TY  - JOUR
AU  - Ristić, Predrag G.
AU  - Rodić, Marko V.
AU  - Filipović, Nenad R.
AU  - Mitić, Dragana M.
AU  - Andjelković, Katarina K.
AU  - Todorović, Tamara R.
PY  - 2021
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5860
AB  - Two square-planar complexes, [PtLCl] (1) and [PdLCl] (2), were synthesized with quinoline-2-carboxaldehyde thiosemicarbazone ligand (HL), and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. In both complexes, L- is coordinated tridentately via the same donor atom set, while the fourth coordination site is occupied by a chloride ion. However, the complexes are not isostructural due to different types of non-covalent intermolecular interactions. These interactions were analyzed using Hirshfeld surfaces and two-dimensional fingerprint plots.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone
EP  - 406
IS  - 4
SP  - 393
VL  - 86
DO  - 10.2298/JSC201126079R
ER  - 

@article{
author = "Ristić, Predrag G. and Rodić, Marko V. and Filipović, Nenad R. and Mitić, Dragana M. and Andjelković, Katarina K. and Todorović, Tamara R.",
year = "2021",
abstract = "Two square-planar complexes, [PtLCl] (1) and [PdLCl] (2), were synthesized with quinoline-2-carboxaldehyde thiosemicarbazone ligand (HL), and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. In both complexes, L- is coordinated tridentately via the same donor atom set, while the fourth coordination site is occupied by a chloride ion. However, the complexes are not isostructural due to different types of non-covalent intermolecular interactions. These interactions were analyzed using Hirshfeld surfaces and two-dimensional fingerprint plots.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone",
pages = "406-393",
number = "4",
volume = "86",
doi = "10.2298/JSC201126079R"
}

Ristić, P. G., Rodić, M. V., Filipović, N. R., Mitić, D. M., Andjelković, K. K.,& Todorović, T. R.. (2021). Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 86(4), 393-406.
https://doi.org/10.2298/JSC201126079R

Ristić PG, Rodić MV, Filipović NR, Mitić DM, Andjelković KK, Todorović TR. Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone. in Journal of the Serbian Chemical Society. 2021;86(4):393-406.
doi:10.2298/JSC201126079R .

Ristić, Predrag G., Rodić, Marko V., Filipović, Nenad R., Mitić, Dragana M., Andjelković, Katarina K., Todorović, Tamara R., "Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone" in Journal of the Serbian Chemical Society, 86, no. 4 (2021):393-406,
https://doi.org/10.2298/JSC201126079R . .

TY  - JOUR
AU  - Todorović, Tamara R.
AU  - Vukasinović, Jelena
AU  - Portalone, Gustavo
AU  - Suleiman, Sherif
AU  - Gligorijević, Nevenka
AU  - Bjelogrlić, Snežana
AU  - Jovanović, Katarina
AU  - Radulović, Siniša
AU  - Andjelković, Katarina
AU  - Cassar, Analisse
AU  - Filipović, Nenad
AU  - Schembri-Wismayer, Pierre
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4388
AB  - Cobalt complexes with semi-and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin.
PB  - Royal Soc Chemistry, Cambridge
T2  - Medchemcomm
T1  - (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines
EP  - 111
IS  - 1
SP  - 103
VL  - 8
DO  - 10.1039/c6md00501b
ER  - 

@article{
author = "Todorović, Tamara R. and Vukasinović, Jelena and Portalone, Gustavo and Suleiman, Sherif and Gligorijević, Nevenka and Bjelogrlić, Snežana and Jovanović, Katarina and Radulović, Siniša and Andjelković, Katarina and Cassar, Analisse and Filipović, Nenad and Schembri-Wismayer, Pierre",
year = "2017",
abstract = "Cobalt complexes with semi-and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Medchemcomm",
title = "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines",
pages = "111-103",
number = "1",
volume = "8",
doi = "10.1039/c6md00501b"
}

Todorović, T. R., Vukasinović, J., Portalone, G., Suleiman, S., Gligorijević, N., Bjelogrlić, S., Jovanović, K., Radulović, S., Andjelković, K., Cassar, A., Filipović, N.,& Schembri-Wismayer, P.. (2017). (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in Medchemcomm
Royal Soc Chemistry, Cambridge., 8(1), 103-111.
https://doi.org/10.1039/c6md00501b

Todorović TR, Vukasinović J, Portalone G, Suleiman S, Gligorijević N, Bjelogrlić S, Jovanović K, Radulović S, Andjelković K, Cassar A, Filipović N, Schembri-Wismayer P. (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in Medchemcomm. 2017;8(1):103-111.
doi:10.1039/c6md00501b .

Todorović, Tamara R., Vukasinović, Jelena, Portalone, Gustavo, Suleiman, Sherif, Gligorijević, Nevenka, Bjelogrlić, Snežana, Jovanović, Katarina, Radulović, Siniša, Andjelković, Katarina, Cassar, Analisse, Filipović, Nenad, Schembri-Wismayer, Pierre, "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines" in Medchemcomm, 8, no. 1 (2017):103-111,
https://doi.org/10.1039/c6md00501b . .

TY  - JOUR
AU  - Todorović, Tamara
AU  - Grubisić, Sonja
AU  - Pregelj, Matej
AU  - Jagodić, Marko
AU  - Misirlić-Dencić, Sonja
AU  - Dulović, Marija
AU  - Marković, Ivanka
AU  - Klisurić, Olivera
AU  - Malesević, Aleksandar
AU  - Mitić, Dragana
AU  - Andjelković, Katarina
AU  - Filipović, Nenad
PY  - 2015
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3708
AB  - Copper(II) complexes with the condensation derivative of methyl hydrazinoacetate and 2-acetylpyridine were synthesized. The X-ray crystal structures for both complexes revealed that they are polymerized isomers. A common feature of both complexes is the bidentate coordination of the ligand by one hydrazone and one pyridine nitrogen atom. In the monomeric complex, the copper(II) center is tetracoordinate, whereas dimerization through chlorido bridges results in a pentacoordinate arrangement about the metal ions in the dimer. The electronic and magnetic properties of both complexes are discussed on the basis of their X-ray structures, electron paramagnetic resonance (EPR) spectroscopy studies, and superconducting quantum interference device (SQUID) magnetization measurements combined with DFT calculations. Magnetostructural comparisons with structurally similar copper(II) complexes are also provided, and a possible correlation has been established. The antitumor activities of the Cu-II complexes were investigated against six different cancer cell lines, and the results suggest that the antiglioma action of the dimeric species is based on oxidative-stress-mediated phosphatidylserine externalization and caspase activation, which indicate apoptosis.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - European Journal of Inorganic Chemistry
T1  - Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands
EP  - 3931
IS  - 23
SP  - 3921
DO  - 10.1002/ejic.201500349
ER  - 

@article{
author = "Todorović, Tamara and Grubisić, Sonja and Pregelj, Matej and Jagodić, Marko and Misirlić-Dencić, Sonja and Dulović, Marija and Marković, Ivanka and Klisurić, Olivera and Malesević, Aleksandar and Mitić, Dragana and Andjelković, Katarina and Filipović, Nenad",
year = "2015",
abstract = "Copper(II) complexes with the condensation derivative of methyl hydrazinoacetate and 2-acetylpyridine were synthesized. The X-ray crystal structures for both complexes revealed that they are polymerized isomers. A common feature of both complexes is the bidentate coordination of the ligand by one hydrazone and one pyridine nitrogen atom. In the monomeric complex, the copper(II) center is tetracoordinate, whereas dimerization through chlorido bridges results in a pentacoordinate arrangement about the metal ions in the dimer. The electronic and magnetic properties of both complexes are discussed on the basis of their X-ray structures, electron paramagnetic resonance (EPR) spectroscopy studies, and superconducting quantum interference device (SQUID) magnetization measurements combined with DFT calculations. Magnetostructural comparisons with structurally similar copper(II) complexes are also provided, and a possible correlation has been established. The antitumor activities of the Cu-II complexes were investigated against six different cancer cell lines, and the results suggest that the antiglioma action of the dimeric species is based on oxidative-stress-mediated phosphatidylserine externalization and caspase activation, which indicate apoptosis.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "European Journal of Inorganic Chemistry",
title = "Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands",
pages = "3931-3921",
number = "23",
doi = "10.1002/ejic.201500349"
}

