TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Quispe, Cristina
AU  - Giordo, Roberta
AU  - Kostić, Aleksandar
AU  - Katanić Stanković, Jelena S.
AU  - Tsouh Fokoue, Patrick Valere
AU  - Carbone, Katya
AU  - Martorell, Miquel
AU  - Kumar, Manoj
AU  - Pintus, Gianfranco
AU  - Sharifi-Rad, Javad
AU  - Docea, Anca Oana
AU  - Calina, Daniela
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6044
AB  - The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.
PB  - Elsevier Masson s.r.l.
T2  - European Journal of Medicinal Chemistry
T1  - Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs
SP  - 114217
VL  - 233
DO  - 10.1016/j.ejmech.2022.114217
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Quispe, Cristina and Giordo, Roberta and Kostić, Aleksandar and Katanić Stanković, Jelena S. and Tsouh Fokoue, Patrick Valere and Carbone, Katya and Martorell, Miquel and Kumar, Manoj and Pintus, Gianfranco and Sharifi-Rad, Javad and Docea, Anca Oana and Calina, Daniela",
year = "2022",
abstract = "The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.",
publisher = "Elsevier Masson s.r.l.",
journal = "European Journal of Medicinal Chemistry",
title = "Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs",
pages = "114217",
volume = "233",
doi = "10.1016/j.ejmech.2022.114217"
}

Popović-Djordjević, J., Quispe, C., Giordo, R., Kostić, A., Katanić Stanković, J. S., Tsouh Fokoue, P. V., Carbone, K., Martorell, M., Kumar, M., Pintus, G., Sharifi-Rad, J., Docea, A. O.,& Calina, D.. (2022). Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. in European Journal of Medicinal Chemistry
Elsevier Masson s.r.l.., 233, 114217.
https://doi.org/10.1016/j.ejmech.2022.114217

Popović-Djordjević J, Quispe C, Giordo R, Kostić A, Katanić Stanković JS, Tsouh Fokoue PV, Carbone K, Martorell M, Kumar M, Pintus G, Sharifi-Rad J, Docea AO, Calina D. Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. in European Journal of Medicinal Chemistry. 2022;233:114217.
doi:10.1016/j.ejmech.2022.114217 .

Popović-Djordjević, Jelena, Quispe, Cristina, Giordo, Roberta, Kostić, Aleksandar, Katanić Stanković, Jelena S., Tsouh Fokoue, Patrick Valere, Carbone, Katya, Martorell, Miquel, Kumar, Manoj, Pintus, Gianfranco, Sharifi-Rad, Javad, Docea, Anca Oana, Calina, Daniela, "Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs" in European Journal of Medicinal Chemistry, 233 (2022):114217,
https://doi.org/10.1016/j.ejmech.2022.114217 . .