TY  - JOUR
AU  - Vidović, Dunja
AU  - Milošević, Nataša
AU  - Pavlović, Nebojša
AU  - Todorović, Nemanja
AU  - Panić, Jelena Čanji
AU  - Ćurčić, Jelena
AU  - Banjac, Nebojša
AU  - Trišović, Nemanja
AU  - Božić, Bojan
AU  - Lalić-Popović, Mladena
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/bmc.5413
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6105
AB  - Passive permeability is one of the key features that determine absorbability and one of the most studied properties in the early phases of drug development. Newly synthesized succinimide derivatives from two different series (1-aryl-3-methylsuccinimides and 1-aryl-3-ethyl-3-methylsuccinimides) with high biological potential have been subjected to estimation of their passive permeability and their association with (a) experimentally obtained anisotropic lipophilicity, (b) in silico–calculated lipophilicity and (c) in silico–predicted permeability and absorbability. Non-cellular-based parallel artificial membrane permeability assay was applied for quantifying their passive permeation, expressed as logPapp. Passive permeation was governed by the lipophilicity of the analysed compounds, and anisotropic lipophilicity was related with statistically significant passive transcellular diffusion (r2 = 0.614, P < 0.001). Moreover, experimentally determined passive permeability, logPapp, was statistically significantly associated with both in silico–predicted absorption constant, ka (r2 = 0.7886, P < 0.001), and human intestinal absorption (HIA) in percentage (r2 = 0.484, P < 0.001), respectively. However, there was no statistically significant relationship between experimentally obtained permeability on non-cellular-based model and in silico–predicted Caco-2 permeability based on the predictions conducted on two different software. Based on the obtained results, anisotropic systems are promising surrogates for determining lipophilicity, except for compounds with acidic functional groups that are completely ionized under (pH = 7.4).
T2  - Biomedical Chromatography
T2  - Biomedical Chromatography
T1  - In silico–in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial membrane permeability assay
IS  - n/a
SP  - e5413
VL  - n/a
DO  - 10.1002/bmc.5413
ER  - 

@article{
author = "Vidović, Dunja and Milošević, Nataša and Pavlović, Nebojša and Todorović, Nemanja and Panić, Jelena Čanji and Ćurčić, Jelena and Banjac, Nebojša and Trišović, Nemanja and Božić, Bojan and Lalić-Popović, Mladena",
abstract = "Passive permeability is one of the key features that determine absorbability and one of the most studied properties in the early phases of drug development. Newly synthesized succinimide derivatives from two different series (1-aryl-3-methylsuccinimides and 1-aryl-3-ethyl-3-methylsuccinimides) with high biological potential have been subjected to estimation of their passive permeability and their association with (a) experimentally obtained anisotropic lipophilicity, (b) in silico–calculated lipophilicity and (c) in silico–predicted permeability and absorbability. Non-cellular-based parallel artificial membrane permeability assay was applied for quantifying their passive permeation, expressed as logPapp. Passive permeation was governed by the lipophilicity of the analysed compounds, and anisotropic lipophilicity was related with statistically significant passive transcellular diffusion (r2 = 0.614, P < 0.001). Moreover, experimentally determined passive permeability, logPapp, was statistically significantly associated with both in silico–predicted absorption constant, ka (r2 = 0.7886, P < 0.001), and human intestinal absorption (HIA) in percentage (r2 = 0.484, P < 0.001), respectively. However, there was no statistically significant relationship between experimentally obtained permeability on non-cellular-based model and in silico–predicted Caco-2 permeability based on the predictions conducted on two different software. Based on the obtained results, anisotropic systems are promising surrogates for determining lipophilicity, except for compounds with acidic functional groups that are completely ionized under (pH = 7.4).",
journal = "Biomedical Chromatography, Biomedical Chromatography",
title = "In silico–in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial membrane permeability assay",
number = "n/a",
pages = "e5413",
volume = "n/a",
doi = "10.1002/bmc.5413"
}

Vidović, D., Milošević, N., Pavlović, N., Todorović, N., Panić, J. Č., Ćurčić, J., Banjac, N., Trišović, N., Božić, B.,& Lalić-Popović, M..In silico–in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial membrane permeability assay. in Biomedical Chromatography, n/a(n/a), e5413.
https://doi.org/10.1002/bmc.5413

Vidović D, Milošević N, Pavlović N, Todorović N, Panić JČ, Ćurčić J, Banjac N, Trišović N, Božić B, Lalić-Popović M. In silico–in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial membrane permeability assay. in Biomedical Chromatography.n/a(n/a):e5413.
doi:10.1002/bmc.5413 .

Vidović, Dunja, Milošević, Nataša, Pavlović, Nebojša, Todorović, Nemanja, Panić, Jelena Čanji, Ćurčić, Jelena, Banjac, Nebojša, Trišović, Nemanja, Božić, Bojan, Lalić-Popović, Mladena, "In silico–in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial membrane permeability assay" in Biomedical Chromatography, n/a, no. n/a:e5413,
https://doi.org/10.1002/bmc.5413 . .

TY  - JOUR
AU  - Milinčić, Danijel D.
AU  - Kostić, Aleksandar Ž.
AU  - Kolašinac, Stefan
AU  - Rac, Vladislav
AU  - Banjac, Nebojša
AU  - Lađarević, Jelena
AU  - Lević, Steva
AU  - Pavlović, Vladimir B.
AU  - Stanojević, Slađana P.
AU  - Nedović, Viktor A.
AU  - Pešić, Mirjana B.
PY  - 2024
UR  - https://www.sciencedirect.com/science/article/pii/S0268005X23008391
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6432
AB  - This study aimed to evaluate the physical (particle size and ζ-potential) and techno-functional properties (emulsifying and foaming) of goat milk powders enriched with grape pomace seed extract (TME), as promising food ingredients in the formulation of functional food. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman spectroscopies, along with advanced chemometric tools were employed as well as Scanning Electron Microscopy (SEM) for analyzing TME powders. All powders exhibited a unimodal particle size distribution and ζ-potential values more negative than −36 mV. ATR-FTIR and Raman spectroscopies combined with principal component analysis (PCA) demonstrated distinct separation among skimmed goat milk (M), thermally treated skimmed goat milk (TM), and TME powders in different spectral regions (amide I, II, III, and fingerprint region). This separation resulted from the applied thermal treatment, the presence of phenolic compounds and their complexes with goat milk proteins, and the formation of Maillard reaction products. SEM analysis confirmed the different morphology and shapes of M, TM and TME powders. The 0.1% solutions of M, TM and TME exhibited good emulsifying properties (emulsion activity index and emulsion stability index) but showed poor foaming properties, except for the M sample. Solution concentrations higher than 0.1% for all samples (0.5% and 1.0%) displayed poor techno-functional properties. In summary, a schematic representation of the arrangement of casein micelles in 0.1% M, TM and TME samples, on oil/water and air/water surfaces was provided. The production of TME powders represents an innovative strategy for waste recovery in the production of functional food ingredients with good emulsifying properties.
T2  - Food Hydrocolloids
T2  - Food HydrocolloidsFood Hydrocolloids
T1  - Goat milk powders enriched with grape pomace seed extract: Physical and techno-functional properties
SP  - 109293
VL  - 146
DO  - 10.1016/j.foodhyd.2023.109293
ER  - 

