dc.creator | Krajnović, Tamara | |
dc.creator | Pantelić, Nebojša Đ. | |
dc.creator | Wolf, Katharina | |
dc.creator | Eichhorn, Thomas | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mijatović, Sanja | |
dc.creator | Wessjohann, Ludger .A. | |
dc.creator | Kaluđerović, Goran .N. | |
dc.date.accessioned | 2022-09-20T10:26:24Z | |
dc.date.available | 2022-09-20T10:26:24Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1996-1944 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/6170 | |
dc.description.abstract | Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC50 = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC50 = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic cell death. The MC50 values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated. © 2022 by the authors. | |
dc.language | English | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/20007/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Materials | |
dc.source | Materials | |
dc.subject | cytotoxicity | |
dc.subject | isoxanthohumol | |
dc.subject | melanoma | |
dc.subject | SBA-15 | |
dc.subject | xanthohumol | |
dc.title | Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells | |
dc.type | article | en |
dc.rights.license | BY | |
dc.citation.issue | 14 | |
dc.citation.rank | M22 | |
dc.citation.volume | 15 | |
dc.identifier.doi | 10.3390/ma15145028 | |
dc.identifier.fulltext | http://aspace.agrif.bg.ac.rs/bitstream/id/24025/Anticancer_Potential_of_pub_2022.pdf | |
dc.type.version | publishedVersion | |