TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Quispe, Cristina
AU  - Giordo, Roberta
AU  - Kostić, Aleksandar
AU  - Katanić Stanković, Jelena S.
AU  - Tsouh Fokoue, Patrick Valere
AU  - Carbone, Katya
AU  - Martorell, Miquel
AU  - Kumar, Manoj
AU  - Pintus, Gianfranco
AU  - Sharifi-Rad, Javad
AU  - Docea, Anca Oana
AU  - Calina, Daniela
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6044
AB  - The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.
PB  - Elsevier Masson s.r.l.
T2  - European Journal of Medicinal Chemistry
T1  - Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs
SP  - 114217
VL  - 233
DO  - 10.1016/j.ejmech.2022.114217
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Quispe, Cristina and Giordo, Roberta and Kostić, Aleksandar and Katanić Stanković, Jelena S. and Tsouh Fokoue, Patrick Valere and Carbone, Katya and Martorell, Miquel and Kumar, Manoj and Pintus, Gianfranco and Sharifi-Rad, Javad and Docea, Anca Oana and Calina, Daniela",
year = "2022",
abstract = "The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.",
publisher = "Elsevier Masson s.r.l.",
journal = "European Journal of Medicinal Chemistry",
title = "Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs",
pages = "114217",
volume = "233",
doi = "10.1016/j.ejmech.2022.114217"
}

Popović-Djordjević, J., Quispe, C., Giordo, R., Kostić, A., Katanić Stanković, J. S., Tsouh Fokoue, P. V., Carbone, K., Martorell, M., Kumar, M., Pintus, G., Sharifi-Rad, J., Docea, A. O.,& Calina, D.. (2022). Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. in European Journal of Medicinal Chemistry
Elsevier Masson s.r.l.., 233, 114217.
https://doi.org/10.1016/j.ejmech.2022.114217

Popović-Djordjević J, Quispe C, Giordo R, Kostić A, Katanić Stanković JS, Tsouh Fokoue PV, Carbone K, Martorell M, Kumar M, Pintus G, Sharifi-Rad J, Docea AO, Calina D. Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. in European Journal of Medicinal Chemistry. 2022;233:114217.
doi:10.1016/j.ejmech.2022.114217 .

Popović-Djordjević, Jelena, Quispe, Cristina, Giordo, Roberta, Kostić, Aleksandar, Katanić Stanković, Jelena S., Tsouh Fokoue, Patrick Valere, Carbone, Katya, Martorell, Miquel, Kumar, Manoj, Pintus, Gianfranco, Sharifi-Rad, Javad, Docea, Anca Oana, Calina, Daniela, "Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs" in European Journal of Medicinal Chemistry, 233 (2022):114217,
https://doi.org/10.1016/j.ejmech.2022.114217 . .

TY  - JOUR
AU  - Vucinić, Slavica
AU  - Antonijević, Biljana
AU  - Tsatsakis, Aristidis M.
AU  - Vassilopoulou, Loukia
AU  - Docea, Anca Oana
AU  - Nosyrev, Alexander E.
AU  - Izotov, Boris N.
AU  - Thiermann, Horst
AU  - Drakoulis, Nikolaos
AU  - Brkić, Dragica
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4411
AB  - Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities. Hundreds of thousands of tons of chemical munitions were disposed of at the sea in the post World War II period, with European, Russian, Japanese and US coasts being the most affected. Sulfur mustard, Lewisite and nerve agents appear to be the most frequently chemical warfare agents disposed of at the sea. Addressing the overall environmental risk, it has been one of the priorities of the world community since that time. Aside from confirming exposure to nerve agents in the alleged use for forensic purposes, the detection and identification of biological markers of exposure are also needed for the diagnosis and treatment of poisoning, in addition to occupational health monitoring for specific profiles of workers. When estimating detrimental effects of acute or potential chronic sub-lethal doses of organophosphorus nerve agents, released accidentally or intentionally into the environment, it is necessary to understand the wide spectra of physical, chemical and toxicological properties of these agents, and predict their ultimate fate in environmental systems.
PB  - Elsevier, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Environmental exposure to organophosphorus nerve agents
EP  - 171
SP  - 163
VL  - 56
DO  - 10.1016/j.etap.2017.09.004
ER  - 

@article{
author = "Vucinić, Slavica and Antonijević, Biljana and Tsatsakis, Aristidis M. and Vassilopoulou, Loukia and Docea, Anca Oana and Nosyrev, Alexander E. and Izotov, Boris N. and Thiermann, Horst and Drakoulis, Nikolaos and Brkić, Dragica",
year = "2017",
abstract = "Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities. Hundreds of thousands of tons of chemical munitions were disposed of at the sea in the post World War II period, with European, Russian, Japanese and US coasts being the most affected. Sulfur mustard, Lewisite and nerve agents appear to be the most frequently chemical warfare agents disposed of at the sea. Addressing the overall environmental risk, it has been one of the priorities of the world community since that time. Aside from confirming exposure to nerve agents in the alleged use for forensic purposes, the detection and identification of biological markers of exposure are also needed for the diagnosis and treatment of poisoning, in addition to occupational health monitoring for specific profiles of workers. When estimating detrimental effects of acute or potential chronic sub-lethal doses of organophosphorus nerve agents, released accidentally or intentionally into the environment, it is necessary to understand the wide spectra of physical, chemical and toxicological properties of these agents, and predict their ultimate fate in environmental systems.",
publisher = "Elsevier, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Environmental exposure to organophosphorus nerve agents",
pages = "171-163",
volume = "56",
doi = "10.1016/j.etap.2017.09.004"
}

Vucinić, S., Antonijević, B., Tsatsakis, A. M., Vassilopoulou, L., Docea, A. O., Nosyrev, A. E., Izotov, B. N., Thiermann, H., Drakoulis, N.,& Brkić, D.. (2017). Environmental exposure to organophosphorus nerve agents. in Environmental Toxicology and Pharmacology
Elsevier, Amsterdam., 56, 163-171.
https://doi.org/10.1016/j.etap.2017.09.004

Vucinić S, Antonijević B, Tsatsakis AM, Vassilopoulou L, Docea AO, Nosyrev AE, Izotov BN, Thiermann H, Drakoulis N, Brkić D. Environmental exposure to organophosphorus nerve agents. in Environmental Toxicology and Pharmacology. 2017;56:163-171.
doi:10.1016/j.etap.2017.09.004 .

Vucinić, Slavica, Antonijević, Biljana, Tsatsakis, Aristidis M., Vassilopoulou, Loukia, Docea, Anca Oana, Nosyrev, Alexander E., Izotov, Boris N., Thiermann, Horst, Drakoulis, Nikolaos, Brkić, Dragica, "Environmental exposure to organophosphorus nerve agents" in Environmental Toxicology and Pharmacology, 56 (2017):163-171,
https://doi.org/10.1016/j.etap.2017.09.004 . .