@article{
author = "Milinčić, Danijel D. and Kostić, Aleksandar Ž. and Kolašinac, Stefan and Rac, Vladislav and Banjac, Nebojša and Lađarević, Jelena and Lević, Steva and Pavlović, Vladimir B. and Stanojević, Slađana P. and Nedović, Viktor A. and Pešić, Mirjana B.",
year = "2024",
abstract = "This study aimed to evaluate the physical (particle size and ζ-potential) and techno-functional properties (emulsifying and foaming) of goat milk powders enriched with grape pomace seed extract (TME), as promising food ingredients in the formulation of functional food. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman spectroscopies, along with advanced chemometric tools were employed as well as Scanning Electron Microscopy (SEM) for analyzing TME powders. All powders exhibited a unimodal particle size distribution and ζ-potential values more negative than −36 mV. ATR-FTIR and Raman spectroscopies combined with principal component analysis (PCA) demonstrated distinct separation among skimmed goat milk (M), thermally treated skimmed goat milk (TM), and TME powders in different spectral regions (amide I, II, III, and fingerprint region). This separation resulted from the applied thermal treatment, the presence of phenolic compounds and their complexes with goat milk proteins, and the formation of Maillard reaction products. SEM analysis confirmed the different morphology and shapes of M, TM and TME powders. The 0.1% solutions of M, TM and TME exhibited good emulsifying properties (emulsion activity index and emulsion stability index) but showed poor foaming properties, except for the M sample. Solution concentrations higher than 0.1% for all samples (0.5% and 1.0%) displayed poor techno-functional properties. In summary, a schematic representation of the arrangement of casein micelles in 0.1% M, TM and TME samples, on oil/water and air/water surfaces was provided. The production of TME powders represents an innovative strategy for waste recovery in the production of functional food ingredients with good emulsifying properties.",
journal = "Food Hydrocolloids, Food HydrocolloidsFood Hydrocolloids",
title = "Goat milk powders enriched with grape pomace seed extract: Physical and techno-functional properties",
pages = "109293",
volume = "146",
doi = "10.1016/j.foodhyd.2023.109293"
}

Milinčić, D. D., Kostić, A. Ž., Kolašinac, S., Rac, V., Banjac, N., Lađarević, J., Lević, S., Pavlović, V. B., Stanojević, S. P., Nedović, V. A.,& Pešić, M. B.. (2024). Goat milk powders enriched with grape pomace seed extract: Physical and techno-functional properties. in Food Hydrocolloids, 146, 109293.
https://doi.org/10.1016/j.foodhyd.2023.109293

Milinčić DD, Kostić AŽ, Kolašinac S, Rac V, Banjac N, Lađarević J, Lević S, Pavlović VB, Stanojević SP, Nedović VA, Pešić MB. Goat milk powders enriched with grape pomace seed extract: Physical and techno-functional properties. in Food Hydrocolloids. 2024;146:109293.
doi:10.1016/j.foodhyd.2023.109293 .

Milinčić, Danijel D., Kostić, Aleksandar Ž., Kolašinac, Stefan, Rac, Vladislav, Banjac, Nebojša, Lađarević, Jelena, Lević, Steva, Pavlović, Vladimir B., Stanojević, Slađana P., Nedović, Viktor A., Pešić, Mirjana B., "Goat milk powders enriched with grape pomace seed extract: Physical and techno-functional properties" in Food Hydrocolloids, 146 (2024):109293,
https://doi.org/10.1016/j.foodhyd.2023.109293 . .

TY  - JOUR
AU  - Vidović, Dunja
AU  - Milošević, Nataša
AU  - Pavlović, Nebojša
AU  - Todorović, Nemanja
AU  - Čanji Panić, Jelena
AU  - Kovačević, Strahinja
AU  - Karadžić Banjac, Milica
AU  - Podunavac-Kuzmanović, Sanja
AU  - Banjac, Nebojša
AU  - Trišović, Nemanja
AU  - Božić, Bojan
AU  - Lalić-Popović, Mladena
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6224
AB  - Percutaneous permeation of twenty-four newly synthesized succinimide derivatives was evaluated using parallel artificial membrane permeability assay (PAMPA) with 70% silicone oil and 30% isopropyl myristate. Different online tools were applied for in silico predicting of their skin permeability. According to the in silico estimation of the transdermal permeation, all compounds are expected to have relatively good ability to permeate the skin, at pH=6. However, for two compounds containing carboxylic groups, the concentration in the acceptor compartment was undetectable indicating limited permeation at pH=7.4. Statistically significant association was found between in silico predicted logKp values by the PreADMET and SwissADME online tools and the percutaneous permeability estimated from the experimental results using the artificial membranes (adj. r2 = 0.371, p = 0.00158 and adj. r2=0.232, p = 0.0135, respectively). The association between permeation through artificial membranes and the calculated logP data was also statistically significant. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) took into account in silico logKp and calculated logP data. The ranking of the lipophilicity and skin permeability parameters was conducted with sum of ranking differences (SRD) analysis which was validated. Based on the obtained results, it is predicted that lipophilicity is a pivotal physico-chemical parameter of the passive permeation of succinimide derivatives through hydrophobic barriers such as the skin. © 2022 Elsevier B.V.
T2  - Journal of Molecular Structure
T2  - Journal of Molecular Structure
T1  - Predicting percutaneous permeation for new succinimide derivatives by in vitro and in silico models
VL  - 1274
DO  - 10.1016/j.molstruc.2022.134516
ER  - 

