dc.creator | Pantelić, Nebojša | |
dc.creator | Zmejkovski, Bojana B. | |
dc.creator | Božić, Bojan | |
dc.creator | Dojčinović, Biljana | |
dc.creator | Banjac, Nebojša | |
dc.creator | Wessjohann, Ludger A. | |
dc.creator | Kaludjerović, Goran N. | |
dc.date.accessioned | 2020-12-17T22:52:33Z | |
dc.date.available | 2020-12-17T22:52:33Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/5306 | |
dc.description.abstract | Two novel triphenyltin(IV) compounds, [Ph(3)SnL1] (L1 = 2-(5-(4- fluorobenzylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (1)) and [Ph(3)SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (H-1 and C-13) NMR spectroscopy, mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV) compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), and HepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. The IC50 values are found to be in the range from 0.11 to 0.50 mu M. Compound 1 exhibits the highest activity toward PC-3 cells (IC50 = 0.115 +/- 0.009 mu M; CV assay). The tin and platinum uptake in PC-3 cells showed a threefold lower uptake of tin in comparison to platinum (as cisplatin). Together with its higher activity this indicates a much higher cell inhibition potential of the tin compounds (calculated to ca. 50 to 100 times). Morphological analysis suggested that the compounds induce apoptosis in PC-3 cells, and flow cytometry analysis revealed that 1 and 2 induce autophagy as well as NO (nitric oxide) production. | en |
dc.publisher | Elsevier Science Inc, New York | |
dc.relation | National Scholarship for Postdoctoral Studies of the Republic of Serbia | |
dc.relation | German Academic Exchange Service (DAAD)Deutscher Akademischer Austausch Dienst (DAAD) [57448219] | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175033/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Inorganic Biochemistry | |
dc.subject | Tin(IV) | en |
dc.subject | In vitro | en |
dc.subject | Prostate cancer | en |
dc.subject | Apoptosis | en |
dc.subject | Autophagy | en |
dc.subject | NO | en |
dc.title | Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)propanoic acid | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.other | 211: - | |
dc.citation.rank | M21 | |
dc.citation.volume | 211 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2020.111207 | |
dc.identifier.scopus | 2-s2.0-85089264363 | |
dc.identifier.pmid | 32801055 | |
dc.identifier.wos | 000566344500012 | |
dc.type.version | publishedVersion | |