Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters
2014
Аутори
Pantelić, NebojšaZmejkovski, Bojana B.
Stanojković, Tatjana P.
Jevtić, Verica V.
Radić, Gordana P.
Trifunović, Srecko R.
Kaludjerović, Goran N.
Sabo, Tibor J.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M.
Кључне речи:
R(2)edda-type esters / characterization / cytotoxicity / selectivityИзвор:
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2014, 79, 6, 649-658Издавач:
- Srpsko hemijsko društvo, Beograd
Финансирање / пројекти:
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
- Модификатори биолошког одговора у физиолошким и патолошким стањима (RS-MESTD-Basic Research (BR or ON)-175011)
DOI: 10.2298/JSC130512022P
ISSN: 0352-5139
WoS: 000338268800003
Scopus: 2-s2.0-84903140555
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Pantelić, Nebojša AU - Zmejkovski, Bojana B. AU - Stanojković, Tatjana P. AU - Jevtić, Verica V. AU - Radić, Gordana P. AU - Trifunović, Srecko R. AU - Kaludjerović, Goran N. AU - Sabo, Tibor J. PY - 2014 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/3417 AB - A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M. PB - Srpsko hemijsko društvo, Beograd T2 - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY T1 - Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters EP - 658 IS - 6 SP - 649 VL - 79 DO - 10.2298/JSC130512022P ER -
@article{ author = "Pantelić, Nebojša and Zmejkovski, Bojana B. and Stanojković, Tatjana P. and Jevtić, Verica V. and Radić, Gordana P. and Trifunović, Srecko R. and Kaludjerović, Goran N. and Sabo, Tibor J.", year = "2014", abstract = "A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY", title = "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters", pages = "658-649", number = "6", volume = "79", doi = "10.2298/JSC130512022P" }
Pantelić, N., Zmejkovski, B. B., Stanojković, T. P., Jevtić, V. V., Radić, G. P., Trifunović, S. R., Kaludjerović, G. N.,& Sabo, T. J.. (2014). Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY Srpsko hemijsko društvo, Beograd., 79(6), 649-658. https://doi.org/10.2298/JSC130512022P
Pantelić N, Zmejkovski BB, Stanojković TP, Jevtić VV, Radić GP, Trifunović SR, Kaludjerović GN, Sabo TJ. Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2014;79(6):649-658. doi:10.2298/JSC130512022P .
Pantelić, Nebojša, Zmejkovski, Bojana B., Stanojković, Tatjana P., Jevtić, Verica V., Radić, Gordana P., Trifunović, Srecko R., Kaludjerović, Goran N., Sabo, Tibor J., "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 79, no. 6 (2014):649-658, https://doi.org/10.2298/JSC130512022P . .