TY  - JOUR
AU  - Sousa, Sergio F.
AU  - Simoes, Manuel
AU  - Filipović, Nenad
PY  - 2020
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5311
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Chemistry
T1  - Editorial: The Chemistry of Biofilms and Their Inhibitors
VL  - 8
DO  - 10.3389/fchem.2020.00746
ER  - 

@article{
author = "Sousa, Sergio F. and Simoes, Manuel and Filipović, Nenad",
year = "2020",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Chemistry",
title = "Editorial: The Chemistry of Biofilms and Their Inhibitors",
volume = "8",
doi = "10.3389/fchem.2020.00746"
}

Sousa, S. F., Simoes, M.,& Filipović, N.. (2020). Editorial: The Chemistry of Biofilms and Their Inhibitors. in Frontiers in Chemistry
Frontiers Media Sa, Lausanne., 8.
https://doi.org/10.3389/fchem.2020.00746

Sousa SF, Simoes M, Filipović N. Editorial: The Chemistry of Biofilms and Their Inhibitors. in Frontiers in Chemistry. 2020;8.
doi:10.3389/fchem.2020.00746 .

Sousa, Sergio F., Simoes, Manuel, Filipović, Nenad, "Editorial: The Chemistry of Biofilms and Their Inhibitors" in Frontiers in Chemistry, 8 (2020),
https://doi.org/10.3389/fchem.2020.00746 . .

TY  - JOUR
AU  - Borges, Anabela
AU  - Simoes, Manuel
AU  - Todorović, Tamara R.
AU  - Filipović, Nenad
AU  - Garcia-Sosa, Alfonso T.
PY  - 2018
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4764
AB  - Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.
PB  - MDPI, BASEL
T2  - Molecules
T1  - Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator
IS  - 6
VL  - 23
DO  - 10.3390/molecules23061385
ER  - 

@article{
author = "Borges, Anabela and Simoes, Manuel and Todorović, Tamara R. and Filipović, Nenad and Garcia-Sosa, Alfonso T.",
year = "2018",
abstract = "Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.",
publisher = "MDPI, BASEL",
journal = "Molecules",
title = "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator",
number = "6",
volume = "23",
doi = "10.3390/molecules23061385"
}

Borges, A., Simoes, M., Todorović, T. R., Filipović, N.,& Garcia-Sosa, A. T.. (2018). Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules
MDPI, BASEL., 23(6).
https://doi.org/10.3390/molecules23061385

Borges A, Simoes M, Todorović TR, Filipović N, Garcia-Sosa AT. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules. 2018;23(6).
doi:10.3390/molecules23061385 .

Borges, Anabela, Simoes, Manuel, Todorović, Tamara R., Filipović, Nenad, Garcia-Sosa, Alfonso T., "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator" in Molecules, 23, no. 6 (2018),
https://doi.org/10.3390/molecules23061385 . .