Todorović, T., Grubisić, S., Pregelj, M., Jagodić, M., Misirlić-Dencić, S., Dulović, M., Marković, I., Klisurić, O., Malesević, A., Mitić, D., Andjelković, K.,& Filipović, N.. (2015). Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands. in European Journal of Inorganic Chemistry
Wiley-V C H Verlag Gmbh, Weinheim.(23), 3921-3931.
https://doi.org/10.1002/ejic.201500349

Todorović T, Grubisić S, Pregelj M, Jagodić M, Misirlić-Dencić S, Dulović M, Marković I, Klisurić O, Malesević A, Mitić D, Andjelković K, Filipović N. Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands. in European Journal of Inorganic Chemistry. 2015;(23):3921-3931.
doi:10.1002/ejic.201500349 .

Todorović, Tamara, Grubisić, Sonja, Pregelj, Matej, Jagodić, Marko, Misirlić-Dencić, Sonja, Dulović, Marija, Marković, Ivanka, Klisurić, Olivera, Malesević, Aleksandar, Mitić, Dragana, Andjelković, Katarina, Filipović, Nenad, "Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands" in European Journal of Inorganic Chemistry, no. 23 (2015):3921-3931,
https://doi.org/10.1002/ejic.201500349 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Polović, Natalija
AU  - Rasković, Brankica
AU  - Misirlić-Dencić, Sonja
AU  - Dulović, Marija
AU  - Pantić, Milena
AU  - Nikšić, Miomir
AU  - Mitić, Dragana
AU  - Andjelković, Katarina
AU  - Todorović, Tamara
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3412
AB  - New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.
PB  - Springer Wien, Wien
T2  - Monatshefte Fur Chemie
T1  - Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes
EP  - 1099
IS  - 7
SP  - 1089
VL  - 145
DO  - 10.1007/s00706-014-1197-6
ER  - 

@article{
author = "Filipović, Nenad and Polović, Natalija and Rasković, Brankica and Misirlić-Dencić, Sonja and Dulović, Marija and Pantić, Milena and Nikšić, Miomir and Mitić, Dragana and Andjelković, Katarina and Todorović, Tamara",
year = "2014",
abstract = "New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte Fur Chemie",
title = "Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes",
pages = "1099-1089",
number = "7",
volume = "145",
doi = "10.1007/s00706-014-1197-6"
}

Filipović, N., Polović, N., Rasković, B., Misirlić-Dencić, S., Dulović, M., Pantić, M., Nikšić, M., Mitić, D., Andjelković, K.,& Todorović, T.. (2014). Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. in Monatshefte Fur Chemie
Springer Wien, Wien., 145(7), 1089-1099.
https://doi.org/10.1007/s00706-014-1197-6

Filipović N, Polović N, Rasković B, Misirlić-Dencić S, Dulović M, Pantić M, Nikšić M, Mitić D, Andjelković K, Todorović T. Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. in Monatshefte Fur Chemie. 2014;145(7):1089-1099.
doi:10.1007/s00706-014-1197-6 .

Filipović, Nenad, Polović, Natalija, Rasković, Brankica, Misirlić-Dencić, Sonja, Dulović, Marija, Pantić, Milena, Nikšić, Miomir, Mitić, Dragana, Andjelković, Katarina, Todorović, Tamara, "Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes" in Monatshefte Fur Chemie, 145, no. 7 (2014):1089-1099,
https://doi.org/10.1007/s00706-014-1197-6 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Marković, Ivanka
AU  - Mitić, Dragana
AU  - Polović, Natalija
AU  - Milcić, Milos
AU  - Dulović, Marija
AU  - Jovanović, Maja
AU  - Pantić, Milena
AU  - Nikšić, Miomir
AU  - Andjelković, Katarina
AU  - Todorović, Tamara
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3500
AB  - In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.
PB  - Wiley, Hoboken
T2  - Journal of Biochemical and Molecular Toxicology
T1  - A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate
EP  - 110
IS  - 3
SP  - 99
VL  - 28
DO  - 10.1002/jbt.21541
ER  - 

@article{
author = "Filipović, Nenad and Marković, Ivanka and Mitić, Dragana and Polović, Natalija and Milcić, Milos and Dulović, Marija and Jovanović, Maja and Pantić, Milena and Nikšić, Miomir and Andjelković, Katarina and Todorović, Tamara",
year = "2014",
abstract = "In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.",
publisher = "Wiley, Hoboken",
journal = "Journal of Biochemical and Molecular Toxicology",
title = "A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate",
pages = "110-99",
number = "3",
volume = "28",
doi = "10.1002/jbt.21541"
}

Filipović, N., Marković, I., Mitić, D., Polović, N., Milcić, M., Dulović, M., Jovanović, M., Pantić, M., Nikšić, M., Andjelković, K.,& Todorović, T.. (2014). A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate. in Journal of Biochemical and Molecular Toxicology
Wiley, Hoboken., 28(3), 99-110.
https://doi.org/10.1002/jbt.21541

Filipović N, Marković I, Mitić D, Polović N, Milcić M, Dulović M, Jovanović M, Pantić M, Nikšić M, Andjelković K, Todorović T. A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate. in Journal of Biochemical and Molecular Toxicology. 2014;28(3):99-110.
doi:10.1002/jbt.21541 .

Filipović, Nenad, Marković, Ivanka, Mitić, Dragana, Polović, Natalija, Milcić, Milos, Dulović, Marija, Jovanović, Maja, Pantić, Milena, Nikšić, Miomir, Andjelković, Katarina, Todorović, Tamara, "A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate" in Journal of Biochemical and Molecular Toxicology, 28, no. 3 (2014):99-110,
https://doi.org/10.1002/jbt.21541 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Grubisić, Sonja
AU  - Jovanović, Maja
AU  - Dulović, Marija
AU  - Marković, Ivanka
AU  - Klisurić, Olivera
AU  - Marinković, Aleksandar
AU  - Mitić, Dragana
AU  - Andjelković, Katarina
AU  - Todorović, Tamara
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3446
AB  - Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated.
PB  - Wiley, Hoboken
T2  - Chemical Biology & Drug Design
T1  - Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity
EP  - 341
IS  - 3
SP  - 333
VL  - 84
DO  - 10.1111/cbdd.12322
ER  - 

@article{
author = "Filipović, Nenad and Grubisić, Sonja and Jovanović, Maja and Dulović, Marija and Marković, Ivanka and Klisurić, Olivera and Marinković, Aleksandar and Mitić, Dragana and Andjelković, Katarina and Todorović, Tamara",
year = "2014",
abstract = "Novel Pd(II) complex with N-heteroaromatic Schiff base ligand, derived from 8-quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL-60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline-based ligands reduce the cell numbers in a dose-dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline-based complexes is predominantly mediated through the induction of apoptotic cell death in HL-60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated.",
publisher = "Wiley, Hoboken",
journal = "Chemical Biology & Drug Design",
title = "Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity",
pages = "341-333",
number = "3",
volume = "84",
doi = "10.1111/cbdd.12322"
}

Filipović, N., Grubisić, S., Jovanović, M., Dulović, M., Marković, I., Klisurić, O., Marinković, A., Mitić, D., Andjelković, K.,& Todorović, T.. (2014). Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity. in Chemical Biology & Drug Design
Wiley, Hoboken., 84(3), 333-341.
https://doi.org/10.1111/cbdd.12322

Filipović N, Grubisić S, Jovanović M, Dulović M, Marković I, Klisurić O, Marinković A, Mitić D, Andjelković K, Todorović T. Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity. in Chemical Biology & Drug Design. 2014;84(3):333-341.
doi:10.1111/cbdd.12322 .