@article{
author = "Vidović, Dunja and Milošević, Nataša and Pavlović, Nebojša and Todorović, Nemanja and Čanji Panić, Jelena and Kovačević, Strahinja and Karadžić Banjac, Milica and Podunavac-Kuzmanović, Sanja and Banjac, Nebojša and Trišović, Nemanja and Božić, Bojan and Lalić-Popović, Mladena",
year = "2023",
abstract = "Percutaneous permeation of twenty-four newly synthesized succinimide derivatives was evaluated using parallel artificial membrane permeability assay (PAMPA) with 70% silicone oil and 30% isopropyl myristate. Different online tools were applied for in silico predicting of their skin permeability. According to the in silico estimation of the transdermal permeation, all compounds are expected to have relatively good ability to permeate the skin, at pH=6. However, for two compounds containing carboxylic groups, the concentration in the acceptor compartment was undetectable indicating limited permeation at pH=7.4. Statistically significant association was found between in silico predicted logKp values by the PreADMET and SwissADME online tools and the percutaneous permeability estimated from the experimental results using the artificial membranes (adj. r2 = 0.371, p = 0.00158 and adj. r2=0.232, p = 0.0135, respectively). The association between permeation through artificial membranes and the calculated logP data was also statistically significant. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) took into account in silico logKp and calculated logP data. The ranking of the lipophilicity and skin permeability parameters was conducted with sum of ranking differences (SRD) analysis which was validated. Based on the obtained results, it is predicted that lipophilicity is a pivotal physico-chemical parameter of the passive permeation of succinimide derivatives through hydrophobic barriers such as the skin. © 2022 Elsevier B.V.",
journal = "Journal of Molecular Structure, Journal of Molecular Structure",
title = "Predicting percutaneous permeation for new succinimide derivatives by in vitro and in silico models",
volume = "1274",
doi = "10.1016/j.molstruc.2022.134516"
}

Vidović, D., Milošević, N., Pavlović, N., Todorović, N., Čanji Panić, J., Kovačević, S., Karadžić Banjac, M., Podunavac-Kuzmanović, S., Banjac, N., Trišović, N., Božić, B.,& Lalić-Popović, M.. (2023). Predicting percutaneous permeation for new succinimide derivatives by in vitro and in silico models. in Journal of Molecular Structure, 1274.
https://doi.org/10.1016/j.molstruc.2022.134516

Vidović D, Milošević N, Pavlović N, Todorović N, Čanji Panić J, Kovačević S, Karadžić Banjac M, Podunavac-Kuzmanović S, Banjac N, Trišović N, Božić B, Lalić-Popović M. Predicting percutaneous permeation for new succinimide derivatives by in vitro and in silico models. in Journal of Molecular Structure. 2023;1274.
doi:10.1016/j.molstruc.2022.134516 .

Vidović, Dunja, Milošević, Nataša, Pavlović, Nebojša, Todorović, Nemanja, Čanji Panić, Jelena, Kovačević, Strahinja, Karadžić Banjac, Milica, Podunavac-Kuzmanović, Sanja, Banjac, Nebojša, Trišović, Nemanja, Božić, Bojan, Lalić-Popović, Mladena, "Predicting percutaneous permeation for new succinimide derivatives by in vitro and in silico models" in Journal of Molecular Structure, 1274 (2023),
https://doi.org/10.1016/j.molstruc.2022.134516 . .

TY  - GEN
AU  - Marković, Jovana
AU  - Mihajlović, Dragana
AU  - Mašković, Pavle
AU  - Banjac, Nebojša
AU  - Mašković, Jelena
AU  - Ivanović, Evica
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6893
AB  - A pumpkin (Cucurbita maxima) contains significant amounts of diverse phytochemicals, including polyphenols (flavonoids, tannins) and carotenoids. Some of these compounds are known antioxidants, capable of neutralizing harmful biological free radicals, thus protecting health of living organisms. However, the numerous food-processing technologies decrease the amounts of naturally occurring antioxidants, due to enzymatic and nonenzymatic oxidation processes. The aim of this research was to determine the influence of different heat treatments (cooking, baking in conventional and microwave oven) on the antioxidant activity of phytochemicals present in the pumpkin.
The antioxidant activity was quantified spectrophotometrically, at the specific wavelengths, utilizing standard colorimetric reactions. The total antioxidant capacity of the analyzed samples was determined by phosphomolybdate method using ascorbic acid as a standard [1]. Antioxidant activity was measured by the inhibition of lipid peroxidation (FTC) [2] and free radical scavenging (DPPH⦁ [3], hydroxyl [4] and ABTS radical cation [5]) methods.
The highest total antioxidant capacity was found in a raw pumpkin sample (5.58±0.33 mg AAE/g), while the lowest value was found in a sample of pumpkin baked in conventional oven (2.88±0.32 mg AAE/g). Inhibition activity against lipid peroxidation (IC50) was the highest in raw pumpkin (16.72±0.73 µg/ml), and the lowest one was in conventional baked pumpkin (8.49±0.31 µg/ml). Free radical scavenging activity measured by DPPH and hydroxyl radicals (IC50) were the highest in raw sample (35.67±1.99 µg/ml) and (19.46±1.60 µg/ml), respectively, while the lowest values were in conventional baked pumpkin (15.68±1.32 µg/ml) and (9.69±2.01 µg/ml), respectively. Antioxidant activity measured by ABTS radical cation scavenging (IC50) was the highest in raw sample (41.63±0.61 µg/ml) and the lowest value was found in a sample baked in conventional oven (21.32±0.45 µg/ml).
The results showed that different heat treatments significantly affected on antioxidant activity, especially baking in conventional way, what makes it the least favorable process in this study.
T2  - Book of abstracts of 1 st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF)
T1  - Effect of different heat treatments on antioxidative activity in pumpkin (Cucurbita maxima)
SP  - 72
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_6893
ER  - 

@misc{
author = "Marković, Jovana and Mihajlović, Dragana and Mašković, Pavle and Banjac, Nebojša and Mašković, Jelena and Ivanović, Evica",
year = "2022",
abstract = "A pumpkin (Cucurbita maxima) contains significant amounts of diverse phytochemicals, including polyphenols (flavonoids, tannins) and carotenoids. Some of these compounds are known antioxidants, capable of neutralizing harmful biological free radicals, thus protecting health of living organisms. However, the numerous food-processing technologies decrease the amounts of naturally occurring antioxidants, due to enzymatic and nonenzymatic oxidation processes. The aim of this research was to determine the influence of different heat treatments (cooking, baking in conventional and microwave oven) on the antioxidant activity of phytochemicals present in the pumpkin.
The antioxidant activity was quantified spectrophotometrically, at the specific wavelengths, utilizing standard colorimetric reactions. The total antioxidant capacity of the analyzed samples was determined by phosphomolybdate method using ascorbic acid as a standard [1]. Antioxidant activity was measured by the inhibition of lipid peroxidation (FTC) [2] and free radical scavenging (DPPH⦁ [3], hydroxyl [4] and ABTS radical cation [5]) methods.
The highest total antioxidant capacity was found in a raw pumpkin sample (5.58±0.33 mg AAE/g), while the lowest value was found in a sample of pumpkin baked in conventional oven (2.88±0.32 mg AAE/g). Inhibition activity against lipid peroxidation (IC50) was the highest in raw pumpkin (16.72±0.73 µg/ml), and the lowest one was in conventional baked pumpkin (8.49±0.31 µg/ml). Free radical scavenging activity measured by DPPH and hydroxyl radicals (IC50) were the highest in raw sample (35.67±1.99 µg/ml) and (19.46±1.60 µg/ml), respectively, while the lowest values were in conventional baked pumpkin (15.68±1.32 µg/ml) and (9.69±2.01 µg/ml), respectively. Antioxidant activity measured by ABTS radical cation scavenging (IC50) was the highest in raw sample (41.63±0.61 µg/ml) and the lowest value was found in a sample baked in conventional oven (21.32±0.45 µg/ml).
The results showed that different heat treatments significantly affected on antioxidant activity, especially baking in conventional way, what makes it the least favorable process in this study.",
journal = "Book of abstracts of 1 st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF)",
title = "Effect of different heat treatments on antioxidative activity in pumpkin (Cucurbita maxima)",
pages = "72",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_6893"
}

