Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type esters
dc.creator | Zmejkovski, Bojana B. | |
dc.creator | Savić, Aleksandar | |
dc.creator | Poljarević, Jelena | |
dc.creator | Pantelić, Nebojša | |
dc.creator | Arandelović, Sandra | |
dc.creator | Radulović, Siniša | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Kaludjerović, Goran N. | |
dc.creator | Sabo, Tibor J. | |
dc.date.accessioned | 2020-12-17T20:56:03Z | |
dc.date.available | 2020-12-17T20:56:03Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0277-5387 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/3400 | |
dc.description.abstract | Six palladium(II) complexes with (S,S)-R(2)edda-type esters ((S,S)-R2edda-type; (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, 1-3; (S,S)-pddch = (S,S)-propylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Et, n-Pr, 4, 5; and (S,S)-eddip = (S,S)-ethylenediamne-N,N'-di-2-propanoate, R = i-Am, 6) were synthesized, characterized by IR, NMR spectroscopy, ESI-MS and elemental analysis. DFT calculations indicate that in case of 1-4, the most stable isomers are with (S,S)- and (R,S)-configuration of nitrogen atoms, but for complex 6 (R,R)- and (R,S)-N,N'-configured isomers. Furthermore, complex 5 was obtained as (S,S)-N,N' configured isomer. Cytotoxicity study was performed against human cervical adenocarcinoma (HeLa), human alveolar basal adenocarcinoma (A549) and non-cancerous human fetal lung fibroblast (MRC-5) cell lines using colorimetric MTT assay. From the investigated palladium(II) complexes 2, 3 and 5 exhibited highest cytotoxic potential against HeLa (IC50: 28.5 +/- 3.9, 29.5 +/- 1.3 and 34.3 +/- 3.2, respectively). | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/256716/EU// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.rights | restrictedAccess | |
dc.source | Polyhedron | |
dc.subject | Palladium(II) complexes | en |
dc.subject | R(2)edda-type ligands | en |
dc.subject | DFT calculations | en |
dc.subject | Diastereoisomers | en |
dc.subject | Cytotoxic activity | en |
dc.title | Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type esters | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 111 | |
dc.citation.other | 80: 106-111 | |
dc.citation.rank | M22 | |
dc.citation.spage | 106 | |
dc.citation.volume | 80 | |
dc.identifier.doi | 10.1016/j.poly.2014.02.026 | |
dc.identifier.scopus | 2-s2.0-84905493340 | |
dc.identifier.wos | 000341348300014 | |
dc.type.version | publishedVersion |