Filipović, Nenad, Grubisić, Sonja, Jovanović, Maja, Dulović, Marija, Marković, Ivanka, Klisurić, Olivera, Marinković, Aleksandar, Mitić, Dragana, Andjelković, Katarina, Todorović, Tamara, "Palladium(II) Complexes with N-Heteroaromatic Bidentate Hydrazone Ligands: The Effect of the Chelate Ring Size and Lipophilicity on in vitro Cytotoxic Activity" in Chemical Biology & Drug Design, 84, no. 3 (2014):333-341,
https://doi.org/10.1111/cbdd.12322 . .

TY  - JOUR
AU  - Begović, Nebojša
AU  - Blagojević, Vladimir A.
AU  - Ostojić, Sanja
AU  - Micić, Darko
AU  - Filipović, Nenad
AU  - Andjelković, Katarina
AU  - Minić, Dragica M.
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3447
AB  - Thermal stability of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands was investigated using a combination of experimental measurements and DFT calculations. All complexes exhibit a reversible second-order transition around 333 K, which can be attributed to structural reorganization of the ligand molecules. Thermal degradation begins in 570-610 K temperature region, with an endothermic peak, followed by exothermic peaks in DSC. TG measurements show a well-defined mass loss corresponding to the initial degradation, while subsequent processes are poorly separated. DFT calculations suggest that the initial degradation step occurs with release of Cl, which then reacts with remaining part of the complex molecule in an exothermic process. This leads to decomposition of the ligand molecule into four fragments corresponding to ethyl chloride, carbon dioxide, methyl amine, and the fragment with the aromatic group. Mass spectrum suggests that creation of these fragments most likely corresponds to the initial degradation, after which some of these coordinate to Pd center, whose coordination sphere is left incomplete by release of Cl. TG measurement to 1123 K indicates that the final degradation product at this temperature is palladium.
PB  - Elsevier, Amsterdam
T2  - Thermochimica Acta
T1  - Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands
EP  - 30
SP  - 23
VL  - 592
DO  - 10.1016/j.tca.2014.08.005
ER  - 

@article{
author = "Begović, Nebojša and Blagojević, Vladimir A. and Ostojić, Sanja and Micić, Darko and Filipović, Nenad and Andjelković, Katarina and Minić, Dragica M.",
year = "2014",
abstract = "Thermal stability of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands was investigated using a combination of experimental measurements and DFT calculations. All complexes exhibit a reversible second-order transition around 333 K, which can be attributed to structural reorganization of the ligand molecules. Thermal degradation begins in 570-610 K temperature region, with an endothermic peak, followed by exothermic peaks in DSC. TG measurements show a well-defined mass loss corresponding to the initial degradation, while subsequent processes are poorly separated. DFT calculations suggest that the initial degradation step occurs with release of Cl, which then reacts with remaining part of the complex molecule in an exothermic process. This leads to decomposition of the ligand molecule into four fragments corresponding to ethyl chloride, carbon dioxide, methyl amine, and the fragment with the aromatic group. Mass spectrum suggests that creation of these fragments most likely corresponds to the initial degradation, after which some of these coordinate to Pd center, whose coordination sphere is left incomplete by release of Cl. TG measurement to 1123 K indicates that the final degradation product at this temperature is palladium.",
publisher = "Elsevier, Amsterdam",
journal = "Thermochimica Acta",
title = "Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands",
pages = "30-23",
volume = "592",
doi = "10.1016/j.tca.2014.08.005"
}

Begović, N., Blagojević, V. A., Ostojić, S., Micić, D., Filipović, N., Andjelković, K.,& Minić, D. M.. (2014). Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands. in Thermochimica Acta
Elsevier, Amsterdam., 592, 23-30.
https://doi.org/10.1016/j.tca.2014.08.005

Begović N, Blagojević VA, Ostojić S, Micić D, Filipović N, Andjelković K, Minić DM. Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands. in Thermochimica Acta. 2014;592:23-30.
doi:10.1016/j.tca.2014.08.005 .

Begović, Nebojša, Blagojević, Vladimir A., Ostojić, Sanja, Micić, Darko, Filipović, Nenad, Andjelković, Katarina, Minić, Dragica M., "Thermally induced structural transformations of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands" in Thermochimica Acta, 592 (2014):23-30,
https://doi.org/10.1016/j.tca.2014.08.005 . .

TY  - JOUR
AU  - Dekanski, Dragana
AU  - Todorović, Tamara
AU  - Mitić, Dragana
AU  - Filipović, Nenad
AU  - Polović, Natalija
AU  - Andjelković, Katarina
PY  - 2013
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3135
AB  - Novel metal-based compounds with therapeutic potential have become the subject of intense investigations in inorganic chemistry and biomedical science. Recently, strong dose-dependent cytotoxic activities of selenosemicarbazone metal complexes against several human cancer cell lines were demonstrated. The aim of the present study was to investigate in vitro antioxidative potential of Ni(II), Cd(II) and Zn(II) selenosemicarbazone complexes. All three investigated complexes exhibited high 2,2'-azinobis(3-ethyl-benzothiazoline-6-sulphonic acid) radical cation (ABTS●+) scavenging capacity, comparable with ascorbic acid. In an acute toxicity study, administration of the compounds was performed orally to mice at single doses. The mice were observed for clinical signs, body weight effects and mortality for 14 days, after which they were sacrificed for gross organ necropsy. The body weight did not vary after administration, and the autoptic analysis failed to show appreciable macroscopic alterations of internal organs. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies.
AB  - Nova jedinjenja na bazi metala sa terapeutskim dejstvom postala su predmet istraživanja u neorganskoj hemiji i biomedicinskim naukama. Pokazana je jaka dozno-zavisna citotoksična aktivnost kompleksa selenosemikarbazona na većem broju ćelijskih linija humanih ćelija kancera. Cilj rada je ispitivanje in vitro antioksidativnog dejstva selenosemikarbazonskih kompleksa nikla, cinka i kadmijuma. Sva tri ispitivana kompleksa pokazala su jaku antioksidativnu aktivnost prema ABTS radikalu, uporedivu sa aktivnošću askorbinske kiseline. Tokom ispitivanja akutne toksičnosti, jedinjenja su oralno davana miševima u pojedinačnim dozama i praćeni su klinički znaci, težina tela i mortalitet nakon 14 dana, a potom su životinje žrtvovane radi autopsije organa. Težina tela nije varirala nakon aplikacije. Generalno, jedinjenja su pokazala mali toksični efekat što i zahteva buduće in vivo terapeutsko ispitivanje.
PB  - Srpsko hemijsko društvo, Beograd
T2  - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
T1  - High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes
T1  - Visoki antioksidativni potencijal i mali toksični efekat selenosemikarbazonskih kompleksa
EP  - 1512
IS  - 10
SP  - 1503
VL  - 78
DO  - 10.2298/JSC130315035D
ER  - 