Marković, J., Mihajlović, D., Mašković, P., Banjac, N., Mašković, J.,& Ivanović, E.. (2022). Effect of different heat treatments on antioxidative activity in pumpkin (Cucurbita maxima). in Book of abstracts of 1 st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF), 72.
https://hdl.handle.net/21.15107/rcub_agrospace_6893

Marković J, Mihajlović D, Mašković P, Banjac N, Mašković J, Ivanović E. Effect of different heat treatments on antioxidative activity in pumpkin (Cucurbita maxima). in Book of abstracts of 1 st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF). 2022;:72.
https://hdl.handle.net/21.15107/rcub_agrospace_6893 .

Marković, Jovana, Mihajlović, Dragana, Mašković, Pavle, Banjac, Nebojša, Mašković, Jelena, Ivanović, Evica, "Effect of different heat treatments on antioxidative activity in pumpkin (Cucurbita maxima)" in Book of abstracts of 1 st European Symposium on Phytochemicals in Medicine and Food (1-EuSPMF) (2022):72,
https://hdl.handle.net/21.15107/rcub_agrospace_6893 .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Božić, Bojan
AU  - Zmejkovski, Bojana B.
AU  - Banjac, Nebojša R.
AU  - Dojčinović, Biljana
AU  - Wessjohann, Ludger A.
AU  - Kaluđerović, Goran N.
PY  - 2021
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5869
AB  - The synthesis of novel triphenyltin(IV) compounds, Ph3SnLn (n = 1–3), with oxaprozin (3-(4,5-diphenyloxazol-2-yl)propanoic acid), HL1, and the new propanoic acid derivatives 3-(4,5bis(4-methoxylphenyl)oxazol-2-yl)propanoic acid, HL2, and 3-(2,5-dioxo-4,4-diphenylimidazolidin1-yl)propanoic acid, HL3, has been performed. The ligands represent commercial drugs or their derivatives and the tin complexes have been characterized by standard analytical methods. The in vitro antiproliferative activity of both ligands and organotin(IV) compounds has been evaluated on the following tumour cell lines: human prostate cancer (PC-3), human colorectal adenocarcinoma (HT29), breast cancer (MCF-7), and hepatocellular cancer (HepG2), as well as on normal mouse embryonic fibroblast cells (NIH3T3) with the aid of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. Contrary to the inactive ligand precursors, all organotin(IV) carboxylates showed very good activity with IC50 values ranging from 0.100 to 0.758 µM. According to the CV assay (IC50 = 0.218 ± 0.025 µM), complex Ph3SnL1 demonstrated the highest cytotoxicity against the caspase 3 deficient MCF-7 cell line. Inductively coupled plasma mass spectrometry (ICP-MS) analysis indicated a two-fold lower concentration of tin in MCF-7 cells in comparison to platinum. To investigate the mechanism of action of the compound Ph3SnL1 on MCF-7 cells, morphological, autophagy and cell cycle analysis, as well as the activation of caspase and ROS/RNS and NO production, has been performed. Results suggest that Ph3SnL1 induces caspase-independent apoptosis in MCF-7 cells.
PB  - MDPI AG
T2  - Molecules
T1  - In Vitro Evaluation of Antiproliferative Properties of Novel Organotin(IV) Carboxylate Compounds with Propanoic Acid Derivatives on a Panel of Human Cancer Cell Lines
IS  - 11
SP  - 3199
VL  - 26
DO  - 10.3390/molecules26113199
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Božić, Bojan and Zmejkovski, Bojana B. and Banjac, Nebojša R. and Dojčinović, Biljana and Wessjohann, Ludger A. and Kaluđerović, Goran N.",
year = "2021",
abstract = "The synthesis of novel triphenyltin(IV) compounds, Ph3SnLn (n = 1–3), with oxaprozin (3-(4,5-diphenyloxazol-2-yl)propanoic acid), HL1, and the new propanoic acid derivatives 3-(4,5bis(4-methoxylphenyl)oxazol-2-yl)propanoic acid, HL2, and 3-(2,5-dioxo-4,4-diphenylimidazolidin1-yl)propanoic acid, HL3, has been performed. The ligands represent commercial drugs or their derivatives and the tin complexes have been characterized by standard analytical methods. The in vitro antiproliferative activity of both ligands and organotin(IV) compounds has been evaluated on the following tumour cell lines: human prostate cancer (PC-3), human colorectal adenocarcinoma (HT29), breast cancer (MCF-7), and hepatocellular cancer (HepG2), as well as on normal mouse embryonic fibroblast cells (NIH3T3) with the aid of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. Contrary to the inactive ligand precursors, all organotin(IV) carboxylates showed very good activity with IC50 values ranging from 0.100 to 0.758 µM. According to the CV assay (IC50 = 0.218 ± 0.025 µM), complex Ph3SnL1 demonstrated the highest cytotoxicity against the caspase 3 deficient MCF-7 cell line. Inductively coupled plasma mass spectrometry (ICP-MS) analysis indicated a two-fold lower concentration of tin in MCF-7 cells in comparison to platinum. To investigate the mechanism of action of the compound Ph3SnL1 on MCF-7 cells, morphological, autophagy and cell cycle analysis, as well as the activation of caspase and ROS/RNS and NO production, has been performed. Results suggest that Ph3SnL1 induces caspase-independent apoptosis in MCF-7 cells.",
publisher = "MDPI AG",
journal = "Molecules",
title = "In Vitro Evaluation of Antiproliferative Properties of Novel Organotin(IV) Carboxylate Compounds with Propanoic Acid Derivatives on a Panel of Human Cancer Cell Lines",
number = "11",
pages = "3199",
volume = "26",
doi = "10.3390/molecules26113199"
}

