrigation purposes" in Environmental Monitoring and Assessment, 195, no. 10 (2023):1237,
https://doi.org/10.1007/s10661-023-11740-6 . .

TY  - JOUR
AU  - Vuković, Sandra
AU  - Popović-Djordjević, Jelena B.
AU  - Kostić, Aleksandar Ž.
AU  - Pantelić, Nebojša D.
AU  - Srećković, Nikola
AU  - Akram, Muhammad
AU  - Laila, Umme
AU  - Katanić Stanković, Jelena S.
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6317
AB  - Ever since ancient times, Allium species have played a significant role in the human diet, in traditional medicine for the treatment of many ailments, and in officinal medicine as a supplemental ingredient. The major metabolites of alliums, as well as their antioxidant and antimicrobial properties, with an emphasis on the species most represented in the Balkan region, are discussed in this review. Due to its richness in endemic species, the Balkan region is considered the genocenter of alliums. There are 56 recorded Allium species in the Balkans, and 17 of them are endemic. The most common and well-studied Allium species in the Balkans are A. cepa (onion), A. sativum (garlic), A. ampeloprasum (leek), A. schoenoprasum (chives), A. fistulosum (Welsh onion), and A. ursinum (wild garlic or bear’s garlic), which are known for their pungent taste and smell, especially noticeable in garlic and onion, and attributed to various organosulfur compounds. These plants are valued for their macronutrients and are used as desirable vegetables and spices. Additionally, phytochemicals such as organosulfur compounds, phenolics, fatty acids, and saponins are associated with the antioxidant and antimicrobial properties of these species, among many other bioactivities. All parts of the plant including the bulb, peel, clove, leaf, pseudostem, root, flower, and seed exhibit antioxidant properties in different in vitro assays. The characteristic phytocompounds that contribute to the antimicrobial activity of alliums include allicin, ajoene, allyl alcohol, and some diallyl sulfides. Nanoparticles synthesized using Allium species are also recognized for their notable antimicrobial properties. © 2023 by the authors.
T2  - Horticulturae
T2  - Horticulturae
T1  - Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties
IS  - 3
VL  - 9
DO  - 10.3390/horticulturae9030408
ER  - 

@article{
author = "Vuković, Sandra and Popović-Djordjević, Jelena B. and Kostić, Aleksandar Ž. and Pantelić, Nebojša D. and Srećković, Nikola and Akram, Muhammad and Laila, Umme and Katanić Stanković, Jelena S.",
year = "2023",
abstract = "Ever since ancient times, Allium species have played a significant role in the human diet, in traditional medicine for the treatment of many ailments, and in officinal medicine as a supplemental ingredient. The major metabolites of alliums, as well as their antioxidant and antimicrobial properties, with an emphasis on the species most represented in the Balkan region, are discussed in this review. Due to its richness in endemic species, the Balkan region is considered the genocenter of alliums. There are 56 recorded Allium species in the Balkans, and 17 of them are endemic. The most common and well-studied Allium species in the Balkans are A. cepa (onion), A. sativum (garlic), A. ampeloprasum (leek), A. schoenoprasum (chives), A. fistulosum (Welsh onion), and A. ursinum (wild garlic or bear’s garlic), which are known for their pungent taste and smell, especially noticeable in garlic and onion, and attributed to various organosulfur compounds. These plants are valued for their macronutrients and are used as desirable vegetables and spices. Additionally, phytochemicals such as organosulfur compounds, phenolics, fatty acids, and saponins are associated with the antioxidant and antimicrobial properties of these species, among many other bioactivities. All parts of the plant including the bulb, peel, clove, leaf, pseudostem, root, flower, and seed exhibit antioxidant properties in different in vitro assays. The characteristic phytocompounds that contribute to the antimicrobial activity of alliums include allicin, ajoene, allyl alcohol, and some diallyl sulfides. Nanoparticles synthesized using Allium species are also recognized for their notable antimicrobial properties. © 2023 by the authors.",
journal = "Horticulturae, Horticulturae",
title = "Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties",
number = "3",
volume = "9",
doi = "10.3390/horticulturae9030408"
}

Vuković, S., Popović-Djordjević, J. B., Kostić, A. Ž., Pantelić, N. D., Srećković, N., Akram, M., Laila, U.,& Katanić Stanković, J. S.. (2023). Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties. in Horticulturae, 9(3).
https://doi.org/10.3390/horticulturae9030408

Vuković S, Popović-Djordjević JB, Kostić AŽ, Pantelić ND, Srećković N, Akram M, Laila U, Katanić Stanković JS. Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties. in Horticulturae. 2023;9(3).
doi:10.3390/horticulturae9030408 .

Vuković, Sandra, Popović-Djordjević, Jelena B., Kostić, Aleksandar Ž., Pantelić, Nebojša D., Srećković, Nikola, Akram, Muhammad, Laila, Umme, Katanić Stanković, Jelena S., "Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties" in Horticulturae, 9, no. 3 (2023),
https://doi.org/10.3390/horticulturae9030408 . .

TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Kostić, Aleksandar Ž.
AU  - Kamiloglu, Senem
AU  - Tomas, Merve
AU  - Mićanović, Nenad
AU  - Capanoglu, Esra
PY  - 2023
UR  - https://doi.org/10.1007/s11101-023-09883-y
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6396
AB  - The common medlar (Mespilus germanica L.) is one of two species within the Mespilus genus (Maloideae subfamily). Its use can be traced back almost 30 centuries, from ancient Assyrians and Babylonians to Greeks and Romans and through modern times. During the Middle Ages it was a popular fruit tree and a highly appreciated ornamental tree in gardens across Europe. However, in modern times, the medlar is often considered an underestimated and underutilized fruit from the Rosaceae family. Nevertheless, it is slowly regaining its ‘medieval glory’ and commercial importance as a food-stuff for human consumption. The medlar plant has a wide array of traditional uses in both gastronomy and medicine. Ripe medlar fruits can be consumed fresh or processed into different products such as juice, concentrate, jam, cheese, leather, and honey. Meanwhile, unripe fruits can be used to prepare pickles or beverages such as cider. The nutritional potential of medlar fruits is attributed to sugars, organic acids, fatty acids, carotenoids, amino acids and proteins, vitamins, and essential elements. Scarce literature describes the richness of medlar fruit in bioactive phenolic compounds such as flavonoids and phenolic acids, which contribute to its antioxidant and antidiabetic properties. Additionally, a few studies describe other biological properties of the medlar plant including antimicrobial, cytotoxic and neurodegenerative effects of medlar fruits and leaves, while reports on the clinical studies are lacking. This review paper summarizes the chemical and nutritional properties of medlar fruit, traditional medicinal uses and biological activity of the medlar plant, relying on the most relevant and up to date scientific literature in the field.
T2  - Phytochemistry Reviews
T2  - Phytochemistry ReviewsPhytochem Rev
T1  - Chemical composition, nutritional and health related properties of the medlar (Mespilus germanica L.): from medieval glory to underutilized fruit
DO  - 10.1007/s11101-023-09883-y
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Kostić, Aleksandar Ž. and Kamiloglu, Senem and Tomas, Merve and Mićanović, Nenad and Capanoglu, Esra",
year = "2023",
abstract = "The common medlar (Mespilus germanica L.) is one of two species within the Mespilus genus (Maloideae subfamily). Its use can be traced back almost 30 centuries, from ancient Assyrians and Babylonians to Greeks and Romans and through modern times. During the Middle Ages it was a popular fruit tree and a highly appreciated ornamental tree in gardens across Europe. However, in modern times, the medlar is often considered an underestimated and underutilized fruit from the Rosaceae family. Nevertheless, it is slowly regaining its ‘medieval glory’ and commercial importance as a food-stuff for human consumption. The medlar plant has a wide array of traditional uses in both gastronomy and medicine. Ripe medlar fruits can be consumed fresh or processed into different products such as juice, concentrate, jam, cheese, leather, and honey. Meanwhile, unripe fruits can be used to prepare pickles or beverages such as cider. The nutritional potential of medlar fruits is attributed to sugars, organic acids, fatty acids, carotenoids, amino acids and proteins, vitamins, and essential elements. Scarce literature describes the richness of medlar fruit in bioactive phenolic compounds such as flavonoids and phenolic acids, which contribute to its antioxidant and antidiabetic properties. Additionally, a few studies describe other biological properties of the medlar plant including antimicrobial, cytotoxic and neurodegenerative effects of medlar fruits and leaves, while reports on the clinical studies are lacking. This review paper summarizes the chemical and nutritional properties of medlar fruit, traditional medicinal uses and biological activity of the medlar plant, relying on the most relevant and up to date scientific literature in the field.",
journal = "Phytochemistry Reviews, Phytochemistry ReviewsPhytochem Rev",
title = "Chemical composition, nutritional and health related properties of the medlar (Mespilus germanica L.): from medieval glory to underutilized fruit",
doi = "10.1007/s11101-023-09883-y"
}

Popović-Djordjević, J., Kostić, A. Ž., Kamiloglu, S., Tomas, M., Mićanović, N.,& Capanoglu, E.. (2023). Chemical composition, nutritional and health related properties of the medlar (Mespilus germanica L.): from medieval glory to underutilized fruit. in Phytochemistry Reviews.
https://doi.org/10.1007/s11101-023-09883-y

Popović-Djordjević J, Kostić AŽ, Kamiloglu S, Tomas M, Mićanović N, Capanoglu E. Chemical composition, nutritional and health related properties of the medlar (Mespilus germanica L.): from medieval glory to underutilized fruit. in Phytochemistry Reviews. 2023;.
doi:10.1007/s11101-023-09883-y .

Popović-Djordjević, Jelena, Kostić, Aleksandar Ž., Kamiloglu, Senem, Tomas, Merve, Mićanović, Nenad, Capanoglu, Esra, "Chemical composition, nutritional and health related properties of the medlar (Mespilus germanica L.): from medieval glory to underutilized fruit" in Phytochemistry Reviews (2023),
https://doi.org/10.1007/s11101-023-09883-y . .

TY  - JOUR
AU  - Rasouli, Hassan
AU  - Ramalho, Teodorico C.
AU  - Popović-Djordjević, Jelena B.
AU  - Devkota, Hari Prasad
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6335
T2  - Frontiers in Pharmacology
T2  - Frontiers in Pharmacology
T1  - Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes
VL  - 14
DO  - 10.3389/fphar.2023.1187057
ER  - 

@article{
author = "Rasouli, Hassan and Ramalho, Teodorico C. and Popović-Djordjević, Jelena B. and Devkota, Hari Prasad",
year = "2023",
journal = "Frontiers in Pharmacology, Frontiers in Pharmacology",
title = "Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes",
volume = "14",
doi = "10.3389/fphar.2023.1187057"
}

Rasouli, H., Ramalho, T. C., Popović-Djordjević, J. B.,& Devkota, H. P.. (2023). Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes. in Frontiers in Pharmacology, 14.
https://doi.org/10.3389/fphar.2023.1187057

Rasouli H, Ramalho TC, Popović-Djordjević JB, Devkota HP. Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes. in Frontiers in Pharmacology. 2023;14.
doi:10.3389/fphar.2023.1187057 .

Rasouli, Hassan, Ramalho, Teodorico C., Popović-Djordjević, Jelena B., Devkota, Hari Prasad, "Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes" in Frontiers in Pharmacology, 14 (2023),
https://doi.org/10.3389/fphar.2023.1187057 . .