@article{
author = "Dekanski, Dragana and Todorović, Tamara and Mitić, Dragana and Filipović, Nenad and Polović, Natalija and Andjelković, Katarina",
year = "2013",
abstract = "Novel metal-based compounds with therapeutic potential have become the subject of intense investigations in inorganic chemistry and biomedical science. Recently, strong dose-dependent cytotoxic activities of selenosemicarbazone metal complexes against several human cancer cell lines were demonstrated. The aim of the present study was to investigate in vitro antioxidative potential of Ni(II), Cd(II) and Zn(II) selenosemicarbazone complexes. All three investigated complexes exhibited high 2,2'-azinobis(3-ethyl-benzothiazoline-6-sulphonic acid) radical cation (ABTS●+) scavenging capacity, comparable with ascorbic acid. In an acute toxicity study, administration of the compounds was performed orally to mice at single doses. The mice were observed for clinical signs, body weight effects and mortality for 14 days, after which they were sacrificed for gross organ necropsy. The body weight did not vary after administration, and the autoptic analysis failed to show appreciable macroscopic alterations of internal organs. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies., Nova jedinjenja na bazi metala sa terapeutskim dejstvom postala su predmet istraživanja u neorganskoj hemiji i biomedicinskim naukama. Pokazana je jaka dozno-zavisna citotoksična aktivnost kompleksa selenosemikarbazona na većem broju ćelijskih linija humanih ćelija kancera. Cilj rada je ispitivanje in vitro antioksidativnog dejstva selenosemikarbazonskih kompleksa nikla, cinka i kadmijuma. Sva tri ispitivana kompleksa pokazala su jaku antioksidativnu aktivnost prema ABTS radikalu, uporedivu sa aktivnošću askorbinske kiseline. Tokom ispitivanja akutne toksičnosti, jedinjenja su oralno davana miševima u pojedinačnim dozama i praćeni su klinički znaci, težina tela i mortalitet nakon 14 dana, a potom su životinje žrtvovane radi autopsije organa. Težina tela nije varirala nakon aplikacije. Generalno, jedinjenja su pokazala mali toksični efekat što i zahteva buduće in vivo terapeutsko ispitivanje.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY",
title = "High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes, Visoki antioksidativni potencijal i mali toksični efekat selenosemikarbazonskih kompleksa",
pages = "1512-1503",
number = "10",
volume = "78",
doi = "10.2298/JSC130315035D"
}

Dekanski, D., Todorović, T., Mitić, D., Filipović, N., Polović, N.,& Andjelković, K.. (2013). High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Srpsko hemijsko društvo, Beograd., 78(10), 1503-1512.
https://doi.org/10.2298/JSC130315035D

Dekanski D, Todorović T, Mitić D, Filipović N, Polović N, Andjelković K. High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2013;78(10):1503-1512.
doi:10.2298/JSC130315035D .

Dekanski, Dragana, Todorović, Tamara, Mitić, Dragana, Filipović, Nenad, Polović, Natalija, Andjelković, Katarina, "High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 78, no. 10 (2013):1503-1512,
https://doi.org/10.2298/JSC130315035D . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Borna, Marija
AU  - Klisurić, Olivera
AU  - Pregelj, Matej
AU  - Jagodić, Marko
AU  - Andjelković, Katarina
AU  - Todorović, Tamara
PY  - 2013
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3288
AB  - Copper(II) and zinc(II) complexes with the condensation derivative of 2-acetylpyridine and hydrolyzed ethyl hydrazinoacetate were synthesized in a one pot reaction. Crystal structure of the zinc(II) complex was determined by single-crystal X-ray diffraction. In this binuclear complex, the ligand is coordinated via pyridine and imine nitrogen, while carboxylate oxygen is a bridge between metal centers. The fifth coordination site is occupied by a chloride, giving a distorted square pyramidal geometry around each zinc(II). The molecular structure of the copper(II) complex was determined from elemental analysis, infrared and electron paramagnetic resonance spectroscopy, molar conductivity, mass spectrometry, and measurements of the magnetic moment. Thermal behavior of both complexes was studied by thermogravimetric analysis coupled with mass spectrometer.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Synthesis, characterization, and thermal behavior of Cu(II) and Zn(II) complexes with (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetic acid (aphaOH). Crystal structure of [Zn-2(aphaO)(2)Cl-2]
EP  - 1560
IS  - 9
SP  - 1549
VL  - 66
DO  - 10.1080/00958972.2013.786052
ER  - 

@article{
author = "Filipović, Nenad and Borna, Marija and Klisurić, Olivera and Pregelj, Matej and Jagodić, Marko and Andjelković, Katarina and Todorović, Tamara",
year = "2013",
abstract = "Copper(II) and zinc(II) complexes with the condensation derivative of 2-acetylpyridine and hydrolyzed ethyl hydrazinoacetate were synthesized in a one pot reaction. Crystal structure of the zinc(II) complex was determined by single-crystal X-ray diffraction. In this binuclear complex, the ligand is coordinated via pyridine and imine nitrogen, while carboxylate oxygen is a bridge between metal centers. The fifth coordination site is occupied by a chloride, giving a distorted square pyramidal geometry around each zinc(II). The molecular structure of the copper(II) complex was determined from elemental analysis, infrared and electron paramagnetic resonance spectroscopy, molar conductivity, mass spectrometry, and measurements of the magnetic moment. Thermal behavior of both complexes was studied by thermogravimetric analysis coupled with mass spectrometer.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Synthesis, characterization, and thermal behavior of Cu(II) and Zn(II) complexes with (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetic acid (aphaOH). Crystal structure of [Zn-2(aphaO)(2)Cl-2]",
pages = "1560-1549",
number = "9",
volume = "66",
doi = "10.1080/00958972.2013.786052"
}

Filipović, N., Borna, M., Klisurić, O., Pregelj, M., Jagodić, M., Andjelković, K.,& Todorović, T.. (2013). Synthesis, characterization, and thermal behavior of Cu(II) and Zn(II) complexes with (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetic acid (aphaOH). Crystal structure of [Zn-2(aphaO)(2)Cl-2]. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 66(9), 1549-1560.
https://doi.org/10.1080/00958972.2013.786052

Filipović N, Borna M, Klisurić O, Pregelj M, Jagodić M, Andjelković K, Todorović T. Synthesis, characterization, and thermal behavior of Cu(II) and Zn(II) complexes with (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetic acid (aphaOH). Crystal structure of [Zn-2(aphaO)(2)Cl-2]. in Journal of Coordination Chemistry. 2013;66(9):1549-1560.
doi:10.1080/00958972.2013.786052 .