Pantelić, N. Đ., Božić, B., Zmejkovski, B. B., Banjac, N. R., Dojčinović, B., Wessjohann, L. A.,& Kaluđerović, G. N.. (2021). In Vitro Evaluation of Antiproliferative Properties of Novel Organotin(IV) Carboxylate Compounds with Propanoic Acid Derivatives on a Panel of Human Cancer Cell Lines. in Molecules
MDPI AG., 26(11), 3199.
https://doi.org/10.3390/molecules26113199

Pantelić NĐ, Božić B, Zmejkovski BB, Banjac NR, Dojčinović B, Wessjohann LA, Kaluđerović GN. In Vitro Evaluation of Antiproliferative Properties of Novel Organotin(IV) Carboxylate Compounds with Propanoic Acid Derivatives on a Panel of Human Cancer Cell Lines. in Molecules. 2021;26(11):3199.
doi:10.3390/molecules26113199 .

Pantelić, Nebojša Đ., Božić, Bojan, Zmejkovski, Bojana B., Banjac, Nebojša R., Dojčinović, Biljana, Wessjohann, Ludger A., Kaluđerović, Goran N., "In Vitro Evaluation of Antiproliferative Properties of Novel Organotin(IV) Carboxylate Compounds with Propanoic Acid Derivatives on a Panel of Human Cancer Cell Lines" in Molecules, 26, no. 11 (2021):3199,
https://doi.org/10.3390/molecules26113199 . .

TY  - JOUR
AU  - Pantelić, Nebojša
AU  - Zmejkovski, Bojana B.
AU  - Božić, Bojan
AU  - Dojčinović, Biljana
AU  - Banjac, Nebojša
AU  - Wessjohann, Ludger A.
AU  - Kaludjerović, Goran N.
PY  - 2020
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5306
AB  - Two novel triphenyltin(IV) compounds, [Ph(3)SnL1] (L1 = 2-(5-(4- fluorobenzylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (1)) and [Ph(3)SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (H-1 and C-13) NMR spectroscopy, mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV) compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), and HepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. The IC50 values are found to be in the range from 0.11 to 0.50 mu M. Compound 1 exhibits the highest activity toward PC-3 cells (IC50 = 0.115 +/- 0.009 mu M; CV assay). The tin and platinum uptake in PC-3 cells showed a threefold lower uptake of tin in comparison to platinum (as cisplatin). Together with its higher activity this indicates a much higher cell inhibition potential of the tin compounds (calculated to ca. 50 to 100 times). Morphological analysis suggested that the compounds induce apoptosis in PC-3 cells, and flow cytometry analysis revealed that 1 and 2 induce autophagy as well as NO (nitric oxide) production.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)propanoic acid
VL  - 211
DO  - 10.1016/j.jinorgbio.2020.111207
ER  - 

@article{
author = "Pantelić, Nebojša and Zmejkovski, Bojana B. and Božić, Bojan and Dojčinović, Biljana and Banjac, Nebojša and Wessjohann, Ludger A. and Kaludjerović, Goran N.",
year = "2020",
abstract = "Two novel triphenyltin(IV) compounds, [Ph(3)SnL1] (L1 = 2-(5-(4- fluorobenzylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (1)) and [Ph(3)SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (H-1 and C-13) NMR spectroscopy, mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV) compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), and HepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. The IC50 values are found to be in the range from 0.11 to 0.50 mu M. Compound 1 exhibits the highest activity toward PC-3 cells (IC50 = 0.115 +/- 0.009 mu M; CV assay). The tin and platinum uptake in PC-3 cells showed a threefold lower uptake of tin in comparison to platinum (as cisplatin). Together with its higher activity this indicates a much higher cell inhibition potential of the tin compounds (calculated to ca. 50 to 100 times). Morphological analysis suggested that the compounds induce apoptosis in PC-3 cells, and flow cytometry analysis revealed that 1 and 2 induce autophagy as well as NO (nitric oxide) production.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)propanoic acid",
volume = "211",
doi = "10.1016/j.jinorgbio.2020.111207"
}

Pantelić, N., Zmejkovski, B. B., Božić, B., Dojčinović, B., Banjac, N., Wessjohann, L. A.,& Kaludjerović, G. N.. (2020). Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)propanoic acid. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 211.
https://doi.org/10.1016/j.jinorgbio.2020.111207

Pantelić N, Zmejkovski BB, Božić B, Dojčinović B, Banjac N, Wessjohann LA, Kaludjerović GN. Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)propanoic acid. in Journal of Inorganic Biochemistry. 2020;211.
doi:10.1016/j.jinorgbio.2020.111207 .

Pantelić, Nebojša, Zmejkovski, Bojana B., Božić, Bojan, Dojčinović, Biljana, Banjac, Nebojša, Wessjohann, Ludger A., Kaludjerović, Goran N., "Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)propanoic acid" in Journal of Inorganic Biochemistry, 211 (2020),
https://doi.org/10.1016/j.jinorgbio.2020.111207 . .

TY  - JOUR
AU  - Kovaević, Strahinja
AU  - Karadzić-Banjac, Milica
AU  - Podunavac-Kuzmanović, Sanja
AU  - Milošević, Nataša
AU  - Curcić, Jelena
AU  - Vulić, Jelena
AU  - Seregelj, Vanja
AU  - Banjac, Nebojša
AU  - Ušćumlić, Gordana
PY  - 2020
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5331
AB  - The present study is focused on a series of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimide derivatives, as potential anticonvulsants. The retention behavior of eleven succinimide derivatives was determined by using reversed phase high performance liquid chromatography (RP-HPLC) and reversed phase high performance thin layer chromatography (RP-HPTLC). The estimated retention behavior was correlated with partition (logP) and distribution coefficients (logD). These high correlations pointed out that the determined retention parameters (logK(0) and R-M(0)) can be considered chromatographic (anisotropic) lipophilicity of the studied succinimide derivatives. The structural properties, which dominantly affect the chromatographic lipophilicity, were determined as well. The significant correlations between the chromatographic lipophilicity and plasma protein binding (PPB), Madin-Darby Canine Kidney (MDCK) cells permeability, volume of distribution (Vd) and absorption constant (Ka) indicate the strong influence of lipophilicity on pharmacokinetics of 1-aryl-3-ethyl-3-methylsuccinimide derivatives. These derivatives have also been tested applying Comprehensive Medicinal Chemistry (CMC) drug-like rules which confirmed their drug-like properties. Besides, their blood-brain penetration (BBB) ability has been estimated applying the set of Clark's rules and by using Pre-ADMET software. Regarding toxicity, it was predicted that only one compound from the set might have toxic effects by blocking the hERG potassium channel. The present study reveals which molecular features in the structure of novel succinimide derivatives could be crucial for their lipophilicity, and consequently for their pharmacokinetic properties. The results indicate that the newly synthesized series of succinimide derivatives should be further considered in design of novel anticonvulsants.
PB  - Elsevier Sci Ltd, Oxford
T2  - Computational Biology and Chemistry
T1  - Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides
VL  - 84
DO  - 10.1016/j.compbiolchem.2019.107161
ER  - 

