Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification
Samo za registrovane korisnike
2022
Autori
Su, Guo-ZhuWang, Shang-Yi
Yang, Xiu-Ying
Stevanović, Zora Dajić
Li, Na
Tanić, Nikola
Arsenijević, Nebojša
Yu, Shi-Shan
Li, Yong
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B. © 2022 Elsevier Ltd
Ključne reči:
Album / Dihydroflavonoid glycoside / Lipid accumulation / Loranthaceae / PISA / Viscum album varIzvor:
Phytochemistry, 2022, 204Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Su, Guo-Zhu AU - Wang, Shang-Yi AU - Yang, Xiu-Ying AU - Stevanović, Zora Dajić AU - Li, Na AU - Tanić, Nikola AU - Arsenijević, Nebojša AU - Yu, Shi-Shan AU - Li, Yong PY - 2022 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/6191 AB - Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B. © 2022 Elsevier Ltd T2 - Phytochemistry T2 - Phytochemistry T1 - Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification VL - 204 DO - 10.1016/j.phytochem.2022.113458 ER -
@article{ author = "Su, Guo-Zhu and Wang, Shang-Yi and Yang, Xiu-Ying and Stevanović, Zora Dajić and Li, Na and Tanić, Nikola and Arsenijević, Nebojša and Yu, Shi-Shan and Li, Yong", year = "2022", abstract = "Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B. © 2022 Elsevier Ltd", journal = "Phytochemistry, Phytochemistry", title = "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification", volume = "204", doi = "10.1016/j.phytochem.2022.113458" }
Su, G., Wang, S., Yang, X., Stevanović, Z. D., Li, N., Tanić, N., Arsenijević, N., Yu, S.,& Li, Y.. (2022). Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification. in Phytochemistry, 204. https://doi.org/10.1016/j.phytochem.2022.113458
Su G, Wang S, Yang X, Stevanović ZD, Li N, Tanić N, Arsenijević N, Yu S, Li Y. Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification. in Phytochemistry. 2022;204. doi:10.1016/j.phytochem.2022.113458 .
Su, Guo-Zhu, Wang, Shang-Yi, Yang, Xiu-Ying, Stevanović, Zora Dajić, Li, Na, Tanić, Nikola, Arsenijević, Nebojša, Yu, Shi-Shan, Li, Yong, "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification" in Phytochemistry, 204 (2022), https://doi.org/10.1016/j.phytochem.2022.113458 . .