Filipović, Nenad, Borna, Marija, Klisurić, Olivera, Pregelj, Matej, Jagodić, Marko, Andjelković, Katarina, Todorović, Tamara, "Synthesis, characterization, and thermal behavior of Cu(II) and Zn(II) complexes with (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetic acid (aphaOH). Crystal structure of [Zn-2(aphaO)(2)Cl-2]" in Journal of Coordination Chemistry, 66, no. 9 (2013):1549-1560,
https://doi.org/10.1080/00958972.2013.786052 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Todorović, Tamara
AU  - Radanović, Dušanka
AU  - Divjaković, Vladimir
AU  - Marković, Rade
AU  - Pajić, Ivana A.
AU  - Andjelković, Katarina
PY  - 2012
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3003
AB  - Two novel cadmium(II) complexes with condensation derivatives of 2-acetylpyridine or 2,6-diacetylpyridine with ethyl hydrazinoacetate hydrochloride were synthesized. X-ray crystal structures of the complexes revealed a bidentate coordination of the 2-acetylpyridine derivative, while the symmetric 2,6-diacetylpyridine derivative was coordinated tridentately. It was found that the oxygen atoms were not coordinated to the cadmium ions, despite the fact that they are the position to form six membered chelate rings. NMR spectroscopy investigations showed that the coordination properties of the ligands do not change in solution. Both complexes possess cytotoxic potential, as determined by the toxicity test to Artemia
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Solid state and solution structures of Cd(II) complexes with two N-heteroaromatic Schiff bases containing ester groups
EP  - 28
IS  - 1
SP  - 19
VL  - 31
DO  - 10.1016/j.poly.2011.07.023
ER  - 

@article{
author = "Filipović, Nenad and Todorović, Tamara and Radanović, Dušanka and Divjaković, Vladimir and Marković, Rade and Pajić, Ivana A. and Andjelković, Katarina",
year = "2012",
abstract = "Two novel cadmium(II) complexes with condensation derivatives of 2-acetylpyridine or 2,6-diacetylpyridine with ethyl hydrazinoacetate hydrochloride were synthesized. X-ray crystal structures of the complexes revealed a bidentate coordination of the 2-acetylpyridine derivative, while the symmetric 2,6-diacetylpyridine derivative was coordinated tridentately. It was found that the oxygen atoms were not coordinated to the cadmium ions, despite the fact that they are the position to form six membered chelate rings. NMR spectroscopy investigations showed that the coordination properties of the ligands do not change in solution. Both complexes possess cytotoxic potential, as determined by the toxicity test to Artemia",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Solid state and solution structures of Cd(II) complexes with two N-heteroaromatic Schiff bases containing ester groups",
pages = "28-19",
number = "1",
volume = "31",
doi = "10.1016/j.poly.2011.07.023"
}

Filipović, N., Todorović, T., Radanović, D., Divjaković, V., Marković, R., Pajić, I. A.,& Andjelković, K.. (2012). Solid state and solution structures of Cd(II) complexes with two N-heteroaromatic Schiff bases containing ester groups. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 31(1), 19-28.
https://doi.org/10.1016/j.poly.2011.07.023

Filipović N, Todorović T, Radanović D, Divjaković V, Marković R, Pajić IA, Andjelković K. Solid state and solution structures of Cd(II) complexes with two N-heteroaromatic Schiff bases containing ester groups. in Polyhedron. 2012;31(1):19-28.
doi:10.1016/j.poly.2011.07.023 .

Filipović, Nenad, Todorović, Tamara, Radanović, Dušanka, Divjaković, Vladimir, Marković, Rade, Pajić, Ivana A., Andjelković, Katarina, "Solid state and solution structures of Cd(II) complexes with two N-heteroaromatic Schiff bases containing ester groups" in Polyhedron, 31, no. 1 (2012):19-28,
https://doi.org/10.1016/j.poly.2011.07.023 . .

TY  - JOUR
AU  - Vujcić, Miroslava
AU  - Lazić, Milan
AU  - Milenković, Milica
AU  - Sladić, Dušan M.
AU  - Radulović, Siniša
AU  - Filipović, Nenad
AU  - Andjelković, Katarina
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2641
AB  - Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Biochemical and Molecular Toxicology
T1  - A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide
EP  - 182
IS  - 3
SP  - 175
VL  - 25
DO  - 10.1002/jbt.20374
ER  - 

@article{
author = "Vujcić, Miroslava and Lazić, Milan and Milenković, Milica and Sladić, Dušan M. and Radulović, Siniša and Filipović, Nenad and Andjelković, Katarina",
year = "2011",
abstract = "Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Biochemical and Molecular Toxicology",
title = "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide",
pages = "182-175",
number = "3",
volume = "25",
doi = "10.1002/jbt.20374"
}

Vujcić, M., Lazić, M., Milenković, M., Sladić, D. M., Radulović, S., Filipović, N.,& Andjelković, K.. (2011). A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology
Wiley-Blackwell, Malden., 25(3), 175-182.
https://doi.org/10.1002/jbt.20374

Vujcić M, Lazić M, Milenković M, Sladić DM, Radulović S, Filipović N, Andjelković K. A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology. 2011;25(3):175-182.
doi:10.1002/jbt.20374 .

Vujcić, Miroslava, Lazić, Milan, Milenković, Milica, Sladić, Dušan M., Radulović, Siniša, Filipović, Nenad, Andjelković, Katarina, "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide" in Journal of Biochemical and Molecular Toxicology, 25, no. 3 (2011):175-182,
https://doi.org/10.1002/jbt.20374 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Todorović, Tamara
AU  - Marković, Rade
AU  - Marinković, Aleksandar
AU  - Tufegdzić, Srdan
AU  - Godjevac, Dejan
AU  - Andjelković, Katarina
PY  - 2010
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2301
AB  - Condensation derivatives of ethyl hydrazinoacetate with 2-formylpyridine and quinoline-2-carboxaldehyde were synthesized. Pd(II), Pt(II) and Cd(II) complexes with the 2-formylpyridine derivative and a Cd(II) complex with the quinoline-2-carboxaldehyde derivative were synthesized and characterized by spectroscopic techniques. In the complexes, both ligands are coordinated in neutral NN bidentate modes, while the remaining two coordination sites are occupied by chloride. All compounds showed biological activity when tested against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
PB  - Springer, Dordrecht
T2  - Transition Metal Chemistry
T1  - Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II)
EP  - 772
IS  - 6
SP  - 765
VL  - 35
DO  - 10.1007/s11243-010-9391-9
ER  - 

@article{
author = "Filipović, Nenad and Todorović, Tamara and Marković, Rade and Marinković, Aleksandar and Tufegdzić, Srdan and Godjevac, Dejan and Andjelković, Katarina",
year = "2010",
abstract = "Condensation derivatives of ethyl hydrazinoacetate with 2-formylpyridine and quinoline-2-carboxaldehyde were synthesized. Pd(II), Pt(II) and Cd(II) complexes with the 2-formylpyridine derivative and a Cd(II) complex with the quinoline-2-carboxaldehyde derivative were synthesized and characterized by spectroscopic techniques. In the complexes, both ligands are coordinated in neutral NN bidentate modes, while the remaining two coordination sites are occupied by chloride. All compounds showed biological activity when tested against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.",
publisher = "Springer, Dordrecht",
journal = "Transition Metal Chemistry",
title = "Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II)",
pages = "772-765",
number = "6",
volume = "35",
doi = "10.1007/s11243-010-9391-9"
}

Filipović, N., Todorović, T., Marković, R., Marinković, A., Tufegdzić, S., Godjevac, D.,& Andjelković, K.. (2010). Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II). in Transition Metal Chemistry
Springer, Dordrecht., 35(6), 765-772.
https://doi.org/10.1007/s11243-010-9391-9

Filipović N, Todorović T, Marković R, Marinković A, Tufegdzić S, Godjevac D, Andjelković K. Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II). in Transition Metal Chemistry. 2010;35(6):765-772.
doi:10.1007/s11243-010-9391-9 .