@article{
author = "Kovaević, Strahinja and Karadzić-Banjac, Milica and Podunavac-Kuzmanović, Sanja and Milošević, Nataša and Curcić, Jelena and Vulić, Jelena and Seregelj, Vanja and Banjac, Nebojša and Ušćumlić, Gordana",
year = "2020",
abstract = "The present study is focused on a series of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimide derivatives, as potential anticonvulsants. The retention behavior of eleven succinimide derivatives was determined by using reversed phase high performance liquid chromatography (RP-HPLC) and reversed phase high performance thin layer chromatography (RP-HPTLC). The estimated retention behavior was correlated with partition (logP) and distribution coefficients (logD). These high correlations pointed out that the determined retention parameters (logK(0) and R-M(0)) can be considered chromatographic (anisotropic) lipophilicity of the studied succinimide derivatives. The structural properties, which dominantly affect the chromatographic lipophilicity, were determined as well. The significant correlations between the chromatographic lipophilicity and plasma protein binding (PPB), Madin-Darby Canine Kidney (MDCK) cells permeability, volume of distribution (Vd) and absorption constant (Ka) indicate the strong influence of lipophilicity on pharmacokinetics of 1-aryl-3-ethyl-3-methylsuccinimide derivatives. These derivatives have also been tested applying Comprehensive Medicinal Chemistry (CMC) drug-like rules which confirmed their drug-like properties. Besides, their blood-brain penetration (BBB) ability has been estimated applying the set of Clark's rules and by using Pre-ADMET software. Regarding toxicity, it was predicted that only one compound from the set might have toxic effects by blocking the hERG potassium channel. The present study reveals which molecular features in the structure of novel succinimide derivatives could be crucial for their lipophilicity, and consequently for their pharmacokinetic properties. The results indicate that the newly synthesized series of succinimide derivatives should be further considered in design of novel anticonvulsants.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Computational Biology and Chemistry",
title = "Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides",
volume = "84",
doi = "10.1016/j.compbiolchem.2019.107161"
}

Kovaević, S., Karadzić-Banjac, M., Podunavac-Kuzmanović, S., Milošević, N., Curcić, J., Vulić, J., Seregelj, V., Banjac, N.,& Ušćumlić, G.. (2020). Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides. in Computational Biology and Chemistry
Elsevier Sci Ltd, Oxford., 84.
https://doi.org/10.1016/j.compbiolchem.2019.107161

Kovaević S, Karadzić-Banjac M, Podunavac-Kuzmanović S, Milošević N, Curcić J, Vulić J, Seregelj V, Banjac N, Ušćumlić G. Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides. in Computational Biology and Chemistry. 2020;84.
doi:10.1016/j.compbiolchem.2019.107161 .

Kovaević, Strahinja, Karadzić-Banjac, Milica, Podunavac-Kuzmanović, Sanja, Milošević, Nataša, Curcić, Jelena, Vulić, Jelena, Seregelj, Vanja, Banjac, Nebojša, Ušćumlić, Gordana, "Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides" in Computational Biology and Chemistry, 84 (2020),
https://doi.org/10.1016/j.compbiolchem.2019.107161 . .

TY  - JOUR
AU  - Kovacević, Strahinja
AU  - Karadzić-Banjac, Milica
AU  - Milošević, Nataša
AU  - Curcić, Jelena
AU  - Marjanović, Dunja
AU  - Todorović, Nemanja
AU  - Krmar, Jovana
AU  - Podunavac-Kuzmanović, Sanja
AU  - Banjac, Nebojša
AU  - Ušćumlić, Gordana
PY  - 2020
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5317
AB  - Numerous structurally different amides and imides including succinimide derivatives exhibit diverse bioactive potential. The development of new compounds requires rationalization in the design in order to provide structural changes that guarantee favorable physico-chemical properties, pharmacological activity and safety. In the present research, a comprehensive study with comparison of the chromatographic lipophilicity and other physico-chemical properties of five groups of 1-arylsuccinimide derivatives was conducted. The chemometric analysis of their physico-chemical properties was carried out by using unsupervised (hierarchical cluster analysis and principal component analysis) and supervised pattern recognition methods (linear discriminant analysis), while the correlations between the in silico molecular features and chromatographic lipophilicity were examined applying linear and non-linear Quantitative Structure-Retention Relationship (QSRR) approaches. The main aim of the conducted research was to determine similarities and dissimilarities among the studied 1-arylsuccinimides, to point out the molecular features which have significant influence on their lipophilicity, as well as to establish high-quality QSRR models which can be used in prediction of chromatographic lipophilicity of structurally similar 1-arylsuccinimides. This study is a continuation of analysis and determination of the physico-chemical properties of 1-arylsuccinimides which could be important guidelines in further in vitro and eventually in vivo studies of their biological potential.
PB  - Elsevier, Amsterdam
T2  - Journal of Chromatography A
T1  - Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents
VL  - 1628
DO  - 10.1016/j.chroma.2020.461439
ER  - 

@article{
author = "Kovacević, Strahinja and Karadzić-Banjac, Milica and Milošević, Nataša and Curcić, Jelena and Marjanović, Dunja and Todorović, Nemanja and Krmar, Jovana and Podunavac-Kuzmanović, Sanja and Banjac, Nebojša and Ušćumlić, Gordana",
year = "2020",
abstract = "Numerous structurally different amides and imides including succinimide derivatives exhibit diverse bioactive potential. The development of new compounds requires rationalization in the design in order to provide structural changes that guarantee favorable physico-chemical properties, pharmacological activity and safety. In the present research, a comprehensive study with comparison of the chromatographic lipophilicity and other physico-chemical properties of five groups of 1-arylsuccinimide derivatives was conducted. The chemometric analysis of their physico-chemical properties was carried out by using unsupervised (hierarchical cluster analysis and principal component analysis) and supervised pattern recognition methods (linear discriminant analysis), while the correlations between the in silico molecular features and chromatographic lipophilicity were examined applying linear and non-linear Quantitative Structure-Retention Relationship (QSRR) approaches. The main aim of the conducted research was to determine similarities and dissimilarities among the studied 1-arylsuccinimides, to point out the molecular features which have significant influence on their lipophilicity, as well as to establish high-quality QSRR models which can be used in prediction of chromatographic lipophilicity of structurally similar 1-arylsuccinimides. This study is a continuation of analysis and determination of the physico-chemical properties of 1-arylsuccinimides which could be important guidelines in further in vitro and eventually in vivo studies of their biological potential.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Chromatography A",
title = "Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents",
volume = "1628",
doi = "10.1016/j.chroma.2020.461439"
}