TY  - JOUR
AU  - Popović-Djordjević, Jelena B.
AU  - Katanić Stanković, Jelena S.
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6373
T2  - Current Topics in Medicinal Chemistry
T2  - Current Topics in Medicinal Chemistry
T1  - Natural Products: What can Nature Offer for the Promotion of Health?
EP  - 628
IS  - 8
SP  - 627
VL  - 23
DO  - 10.2174/156802662308230522111136
ER  - 

@article{
author = "Popović-Djordjević, Jelena B. and Katanić Stanković, Jelena S.",
year = "2023",
journal = "Current Topics in Medicinal Chemistry, Current Topics in Medicinal Chemistry",
title = "Natural Products: What can Nature Offer for the Promotion of Health?",
pages = "628-627",
number = "8",
volume = "23",
doi = "10.2174/156802662308230522111136"
}

Popović-Djordjević, J. B.,& Katanić Stanković, J. S.. (2023). Natural Products: What can Nature Offer for the Promotion of Health?. in Current Topics in Medicinal Chemistry, 23(8), 627-628.
https://doi.org/10.2174/156802662308230522111136

Popović-Djordjević JB, Katanić Stanković JS. Natural Products: What can Nature Offer for the Promotion of Health?. in Current Topics in Medicinal Chemistry. 2023;23(8):627-628.
doi:10.2174/156802662308230522111136 .

Popović-Djordjević, Jelena B., Katanić Stanković, Jelena S., "Natural Products: What can Nature Offer for the Promotion of Health?" in Current Topics in Medicinal Chemistry, 23, no. 8 (2023):627-628,
https://doi.org/10.2174/156802662308230522111136 . .

TY  - JOUR
AU  - Rasouli, Hassan
AU  - Ramalho, Teodorico C.
AU  - Popović-Djordjević, Jelena B.
AU  - Devkota, Hari Prasad
PY  - 2023
UR  - https://www.frontiersin.org/articles/10.3389/fphar.2023.1187057
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6374
T2  - Frontiers in Pharmacology
T2  - Frontiers in Pharmacology
T1  - Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes
VL  - 14
DO  - 10.3389/fphar.2023.1187057/full
ER  - 

@article{
author = "Rasouli, Hassan and Ramalho, Teodorico C. and Popović-Djordjević, Jelena B. and Devkota, Hari Prasad",
year = "2023",
journal = "Frontiers in Pharmacology, Frontiers in Pharmacology",
title = "Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes",
volume = "14",
doi = "10.3389/fphar.2023.1187057/full"
}

Rasouli, H., Ramalho, T. C., Popović-Djordjević, J. B.,& Devkota, H. P.. (2023). Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes. in Frontiers in Pharmacology, 14.
https://doi.org/10.3389/fphar.2023.1187057/full

Rasouli H, Ramalho TC, Popović-Djordjević JB, Devkota HP. Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes. in Frontiers in Pharmacology. 2023;14.
doi:10.3389/fphar.2023.1187057/full .

Rasouli, Hassan, Ramalho, Teodorico C., Popović-Djordjević, Jelena B., Devkota, Hari Prasad, "Editorial: New opportunities in drug design for the management and treatment of type 2 diabetes" in Frontiers in Pharmacology, 14 (2023),
https://doi.org/10.3389/fphar.2023.1187057/full . .

Koirala, N., Butnariu, M., Panthi, M., Gurung, R., Adhikari, S., Subba, R. K., Acharya, Z., Popović-Djordjević, J., Dhara, A. K., Nayak, A. K.,& Chattopadhyay, D.. (2023). Chapter 12 - Antibiotics in the management of tuberculosis and cancer. in Antibiotics - Therapeutic Spectrum and Limitations
Academic Press., 251-294.
https://hdl.handle.net/21.15107/rcub_agrospace_6408

Koirala N, Butnariu M, Panthi M, Gurung R, Adhikari S, Subba RK, Acharya Z, Popović-Djordjević J, Dhara AK, Nayak AK, Chattopadhyay D. Chapter 12 - Antibiotics in the management of tuberculosis and cancer. in Antibiotics - Therapeutic Spectrum and Limitations. 2023;:251-294.
https://hdl.handle.net/21.15107/rcub_agrospace_6408 .

Koirala, Niranjan, Butnariu, Monica, Panthi, Mamata, Gurung, Roshani, Adhikari, Sundar, Subba, Romit Kumar, Acharya, Zenisha, Popović-Djordjević, Jelena, Dhara, Amal Kumar, Nayak, Amit Kumar, Chattopadhyay, Debprasad, "Chapter 12 - Antibiotics in the management of tuberculosis and cancer" in Antibiotics - Therapeutic Spectrum and Limitations (2023):251-294,
https://hdl.handle.net/21.15107/rcub_agrospace_6408 .

TY  - JOUR
AU  - Hassani, Samira
AU  - Ghanbari, Fahimeh
AU  - Lotfi, Marzieh
AU  - Alam, Waqas
AU  - Aschner, Michael
AU  - Popović-Djordjević, Jelena
AU  - Shahcheraghi, Seyed Hossein
AU  - Khan, Haroon
PY  - 2023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/37755616
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6462
AB  - Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic compounds are of interest in the development of cancer drugs due to their medicinal properties and ability to target different molecular pathways. Gallic acid (GA), as one of the main components of phenol, which is abundantly present in plant compounds such as walnut, sumac, grapes, tea leaves, oak bark, and other plant compounds, has antitumor properties. GA can prevent cancer progression, cell invasion, and metastasis by targeting molecular pathways and is an effective complement to chemotherapy drugs and combating multidrug resistance (MDR). In this review, we discuss various mechanisms related to cancer, the therapeutic potential of GA, the antitumor properties of GA in various cancers, and the targeted delivery of GA with nanocarriers.
T2  - Medical Oncology (Northwood, London, England)
T2  - Medical Oncology (Northwood, London, England)Med Oncol
T1  - How gallic acid regulates molecular signaling: role in cancer drug resistance
IS  - 11
SP  - 308
VL  - 40
DO  - 10.1007/s12032-023-02178-4
ER  - 

@article{
author = "Hassani, Samira and Ghanbari, Fahimeh and Lotfi, Marzieh and Alam, Waqas and Aschner, Michael and Popović-Djordjević, Jelena and Shahcheraghi, Seyed Hossein and Khan, Haroon",
year = "2023",
abstract = "Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic compounds are of interest in the development of cancer drugs due to their medicinal properties and ability to target different molecular pathways. Gallic acid (GA), as one of the main components of phenol, which is abundantly present in plant compounds such as walnut, sumac, grapes, tea leaves, oak bark, and other plant compounds, has antitumor properties. GA can prevent cancer progression, cell invasion, and metastasis by targeting molecular pathways and is an effective complement to chemotherapy drugs and combating multidrug resistance (MDR). In this review, we discuss various mechanisms related to cancer, the therapeutic potential of GA, the antitumor properties of GA in various cancers, and the targeted delivery of GA with nanocarriers.",
journal = "Medical Oncology (Northwood, London, England), Medical Oncology (Northwood, London, England)Med Oncol",
title = "How gallic acid regulates molecular signaling: role in cancer drug resistance",
number = "11",
pages = "308",
volume = "40",
doi = "10.1007/s12032-023-02178-4"
}

Hassani, S., Ghanbari, F., Lotfi, M., Alam, W., Aschner, M., Popović-Djordjević, J., Shahcheraghi, S. H.,& Khan, H.. (2023). How gallic acid regulates molecular signaling: role in cancer drug resistance. in Medical Oncology (Northwood, London, England), 40(11), 308.
https://doi.org/10.1007/s12032-023-02178-4

Hassani S, Ghanbari F, Lotfi M, Alam W, Aschner M, Popović-Djordjević J, Shahcheraghi SH, Khan H. How gallic acid regulates molecular signaling: role in cancer drug resistance. in Medical Oncology (Northwood, London, England). 2023;40(11):308.
doi:10.1007/s12032-023-02178-4 .

Hassani, Samira, Ghanbari, Fahimeh, Lotfi, Marzieh, Alam, Waqas, Aschner, Michael, Popović-Djordjević, Jelena, Shahcheraghi, Seyed Hossein, Khan, Haroon, "How gallic acid regulates molecular signaling: role in cancer drug resistance" in Medical Oncology (Northwood, London, England), 40, no. 11 (2023):308,
https://doi.org/10.1007/s12032-023-02178-4 . .

TY  - JOUR
AU  - Jevremović, Stefan
AU  - Milivojević, Jasminka
AU  - Katanić Stanković, Jelena
AU  - Popović Đorđević, Jelena
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6537
AB  - Raspberry (Rubus idaeus L.) is the most important type of berry fruit in the Republic of Serbia. The bioaccumulation factor (BF) for the elements detected in the fruits of the raspberry cultivars 'Willamette' and 'Meeker' was calculated to determine their bioaccumulation potential. In addition, the nutritional quality of fruits in relation to nutritionally essential elements was evaluated and compared with the recommended daily intake. For determining the concentrations of 19 macro- and microelements in fruits and the soil, the analytical technique of optical emission spectrometry with inductively coupled plasma was used. Among the analyzed elements, As, Cd, Co, Cr, Li and Mo were below the limit of detection in the fruits of both raspberry cultivars, whereas Na and Ni were detected only in fruits of the 'Meeker' cultivar. All analyzed elements were detected in the soil. The results of the work indicated the high potential of the studied cultivars to accumulate nutritional elements K and Ca. In both raspberry cultivars, there were no substantial differences in the bioaccumulation of most elements. However, two elements (B and Mn) can be singled out; the BF for B in the 'Willamette' fruit was 3 times lower compared to the BF in the 'Meeker' fruit, whereas, the BF value for Mn in the 'Willamette' fruit was almost 8 times higher compared to the BF value for the 'Meeker' fruit. Furthermore, the cultivars did not tend to accumulate potentially toxic elements such as Ba, Co, Cu and Ni. The nutritional evaluation revealed that the studied raspberry fruits are a good source of K, Ca, Mg, Fe, Mn and Cu. Based on the BF values, differences observed in the accumulation of B, Ba, Na, Ni and Mn may be attributed to the characteristics of the cultivars.
PB  - Kragujevac University, Institute for Information Technologies
T2  - Book of Proceedings of 2nd International Conference on Chemo and Bioinformatics
T1  - Bioaccumulation potential of 'Meeker' and 'Willamette' raspberry (Rubus idaeus L.) fruits towards macro- and microelements and their nutritional evaluation
EP  - 155
SP  - 152
DO  - 10.46793/ICCBI23.152J
ER  - 

