TY  - JOUR
AU  - Pantelić, Nebojša
AU  - Lerbs, Martina
AU  - Wolf, Katharina
AU  - Wessjohann, Ludger A.
AU  - Kaludjerović, Goran N.
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4997
AB  - Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(3,4-dihydro-3,4-dioxo-1-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dihydro-1,4-dioxo-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (H-1, C-13, Sn-119) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel synthesized organotin(IV) compounds against human cervix adenocarcinoma (HeLa), human colon carcinoma (HT-29) and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indicate that synthesized compounds exhibited remarkable antiproliferative activity toward all tested cell lines with IC50 in the range from 0.17 to 0.87 mu M. Complex 1 showed the greatest activity against HT-29 cells, with IC50 value of 0.21 +/- 0.01 mu M, 119 times better than cisplatin, while complex 2 demonstrated the highest activity toward HeLa cells, IC50 = 0.17 +/- 0.01 mu M, which is similar to 26 times better than cisplatin.
PB  - Srpsko hemijsko društvo, Beograd
T2  - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
T1  - In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives
EP  - 1127
IS  - 10
SP  - 1119
VL  - 84
DO  - 10.2298/JSC190322032P
ER  - 

@article{
author = "Pantelić, Nebojša and Lerbs, Martina and Wolf, Katharina and Wessjohann, Ludger A. and Kaludjerović, Goran N.",
year = "2019",
abstract = "Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(3,4-dihydro-3,4-dioxo-1-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dihydro-1,4-dioxo-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (H-1, C-13, Sn-119) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel synthesized organotin(IV) compounds against human cervix adenocarcinoma (HeLa), human colon carcinoma (HT-29) and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indicate that synthesized compounds exhibited remarkable antiproliferative activity toward all tested cell lines with IC50 in the range from 0.17 to 0.87 mu M. Complex 1 showed the greatest activity against HT-29 cells, with IC50 value of 0.21 +/- 0.01 mu M, 119 times better than cisplatin, while complex 2 demonstrated the highest activity toward HeLa cells, IC50 = 0.17 +/- 0.01 mu M, which is similar to 26 times better than cisplatin.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY",
title = "In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives",
pages = "1127-1119",
number = "10",
volume = "84",
doi = "10.2298/JSC190322032P"
}

Pantelić, N., Lerbs, M., Wolf, K., Wessjohann, L. A.,& Kaludjerović, G. N.. (2019). In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Srpsko hemijsko društvo, Beograd., 84(10), 1119-1127.
https://doi.org/10.2298/JSC190322032P

Pantelić N, Lerbs M, Wolf K, Wessjohann LA, Kaludjerović GN. In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2019;84(10):1119-1127.
doi:10.2298/JSC190322032P .

Pantelić, Nebojša, Lerbs, Martina, Wolf, Katharina, Wessjohann, Ludger A., Kaludjerović, Goran N., "In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 84, no. 10 (2019):1119-1127,
https://doi.org/10.2298/JSC190322032P . .