Filipović, Nenad, Todorović, Tamara, Marković, Rade, Marinković, Aleksandar, Tufegdzić, Srdan, Godjevac, Dejan, Andjelković, Katarina, "Synthesis, characterization and biological activities of N-heteroaromatic hydrazones and their complexes with Pd(II), Pt(II) and Cd(II)" in Transition Metal Chemistry, 35, no. 6 (2010):765-772,
https://doi.org/10.1007/s11243-010-9391-9 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Borrmann, Horst
AU  - Todorović, Tamara
AU  - Borna, Marija
AU  - Spasojević, Vojislav
AU  - Sladić, Dušan M.
AU  - Novaković, Irena
AU  - Andjelković, Katarina
PY  - 2009
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1998
AB  - Three novel copper(II) complexes as condensation derivatives of 2-pyridinecarboxaldehyde, 2-acetylpyridine or 2-quinolinecarboxaldehyde with ethyl hydrazinoacetate hydrochloride were synthesized. X-ray crystal structures of all three complexes were determined. Crystallographic data indicate a common basis of the structures with some major differences. Both pyridine derivatives form complexes of the type [CuCl2L] with distorted square-planar geometry around copper(II), but show a decisive difference in the side chain orientation. The quinoline derivative forms a dimeric complex of type [Cu2Cl4L2] with distorted trigonal bipyramidal geometry around copper(II), but a rather short Cu center dot center dot center dot Cu contact, which is reflected in its magnetic properties. All three complexes showed antibacterial activity.
PB  - Elsevier Science Sa, Lausanne
T2  - Inorganica Chimica Acta
T1  - Copper(II) complexes of N-heteroaromatic hydrazones: Synthesis, X-ray structure, magnetic behavior, and antibacterial activity
EP  - 2000
IS  - 6
SP  - 1996
VL  - 362
DO  - 10.1016/j.ica.2008.09.019
ER  - 

@article{
author = "Filipović, Nenad and Borrmann, Horst and Todorović, Tamara and Borna, Marija and Spasojević, Vojislav and Sladić, Dušan M. and Novaković, Irena and Andjelković, Katarina",
year = "2009",
abstract = "Three novel copper(II) complexes as condensation derivatives of 2-pyridinecarboxaldehyde, 2-acetylpyridine or 2-quinolinecarboxaldehyde with ethyl hydrazinoacetate hydrochloride were synthesized. X-ray crystal structures of all three complexes were determined. Crystallographic data indicate a common basis of the structures with some major differences. Both pyridine derivatives form complexes of the type [CuCl2L] with distorted square-planar geometry around copper(II), but show a decisive difference in the side chain orientation. The quinoline derivative forms a dimeric complex of type [Cu2Cl4L2] with distorted trigonal bipyramidal geometry around copper(II), but a rather short Cu center dot center dot center dot Cu contact, which is reflected in its magnetic properties. All three complexes showed antibacterial activity.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Inorganica Chimica Acta",
title = "Copper(II) complexes of N-heteroaromatic hydrazones: Synthesis, X-ray structure, magnetic behavior, and antibacterial activity",
pages = "2000-1996",
number = "6",
volume = "362",
doi = "10.1016/j.ica.2008.09.019"
}

Filipović, N., Borrmann, H., Todorović, T., Borna, M., Spasojević, V., Sladić, D. M., Novaković, I.,& Andjelković, K.. (2009). Copper(II) complexes of N-heteroaromatic hydrazones: Synthesis, X-ray structure, magnetic behavior, and antibacterial activity. in Inorganica Chimica Acta
Elsevier Science Sa, Lausanne., 362(6), 1996-2000.
https://doi.org/10.1016/j.ica.2008.09.019

Filipović N, Borrmann H, Todorović T, Borna M, Spasojević V, Sladić DM, Novaković I, Andjelković K. Copper(II) complexes of N-heteroaromatic hydrazones: Synthesis, X-ray structure, magnetic behavior, and antibacterial activity. in Inorganica Chimica Acta. 2009;362(6):1996-2000.
doi:10.1016/j.ica.2008.09.019 .

Filipović, Nenad, Borrmann, Horst, Todorović, Tamara, Borna, Marija, Spasojević, Vojislav, Sladić, Dušan M., Novaković, Irena, Andjelković, Katarina, "Copper(II) complexes of N-heteroaromatic hydrazones: Synthesis, X-ray structure, magnetic behavior, and antibacterial activity" in Inorganica Chimica Acta, 362, no. 6 (2009):1996-2000,
https://doi.org/10.1016/j.ica.2008.09.019 . .

TY  - JOUR
AU  - Todorović, Tamara R.
AU  - Bacchi, Alessia
AU  - Sladić, Dušan M.
AU  - Todorović, Nina M.
AU  - Božić, Tatjana T.
AU  - Radanović, Dušanka
AU  - Filipović, Nenad
AU  - Pelizzi, Giancarlo
AU  - Andjelković, Katarina
PY  - 2009
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2011
AB  - Five new complexes of Pt(II), Pd(II), Co(III) and Ni(II) with 2-pyridine(quinoline) carboxaldehyde selenose-micarbazones were synthesized and characterized. Crystal structures of Pt(II) complex with the pyridine derivative and Co(III) complex with the quinoline derivative were determined. In all complexes the ligands were coordinated through N2Se donor atom set forming either square-planar (Pt, Pd) or octahedral (Co, Ni) geometry. All complexes showed biological activity.
PB  - Elsevier Science Sa, Lausanne
T2  - Inorganica Chimica Acta
T1  - Synthesis, characterization and biological activity evaluation of Pt(II), Pd(II), Co(III) and Ni(II) complexes with N-heteroaromatic selenosemicarbazones
EP  - 3820
IS  - 10
SP  - 3813
VL  - 362
DO  - 10.1016/j.ica.2009.04.047
ER  - 

@article{
author = "Todorović, Tamara R. and Bacchi, Alessia and Sladić, Dušan M. and Todorović, Nina M. and Božić, Tatjana T. and Radanović, Dušanka and Filipović, Nenad and Pelizzi, Giancarlo and Andjelković, Katarina",
year = "2009",
abstract = "Five new complexes of Pt(II), Pd(II), Co(III) and Ni(II) with 2-pyridine(quinoline) carboxaldehyde selenose-micarbazones were synthesized and characterized. Crystal structures of Pt(II) complex with the pyridine derivative and Co(III) complex with the quinoline derivative were determined. In all complexes the ligands were coordinated through N2Se donor atom set forming either square-planar (Pt, Pd) or octahedral (Co, Ni) geometry. All complexes showed biological activity.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Inorganica Chimica Acta",
title = "Synthesis, characterization and biological activity evaluation of Pt(II), Pd(II), Co(III) and Ni(II) complexes with N-heteroaromatic selenosemicarbazones",
pages = "3820-3813",
number = "10",
volume = "362",
doi = "10.1016/j.ica.2009.04.047"
}

Todorović, T. R., Bacchi, A., Sladić, D. M., Todorović, N. M., Božić, T. T., Radanović, D., Filipović, N., Pelizzi, G.,& Andjelković, K.. (2009). Synthesis, characterization and biological activity evaluation of Pt(II), Pd(II), Co(III) and Ni(II) complexes with N-heteroaromatic selenosemicarbazones. in Inorganica Chimica Acta
Elsevier Science Sa, Lausanne., 362(10), 3813-3820.
https://doi.org/10.1016/j.ica.2009.04.047

Todorović TR, Bacchi A, Sladić DM, Todorović NM, Božić TT, Radanović D, Filipović N, Pelizzi G, Andjelković K. Synthesis, characterization and biological activity evaluation of Pt(II), Pd(II), Co(III) and Ni(II) complexes with N-heteroaromatic selenosemicarbazones. in Inorganica Chimica Acta. 2009;362(10):3813-3820.
doi:10.1016/j.ica.2009.04.047 .

Todorović, Tamara R., Bacchi, Alessia, Sladić, Dušan M., Todorović, Nina M., Božić, Tatjana T., Radanović, Dušanka, Filipović, Nenad, Pelizzi, Giancarlo, Andjelković, Katarina, "Synthesis, characterization and biological activity evaluation of Pt(II), Pd(II), Co(III) and Ni(II) complexes with N-heteroaromatic selenosemicarbazones" in Inorganica Chimica Acta, 362, no. 10 (2009):3813-3820,
https://doi.org/10.1016/j.ica.2009.04.047 . .