@article{
author = "Jevremović, Stefan and Milivojević, Jasminka and Katanić Stanković, Jelena and Popović Đorđević, Jelena",
year = "2023",
abstract = "Raspberry (Rubus idaeus L.) is the most important type of berry fruit in the Republic of Serbia. The bioaccumulation factor (BF) for the elements detected in the fruits of the raspberry cultivars 'Willamette' and 'Meeker' was calculated to determine their bioaccumulation potential. In addition, the nutritional quality of fruits in relation to nutritionally essential elements was evaluated and compared with the recommended daily intake. For determining the concentrations of 19 macro- and microelements in fruits and the soil, the analytical technique of optical emission spectrometry with inductively coupled plasma was used. Among the analyzed elements, As, Cd, Co, Cr, Li and Mo were below the limit of detection in the fruits of both raspberry cultivars, whereas Na and Ni were detected only in fruits of the 'Meeker' cultivar. All analyzed elements were detected in the soil. The results of the work indicated the high potential of the studied cultivars to accumulate nutritional elements K and Ca. In both raspberry cultivars, there were no substantial differences in the bioaccumulation of most elements. However, two elements (B and Mn) can be singled out; the BF for B in the 'Willamette' fruit was 3 times lower compared to the BF in the 'Meeker' fruit, whereas, the BF value for Mn in the 'Willamette' fruit was almost 8 times higher compared to the BF value for the 'Meeker' fruit. Furthermore, the cultivars did not tend to accumulate potentially toxic elements such as Ba, Co, Cu and Ni. The nutritional evaluation revealed that the studied raspberry fruits are a good source of K, Ca, Mg, Fe, Mn and Cu. Based on the BF values, differences observed in the accumulation of B, Ba, Na, Ni and Mn may be attributed to the characteristics of the cultivars.",
publisher = "Kragujevac University, Institute for Information Technologies",
journal = "Book of Proceedings of 2nd International Conference on Chemo and Bioinformatics",
title = "Bioaccumulation potential of 'Meeker' and 'Willamette' raspberry (Rubus idaeus L.) fruits towards macro- and microelements and their nutritional evaluation",
pages = "155-152",
doi = "10.46793/ICCBI23.152J"
}

Jevremović, S., Milivojević, J., Katanić Stanković, J.,& Popović Đorđević, J.. (2023). Bioaccumulation potential of 'Meeker' and 'Willamette' raspberry (Rubus idaeus L.) fruits towards macro- and microelements and their nutritional evaluation. in Book of Proceedings of 2nd International Conference on Chemo and Bioinformatics
Kragujevac University, Institute for Information Technologies., 152-155.
https://doi.org/10.46793/ICCBI23.152J

Jevremović S, Milivojević J, Katanić Stanković J, Popović Đorđević J. Bioaccumulation potential of 'Meeker' and 'Willamette' raspberry (Rubus idaeus L.) fruits towards macro- and microelements and their nutritional evaluation. in Book of Proceedings of 2nd International Conference on Chemo and Bioinformatics. 2023;:152-155.
doi:10.46793/ICCBI23.152J .

Jevremović, Stefan, Milivojević, Jasminka, Katanić Stanković, Jelena, Popović Đorđević, Jelena, "Bioaccumulation potential of 'Meeker' and 'Willamette' raspberry (Rubus idaeus L.) fruits towards macro- and microelements and their nutritional evaluation" in Book of Proceedings of 2nd International Conference on Chemo and Bioinformatics (2023):152-155,
https://doi.org/10.46793/ICCBI23.152J . .

TY  - CONF
AU  - Vasić, Dušan
AU  - Pećinar, Ilinka
AU  - Mićanović, Nenad
AU  - Luiz Fernando Cappa, de Oliveira
AU  - Popović-Đorđević, Jelena
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6814
AB  - Nowadays, Raman spectroscopy is widely utilized for analyzing various plant materials which provides data about the 
chemical composition and structural characteristics (“fingerprint”). It is also used for semi-quantitative and quantitative 
analyses [1,2]. This paper reports the evaluation of phytochemical composition of fruits that commonly grow in Serbia using 
Raman microspectroscopy, and the differentiation between the samples according to their chemical composition by apply ing Principal Component Analysis (PCA) of the obtained Raman spectra. Twelve fruits belonging to the families Rosaceae 
(red raspberry - Rubus idaeus L, blackberry -Rubus ceasius L., strawberry - Fragaria vesca L., rosehip - Rosa canina L., 
plum - Prunus domestica L., blackthorn - Prunus spinosa L., sour cherry - Prunus cerasus L., apple - Malus pumila Miller, 
common hawthorn - Crategus monogyna Jacq., medlar - Crataegus germanica L.), Grossulariaceae (red currant - Ribes 
rubra L.) and Ericaceae (blueberry - Vaccinium myrtillus L.) were studied. Fruits were selected with respect to their signifi cance in every-day diet and use in food industry. For fruits, Raman scattering was excited by wavelength of 785 nm using 
XploRA Raman spectrometer. PCA was performed using PAST software [3]. 
Food processing is essential to preserve and extend the shelf life of food products. Most of the studied fruits are intended 
for fresh consumption, whereas all of them can be processed. Apples, cherries and plums are processed, by juicing, mak ing syrups, fermentation or canning [4]. Berries could be used in products like fruit pulp, jams, juices, and nectars [5]. The 
blackthorn fruits are mostly used in jellies, syrups, vinegar, and conserves as well as for liquor making. Rosehip is used 
in the making of traditional probiotic drinks, soups, various beverages, whereas the fresh or dried fruits of hawthorn are 
used to make preserves, teas, and food supplements [6]. Medlar fruits are used to make jams, marmalades, jelly, candy, 
sauces, and wines [7]. 
The differences between the fruit samples related to the composition and structural diversity of the detected compounds 
were observed in the spectra, which confirmed the complexity of the studied fruits. The obtained spectra included char acteristic bands that may be associated to the most important compounds found in fruits, carbohydrates, carotenoids and 
phenolic compounds [1,2]. The band characteristic for the (C=C) structural feature of phenolics (around 1600 cm-1) was 
medium intensity in the Raman spectra of some berries (blackberry, strawberry, red currant), sour cherry and medlar, 
whereas a very week intensity band was observed in the raspberry and apple spectra. The band associated to (C=C) of 
flavonoids was weak and medium intensity in the spectra of hawthorn and blueberry, respectively. The most abundant 
macronutrients in the majority of the studied fruits are carbohydrates, and the bands related to this class of compounds 
appeared with different intensity in the 400-1460 cm-1 region. The carotenoids “fingerprint” was dominant in the rosehip 
and hawthorn spectra. The score plot of the first and second PCs described 66.18% of the data variance. It can be seen 
that the data along the PC1 axis can be divided into eight classes of objects: cherry, plum, thorn, blueberry, blackberry and 
apple differed from other fruit samples in carbohydrate content (according to higher intensity loadings at 393 and 1066 
cm-1), while hawthorn, rosehip, currant, strawberry and raspberry differed from the previously mentioned fruits in carotene 
content (loadings at 998, 1150 and 1516 cm-1). PC2 described mainly the similarities in carotenoid content between haw thorn, rosehip, sour cherry and plum, suggesting a similar carotenoid profile of these fruits. The obtained results confirmed 
the differences in the chemical profile of the studied fruits. Raman spectroscopy as a non-destructive, simple, rapid, low cost and eco-friendly method combined with PCA, could be used as a valuable tool for providing an insight into chemical 
profiles of the most consumed Serbian fruits.
T1  - Raman spectroscopy as a tool for chemical characterisation  of 12 Serbian fruits
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_6814
ER  - 

@conference{
author = "Vasić, Dušan and Pećinar, Ilinka and Mićanović, Nenad and Luiz Fernando Cappa, de Oliveira and Popović-Đorđević, Jelena",
year = "2023",
abstract = "Nowadays, Raman spectroscopy is widely utilized for analyzing various plant materials which provides data about the 
chemical composition and structural characteristics (“fingerprint”). It is also used for semi-quantitative and quantitative 
analyses [1,2]. This paper reports the evaluation of phytochemical composition of fruits that commonly grow in Serbia using 
Raman microspectroscopy, and the differentiation between the samples according to their chemical composition by apply ing Principal Component Analysis (PCA) of the obtained Raman spectra. Twelve fruits belonging to the families Rosaceae 
(red raspberry - Rubus idaeus L, blackberry -Rubus ceasius L., strawberry - Fragaria vesca L., rosehip - Rosa canina L., 
plum - Prunus domestica L., blackthorn - Prunus spinosa L., sour cherry - Prunus cerasus L., apple - Malus pumila Miller, 
common hawthorn - Crategus monogyna Jacq., medlar - Crataegus germanica L.), Grossulariaceae (red currant - Ribes 
rubra L.) and Ericaceae (blueberry - Vaccinium myrtillus L.) were studied. Fruits were selected with respect to their signifi cance in every-day diet and use in food industry. For fruits, Raman scattering was excited by wavelength of 785 nm using 
XploRA Raman spectrometer. PCA was performed using PAST software [3]. 
Food processing is essential to preserve and extend the shelf life of food products. Most of the studied fruits are intended 
for fresh consumption, whereas all of them can be processed. Apples, cherries and plums are processed, by juicing, mak ing syrups, fermentation or canning [4]. Berries could be used in products like fruit pulp, jams, juices, and nectars [5]. The 
blackthorn fruits are mostly used in jellies, syrups, vinegar, and conserves as well as for liquor making. Rosehip is used 
in the making of traditional probiotic drinks, soups, various beverages, whereas the fresh or dried fruits of hawthorn are 
used to make preserves, teas, and food supplements [6]. Medlar fruits are used to make jams, marmalades, jelly, candy, 
sauces, and wines [7]. 
The differences between the fruit samples related to the composition and structural diversity of the detected compounds 
were observed in the spectra, which confirmed the complexity of the studied fruits. The obtained spectra included char acteristic bands that may be associated to the most important compounds found in fruits, carbohydrates, carotenoids and 
phenolic compounds [1,2]. The band characteristic for the (C=C) structural feature of phenolics (around 1600 cm-1) was 
medium intensity in the Raman spectra of some berries (blackberry, strawberry, red currant), sour cherry and medlar, 
whereas a very week intensity band was observed in the raspberry and apple spectra. The band associated to (C=C) of 
flavonoids was weak and medium intensity in the spectra of hawthorn and blueberry, respectively. The most abundant 
macronutrients in the majority of the studied fruits are carbohydrates, and the bands related to this class of compounds 
appeared with different intensity in the 400-1460 cm-1 region. The carotenoids “fingerprint” was dominant in the rosehip 
and hawthorn spectra. The score plot of the first and second PCs described 66.18% of the data variance. It can be seen 
that the data along the PC1 axis can be divided into eight classes of objects: cherry, plum, thorn, blueberry, blackberry and 
apple differed from other fruit samples in carbohydrate content (according to higher intensity loadings at 393 and 1066 
cm-1), while hawthorn, rosehip, currant, strawberry and raspberry differed from the previously mentioned fruits in carotene 
content (loadings at 998, 1150 and 1516 cm-1). PC2 described mainly the similarities in carotenoid content between haw thorn, rosehip, sour cherry and plum, suggesting a similar carotenoid profile of these fruits. The obtained results confirmed 
the differences in the chemical profile of the studied fruits. Raman spectroscopy as a non-destructive, simple, rapid, low cost and eco-friendly method combined with PCA, could be used as a valuable tool for providing an insight into chemical 
profiles of the most consumed Serbian fruits.",
title = "Raman spectroscopy as a tool for chemical characterisation  of 12 Serbian fruits",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_6814"
}

Vasić, D., Pećinar, I., Mićanović, N., Luiz Fernando Cappa, d. O.,& Popović-Đorđević, J.. (2023). Raman spectroscopy as a tool for chemical characterisation  of 12 Serbian fruits. .
https://hdl.handle.net/21.15107/rcub_agrospace_6814

Vasić D, Pećinar I, Mićanović N, Luiz Fernando Cappa DO, Popović-Đorđević J. Raman spectroscopy as a tool for chemical characterisation  of 12 Serbian fruits. 2023;.
https://hdl.handle.net/21.15107/rcub_agrospace_6814 .

