TY  - JOUR
AU  - Vujcić, Miroslava
AU  - Lazić, Milan
AU  - Milenković, Milica
AU  - Sladić, Dušan M.
AU  - Radulović, Siniša
AU  - Filipović, Nenad
AU  - Andjelković, Katarina
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2641
AB  - Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Biochemical and Molecular Toxicology
T1  - A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide
EP  - 182
IS  - 3
SP  - 175
VL  - 25
DO  - 10.1002/jbt.20374
ER  - 

@article{
author = "Vujcić, Miroslava and Lazić, Milan and Milenković, Milica and Sladić, Dušan M. and Radulović, Siniša and Filipović, Nenad and Andjelković, Katarina",
year = "2011",
abstract = "Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Biochemical and Molecular Toxicology",
title = "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide",
pages = "182-175",
number = "3",
volume = "25",
doi = "10.1002/jbt.20374"
}

Vujcić, M., Lazić, M., Milenković, M., Sladić, D. M., Radulović, S., Filipović, N.,& Andjelković, K.. (2011). A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology
Wiley-Blackwell, Malden., 25(3), 175-182.
https://doi.org/10.1002/jbt.20374

Vujcić M, Lazić M, Milenković M, Sladić DM, Radulović S, Filipović N, Andjelković K. A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology. 2011;25(3):175-182.
doi:10.1002/jbt.20374 .

Vujcić, Miroslava, Lazić, Milan, Milenković, Milica, Sladić, Dušan M., Radulović, Siniša, Filipović, Nenad, Andjelković, Katarina, "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide" in Journal of Biochemical and Molecular Toxicology, 25, no. 3 (2011):175-182,
https://doi.org/10.1002/jbt.20374 . .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Bacchi, Alessia
AU  - Lazić, Milan
AU  - Pelizzi, Giancarlo
AU  - Radulović, Siniša
AU  - Sladić, Dušan M.
AU  - Todorović, Tamara R.
AU  - Andjelković, Katarina
PY  - 2008
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1832
AB  - A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells.
PB  - Elsevier, Amsterdam
T2  - Inorganic Chemistry Communications
T1  - Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide
EP  - 50
IS  - 1
SP  - 47
VL  - 11
DO  - 10.1016/j.inoche.2007.10.013
ER  - 

@article{
author = "Filipović, Nenad and Bacchi, Alessia and Lazić, Milan and Pelizzi, Giancarlo and Radulović, Siniša and Sladić, Dušan M. and Todorović, Tamara R. and Andjelković, Katarina",
year = "2008",
abstract = "A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells.",
publisher = "Elsevier, Amsterdam",
journal = "Inorganic Chemistry Communications",
title = "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide",
pages = "50-47",
number = "1",
volume = "11",
doi = "10.1016/j.inoche.2007.10.013"
}

Filipović, N., Bacchi, A., Lazić, M., Pelizzi, G., Radulović, S., Sladić, D. M., Todorović, T. R.,& Andjelković, K.. (2008). Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications
Elsevier, Amsterdam., 11(1), 47-50.
https://doi.org/10.1016/j.inoche.2007.10.013

Filipović N, Bacchi A, Lazić M, Pelizzi G, Radulović S, Sladić DM, Todorović TR, Andjelković K. Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications. 2008;11(1):47-50.
doi:10.1016/j.inoche.2007.10.013 .

Filipović, Nenad, Bacchi, Alessia, Lazić, Milan, Pelizzi, Giancarlo, Radulović, Siniša, Sladić, Dušan M., Todorović, Tamara R., Andjelković, Katarina, "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide" in Inorganic Chemistry Communications, 11, no. 1 (2008):47-50,
https://doi.org/10.1016/j.inoche.2007.10.013 . .