TY  - JOUR
AU  - Solarz, Daria
AU  - Witko, Tomasz
AU  - Karcz, Robert
AU  - Malagurski, Ivana
AU  - Ponjavic, Marijana
AU  - Levic, Steva
AU  - Nesic, Aleksandra
AU  - Guzik, Maciej
AU  - Savic, Sanja
AU  - Nikodinovic-Runic, Jasmina
PY  - 2023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/37577093
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6430
AB  - Polyhydroxyoctanoate, as a biocompatible and biodegradable biopolymer, represents an ideal candidate for biomedical applications. However, physical properties make it unsuitable for electrospinning, currently the most widely used technique for fabrication of fibrous scaffolds. To overcome this, it was blended with polylactic acid and polymer blend fibrous biomaterials were produced by electrospinning. The obtained PLA/PHO fibers were cylindrical, smaller in size, more hydrophilic and had a higher degree of biopolymer crystallinity and more favorable mechanical properties in comparison to the pure PLA sample. Cytotoxicity evaluation with human lung fibroblasts (MRC5 cells) combined with confocal microscopy were used to visualize mouse embryonic fibroblasts (MEF 3T3 cell line) migration and distribution showed that PLA/PHO samples support exceptional cell adhesion and viability, indicating excellent biocompatibility. The obtained results suggest that PLA/PHO fibrous biomaterials can be potentially used as biocompatible, biomimetic scaffolds for tissue engineering applications.
T2  - RSC advances
T2  - RSC advancesRSC Adv
T1  - Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/P(3HO) scaffolds for tissue engineering applications
EP  - 24128
IS  - 34
SP  - 24112
VL  - 13
DO  - 10.1039/d3ra03021k
ER  - 

@article{
author = "Solarz, Daria and Witko, Tomasz and Karcz, Robert and Malagurski, Ivana and Ponjavic, Marijana and Levic, Steva and Nesic, Aleksandra and Guzik, Maciej and Savic, Sanja and Nikodinovic-Runic, Jasmina",
year = "2023",
abstract = "Polyhydroxyoctanoate, as a biocompatible and biodegradable biopolymer, represents an ideal candidate for biomedical applications. However, physical properties make it unsuitable for electrospinning, currently the most widely used technique for fabrication of fibrous scaffolds. To overcome this, it was blended with polylactic acid and polymer blend fibrous biomaterials were produced by electrospinning. The obtained PLA/PHO fibers were cylindrical, smaller in size, more hydrophilic and had a higher degree of biopolymer crystallinity and more favorable mechanical properties in comparison to the pure PLA sample. Cytotoxicity evaluation with human lung fibroblasts (MRC5 cells) combined with confocal microscopy were used to visualize mouse embryonic fibroblasts (MEF 3T3 cell line) migration and distribution showed that PLA/PHO samples support exceptional cell adhesion and viability, indicating excellent biocompatibility. The obtained results suggest that PLA/PHO fibrous biomaterials can be potentially used as biocompatible, biomimetic scaffolds for tissue engineering applications.",
journal = "RSC advances, RSC advancesRSC Adv",
title = "Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/P(3HO) scaffolds for tissue engineering applications",
pages = "24128-24112",
number = "34",
volume = "13",
doi = "10.1039/d3ra03021k"
}

Solarz, D., Witko, T., Karcz, R., Malagurski, I., Ponjavic, M., Levic, S., Nesic, A., Guzik, M., Savic, S.,& Nikodinovic-Runic, J.. (2023). Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/P(3HO) scaffolds for tissue engineering applications. in RSC advances, 13(34), 24112-24128.
https://doi.org/10.1039/d3ra03021k

Solarz D, Witko T, Karcz R, Malagurski I, Ponjavic M, Levic S, Nesic A, Guzik M, Savic S, Nikodinovic-Runic J. Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/P(3HO) scaffolds for tissue engineering applications. in RSC advances. 2023;13(34):24112-24128.
doi:10.1039/d3ra03021k .

Solarz, Daria, Witko, Tomasz, Karcz, Robert, Malagurski, Ivana, Ponjavic, Marijana, Levic, Steva, Nesic, Aleksandra, Guzik, Maciej, Savic, Sanja, Nikodinovic-Runic, Jasmina, "Biological and physiochemical studies of electrospun polylactid/polyhydroxyoctanoate PLA/P(3HO) scaffolds for tissue engineering applications" in RSC advances, 13, no. 34 (2023):24112-24128,
https://doi.org/10.1039/d3ra03021k . .