Vasić, Dušan, Pećinar, Ilinka, Mićanović, Nenad, Luiz Fernando Cappa, de Oliveira, Popović-Đorđević, Jelena, "Raman spectroscopy as a tool for chemical characterisation  of 12 Serbian fruits" (2023),
https://hdl.handle.net/21.15107/rcub_agrospace_6814 .

TY  - JOUR
AU  - Katanić Stanković, Jelena S.
AU  - Mićanović, Nenad
AU  - Grozdanić, Nadja
AU  - Kostić, Aleksandar Ž
AU  - Gašić, Uroš
AU  - Stanojković, Tatjana
AU  - Popović-Djordjević, Jelena B.
PY  - 2022
UR  - https://www.mdpi.com/2311-7524/8/11/1053
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6387
AB  - Plant-based food represents an excellent source of different nutrients and bioactive compounds, such as phenolics, carotenoids, vitamins, etc., with proven health benefits for humans. The content of selected phytochemicals, polyphenolic profile, and biological activity (antioxidant potential and α-glucosidase inhibitory activity) of fruit extracts of medlar (Mespilus germanica L.), blackthorn (Prunus spinosa L.), and common hawthorn (Crataegus monogyna Jacq.), the neglected Rosaceae species originated from Serbia were studied. Targeted UHPLC/(−)HESI–MS/MS quantitative analysis of phenolic compounds revealed pinocembrin only in medlar fruit extract, and it is the first report of this flavanone in medlar fruits. Total phenolic content did not differ between extracts, whereas significant differences were observed for the contents of total flavonoids, total phenolic acids, and total gallotannins. Monomeric anthocyanins and total anthocyanins were significantly higher in blackthorn compared to medlar and hawthorn fruit extracts (p < 0.05). DPPH· and ABTS·+ scavenging activities for examined fruits were modest compared to other natural antioxidants and BHT. The most potent inhibitory activity toward α-glucosidase expressed medlar and blackthorn extracts with IC50 values of 129.46 and 199.84 μg/mL, respectively, which was higher compared to the standard drug acarbose.
T2  - Horticulturae
T2  - Horticulturae
T1  - Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia
IS  - 11
SP  - 1053
VL  - 8
DO  - 10.3390/horticulturae8111053
ER  - 

@article{
author = "Katanić Stanković, Jelena S. and Mićanović, Nenad and Grozdanić, Nadja and Kostić, Aleksandar Ž and Gašić, Uroš and Stanojković, Tatjana and Popović-Djordjević, Jelena B.",
year = "2022",
abstract = "Plant-based food represents an excellent source of different nutrients and bioactive compounds, such as phenolics, carotenoids, vitamins, etc., with proven health benefits for humans. The content of selected phytochemicals, polyphenolic profile, and biological activity (antioxidant potential and α-glucosidase inhibitory activity) of fruit extracts of medlar (Mespilus germanica L.), blackthorn (Prunus spinosa L.), and common hawthorn (Crataegus monogyna Jacq.), the neglected Rosaceae species originated from Serbia were studied. Targeted UHPLC/(−)HESI–MS/MS quantitative analysis of phenolic compounds revealed pinocembrin only in medlar fruit extract, and it is the first report of this flavanone in medlar fruits. Total phenolic content did not differ between extracts, whereas significant differences were observed for the contents of total flavonoids, total phenolic acids, and total gallotannins. Monomeric anthocyanins and total anthocyanins were significantly higher in blackthorn compared to medlar and hawthorn fruit extracts (p < 0.05). DPPH· and ABTS·+ scavenging activities for examined fruits were modest compared to other natural antioxidants and BHT. The most potent inhibitory activity toward α-glucosidase expressed medlar and blackthorn extracts with IC50 values of 129.46 and 199.84 μg/mL, respectively, which was higher compared to the standard drug acarbose.",
journal = "Horticulturae, Horticulturae",
title = "Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia",
number = "11",
pages = "1053",
volume = "8",
doi = "10.3390/horticulturae8111053"
}

Katanić Stanković, J. S., Mićanović, N., Grozdanić, N., Kostić, A. Ž., Gašić, U., Stanojković, T.,& Popović-Djordjević, J. B.. (2022). Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia. in Horticulturae, 8(11), 1053.
https://doi.org/10.3390/horticulturae8111053

Katanić Stanković JS, Mićanović N, Grozdanić N, Kostić AŽ, Gašić U, Stanojković T, Popović-Djordjević JB. Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia. in Horticulturae. 2022;8(11):1053.
doi:10.3390/horticulturae8111053 .

Katanić Stanković, Jelena S., Mićanović, Nenad, Grozdanić, Nadja, Kostić, Aleksandar Ž, Gašić, Uroš, Stanojković, Tatjana, Popović-Djordjević, Jelena B., "Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia" in Horticulturae, 8, no. 11 (2022):1053,
https://doi.org/10.3390/horticulturae8111053 . .

TY  - JOUR
AU  - Popović-Djordjević, Jelena B.
AU  - Kostić, Aleksandar Ž.
AU  - Rajković, Miloš B.
AU  - Miljković, Irena
AU  - Krstić, Đurđa
AU  - Caruso, Gianluca
AU  - Siavash Moghaddam, Sina
AU  - Brčeski, Ilija
PY  - 2022
UR  - https://doi.org/10.1007/s12011-021-02639-9
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6389
AB  - Vegetables are important contributors to a healthy diet, and their adequate daily intake can help prevent some of the major illnesses. The aim of the study was to examine the content of the major and trace elements in selected organically grown (OG) and conventionally grown (CG) vegetables (cabbage, kohlrabi, Brussels sprout, beetroot, carrot, potato, and onion), taken from city green markets. Multi-elemental analysis was carried out by inductively coupled plasma method with optical emission spectrometry (ICP-OES). Nutritional quality evaluation in comparison to nutritional reference values was done. In studied vegetables, Al, Ca, K, Fe (with the exception of organic kohlrabi), Mg, Na, P, S, and Zn were quantified in all samples, whereas As, Cd, Co, Hg, Se, and V were below the limit of detection for these elements. Macroelements and trace elements were found at higher concentrations in OG and CG vegetables, respectively. Differences in concentrations of studied elements between the same vegetable species produced in two agricultural systems were significant, except for beetroot (p ≤ 0.05). Principal component analysis and hierarchical cluster analysis results showed that the botanical origin had higher influence on sample differentiation than the agronomic practice, which was in accordance with the results obtained by Mann-Whitney U test. Good quality of both OG and CG vegetables in respect of nutritionally beneficial elements was observed.
T2  - Biological Trace Element Research
T2  - Biological Trace Element ResearchBiol Trace Elem Res
T1  - Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation
EP  - 436
IS  - 1
SP  - 426
VL  - 200
DO  - 10.1007/s12011-021-02639-9
ER  - 

@article{
author = "Popović-Djordjević, Jelena B. and Kostić, Aleksandar Ž. and Rajković, Miloš B. and Miljković, Irena and Krstić, Đurđa and Caruso, Gianluca and Siavash Moghaddam, Sina and Brčeski, Ilija",
year = "2022",
abstract = "Vegetables are important contributors to a healthy diet, and their adequate daily intake can help prevent some of the major illnesses. The aim of the study was to examine the content of the major and trace elements in selected organically grown (OG) and conventionally grown (CG) vegetables (cabbage, kohlrabi, Brussels sprout, beetroot, carrot, potato, and onion), taken from city green markets. Multi-elemental analysis was carried out by inductively coupled plasma method with optical emission spectrometry (ICP-OES). Nutritional quality evaluation in comparison to nutritional reference values was done. In studied vegetables, Al, Ca, K, Fe (with the exception of organic kohlrabi), Mg, Na, P, S, and Zn were quantified in all samples, whereas As, Cd, Co, Hg, Se, and V were below the limit of detection for these elements. Macroelements and trace elements were found at higher concentrations in OG and CG vegetables, respectively. Differences in concentrations of studied elements between the same vegetable species produced in two agricultural systems were significant, except for beetroot (p ≤ 0.05). Principal component analysis and hierarchical cluster analysis results showed that the botanical origin had higher influence on sample differentiation than the agronomic practice, which was in accordance with the results obtained by Mann-Whitney U test. Good quality of both OG and CG vegetables in respect of nutritionally beneficial elements was observed.",
journal = "Biological Trace Element Research, Biological Trace Element ResearchBiol Trace Elem Res",
title = "Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation",
pages = "436-426",
number = "1",
volume = "200",
doi = "10.1007/s12011-021-02639-9"
}

Popović-Djordjević, J. B., Kostić, A. Ž., Rajković, M. B., Miljković, I., Krstić, Đ., Caruso, G., Siavash Moghaddam, S.,& Brčeski, I.. (2022). Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation. in Biological Trace Element Research, 200(1), 426-436.
https://doi.org/10.1007/s12011-021-02639-9

Popović-Djordjević JB, Kostić AŽ, Rajković MB, Miljković I, Krstić Đ, Caruso G, Siavash Moghaddam S, Brčeski I. Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation. in Biological Trace Element Research. 2022;200(1):426-436.
doi:10.1007/s12011-021-02639-9 .

Popović-Djordjević, Jelena B., Kostić, Aleksandar Ž., Rajković, Miloš B., Miljković, Irena, Krstić, Đurđa, Caruso, Gianluca, Siavash Moghaddam, Sina, Brčeski, Ilija, "Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation" in Biological Trace Element Research, 200, no. 1 (2022):426-436,
https://doi.org/10.1007/s12011-021-02639-9 . .

TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Špirović-Trifunović, Bojana
AU  - Pećinar, Ilinka
AU  - Fernando Cappa de Oliveira, Luiz
AU  - Krstić, Đurđa
AU  - Mihajlović, Dragana
AU  - Akšić, Milica Fotirić
AU  - Simal-Gandara, Jesus
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6235
AB  - Rosehip (Rosa canina L.) seeds are rich in bioactive compounds and nutrients and hence with a great potential to be employed in production of functional foods. This work aimed to evaluate the fatty acid composition of seed oil from wild and cultivated rosehip collected at different locations in the Republic of Serbia. Unsaturated fatty acids were dominant in majority of seed oil samples, with linoleic (LA), α-linolenic (ALA) and oleic (OA) acids (24.53–46.68 %, 4.73–12.39 % and 3.89–13.82 %, respectively) as the most abundant ones. Based on the analyses of most dominant bands in Raman spectra of seeds (∼1265 and ∼1660 cm-1) characteristic for unsaturated fatty acids, ANOVA revealed significantly higher content in two seed samples (5SW and 10SC). Ratios of UFAs/ SFAs, ω-6/ω-3 and LA/ALA and desirable fatty acids (DFA) indicated that most studied rosehip seed oils showed good quality. Factors such as genetic characteristics and agro-ecological conditions most likely affected FAs composition of seed oils. © 2022 The Authors
T2  - Industrial Crops and Products
T2  - Industrial Crops and Products
T1  - Fatty acids in seed oil of wild and cultivated rosehip (Rosa canina L.) from different locations in Serbia
VL  - 191
DO  - 10.1016/j.indcrop.2022.115797
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Špirović-Trifunović, Bojana and Pećinar, Ilinka and Fernando Cappa de Oliveira, Luiz and Krstić, Đurđa and Mihajlović, Dragana and Akšić, Milica Fotirić and Simal-Gandara, Jesus",
year = "2022",
abstract = "Rosehip (Rosa canina L.) seeds are rich in bioactive compounds and nutrients and hence with a great potential to be employed in production of functional foods. This work aimed to evaluate the fatty acid composition of seed oil from wild and cultivated rosehip collected at different locations in the Republic of Serbia. Unsaturated fatty acids were dominant in majority of seed oil samples, with linoleic (LA), α-linolenic (ALA) and oleic (OA) acids (24.53–46.68 %, 4.73–12.39 % and 3.89–13.82 %, respectively) as the most abundant ones. Based on the analyses of most dominant bands in Raman spectra of seeds (∼1265 and ∼1660 cm-1) characteristic for unsaturated fatty acids, ANOVA revealed significantly higher content in two seed samples (5SW and 10SC). Ratios of UFAs/ SFAs, ω-6/ω-3 and LA/ALA and desirable fatty acids (DFA) indicated that most studied rosehip seed oils showed good quality. Factors such as genetic characteristics and agro-ecological conditions most likely affected FAs composition of seed oils. © 2022 The Authors",
journal = "Industrial Crops and Products, Industrial Crops and Products",
title = "Fatty acids in seed oil of wild and cultivated rosehip (Rosa canina L.) from different locations in Serbia",
volume = "191",
doi = "10.1016/j.indcrop.2022.115797"
}

Popović-Djordjević, J., Špirović-Trifunović, B., Pećinar, I., Fernando Cappa de Oliveira, L., Krstić, Đ., Mihajlović, D., Akšić, M. F.,& Simal-Gandara, J.. (2022). Fatty acids in seed oil of wild and cultivated rosehip (Rosa canina L.) from different locations in Serbia. in Industrial Crops and Products, 191.
https://doi.org/10.1016/j.indcrop.2022.115797

Popović-Djordjević J, Špirović-Trifunović B, Pećinar I, Fernando Cappa de Oliveira L, Krstić Đ, Mihajlović D, Akšić MF, Simal-Gandara J. Fatty acids in seed oil of wild and cultivated rosehip (Rosa canina L.) from different locations in Serbia. in Industrial Crops and Products. 2022;191.
doi:10.1016/j.indcrop.2022.115797 .

Popović-Djordjević, Jelena, Špirović-Trifunović, Bojana, Pećinar, Ilinka, Fernando Cappa de Oliveira, Luiz, Krstić, Đurđa, Mihajlović, Dragana, Akšić, Milica Fotirić, Simal-Gandara, Jesus, "Fatty acids in seed oil of wild and cultivated rosehip (Rosa canina L.) from different locations in Serbia" in Industrial Crops and Products, 191 (2022),
https://doi.org/10.1016/j.indcrop.2022.115797 . .

TY  - JOUR
AU  - Popović-Djordjević, Jelena B.
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6248
AB  - The University of Belgrade was chosen to host an international conference “1st European Symposium on Phytochemicals in Medicine and Food”, that was successfully held on 7–9. September 2022 in Belgrade, the capital city of Serbia. The main goals of the conference were to promote the scientific achievements of researchers in the field of natural products and their implementation in food and medicine, as well as to bring together well recognized scientists from all around the world and young researchers that are starting their careers in the research fields covered by the conference topics. In that respect 1-EuSPMF fulfilled the expectations of the participants and the organizers. © 2022 The Authors. Food Frontiers published by John Wiley & Sons Australia, Ltd and Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University.
T2  - Food Frontiers
T2  - Food Frontiers
T1  - 1st European Symposium on Phytochemicals in Medicine and Food—Insight into the conference
DO  - 10.1002/fft2.195
ER  - 

@article{
author = "Popović-Djordjević, Jelena B.",
year = "2022",
abstract = "The University of Belgrade was chosen to host an international conference “1st European Symposium on Phytochemicals in Medicine and Food”, that was successfully held on 7–9. September 2022 in Belgrade, the capital city of Serbia. The main goals of the conference were to promote the scientific achievements of researchers in the field of natural products and their implementation in food and medicine, as well as to bring together well recognized scientists from all around the world and young researchers that are starting their careers in the research fields covered by the conference topics. In that respect 1-EuSPMF fulfilled the expectations of the participants and the organizers. © 2022 The Authors. Food Frontiers published by John Wiley & Sons Australia, Ltd and Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University.",
journal = "Food Frontiers, Food Frontiers",
title = "1st European Symposium on Phytochemicals in Medicine and Food—Insight into the conference",
doi = "10.1002/fft2.195"
}

Popović-Djordjević, J. B.. (2022). 1st European Symposium on Phytochemicals in Medicine and Food—Insight into the conference. in Food Frontiers.
https://doi.org/10.1002/fft2.195

Popović-Djordjević JB. 1st European Symposium on Phytochemicals in Medicine and Food—Insight into the conference. in Food Frontiers. 2022;.
doi:10.1002/fft2.195 .

Popović-Djordjević, Jelena B., "1st European Symposium on Phytochemicals in Medicine and Food—Insight into the conference" in Food Frontiers (2022),
https://doi.org/10.1002/fft2.195 . .

TY  - JOUR
AU  - Dolijanović, Željko
AU  - Nikolić, Svetlana Roljević
AU  - Dragicevic, Vesna
AU  - Mutić, Jelena
AU  - Šeremešić, Srđan
AU  - Jovović, Zoran
AU  - Popović Djordjević, Jelena
PY  - 2022
UR  - https://www.mdpi.com/2073-4395/12/6/1321
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6388
AB  - Tillage methods and intensity can be used as means of improving macronutrient and trace element concentration in soil and crops. A two-year field experiment was conducted to examine the impact of two cropping systems—intensive (ICS) and conservation (CCS), on the macro- and microelements in the soil and their accumulation in the grain of two cultivars of winter wheat. The experiment was conducted in a randomized complete block design with three replications of each tillage treatment. The results showed that the content of available N (0.7 kg ha−1) and organic matter (0.04%) slightly increased in CCS compared to ICS. The concentrations of Ca, K, and S macroelements and microelements such as Ba, Cr, Hg, and Sr in the soil were significantly higher in CCS than in ICS. Higher concentrations of macroelements K and P, microelements such as Fe, Zn, and As, and the greater value of the bioaccumulation factor for elements essential to humans such as P, Cu, Fe, and Zn, were also found in CCS compared to ICS. On the other hand, wheat cultivars grown in ICS were more efficient at accumulating macroelements and some trace elements than ones grown in CCS. While it is not without challenges, the conservation cropping system could represent an important part of the long-term strategy to sustainably improve soil fertility and the nutritional quality of the wheat grain.
T2  - Agronomy
T2  - Agronomy
T1  - Mineral Composition of Soil and the Wheat Grain in Intensive and Conservation Cropping Systems
IS  - 6
SP  - 1321
VL  - 12
DO  - 10.3390/agronomy12061321
ER  - 

@article{
author = "Dolijanović, Željko and Nikolić, Svetlana Roljević and Dragicevic, Vesna and Mutić, Jelena and Šeremešić, Srđan and Jovović, Zoran and Popović Djordjević, Jelena",
year = "2022",
abstract = "Tillage methods and intensity can be used as means of improving macronutrient and trace element concentration in soil and crops. A two-year field experiment was conducted to examine the impact of two cropping systems—intensive (ICS) and conservation (CCS), on the macro- and microelements in the soil and their accumulation in the grain of two cultivars of winter wheat. The experiment was conducted in a randomized complete block design with three replications of each tillage treatment. The results showed that the content of available N (0.7 kg ha−1) and organic matter (0.04%) slightly increased in CCS compared to ICS. The concentrations of Ca, K, and S macroelements and microelements such as Ba, Cr, Hg, and Sr in the soil were significantly higher in CCS than in ICS. Higher concentrations of macroelements K and P, microelements such as Fe, Zn, and As, and the greater value of the bioaccumulation factor for elements essential to humans such as P, Cu, Fe, and Zn, were also found in CCS compared to ICS. On the other hand, wheat cultivars grown in ICS were more efficient at accumulating macroelements and some trace elements than ones grown in CCS. While it is not without challenges, the conservation cropping system could represent an important part of the long-term strategy to sustainably improve soil fertility and the nutritional quality of the wheat grain.",
journal = "Agronomy, Agronomy",
title = "Mineral Composition of Soil and the Wheat Grain in Intensive and Conservation Cropping Systems",
number = "6",
pages = "1321",
volume = "12",
doi = "10.3390/agronomy12061321"
}

Dolijanović, Ž., Nikolić, S. R., Dragicevic, V., Mutić, J., Šeremešić, S., Jovović, Z.,& Popović Djordjević, J.. (2022). Mineral Composition of Soil and the Wheat Grain in Intensive and Conservation Cropping Systems. in Agronomy, 12(6), 1321.
https://doi.org/10.3390/agronomy12061321

Dolijanović Ž, Nikolić SR, Dragicevic V, Mutić J, Šeremešić S, Jovović Z, Popović Djordjević J. Mineral Composition of Soil and the Wheat Grain in Intensive and Conservation Cropping Systems. in Agronomy. 2022;12(6):1321.
doi:10.3390/agronomy12061321 .

Dolijanović, Željko, Nikolić, Svetlana Roljević, Dragicevic, Vesna, Mutić, Jelena, Šeremešić, Srđan, Jovović, Zoran, Popović Djordjević, Jelena, "Mineral Composition of Soil and the Wheat Grain in Intensive and Conservation Cropping Systems" in Agronomy, 12, no. 6 (2022):1321,
https://doi.org/10.3390/agronomy12061321 . .

