Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells
Authors
Krajnović, TamaraPantelić, Nebojša Đ.
Wolf, Katharina
Eichhorn, Thomas
Maksimović-Ivanić, Danijela
Mijatović, Sanja
Wessjohann, Ludger .A.
Kaluđerović, Goran .N.
Article (Published version)
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Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC50 = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC50 = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic c...ell death. The MC50 values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated. © 2022 by the authors.
Keywords:
cytotoxicity / isoxanthohumol / melanoma / SBA-15 / xanthohumolSource:
Materials, 2022, 15, 14Funding / projects:
- Razvoj tehnologije gajenja kukuruza sa ekološkim pristupom (RS-20007)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200116 (University of Belgrade, Faculty of Agriculture) (RS-200116)
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Poljoprivredni fakultetTY - JOUR AU - Krajnović, Tamara AU - Pantelić, Nebojša Đ. AU - Wolf, Katharina AU - Eichhorn, Thomas AU - Maksimović-Ivanić, Danijela AU - Mijatović, Sanja AU - Wessjohann, Ludger .A. AU - Kaluđerović, Goran .N. PY - 2022 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/6170 AB - Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC50 = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC50 = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic cell death. The MC50 values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated. © 2022 by the authors. T2 - Materials T2 - Materials T1 - Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells IS - 14 VL - 15 DO - 10.3390/ma15145028 ER -
@article{ author = "Krajnović, Tamara and Pantelić, Nebojša Đ. and Wolf, Katharina and Eichhorn, Thomas and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Wessjohann, Ludger .A. and Kaluđerović, Goran .N.", year = "2022", abstract = "Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC50 = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC50 = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic cell death. The MC50 values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated. © 2022 by the authors.", journal = "Materials, Materials", title = "Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells", number = "14", volume = "15", doi = "10.3390/ma15145028" }
Krajnović, T., Pantelić, N. Đ., Wolf, K., Eichhorn, T., Maksimović-Ivanić, D., Mijatović, S., Wessjohann, L. .A.,& Kaluđerović, G. .N.. (2022). Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells. in Materials, 15(14). https://doi.org/10.3390/ma15145028
Krajnović T, Pantelić NĐ, Wolf K, Eichhorn T, Maksimović-Ivanić D, Mijatović S, Wessjohann L., Kaluđerović G.. Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells. in Materials. 2022;15(14). doi:10.3390/ma15145028 .
Krajnović, Tamara, Pantelić, Nebojša Đ., Wolf, Katharina, Eichhorn, Thomas, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Wessjohann, Ludger .A., Kaluđerović, Goran .N., "Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells" in Materials, 15, no. 14 (2022), https://doi.org/10.3390/ma15145028 . .