TY  - JOUR
AU  - Gligorijević, Nevenka
AU  - Todorović, Tamara
AU  - Radulović, Siniša
AU  - Sladić, Dušan M.
AU  - Filipović, Nenad
AU  - Godjevac, Dejan
AU  - Jeremić, Dejan
AU  - Andjelković, Katarina
PY  - 2009
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2034
AB  - New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones
EP  - 1629
IS  - 4
SP  - 1623
VL  - 44
DO  - 10.1016/j.ejmech.2008.07.033
ER  - 

@article{
author = "Gligorijević, Nevenka and Todorović, Tamara and Radulović, Siniša and Sladić, Dušan M. and Filipović, Nenad and Godjevac, Dejan and Jeremić, Dejan and Andjelković, Katarina",
year = "2009",
abstract = "New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones",
pages = "1629-1623",
number = "4",
volume = "44",
doi = "10.1016/j.ejmech.2008.07.033"
}

Gligorijević, N., Todorović, T., Radulović, S., Sladić, D. M., Filipović, N., Godjevac, D., Jeremić, D.,& Andjelković, K.. (2009). Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 44(4), 1623-1629.
https://doi.org/10.1016/j.ejmech.2008.07.033

Gligorijević N, Todorović T, Radulović S, Sladić DM, Filipović N, Godjevac D, Jeremić D, Andjelković K. Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry. 2009;44(4):1623-1629.
doi:10.1016/j.ejmech.2008.07.033 .

Gligorijević, Nevenka, Todorović, Tamara, Radulović, Siniša, Sladić, Dušan M., Filipović, Nenad, Godjevac, Dejan, Jeremić, Dejan, Andjelković, Katarina, "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones" in European Journal of Medicinal Chemistry, 44, no. 4 (2009):1623-1629,
https://doi.org/10.1016/j.ejmech.2008.07.033 . .

TY  - JOUR
AU  - Todorović, Tamara R.
AU  - Rychlewska, Urszula
AU  - Warzajtis, Beata
AU  - Radanović, Dušanka
AU  - Filipović, Nenad
AU  - Pajić, Ivana A.
AU  - Sladić, Dušan M.
AU  - Andjelković, Katarina
PY  - 2009
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2105
AB  - The bimetallic [Ni-2(H(2)L2)(2)](ClO4)(4) (1), [Ni-2(HL2)(H(2)L2)](ClO4)(3) (2) and [Zn-2(H(2)L2)(2)](BF4)(4) (3) complexes (H(2)L2 = N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide) were synthesized and characterized. The structure of complexes (1) and (2) was established by X-ray analysis. NMR spectroscopy was used for the characterization of complex (3). The complexes (1) and (2) were obtained from the same synthetic reaction and two crystal types of these complexes have been isolated during the fractional crystallization process. In complex (1) each Ni(II) ion is coordinated with two NNO donor atom sets from two H(2)L2 ligands forming an octahedral geometry. Similarly, in complex (2) the octahedral geometry of each Ni(II) ion is attained by coordination of two NNO donor atom sets, one from the neutral and the other from the monoanionic form of the ligand. The antimicrobial activity of the ligand and complexes is also presented.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Synthesis, characterization and antimicrobial activity of Ni(II) and Zn(II) complexes with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. Crystal structures of two highly solvated bimetallic complexes of Ni(II)
EP  - 2402
IS  - 12
SP  - 2397
VL  - 28
DO  - 10.1016/j.poly.2009.05.002
ER  - 

@article{
author = "Todorović, Tamara R. and Rychlewska, Urszula and Warzajtis, Beata and Radanović, Dušanka and Filipović, Nenad and Pajić, Ivana A. and Sladić, Dušan M. and Andjelković, Katarina",
year = "2009",
abstract = "The bimetallic [Ni-2(H(2)L2)(2)](ClO4)(4) (1), [Ni-2(HL2)(H(2)L2)](ClO4)(3) (2) and [Zn-2(H(2)L2)(2)](BF4)(4) (3) complexes (H(2)L2 = N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide) were synthesized and characterized. The structure of complexes (1) and (2) was established by X-ray analysis. NMR spectroscopy was used for the characterization of complex (3). The complexes (1) and (2) were obtained from the same synthetic reaction and two crystal types of these complexes have been isolated during the fractional crystallization process. In complex (1) each Ni(II) ion is coordinated with two NNO donor atom sets from two H(2)L2 ligands forming an octahedral geometry. Similarly, in complex (2) the octahedral geometry of each Ni(II) ion is attained by coordination of two NNO donor atom sets, one from the neutral and the other from the monoanionic form of the ligand. The antimicrobial activity of the ligand and complexes is also presented.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Synthesis, characterization and antimicrobial activity of Ni(II) and Zn(II) complexes with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. Crystal structures of two highly solvated bimetallic complexes of Ni(II)",
pages = "2402-2397",
number = "12",
volume = "28",
doi = "10.1016/j.poly.2009.05.002"
}

Todorović, T. R., Rychlewska, U., Warzajtis, B., Radanović, D., Filipović, N., Pajić, I. A., Sladić, D. M.,& Andjelković, K.. (2009). Synthesis, characterization and antimicrobial activity of Ni(II) and Zn(II) complexes with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. Crystal structures of two highly solvated bimetallic complexes of Ni(II). in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 28(12), 2397-2402.
https://doi.org/10.1016/j.poly.2009.05.002

Todorović TR, Rychlewska U, Warzajtis B, Radanović D, Filipović N, Pajić IA, Sladić DM, Andjelković K. Synthesis, characterization and antimicrobial activity of Ni(II) and Zn(II) complexes with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. Crystal structures of two highly solvated bimetallic complexes of Ni(II). in Polyhedron. 2009;28(12):2397-2402.
doi:10.1016/j.poly.2009.05.002 .

Todorović, Tamara R., Rychlewska, Urszula, Warzajtis, Beata, Radanović, Dušanka, Filipović, Nenad, Pajić, Ivana A., Sladić, Dušan M., Andjelković, Katarina, "Synthesis, characterization and antimicrobial activity of Ni(II) and Zn(II) complexes with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. Crystal structures of two highly solvated bimetallic complexes of Ni(II)" in Polyhedron, 28, no. 12 (2009):2397-2402,
https://doi.org/10.1016/j.poly.2009.05.002 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Bacchi, Alessia
AU  - Lazić, Milan
AU  - Pelizzi, Giancarlo
AU  - Radulović, Siniša
AU  - Sladić, Dušan M.
AU  - Todorović, Tamara R.
AU  - Andjelković, Katarina
PY  - 2008
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1832
AB  - A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells.
PB  - Elsevier, Amsterdam
T2  - Inorganic Chemistry Communications
T1  - Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide
EP  - 50
IS  - 1
SP  - 47
VL  - 11
DO  - 10.1016/j.inoche.2007.10.013
ER  - 

@article{
author = "Filipović, Nenad and Bacchi, Alessia and Lazić, Milan and Pelizzi, Giancarlo and Radulović, Siniša and Sladić, Dušan M. and Todorović, Tamara R. and Andjelković, Katarina",
year = "2008",
abstract = "A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells.",
publisher = "Elsevier, Amsterdam",
journal = "Inorganic Chemistry Communications",
title = "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide",
pages = "50-47",
number = "1",
volume = "11",
doi = "10.1016/j.inoche.2007.10.013"
}

Filipović, N., Bacchi, A., Lazić, M., Pelizzi, G., Radulović, S., Sladić, D. M., Todorović, T. R.,& Andjelković, K.. (2008). Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications
Elsevier, Amsterdam., 11(1), 47-50.
https://doi.org/10.1016/j.inoche.2007.10.013

Filipović N, Bacchi A, Lazić M, Pelizzi G, Radulović S, Sladić DM, Todorović TR, Andjelković K. Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications. 2008;11(1):47-50.
doi:10.1016/j.inoche.2007.10.013 .