TY  - JOUR
AU  - Jaćimović, Simona
AU  - Popović-Djordjević, Jelena
AU  - Sarić, Beka
AU  - Krstić, Aleksandar
AU  - Mickovski-Stefanović, Violeta
AU  - Pantelić, Nebojša Đ
PY  - 2022
UR  - https://www.mdpi.com/2304-8158/11/10/1445
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6390
AB  - Cocoa beans are part of the cocoa plant fruit (Theobroma cacao L.) used to prepare various products such as chocolate, cocoa butter, jelly, liqueurs, cosmetics, etc. Dark chocolate is consumed worldwide by different populations and is known for its good taste, making it one of the most favoured food products. This work aimed to determine the content of total polyphenols (TPC), total flavonoids (TFC), and the antioxidant potential measured through the ability to scavenge DPPH free radicals (DPPH), ferric reducing power (FRAP), and total antioxidant capacity (TAC), as well as major and trace elements contained in twelve commercially available dark chocolate samples, with cocoa content ranging from 40% to 99%. The total polyphenols content ranged between 10.55 and 39.82 mg/g GAE, while the total flavonoid content was from 10.04 to 37.85 mg/g CE. All applied antioxidant assays indicate that the sample with the highest cocoa percentage shows the greatest antioxidant activity (DPPH: 48.34% of inhibition; FRAP: 89.00 mg/g GAE; TAC: 83.86 mg/g AAE). Statistical methods were applied to establish the differences between the samples concerning TPC, TFC, DPPH, FRAP and TAC, as well as to differentiate the samples according to the mineral content. The results indicated that the differences in TPC and TFC between different samples depended on the cocoa content and the addition of dried fruit pieces. A good correlation between antioxidant potency composite index (ACI) and declared cocoa content was noticed (R2 = 0.8034), indicating that the declared percentage of cocoa is a reliable indicator for antioxidant activity of analysed dark chocolate samples. The nutritional evaluation proved that the studied chocolate samples were an excellent source of Mg, Fe, Mn and Cu.
T2  - Foods
T2  - Foods
T1  - Antioxidant Activity and Multi-Elemental Analysis of Dark Chocolate
IS  - 10
SP  - 1445
VL  - 11
DO  - 10.3390/foods11101445
ER  - 

@article{
author = "Jaćimović, Simona and Popović-Djordjević, Jelena and Sarić, Beka and Krstić, Aleksandar and Mickovski-Stefanović, Violeta and Pantelić, Nebojša Đ",
year = "2022",
abstract = "Cocoa beans are part of the cocoa plant fruit (Theobroma cacao L.) used to prepare various products such as chocolate, cocoa butter, jelly, liqueurs, cosmetics, etc. Dark chocolate is consumed worldwide by different populations and is known for its good taste, making it one of the most favoured food products. This work aimed to determine the content of total polyphenols (TPC), total flavonoids (TFC), and the antioxidant potential measured through the ability to scavenge DPPH free radicals (DPPH), ferric reducing power (FRAP), and total antioxidant capacity (TAC), as well as major and trace elements contained in twelve commercially available dark chocolate samples, with cocoa content ranging from 40% to 99%. The total polyphenols content ranged between 10.55 and 39.82 mg/g GAE, while the total flavonoid content was from 10.04 to 37.85 mg/g CE. All applied antioxidant assays indicate that the sample with the highest cocoa percentage shows the greatest antioxidant activity (DPPH: 48.34% of inhibition; FRAP: 89.00 mg/g GAE; TAC: 83.86 mg/g AAE). Statistical methods were applied to establish the differences between the samples concerning TPC, TFC, DPPH, FRAP and TAC, as well as to differentiate the samples according to the mineral content. The results indicated that the differences in TPC and TFC between different samples depended on the cocoa content and the addition of dried fruit pieces. A good correlation between antioxidant potency composite index (ACI) and declared cocoa content was noticed (R2 = 0.8034), indicating that the declared percentage of cocoa is a reliable indicator for antioxidant activity of analysed dark chocolate samples. The nutritional evaluation proved that the studied chocolate samples were an excellent source of Mg, Fe, Mn and Cu.",
journal = "Foods, Foods",
title = "Antioxidant Activity and Multi-Elemental Analysis of Dark Chocolate",
number = "10",
pages = "1445",
volume = "11",
doi = "10.3390/foods11101445"
}

Jaćimović, S., Popović-Djordjević, J., Sarić, B., Krstić, A., Mickovski-Stefanović, V.,& Pantelić, N. Đ.. (2022). Antioxidant Activity and Multi-Elemental Analysis of Dark Chocolate. in Foods, 11(10), 1445.
https://doi.org/10.3390/foods11101445

Jaćimović S, Popović-Djordjević J, Sarić B, Krstić A, Mickovski-Stefanović V, Pantelić NĐ. Antioxidant Activity and Multi-Elemental Analysis of Dark Chocolate. in Foods. 2022;11(10):1445.
doi:10.3390/foods11101445 .

Jaćimović, Simona, Popović-Djordjević, Jelena, Sarić, Beka, Krstić, Aleksandar, Mickovski-Stefanović, Violeta, Pantelić, Nebojša Đ, "Antioxidant Activity and Multi-Elemental Analysis of Dark Chocolate" in Foods, 11, no. 10 (2022):1445,
https://doi.org/10.3390/foods11101445 . .

Popović-Djordjević, J. B., Fotirić Akšić, M., Katanić Stanković, J. S., Pantelić, N. Đ., Mihailović, V.,& Aftab, T.. (2022). Wild-Growing Species in the Service of Medicine: Environmental Challenges and Sustainable Production. in Environmental Challenges and Medicinal Plants: Sustainable Production Solutions under Adverse Conditions
Springer International Publishing., 49-104.
https://hdl.handle.net/21.15107/rcub_agrospace_6409

Popović-Djordjević JB, Fotirić Akšić M, Katanić Stanković JS, Pantelić NĐ, Mihailović V, Aftab T. Wild-Growing Species in the Service of Medicine: Environmental Challenges and Sustainable Production. in Environmental Challenges and Medicinal Plants: Sustainable Production Solutions under Adverse Conditions. 2022;:49-104.
https://hdl.handle.net/21.15107/rcub_agrospace_6409 .

Popović-Djordjević, Jelena B., Fotirić Akšić, Milica, Katanić Stanković, Jelena S., Pantelić, Nebojša Đ., Mihailović, Vladimir, Aftab, Tariq, "Wild-Growing Species in the Service of Medicine: Environmental Challenges and Sustainable Production" in Environmental Challenges and Medicinal Plants: Sustainable Production Solutions under Adverse Conditions (2022):49-104,
https://hdl.handle.net/21.15107/rcub_agrospace_6409 .

TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Quispe, Cristina
AU  - Giordo, Roberta
AU  - Kostić, Aleksandar
AU  - Katanić Stanković, Jelena S.
AU  - Tsouh Fokoue, Patrick Valere
AU  - Carbone, Katya
AU  - Martorell, Miquel
AU  - Kumar, Manoj
AU  - Pintus, Gianfranco
AU  - Sharifi-Rad, Javad
AU  - Docea, Anca Oana
AU  - Calina, Daniela
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6044
AB  - The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.
PB  - Elsevier Masson s.r.l.
T2  - European Journal of Medicinal Chemistry
T1  - Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs
SP  - 114217
VL  - 233
DO  - 10.1016/j.ejmech.2022.114217
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Quispe, Cristina and Giordo, Roberta and Kostić, Aleksandar and Katanić Stanković, Jelena S. and Tsouh Fokoue, Patrick Valere and Carbone, Katya and Martorell, Miquel and Kumar, Manoj and Pintus, Gianfranco and Sharifi-Rad, Javad and Docea, Anca Oana and Calina, Daniela",
year = "2022",
abstract = "The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.",
publisher = "Elsevier Masson s.r.l.",
journal = "European Journal of Medicinal Chemistry",
title = "Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs",
pages = "114217",
volume = "233",
doi = "10.1016/j.ejmech.2022.114217"
}

Popović-Djordjević, J., Quispe, C., Giordo, R., Kostić, A., Katanić Stanković, J. S., Tsouh Fokoue, P. V., Carbone, K., Martorell, M., Kumar, M., Pintus, G., Sharifi-Rad, J., Docea, A. O.,& Calina, D.. (2022). Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. in European Journal of Medicinal Chemistry
Elsevier Masson s.r.l.., 233, 114217.
https://doi.org/10.1016/j.ejmech.2022.114217

Popović-Djordjević J, Quispe C, Giordo R, Kostić A, Katanić Stanković JS, Tsouh Fokoue PV, Carbone K, Martorell M, Kumar M, Pintus G, Sharifi-Rad J, Docea AO, Calina D. Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. in European Journal of Medicinal Chemistry. 2022;233:114217.
doi:10.1016/j.ejmech.2022.114217 .

Popović-Djordjević, Jelena, Quispe, Cristina, Giordo, Roberta, Kostić, Aleksandar, Katanić Stanković, Jelena S., Tsouh Fokoue, Patrick Valere, Carbone, Katya, Martorell, Miquel, Kumar, Manoj, Pintus, Gianfranco, Sharifi-Rad, Javad, Docea, Anca Oana, Calina, Daniela, "Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs" in European Journal of Medicinal Chemistry, 233 (2022):114217,
https://doi.org/10.1016/j.ejmech.2022.114217 . .

TY  - JOUR
AU  - Mokhtar Mohamed Abdelahi, Mohamed
AU  - El Bakri, Youness
AU  - Lai, Chin-Hung
AU  - Subramani, Karthikeyan
AU  - Anouar, El Hassane
AU  - Ahmad, Sajjad
AU  - Benchidmi, Mohammed
AU  - Mague, Joel T.
AU  - Popović-Djordjević, Jelena
AU  - Goumri-Said, Souraya
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6001
AB  - An efficient pathway was disclosed for the synthesis of 3-chloro-6-nitro-1H-indazole derivatives by 1,3-dipolar cycloaddition on dipolarophile compounds 2 and 3. Faced the problem of separation of two regioisomers, a click chemistry method has allowed us to obtain regioisomers of triazole-1,4 with good yields from 82 to 90% were employed. Also, the antileishmanial biological potency of the compounds was achieved using an MTT assay that reported compound 13 as a promising growth inhibitor of Leishmania major. Molecular docking demonstrated highly stable binding with the Leishmania trypanothione reductase enzyme and produced a network of hydrophobic and hydrophilic interactions. Molecular dynamics simulations were performed for TryR-13 complex to understand its structural and intermolecular affinity stability in a biological environment. The studied complex remained in good equilibrium with a structure deviation of ∼1–3 Å. MM/GBSA binding free energies illustrated the high stability of TryR-13 complex. The studied compounds are promising leads for structural optimisation to enhance the antileishmanial activity.
PB  - Taylor and Francis Ltd.
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Novel 3-chloro-6-nitro-1H-indazole derivatives as promising antileishmanial candidates: synthesis, biological activity, and molecular modelling studies
EP  - 167
IS  - 1
SP  - 151
VL  - 37
DO  - 10.1080/14756366.2021.1995380
ER  - 

@article{
author = "Mokhtar Mohamed Abdelahi, Mohamed and El Bakri, Youness and Lai, Chin-Hung and Subramani, Karthikeyan and Anouar, El Hassane and Ahmad, Sajjad and Benchidmi, Mohammed and Mague, Joel T. and Popović-Djordjević, Jelena and Goumri-Said, Souraya",
year = "2022",
abstract = "An efficient pathway was disclosed for the synthesis of 3-chloro-6-nitro-1H-indazole derivatives by 1,3-dipolar cycloaddition on dipolarophile compounds 2 and 3. Faced the problem of separation of two regioisomers, a click chemistry method has allowed us to obtain regioisomers of triazole-1,4 with good yields from 82 to 90% were employed. Also, the antileishmanial biological potency of the compounds was achieved using an MTT assay that reported compound 13 as a promising growth inhibitor of Leishmania major. Molecular docking demonstrated highly stable binding with the Leishmania trypanothione reductase enzyme and produced a network of hydrophobic and hydrophilic interactions. Molecular dynamics simulations were performed for TryR-13 complex to understand its structural and intermolecular affinity stability in a biological environment. The studied complex remained in good equilibrium with a structure deviation of ∼1–3 Å. MM/GBSA binding free energies illustrated the high stability of TryR-13 complex. The studied compounds are promising leads for structural optimisation to enhance the antileishmanial activity.",
publisher = "Taylor and Francis Ltd.",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Novel 3-chloro-6-nitro-1H-indazole derivatives as promising antileishmanial candidates: synthesis, biological activity, and molecular modelling studies",
pages = "167-151",
number = "1",
volume = "37",
doi = "10.1080/14756366.2021.1995380"
}

Mokhtar Mohamed Abdelahi, M., El Bakri, Y., Lai, C., Subramani, K., Anouar, E. H., Ahmad, S., Benchidmi, M., Mague, J. T., Popović-Djordjević, J.,& Goumri-Said, S.. (2022). Novel 3-chloro-6-nitro-1H-indazole derivatives as promising antileishmanial candidates: synthesis, biological activity, and molecular modelling studies. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor and Francis Ltd.., 37(1), 151-167.
https://doi.org/10.1080/14756366.2021.1995380

Mokhtar Mohamed Abdelahi M, El Bakri Y, Lai C, Subramani K, Anouar EH, Ahmad S, Benchidmi M, Mague JT, Popović-Djordjević J, Goumri-Said S. Novel 3-chloro-6-nitro-1H-indazole derivatives as promising antileishmanial candidates: synthesis, biological activity, and molecular modelling studies. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2022;37(1):151-167.
doi:10.1080/14756366.2021.1995380 .

