In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives
2019
Аутори
Pantelić, NebojšaLerbs, Martina
Wolf, Katharina
Wessjohann, Ludger A.
Kaludjerović, Goran N.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(3,4-dihydro-3,4-dioxo-1-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dihydro-1,4-dioxo-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (H-1, C-13, Sn-119) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel synthesized organotin(IV) compounds against human cervix adenocarcinoma (HeLa), human colon carcinoma (HT-29) and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indicate that synthesized compounds exhibited remarkable antiproliferative activity toward all tested cell lines with IC50 in the range from 0.17 to 0.87 mu M. Complex 1 showed the greatest activity against HT-29 cells, with IC50 value of 0.21 +/- 0.01 mu M, 119 times better than cisplatin, while complex 2 demonstrated... the highest activity toward HeLa cells, IC50 = 0.17 +/- 0.01 mu M, which is similar to 26 times better than cisplatin.
Кључне речи:
organotin(IV) compounds / characterization / antitumor agents / cytotoxicityИзвор:
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2019, 84, 10, 1119-1127Издавач:
- Srpsko hemijsko društvo, Beograd
Финансирање / пројекти:
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-172035)
- National scholarship for postdoctoral studies of the Republic of Serbia
DOI: 10.2298/JSC190322032P
ISSN: 0352-5139
WoS: 000496149600006
Scopus: 2-s2.0-85074892899
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Pantelić, Nebojša AU - Lerbs, Martina AU - Wolf, Katharina AU - Wessjohann, Ludger A. AU - Kaludjerović, Goran N. PY - 2019 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4997 AB - Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(3,4-dihydro-3,4-dioxo-1-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dihydro-1,4-dioxo-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (H-1, C-13, Sn-119) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel synthesized organotin(IV) compounds against human cervix adenocarcinoma (HeLa), human colon carcinoma (HT-29) and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indicate that synthesized compounds exhibited remarkable antiproliferative activity toward all tested cell lines with IC50 in the range from 0.17 to 0.87 mu M. Complex 1 showed the greatest activity against HT-29 cells, with IC50 value of 0.21 +/- 0.01 mu M, 119 times better than cisplatin, while complex 2 demonstrated the highest activity toward HeLa cells, IC50 = 0.17 +/- 0.01 mu M, which is similar to 26 times better than cisplatin. PB - Srpsko hemijsko društvo, Beograd T2 - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY T1 - In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives EP - 1127 IS - 10 SP - 1119 VL - 84 DO - 10.2298/JSC190322032P ER -
@article{ author = "Pantelić, Nebojša and Lerbs, Martina and Wolf, Katharina and Wessjohann, Ludger A. and Kaludjerović, Goran N.", year = "2019", abstract = "Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(3,4-dihydro-3,4-dioxo-1-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dihydro-1,4-dioxo-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (H-1, C-13, Sn-119) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel synthesized organotin(IV) compounds against human cervix adenocarcinoma (HeLa), human colon carcinoma (HT-29) and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indicate that synthesized compounds exhibited remarkable antiproliferative activity toward all tested cell lines with IC50 in the range from 0.17 to 0.87 mu M. Complex 1 showed the greatest activity against HT-29 cells, with IC50 value of 0.21 +/- 0.01 mu M, 119 times better than cisplatin, while complex 2 demonstrated the highest activity toward HeLa cells, IC50 = 0.17 +/- 0.01 mu M, which is similar to 26 times better than cisplatin.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY", title = "In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives", pages = "1127-1119", number = "10", volume = "84", doi = "10.2298/JSC190322032P" }
Pantelić, N., Lerbs, M., Wolf, K., Wessjohann, L. A.,& Kaludjerović, G. N.. (2019). In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY Srpsko hemijsko društvo, Beograd., 84(10), 1119-1127. https://doi.org/10.2298/JSC190322032P
Pantelić N, Lerbs M, Wolf K, Wessjohann LA, Kaludjerović GN. In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2019;84(10):1119-1127. doi:10.2298/JSC190322032P .
Pantelić, Nebojša, Lerbs, Martina, Wolf, Katharina, Wessjohann, Ludger A., Kaludjerović, Goran N., "In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 84, no. 10 (2019):1119-1127, https://doi.org/10.2298/JSC190322032P . .