Kovacević, S., Karadzić-Banjac, M., Milošević, N., Curcić, J., Marjanović, D., Todorović, N., Krmar, J., Podunavac-Kuzmanović, S., Banjac, N.,& Ušćumlić, G.. (2020). Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents. in Journal of Chromatography A
Elsevier, Amsterdam., 1628.
https://doi.org/10.1016/j.chroma.2020.461439

Kovacević S, Karadzić-Banjac M, Milošević N, Curcić J, Marjanović D, Todorović N, Krmar J, Podunavac-Kuzmanović S, Banjac N, Ušćumlić G. Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents. in Journal of Chromatography A. 2020;1628.
doi:10.1016/j.chroma.2020.461439 .

Kovacević, Strahinja, Karadzić-Banjac, Milica, Milošević, Nataša, Curcić, Jelena, Marjanović, Dunja, Todorović, Nemanja, Krmar, Jovana, Podunavac-Kuzmanović, Sanja, Banjac, Nebojša, Ušćumlić, Gordana, "Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents" in Journal of Chromatography A, 1628 (2020),
https://doi.org/10.1016/j.chroma.2020.461439 . .

TY  - GEN
AU  - Paunović, Dragana
AU  - Marković, Jovana
AU  - Ivanović, Evica
AU  - Rabrenović, Biljana
AU  - Despotović, Saša
AU  - Banjac, Nebojša
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6891
AB  - Pumpkin contains a high content of carotenoids, the majority of which are alpha-carotene, beta-carotene, alpha-cryptoxanthin, lutein/zeaxanthin and violaxanthin. The main beneficial effect of carotenoids derives from their antioxidant activity, i.e. protecting cells against the harmful effects of free radicals. The aim of this study was to determine the content of total pumpkin carotenoids during cooking, baking in oven and a microwave oven to examine how different heat treatments affect on the stability of the carotenoids. The standard spectrophotometric method was used to determine the content of total carotenoids, measuring the absorbance of extracted samples at a wavelength of 445 nm. Samples were extracted by petrolether. According to the obtained results, the highest content of carotenoids was in fresh pumpkin (172,93 μg/g dry matter), then in a pumpkin baked in the oven (66,63 μg/g dry matter), then in a pumpkin baked in microwave oven (65,97 μg/g dry matter) and the lowest content of total carotenoids was determined in cooked pumpkin (54,42 μg/g dry matter). These results indicated that different heat treatments were significantly affected on the stability of carotenoids in pumpkin. The higher losses were during cooking, while the losses of baking in the oven and microwave oven were similar.
T2  - 1st International Conference on Advanced Production and Processing
T1  - Stability of carotenoids in pumpkin during the different heat treatments
SP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_6891
ER  - 

@misc{
author = "Paunović, Dragana and Marković, Jovana and Ivanović, Evica and Rabrenović, Biljana and Despotović, Saša and Banjac, Nebojša",
year = "2019",
abstract = "Pumpkin contains a high content of carotenoids, the majority of which are alpha-carotene, beta-carotene, alpha-cryptoxanthin, lutein/zeaxanthin and violaxanthin. The main beneficial effect of carotenoids derives from their antioxidant activity, i.e. protecting cells against the harmful effects of free radicals. The aim of this study was to determine the content of total pumpkin carotenoids during cooking, baking in oven and a microwave oven to examine how different heat treatments affect on the stability of the carotenoids. The standard spectrophotometric method was used to determine the content of total carotenoids, measuring the absorbance of extracted samples at a wavelength of 445 nm. Samples were extracted by petrolether. According to the obtained results, the highest content of carotenoids was in fresh pumpkin (172,93 μg/g dry matter), then in a pumpkin baked in the oven (66,63 μg/g dry matter), then in a pumpkin baked in microwave oven (65,97 μg/g dry matter) and the lowest content of total carotenoids was determined in cooked pumpkin (54,42 μg/g dry matter). These results indicated that different heat treatments were significantly affected on the stability of carotenoids in pumpkin. The higher losses were during cooking, while the losses of baking in the oven and microwave oven were similar.",
journal = "1st International Conference on Advanced Production and Processing",
title = "Stability of carotenoids in pumpkin during the different heat treatments",
pages = "32",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_6891"
}

Paunović, D., Marković, J., Ivanović, E., Rabrenović, B., Despotović, S.,& Banjac, N.. (2019). Stability of carotenoids in pumpkin during the different heat treatments. in 1st International Conference on Advanced Production and Processing, 32.
https://hdl.handle.net/21.15107/rcub_agrospace_6891

Paunović D, Marković J, Ivanović E, Rabrenović B, Despotović S, Banjac N. Stability of carotenoids in pumpkin during the different heat treatments. in 1st International Conference on Advanced Production and Processing. 2019;:32.
https://hdl.handle.net/21.15107/rcub_agrospace_6891 .

Paunović, Dragana, Marković, Jovana, Ivanović, Evica, Rabrenović, Biljana, Despotović, Saša, Banjac, Nebojša, "Stability of carotenoids in pumpkin during the different heat treatments" in 1st International Conference on Advanced Production and Processing (2019):32,
https://hdl.handle.net/21.15107/rcub_agrospace_6891 .