Mokhtar Mohamed Abdelahi, Mohamed, El Bakri, Youness, Lai, Chin-Hung, Subramani, Karthikeyan, Anouar, El Hassane, Ahmad, Sajjad, Benchidmi, Mohammed, Mague, Joel T., Popović-Djordjević, Jelena, Goumri-Said, Souraya, "Novel 3-chloro-6-nitro-1H-indazole derivatives as promising antileishmanial candidates: synthesis, biological activity, and molecular modelling studies" in Journal of Enzyme Inhibition and Medicinal Chemistry, 37, no. 1 (2022):151-167,
https://doi.org/10.1080/14756366.2021.1995380 . .

TY  - JOUR
AU  - Lakićević, Svetlana H.
AU  - Karabegović, Ivana T.
AU  - Cvetković, Dragan J.
AU  - Lazić, Miodrag L.
AU  - Jančić, Rade
AU  - Popović-Djordjević, Jelena B.
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6068
AB  - Autochthones grape variety of ‘Prokupac’ (Vitis vinifera L.) is being increasingly cultivated in the Republic of Serbia and is one of the predominant varieties in the vineyards of southern Serbia. ‘Prokupac’ grapes are used to produce red wine with specific and distinctive varietal aromatic characteristics. Medicinal herbs can be effectively combined in alcoholic beverages. The aim of this study was to evaluate the effect of medicinal herbs on the aroma profile and sensory characteristics of ‘Prokupac’ red wine. The analysis of the aromatic composition was conducted on ‘Prokupac’ wine (control) and ‘Prokupac’ wine aromatised with selected medicinal herbs: anise (Pimpinella anisum L.), cinnamon (Cinnamomum verum J. Presl.), wormwood (Artemisia absinthium L.) and licorice (Glycyrrhiza glabra L.). The analysis of volatile aromatic compounds in the wines, performed by the gas chromatography-mass spectrometry (GC/MS) method, identified 48 compounds that were classified in the following groups: alcohols, aldehydes, ketones, acids, ethyl esters and terpenes. Sensory analysis of wines was performed including visual, olfactory, gustatory and gustatory-olfactory perceptions. Terpenes were not identified in the ‘Prokupac’ control wine, while the highest content of all identified aromatic compounds was found in wines aromatised with anise, wormwood and cinnamon. The results indicated that selected medicinal herbs affected the composition and content of volatile aromatic compounds, as well as the sensory characteristics of analyzed wines. The unique aroma profile and pleasant taste of the wine aromatised with cinnamon contributed to its differentiation from other wines, and classification as very good wine.
PB  - MDPI
T2  - Horticulturae
T1  - Insight into the Aroma Profile and Sensory Characteristics of ‘Prokupac’ Red Wine Aromatised with Medicinal Herbs
IS  - 4
SP  - 277
VL  - 8
DO  - 10.3390/horticulturae8040277
ER  - 

@article{
author = "Lakićević, Svetlana H. and Karabegović, Ivana T. and Cvetković, Dragan J. and Lazić, Miodrag L. and Jančić, Rade and Popović-Djordjević, Jelena B.",
year = "2022",
abstract = "Autochthones grape variety of ‘Prokupac’ (Vitis vinifera L.) is being increasingly cultivated in the Republic of Serbia and is one of the predominant varieties in the vineyards of southern Serbia. ‘Prokupac’ grapes are used to produce red wine with specific and distinctive varietal aromatic characteristics. Medicinal herbs can be effectively combined in alcoholic beverages. The aim of this study was to evaluate the effect of medicinal herbs on the aroma profile and sensory characteristics of ‘Prokupac’ red wine. The analysis of the aromatic composition was conducted on ‘Prokupac’ wine (control) and ‘Prokupac’ wine aromatised with selected medicinal herbs: anise (Pimpinella anisum L.), cinnamon (Cinnamomum verum J. Presl.), wormwood (Artemisia absinthium L.) and licorice (Glycyrrhiza glabra L.). The analysis of volatile aromatic compounds in the wines, performed by the gas chromatography-mass spectrometry (GC/MS) method, identified 48 compounds that were classified in the following groups: alcohols, aldehydes, ketones, acids, ethyl esters and terpenes. Sensory analysis of wines was performed including visual, olfactory, gustatory and gustatory-olfactory perceptions. Terpenes were not identified in the ‘Prokupac’ control wine, while the highest content of all identified aromatic compounds was found in wines aromatised with anise, wormwood and cinnamon. The results indicated that selected medicinal herbs affected the composition and content of volatile aromatic compounds, as well as the sensory characteristics of analyzed wines. The unique aroma profile and pleasant taste of the wine aromatised with cinnamon contributed to its differentiation from other wines, and classification as very good wine.",
publisher = "MDPI",
journal = "Horticulturae",
title = "Insight into the Aroma Profile and Sensory Characteristics of ‘Prokupac’ Red Wine Aromatised with Medicinal Herbs",
number = "4",
pages = "277",
volume = "8",
doi = "10.3390/horticulturae8040277"
}

Lakićević, S. H., Karabegović, I. T., Cvetković, D. J., Lazić, M. L., Jančić, R.,& Popović-Djordjević, J. B.. (2022). Insight into the Aroma Profile and Sensory Characteristics of ‘Prokupac’ Red Wine Aromatised with Medicinal Herbs. in Horticulturae
MDPI., 8(4), 277.
https://doi.org/10.3390/horticulturae8040277

Lakićević SH, Karabegović IT, Cvetković DJ, Lazić ML, Jančić R, Popović-Djordjević JB. Insight into the Aroma Profile and Sensory Characteristics of ‘Prokupac’ Red Wine Aromatised with Medicinal Herbs. in Horticulturae. 2022;8(4):277.
doi:10.3390/horticulturae8040277 .

Lakićević, Svetlana H., Karabegović, Ivana T., Cvetković, Dragan J., Lazić, Miodrag L., Jančić, Rade, Popović-Djordjević, Jelena B., "Insight into the Aroma Profile and Sensory Characteristics of ‘Prokupac’ Red Wine Aromatised with Medicinal Herbs" in Horticulturae, 8, no. 4 (2022):277,
https://doi.org/10.3390/horticulturae8040277 . .

TY  - JOUR
AU  - Popović-Đorđević, Jelena
PY  - 2021
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5917
PB  - Bentham Science Publishers
T2  - Current Medicinal Chemistry
T1  - Hot natural products for the prevention and treatment of diabetes mellitus (dm)
EP  - 4591
IS  - 23
SP  - 4590
VL  - 28
DO  - 10.2174/092986732823210802143522
ER  - 

@article{
author = "Popović-Đorđević, Jelena",
year = "2021",
publisher = "Bentham Science Publishers",
journal = "Current Medicinal Chemistry",
title = "Hot natural products for the prevention and treatment of diabetes mellitus (dm)",
pages = "4591-4590",
number = "23",
volume = "28",
doi = "10.2174/092986732823210802143522"
}

Popović-Đorđević, J.. (2021). Hot natural products for the prevention and treatment of diabetes mellitus (dm). in Current Medicinal Chemistry
Bentham Science Publishers., 28(23), 4590-4591.
https://doi.org/10.2174/092986732823210802143522

Popović-Đorđević J. Hot natural products for the prevention and treatment of diabetes mellitus (dm). in Current Medicinal Chemistry. 2021;28(23):4590-4591.
doi:10.2174/092986732823210802143522 .

Popović-Đorđević, Jelena, "Hot natural products for the prevention and treatment of diabetes mellitus (dm)" in Current Medicinal Chemistry, 28, no. 23 (2021):4590-4591,
https://doi.org/10.2174/092986732823210802143522 . .

TY  - JOUR
AU  - Pećinar, Ilinka
AU  - Krstić, Djurdja
AU  - Caruso, Gianluca
AU  - Popović-Djordjević, Jelena
PY  - 2021
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5825
AB  - Rosehip (pseudo-fruit) of dog rose (Rosa canina L.) is highly valued, and owing to nutritional and sensory properties it has a significant place in the food industry. This work represents an innovative report focusing on the evaluation of the phytochemical composition of rosehips (hypanthium and seed) grown in different locations in Serbia, using Raman microspectroscopy combined with multivariate data analysis. Some significant differences arose between the analysed rosehip samples with regard to the chemical profile of both hypanthium parenchyma cells and seed, although no evident discrimination was recorded between the samples of wild and cultivated rosehip. The differences between the hypanthium samples compared were mainly determined by the content of carotenoids, phenolic compounds and polysaccharides, whereas phenolics, polysaccharides (pectin, cellulose and hemicellulose) and lipids (to a lower extent) contributed to the seed sample discrimination. The differences observed between the rosehip samples may be attributed to abiotic factors (growing, ripening and storage conditions), which had a significant impact on the carotenoid and polyphenols biosynthesis.
PB  - Royal Society Publishing
T2  - Royal Society Open Science
T1  - Rapid characterization of hypanthium and seed in wild and cultivated rosehip: application of Raman microscopy combined with multivariate analysis
IS  - 3
SP  - 202064
VL  - 8
DO  - 10.1098/rsos.202064
ER  - 

@article{
author = "Pećinar, Ilinka and Krstić, Djurdja and Caruso, Gianluca and Popović-Djordjević, Jelena",
year = "2021",
abstract = "Rosehip (pseudo-fruit) of dog rose (Rosa canina L.) is highly valued, and owing to nutritional and sensory properties it has a significant place in the food industry. This work represents an innovative report focusing on the evaluation of the phytochemical composition of rosehips (hypanthium and seed) grown in different locations in Serbia, using Raman microspectroscopy combined with multivariate data analysis. Some significant differences arose between the analysed rosehip samples with regard to the chemical profile of both hypanthium parenchyma cells and seed, although no evident discrimination was recorded between the samples of wild and cultivated rosehip. The differences between the hypanthium samples compared were mainly determined by the content of carotenoids, phenolic compounds and polysaccharides, whereas phenolics, polysaccharides (pectin, cellulose and hemicellulose) and lipids (to a lower extent) contributed to the seed sample discrimination. The differences observed between the rosehip samples may be attributed to abiotic factors (growing, ripening and storage conditions), which had a significant impact on the carotenoid and polyphenols biosynthesis.",
publisher = "Royal Society Publishing",
journal = "Royal Society Open Science",
title = "Rapid characterization of hypanthium and seed in wild and cultivated rosehip: application of Raman microscopy combined with multivariate analysis",
number = "3",
pages = "202064",
volume = "8",
doi = "10.1098/rsos.202064"
}

Pećinar, I., Krstić, D., Caruso, G.,& Popović-Djordjević, J.. (2021). Rapid characterization of hypanthium and seed in wild and cultivated rosehip: application of Raman microscopy combined with multivariate analysis. in Royal Society Open Science
Royal Society Publishing., 8(3), 202064.
https://doi.org/10.1098/rsos.202064

Pećinar I, Krstić D, Caruso G, Popović-Djordjević J. Rapid characterization of hypanthium and seed in wild and cultivated rosehip: application of Raman microscopy combined with multivariate analysis. in Royal Society Open Science. 2021;8(3):202064.
doi:10.1098/rsos.202064 .

