Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator
Апстракт
Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of ...co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.
Кључне речи:
antibacterial resistance / antivirulence/antipathogenic compounds / biofilm prevention / cobalt complex / furvina / pyocyanin / pyoverdine / quorum sensing inhibition / transcriptional activator protein LasRИзвор:
Molecules, 2018, 23, 6Издавач:
- MDPI, BASEL
Финансирање / пројекти:
- FEDER funds through COMPETE2020 Programa Operacional Competitividade e Internacionalizacao (POCI)
- national funds through FCT Fundacao para a Ciencia e a Tecnologia [SFRH/BPD/98684/2013]
- FEDER Fundo Europeu de Desenvolvimento Regional, through COMPETE2020-Programa Operacional Competitividade e Internacionalizacao (POCI) and Programa Operacional Regional do Norte (NORTE2020) [NORTE-01-0145-FEDER-000005-LEPABE-2-ECO-INNOVATION]
- Estonian Ministry of Education and ResearchMinistry of Education and Research, Estonia [IUT34-14]
- Модулација сигналних путева који контролишу интрацелуларни енергетски баланс у терапији тумора и неуро-имуно-ендокриних поремећаја (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
- EU COST ActionEuropean Union (EU)European Cooperation in Science and Technology (COST) [CM1307, CA15135]
DOI: 10.3390/molecules23061385
ISSN: 1420-3049
PubMed: 29890626
WoS: 000435875400146
Scopus: 2-s2.0-85048340576
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Borges, Anabela AU - Simoes, Manuel AU - Todorović, Tamara R. AU - Filipović, Nenad AU - Garcia-Sosa, Alfonso T. PY - 2018 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4764 AB - Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design. PB - MDPI, BASEL T2 - Molecules T1 - Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator IS - 6 VL - 23 DO - 10.3390/molecules23061385 ER -
@article{ author = "Borges, Anabela and Simoes, Manuel and Todorović, Tamara R. and Filipović, Nenad and Garcia-Sosa, Alfonso T.", year = "2018", abstract = "Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.", publisher = "MDPI, BASEL", journal = "Molecules", title = "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator", number = "6", volume = "23", doi = "10.3390/molecules23061385" }
Borges, A., Simoes, M., Todorović, T. R., Filipović, N.,& Garcia-Sosa, A. T.. (2018). Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules MDPI, BASEL., 23(6). https://doi.org/10.3390/molecules23061385
Borges A, Simoes M, Todorović TR, Filipović N, Garcia-Sosa AT. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules. 2018;23(6). doi:10.3390/molecules23061385 .
Borges, Anabela, Simoes, Manuel, Todorović, Tamara R., Filipović, Nenad, Garcia-Sosa, Alfonso T., "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator" in Molecules, 23, no. 6 (2018), https://doi.org/10.3390/molecules23061385 . .