TY  - JOUR
AU  - Pantelić, Nebojša
AU  - Zmejkovski, Bojana B.
AU  - Stanojković, Tatjana P.
AU  - Jevtić, Verica V.
AU  - Radić, Gordana P.
AU  - Trifunović, Srecko R.
AU  - Kaludjerović, Goran N.
AU  - Sabo, Tibor J.
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3417
AB  - A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M.
PB  - Srpsko hemijsko društvo, Beograd
T2  - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
T1  - Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters
EP  - 658
IS  - 6
SP  - 649
VL  - 79
DO  - 10.2298/JSC130512022P
ER  - 

@article{
author = "Pantelić, Nebojša and Zmejkovski, Bojana B. and Stanojković, Tatjana P. and Jevtić, Verica V. and Radić, Gordana P. and Trifunović, Srecko R. and Kaludjerović, Goran N. and Sabo, Tibor J.",
year = "2014",
abstract = "A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY",
title = "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters",
pages = "658-649",
number = "6",
volume = "79",
doi = "10.2298/JSC130512022P"
}

Pantelić, N., Zmejkovski, B. B., Stanojković, T. P., Jevtić, V. V., Radić, G. P., Trifunović, S. R., Kaludjerović, G. N.,& Sabo, T. J.. (2014). Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Srpsko hemijsko društvo, Beograd., 79(6), 649-658.
https://doi.org/10.2298/JSC130512022P

Pantelić N, Zmejkovski BB, Stanojković TP, Jevtić VV, Radić GP, Trifunović SR, Kaludjerović GN, Sabo TJ. Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2014;79(6):649-658.
doi:10.2298/JSC130512022P .

Pantelić, Nebojša, Zmejkovski, Bojana B., Stanojković, Tatjana P., Jevtić, Verica V., Radić, Gordana P., Trifunović, Srecko R., Kaludjerović, Goran N., Sabo, Tibor J., "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 79, no. 6 (2014):649-658,
https://doi.org/10.2298/JSC130512022P . .