Pećinar, Ilinka, Krstić, Djurdja, Caruso, Gianluca, Popović-Djordjević, Jelena, "Rapid characterization of hypanthium and seed in wild and cultivated rosehip: application of Raman microscopy combined with multivariate analysis" in Royal Society Open Science, 8, no. 3 (2021):202064,
https://doi.org/10.1098/rsos.202064 . .

TY  - JOUR
AU  - Mousavi, Afsaneh
AU  - Pourakbar, Latifeh
AU  - Moghaddam, Sina Siavash
AU  - Popović-Djordjević, Jelena
PY  - 2021
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5842
AB  - The effects of Cd application alone or along with ethylenediaminetetraacetic acid (EDTA) and maleic acid (MA) were explored in okra (Abelmoschus esculentus.L.). Okra plants were planted in hydroponic conditions and in the 4-leaf stage, they were exposed to cadmium nitrate at three levels (0, 50, and 100 mg/L) and/or EDTA and MA at two levels (0.5 and 1.0 mM) and the combined application of different Cd concentrations with EDTA and MA for one month. The results showed a decrease in shoot and root dry weight and length and an increase in malondialdehyde (MDA), cell death, Cd accumulation, anthocyanins, and phenol and total flavonoid contents in the Cd-treated plants. The application of EDTA and MA alleviated the detrimental impacts of Cd on the okra plants by the improved management of translocation, compartmentation, and tolerance index. HPLC method revealed that rosmaric and coumaric acids were the most abundant phenolic compounds among the studied compounds. The variations of the phenolic compounds in the Cd-treated plants versus the control showed that the greatest increase was in chlorogenic acid (101.91%) and the greatest decline in coumaric acid (60.90%). The highest increase and decrease in the plants exposed to Cd with EDTA or MA versus the plants only exposed to Cd were related to coumaric acid (106.60%) and chlorogenic acid (43.45%) related to the treatment of 100 mg/L Cd +1 mM MA, respectively. In conclusion, okra has good potential for the phytoremediation of Cd and the EDTA and MA increased the phytoextraction efficiency.
PB  - Elsevier Ltd
T2  - Journal of Environmental Chemical Engineering
T1  - The effect of the exogenous application of EDTA and maleic acid on tolerance, phenolic compounds, and cadmium phytoremediation by okra (Abelmoschus esculentus L.) exposed to Cd stress
IS  - 4
SP  - 105456
VL  - 9
DO  - 10.1016/j.jece.2021.105456
ER  - 

@article{
author = "Mousavi, Afsaneh and Pourakbar, Latifeh and Moghaddam, Sina Siavash and Popović-Djordjević, Jelena",
year = "2021",
abstract = "The effects of Cd application alone or along with ethylenediaminetetraacetic acid (EDTA) and maleic acid (MA) were explored in okra (Abelmoschus esculentus.L.). Okra plants were planted in hydroponic conditions and in the 4-leaf stage, they were exposed to cadmium nitrate at three levels (0, 50, and 100 mg/L) and/or EDTA and MA at two levels (0.5 and 1.0 mM) and the combined application of different Cd concentrations with EDTA and MA for one month. The results showed a decrease in shoot and root dry weight and length and an increase in malondialdehyde (MDA), cell death, Cd accumulation, anthocyanins, and phenol and total flavonoid contents in the Cd-treated plants. The application of EDTA and MA alleviated the detrimental impacts of Cd on the okra plants by the improved management of translocation, compartmentation, and tolerance index. HPLC method revealed that rosmaric and coumaric acids were the most abundant phenolic compounds among the studied compounds. The variations of the phenolic compounds in the Cd-treated plants versus the control showed that the greatest increase was in chlorogenic acid (101.91%) and the greatest decline in coumaric acid (60.90%). The highest increase and decrease in the plants exposed to Cd with EDTA or MA versus the plants only exposed to Cd were related to coumaric acid (106.60%) and chlorogenic acid (43.45%) related to the treatment of 100 mg/L Cd +1 mM MA, respectively. In conclusion, okra has good potential for the phytoremediation of Cd and the EDTA and MA increased the phytoextraction efficiency.",
publisher = "Elsevier Ltd",
journal = "Journal of Environmental Chemical Engineering",
title = "The effect of the exogenous application of EDTA and maleic acid on tolerance, phenolic compounds, and cadmium phytoremediation by okra (Abelmoschus esculentus L.) exposed to Cd stress",
number = "4",
pages = "105456",
volume = "9",
doi = "10.1016/j.jece.2021.105456"
}

Mousavi, A., Pourakbar, L., Moghaddam, S. S.,& Popović-Djordjević, J.. (2021). The effect of the exogenous application of EDTA and maleic acid on tolerance, phenolic compounds, and cadmium phytoremediation by okra (Abelmoschus esculentus L.) exposed to Cd stress. in Journal of Environmental Chemical Engineering
Elsevier Ltd., 9(4), 105456.
https://doi.org/10.1016/j.jece.2021.105456

Mousavi A, Pourakbar L, Moghaddam SS, Popović-Djordjević J. The effect of the exogenous application of EDTA and maleic acid on tolerance, phenolic compounds, and cadmium phytoremediation by okra (Abelmoschus esculentus L.) exposed to Cd stress. in Journal of Environmental Chemical Engineering. 2021;9(4):105456.
doi:10.1016/j.jece.2021.105456 .

Mousavi, Afsaneh, Pourakbar, Latifeh, Moghaddam, Sina Siavash, Popović-Djordjević, Jelena, "The effect of the exogenous application of EDTA and maleic acid on tolerance, phenolic compounds, and cadmium phytoremediation by okra (Abelmoschus esculentus L.) exposed to Cd stress" in Journal of Environmental Chemical Engineering, 9, no. 4 (2021):105456,
https://doi.org/10.1016/j.jece.2021.105456 . .

TY  - JOUR
AU  - Echave, Javier
AU  - Fraga-Corral, Maria
AU  - Garcia-Perez, Pascual
AU  - Popović-Djordjević, Jelena
AU  - Avdović, Edina H.
AU  - Radulović, Milanka
AU  - Xiao, Jianbo
AU  - Prieto, Miguel A.
AU  - Simal-Gandara, Jesus
PY  - 2021
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5929
AB  - Seaweeds are industrially exploited for obtaining pigments, polysaccharides, or phenolic compounds with application in diverse fields. Nevertheless, their rich composition in fiber, minerals, and proteins, has pointed them as a useful source of these components. Seaweed proteins are nutritionally valuable and include several specific enzymes, glycoproteins, cell wall-attached proteins, phycobiliproteins, lectins, or peptides. Extraction of seaweed proteins requires the application of disruptive methods due to the heterogeneous cell wall composition of each macroalgae group. Hence, non-protein molecules like phenolics or polysaccharides may also be co-extracted, affecting the extraction yield. Therefore, depending on the macroalgae and target protein characteristics, the sample pretreatment, extraction and purification techniques must be carefully chosen. Traditional methods like solid–liquid or enzyme-assisted extraction (SLE or EAE) have proven successful. However, alternative techniques as ultrasound-or microwave-assisted extraction (UAE or MAE) can be more efficient. To obtain protein hydrolysates, these proteins are subjected to hydrolyzation reactions, whether with proteases or physical or chemical treatments that disrupt the proteins native folding. These hydrolysates and derived peptides are accounted for bioactive properties, like antioxidant, anti-inflammatory, antimicrobial, or antihypertensive activities, which can be applied to different sectors. In this work, current methods and challenges for protein extraction and purification from seaweeds are addressed, focusing on their potential industrial applications in the food, cosmetic, and pharmaceutical industries.
PB  - MDPI
T2  - Marine Drugs
T1  - Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications
IS  - 9
SP  - 500
VL  - 19
DO  - 10.3390/md19090500
ER  - 

@article{
author = "Echave, Javier and Fraga-Corral, Maria and Garcia-Perez, Pascual and Popović-Djordjević, Jelena and Avdović, Edina H. and Radulović, Milanka and Xiao, Jianbo and Prieto, Miguel A. and Simal-Gandara, Jesus",
year = "2021",
abstract = "Seaweeds are industrially exploited for obtaining pigments, polysaccharides, or phenolic compounds with application in diverse fields. Nevertheless, their rich composition in fiber, minerals, and proteins, has pointed them as a useful source of these components. Seaweed proteins are nutritionally valuable and include several specific enzymes, glycoproteins, cell wall-attached proteins, phycobiliproteins, lectins, or peptides. Extraction of seaweed proteins requires the application of disruptive methods due to the heterogeneous cell wall composition of each macroalgae group. Hence, non-protein molecules like phenolics or polysaccharides may also be co-extracted, affecting the extraction yield. Therefore, depending on the macroalgae and target protein characteristics, the sample pretreatment, extraction and purification techniques must be carefully chosen. Traditional methods like solid–liquid or enzyme-assisted extraction (SLE or EAE) have proven successful. However, alternative techniques as ultrasound-or microwave-assisted extraction (UAE or MAE) can be more efficient. To obtain protein hydrolysates, these proteins are subjected to hydrolyzation reactions, whether with proteases or physical or chemical treatments that disrupt the proteins native folding. These hydrolysates and derived peptides are accounted for bioactive properties, like antioxidant, anti-inflammatory, antimicrobial, or antihypertensive activities, which can be applied to different sectors. In this work, current methods and challenges for protein extraction and purification from seaweeds are addressed, focusing on their potential industrial applications in the food, cosmetic, and pharmaceutical industries.",
publisher = "MDPI",
journal = "Marine Drugs",
title = "Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications",
number = "9",
pages = "500",
volume = "19",
doi = "10.3390/md19090500"
}

Echave, J., Fraga-Corral, M., Garcia-Perez, P., Popović-Djordjević, J., Avdović, E. H., Radulović, M., Xiao, J., Prieto, M. A.,& Simal-Gandara, J.. (2021). Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications. in Marine Drugs
MDPI., 19(9), 500.
https://doi.org/10.3390/md19090500

Echave J, Fraga-Corral M, Garcia-Perez P, Popović-Djordjević J, Avdović EH, Radulović M, Xiao J, Prieto MA, Simal-Gandara J. Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications. in Marine Drugs. 2021;19(9):500.
doi:10.3390/md19090500 .

Echave, Javier, Fraga-Corral, Maria, Garcia-Perez, Pascual, Popović-Djordjević, Jelena, Avdović, Edina H., Radulović, Milanka, Xiao, Jianbo, Prieto, Miguel A., Simal-Gandara, Jesus, "Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications" in Marine Drugs, 19, no. 9 (2021):500,
https://doi.org/10.3390/md19090500 . .