Filipović, Nenad, Bacchi, Alessia, Lazić, Milan, Pelizzi, Giancarlo, Radulović, Siniša, Sladić, Dušan M., Todorović, Tamara R., Andjelković, Katarina, "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide" in Inorganic Chemistry Communications, 11, no. 1 (2008):47-50,
https://doi.org/10.1016/j.inoche.2007.10.013 . .

TY  - CONF
AU  - Filipović, Nenad
AU  - Todorović, Tamara
AU  - Sladić, Dušan M.
AU  - Novaković, Irena
AU  - Jeremić, D.A.
AU  - Andjelković, K.K.
PY  - 2007
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1361
AB  - New complexes of Pt(II) with condensation derivatives of ethyl hydrazino acetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, H-1- and C-13-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity.
PB  - 8th Conference of the Yugoslav Materials Research Society
C3  - Materials Science Forum
T1  - Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands
EP  - 427
SP  - 423
VL  - 555
DO  - 10.4028/0-87849-441-3.423
ER  - 

@conference{
author = "Filipović, Nenad and Todorović, Tamara and Sladić, Dušan M. and Novaković, Irena and Jeremić, D.A. and Andjelković, K.K.",
year = "2007",
abstract = "New complexes of Pt(II) with condensation derivatives of ethyl hydrazino acetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, H-1- and C-13-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity.",
publisher = "8th Conference of the Yugoslav Materials Research Society",
journal = "Materials Science Forum",
title = "Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands",
pages = "427-423",
volume = "555",
doi = "10.4028/0-87849-441-3.423"
}

Filipović, N., Todorović, T., Sladić, D. M., Novaković, I., Jeremić, D.A.,& Andjelković, K.K.. (2007). Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands. in Materials Science Forum
8th Conference of the Yugoslav Materials Research Society., 555, 423-427.
https://doi.org/10.4028/0-87849-441-3.423

Filipović N, Todorović T, Sladić DM, Novaković I, Jeremić D, Andjelković K. Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands. in Materials Science Forum. 2007;555:423-427.
doi:10.4028/0-87849-441-3.423 .

Filipović, Nenad, Todorović, Tamara, Sladić, Dušan M., Novaković, Irena, Jeremić, D.A., Andjelković, K.K., "Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands" in Materials Science Forum, 555 (2007):423-427,
https://doi.org/10.4028/0-87849-441-3.423 . .

TY  - JOUR
AU  - Todorović, Tamara R.
AU  - Bacchi, Alessia
AU  - Juranić, Nenad O.
AU  - Sladić, Dušan M.
AU  - Pelizzi, Giancarlo
AU  - Božić, Tatjana T.
AU  - Filipović, Nenad
AU  - Andjelković, Katarina
PY  - 2007
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1554
AB  - New complexes of Cd(II), Zn(II) and Ni(II) with 2-quinolinecarboxaldehyde selenosernicarbazone (Hqasesc) were synthesized and structurally characterized. The structure of the ligand, Cd(II) and Zn(II) complexes was determined by NMR and IR spectroscopy, elemental microanalysis and molar conductivity measurements. Both complexes occur in solution in two forms, the major tetrahedral and minor octahedral. In the major Cd(II) complex one qasesc(-) ligand is coordinated as a tridentate, the fourth coordination site being occupied by acetate, while in the major Zn(II) complex two qasesc- ligands are coordinated as bidentates. In both minor complexes two qasesc- ligands are coordinated as tridentates forming the octahedral geometry around the central metal ion. The only paramagnetic complex in the series is Ni(II) complex for which X-ray structure analysis was performed. The complex has the angularly distorted octahedral geometry with two qasesc- ligands coordinated as tridentates, in a similar way as in the minor complexes of Cd(11) and Zn(11).
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Synthesis and characterization of novel Cd(II), Zn(II) and Ni(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone. Crystal structure of bis(2-quinolinecarboxaldehyde selenosemicarbazonato)nickel(II)
EP  - 3436
IS  - 13
SP  - 3428
VL  - 26
DO  - 10.1016/j.poly.2007.03.023
ER  - 

@article{
author = "Todorović, Tamara R. and Bacchi, Alessia and Juranić, Nenad O. and Sladić, Dušan M. and Pelizzi, Giancarlo and Božić, Tatjana T. and Filipović, Nenad and Andjelković, Katarina",
year = "2007",
abstract = "New complexes of Cd(II), Zn(II) and Ni(II) with 2-quinolinecarboxaldehyde selenosernicarbazone (Hqasesc) were synthesized and structurally characterized. The structure of the ligand, Cd(II) and Zn(II) complexes was determined by NMR and IR spectroscopy, elemental microanalysis and molar conductivity measurements. Both complexes occur in solution in two forms, the major tetrahedral and minor octahedral. In the major Cd(II) complex one qasesc(-) ligand is coordinated as a tridentate, the fourth coordination site being occupied by acetate, while in the major Zn(II) complex two qasesc- ligands are coordinated as bidentates. In both minor complexes two qasesc- ligands are coordinated as tridentates forming the octahedral geometry around the central metal ion. The only paramagnetic complex in the series is Ni(II) complex for which X-ray structure analysis was performed. The complex has the angularly distorted octahedral geometry with two qasesc- ligands coordinated as tridentates, in a similar way as in the minor complexes of Cd(11) and Zn(11).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Synthesis and characterization of novel Cd(II), Zn(II) and Ni(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone. Crystal structure of bis(2-quinolinecarboxaldehyde selenosemicarbazonato)nickel(II)",
pages = "3436-3428",
number = "13",
volume = "26",
doi = "10.1016/j.poly.2007.03.023"
}

Todorović, T. R., Bacchi, A., Juranić, N. O., Sladić, D. M., Pelizzi, G., Božić, T. T., Filipović, N.,& Andjelković, K.. (2007). Synthesis and characterization of novel Cd(II), Zn(II) and Ni(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone. Crystal structure of bis(2-quinolinecarboxaldehyde selenosemicarbazonato)nickel(II). in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 26(13), 3428-3436.
https://doi.org/10.1016/j.poly.2007.03.023

Todorović TR, Bacchi A, Juranić NO, Sladić DM, Pelizzi G, Božić TT, Filipović N, Andjelković K. Synthesis and characterization of novel Cd(II), Zn(II) and Ni(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone. Crystal structure of bis(2-quinolinecarboxaldehyde selenosemicarbazonato)nickel(II). in Polyhedron. 2007;26(13):3428-3436.
doi:10.1016/j.poly.2007.03.023 .

Todorović, Tamara R., Bacchi, Alessia, Juranić, Nenad O., Sladić, Dušan M., Pelizzi, Giancarlo, Božić, Tatjana T., Filipović, Nenad, Andjelković, Katarina, "Synthesis and characterization of novel Cd(II), Zn(II) and Ni(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone. Crystal structure of bis(2-quinolinecarboxaldehyde selenosemicarbazonato)nickel(II)" in Polyhedron, 26, no. 13 (2007):3428-3436,
https://doi.org/10.1016/j.poly.2007.03.023 . .