Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients
Nema prikaza
Autori
Peruničić-Peković, GordanaPljesa, S.
Rasić-Milutinović, Z.
Stanković, S.
Ilić, M.
Maletić, Radojka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in patients on hemodialysis. The study population consisted of 42 hemodialysis patients with different parameters of malnutrition. Blood samples were taken after an overnight fast, and plasma lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured by using conventional enzymatic methods. Serum urea and creatinine levels were also measured by routine procedures. Plasma high-sensitivity C-reactive protein level (hs-CRP), TNF-alpha, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Standard Doppler echo examinations were used to determine plaque on carotid arteries, and end-diastolic diameter (EDD) and ejection frac...tion (EF) were measured by echocardiography. Malnourished patients exhibited significantly greater evidence of cardiovascular disease and carotid plaques. Factor (principal component) analysis indicated 6 latent factors with 67.5% of the variance explained within all investigated parameters. Cluster analysis was used to distinguish the inflammatory markers and the nutritional markers from other parameters and to visualize similarities between variables. In summary, this cross-sectional study in hemodialysis patients found a high prevalence of malnutrition, inflammation, carotid plaques, and cardiovascular disease. Malnourished dialysis patients are more often found with cardiovascular disease and carotid plaques. In addition, these patients have higher levels of inflammatory cytokines, which may partly explain the elevated risk for atherosclerotic vascular disease.
Ključne reči:
inflammation / malnutrition / cardiovascular disease / hemodialysisIzvor:
Canadian Journal of Physiology and Pharmacology, 2008, 86, 4, 205-209Izdavač:
- Canadian Science Publishing, Nrc Research Press, Ottawa
DOI: 10.1139/Y08-018
ISSN: 0008-4212
PubMed: 18418430
WoS: 000255517000010
Scopus: 2-s2.0-42149171121
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Peruničić-Peković, Gordana AU - Pljesa, S. AU - Rasić-Milutinović, Z. AU - Stanković, S. AU - Ilić, M. AU - Maletić, Radojka PY - 2008 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/1803 AB - Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in patients on hemodialysis. The study population consisted of 42 hemodialysis patients with different parameters of malnutrition. Blood samples were taken after an overnight fast, and plasma lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured by using conventional enzymatic methods. Serum urea and creatinine levels were also measured by routine procedures. Plasma high-sensitivity C-reactive protein level (hs-CRP), TNF-alpha, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Standard Doppler echo examinations were used to determine plaque on carotid arteries, and end-diastolic diameter (EDD) and ejection fraction (EF) were measured by echocardiography. Malnourished patients exhibited significantly greater evidence of cardiovascular disease and carotid plaques. Factor (principal component) analysis indicated 6 latent factors with 67.5% of the variance explained within all investigated parameters. Cluster analysis was used to distinguish the inflammatory markers and the nutritional markers from other parameters and to visualize similarities between variables. In summary, this cross-sectional study in hemodialysis patients found a high prevalence of malnutrition, inflammation, carotid plaques, and cardiovascular disease. Malnourished dialysis patients are more often found with cardiovascular disease and carotid plaques. In addition, these patients have higher levels of inflammatory cytokines, which may partly explain the elevated risk for atherosclerotic vascular disease. PB - Canadian Science Publishing, Nrc Research Press, Ottawa T2 - Canadian Journal of Physiology and Pharmacology T1 - Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients EP - 209 IS - 4 SP - 205 VL - 86 DO - 10.1139/Y08-018 ER -
@article{ author = "Peruničić-Peković, Gordana and Pljesa, S. and Rasić-Milutinović, Z. and Stanković, S. and Ilić, M. and Maletić, Radojka", year = "2008", abstract = "Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in patients on hemodialysis. The study population consisted of 42 hemodialysis patients with different parameters of malnutrition. Blood samples were taken after an overnight fast, and plasma lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured by using conventional enzymatic methods. Serum urea and creatinine levels were also measured by routine procedures. Plasma high-sensitivity C-reactive protein level (hs-CRP), TNF-alpha, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Standard Doppler echo examinations were used to determine plaque on carotid arteries, and end-diastolic diameter (EDD) and ejection fraction (EF) were measured by echocardiography. Malnourished patients exhibited significantly greater evidence of cardiovascular disease and carotid plaques. Factor (principal component) analysis indicated 6 latent factors with 67.5% of the variance explained within all investigated parameters. Cluster analysis was used to distinguish the inflammatory markers and the nutritional markers from other parameters and to visualize similarities between variables. In summary, this cross-sectional study in hemodialysis patients found a high prevalence of malnutrition, inflammation, carotid plaques, and cardiovascular disease. Malnourished dialysis patients are more often found with cardiovascular disease and carotid plaques. In addition, these patients have higher levels of inflammatory cytokines, which may partly explain the elevated risk for atherosclerotic vascular disease.", publisher = "Canadian Science Publishing, Nrc Research Press, Ottawa", journal = "Canadian Journal of Physiology and Pharmacology", title = "Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients", pages = "209-205", number = "4", volume = "86", doi = "10.1139/Y08-018" }
Peruničić-Peković, G., Pljesa, S., Rasić-Milutinović, Z., Stanković, S., Ilić, M.,& Maletić, R.. (2008). Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients. in Canadian Journal of Physiology and Pharmacology Canadian Science Publishing, Nrc Research Press, Ottawa., 86(4), 205-209. https://doi.org/10.1139/Y08-018
Peruničić-Peković G, Pljesa S, Rasić-Milutinović Z, Stanković S, Ilić M, Maletić R. Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients. in Canadian Journal of Physiology and Pharmacology. 2008;86(4):205-209. doi:10.1139/Y08-018 .
Peruničić-Peković, Gordana, Pljesa, S., Rasić-Milutinović, Z., Stanković, S., Ilić, M., Maletić, Radojka, "Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients" in Canadian Journal of Physiology and Pharmacology, 86, no. 4 (2008):205-209, https://doi.org/10.1139/Y08-018 . .