TY  - JOUR
AU  - Pešić, Mirjana
AU  - Milincić, Danijel D.
AU  - Kostić, Aleksandar
AU  - Stanisavljević, Nemanja S.
AU  - Vukotić, Goran
AU  - Kojić, Milan
AU  - Gašić, Uroš M.
AU  - Barać, Miroljub
AU  - Stanojević, Sladjana
AU  - Popović, Dušanka A.
AU  - Banjac, Nebojša
AU  - Tešić, Živoslav
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5034
AB  - The aim of this study was to evaluate the effect of enriching a complex food matrix (FM) with grape extracts on polyphenol content, composition, bioaccessibility and antioxidant activity during digestion. The grape extracts and FM were separately tested under the same conditions as controls. The FM by itself contains a significant amount of phenolic acids and flavonols, influencing the final recovery of polyphenols from grape extracts. The FM significantly increased the total recovery of polyphenols after digestion of grape seed extracts compared to those digested without the FM; however, a low recovery of proantocyanidins and total flavonoids was observed. Digestive fluids and FM compounds significantly increased the total polyphenol content of grape digests and significantly contributed to their ABTS(center dot+) scavenging activity and ferrous-ion-chelating capacity. The present study suggested that enrichment of meat-and cereal-based products with grape polyphenol extracts could be a good strategy to formulate a healthier diet.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - In vitro digestion of meat- and cereal-based food matrix enriched with grape extracts: How are polyphenol composition, bioaccessibility and antioxidant activity affected?
EP  - 44
SP  - 28
VL  - 284
DO  - 10.1016/j.foodchem.2019.01.107
ER  - 

@article{
author = "Pešić, Mirjana and Milincić, Danijel D. and Kostić, Aleksandar and Stanisavljević, Nemanja S. and Vukotić, Goran and Kojić, Milan and Gašić, Uroš M. and Barać, Miroljub and Stanojević, Sladjana and Popović, Dušanka A. and Banjac, Nebojša and Tešić, Živoslav",
year = "2019",
abstract = "The aim of this study was to evaluate the effect of enriching a complex food matrix (FM) with grape extracts on polyphenol content, composition, bioaccessibility and antioxidant activity during digestion. The grape extracts and FM were separately tested under the same conditions as controls. The FM by itself contains a significant amount of phenolic acids and flavonols, influencing the final recovery of polyphenols from grape extracts. The FM significantly increased the total recovery of polyphenols after digestion of grape seed extracts compared to those digested without the FM; however, a low recovery of proantocyanidins and total flavonoids was observed. Digestive fluids and FM compounds significantly increased the total polyphenol content of grape digests and significantly contributed to their ABTS(center dot+) scavenging activity and ferrous-ion-chelating capacity. The present study suggested that enrichment of meat-and cereal-based products with grape polyphenol extracts could be a good strategy to formulate a healthier diet.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "In vitro digestion of meat- and cereal-based food matrix enriched with grape extracts: How are polyphenol composition, bioaccessibility and antioxidant activity affected?",
pages = "44-28",
volume = "284",
doi = "10.1016/j.foodchem.2019.01.107"
}

Pešić, M., Milincić, D. D., Kostić, A., Stanisavljević, N. S., Vukotić, G., Kojić, M., Gašić, U. M., Barać, M., Stanojević, S., Popović, D. A., Banjac, N.,& Tešić, Ž.. (2019). In vitro digestion of meat- and cereal-based food matrix enriched with grape extracts: How are polyphenol composition, bioaccessibility and antioxidant activity affected?. in Food Chemistry
Elsevier Sci Ltd, Oxford., 284, 28-44.
https://doi.org/10.1016/j.foodchem.2019.01.107

Pešić M, Milincić DD, Kostić A, Stanisavljević NS, Vukotić G, Kojić M, Gašić UM, Barać M, Stanojević S, Popović DA, Banjac N, Tešić Ž. In vitro digestion of meat- and cereal-based food matrix enriched with grape extracts: How are polyphenol composition, bioaccessibility and antioxidant activity affected?. in Food Chemistry. 2019;284:28-44.
doi:10.1016/j.foodchem.2019.01.107 .

Pešić, Mirjana, Milincić, Danijel D., Kostić, Aleksandar, Stanisavljević, Nemanja S., Vukotić, Goran, Kojić, Milan, Gašić, Uroš M., Barać, Miroljub, Stanojević, Sladjana, Popović, Dušanka A., Banjac, Nebojša, Tešić, Živoslav, "In vitro digestion of meat- and cereal-based food matrix enriched with grape extracts: How are polyphenol composition, bioaccessibility and antioxidant activity affected?" in Food Chemistry, 284 (2019):28-44,
https://doi.org/10.1016/j.foodchem.2019.01.107 . .

TY  - JOUR
AU  - Pantelić, Nebojša
AU  - Zmejkovski, Bojana B.
AU  - Zizak, Zeljko
AU  - Banjac, Nebojša
AU  - Božić, Bojan D.
AU  - Stanojković, Tatjana P.
AU  - Kaludjerović, Goran N.
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5032
AB  - A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC50 values in the range of 0.22 to 0.53 mu M. The highest activity organotin(IV) compound expressed against the HeLa cells (IC50=0.22 +/- 0.04 mu M). The ligand precursor did not show anticancer activity (IC50>200 mu M). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase.
PB  - Hindawi Ltd, London
T2  - Journal of Chemistry
T1  - Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione
VL  - 2019
DO  - 10.1155/2019/2905840
ER  - 

@article{
author = "Pantelić, Nebojša and Zmejkovski, Bojana B. and Zizak, Zeljko and Banjac, Nebojša and Božić, Bojan D. and Stanojković, Tatjana P. and Kaludjerović, Goran N.",
year = "2019",
abstract = "A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC50 values in the range of 0.22 to 0.53 mu M. The highest activity organotin(IV) compound expressed against the HeLa cells (IC50=0.22 +/- 0.04 mu M). The ligand precursor did not show anticancer activity (IC50>200 mu M). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase.",
publisher = "Hindawi Ltd, London",
journal = "Journal of Chemistry",
title = "Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione",
volume = "2019",
doi = "10.1155/2019/2905840"
}

Pantelić, N., Zmejkovski, B. B., Zizak, Z., Banjac, N., Božić, B. D., Stanojković, T. P.,& Kaludjerović, G. N.. (2019). Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione. in Journal of Chemistry
Hindawi Ltd, London., 2019.
https://doi.org/10.1155/2019/2905840

Pantelić N, Zmejkovski BB, Zizak Z, Banjac N, Božić BD, Stanojković TP, Kaludjerović GN. Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione. in Journal of Chemistry. 2019;2019.
doi:10.1155/2019/2905840 .

Pantelić, Nebojša, Zmejkovski, Bojana B., Zizak, Zeljko, Banjac, Nebojša, Božić, Bojan D., Stanojković, Tatjana P., Kaludjerović, Goran N., "Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione" in Journal of Chemistry, 2019 (2019),
https://doi.org/10.1155/2019/2905840 . .

TY  - JOUR
AU  - Radivojević, Jelena
AU  - Ivanović, Evica
AU  - Popović-Djordjević, Jelena
AU  - Trišović, Nemanja
AU  - Banjac, Nebojša
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5224
AB  - The solvent influence on absorption spectra of food azo dyes was examined by the method of Linear Solvation Energy Relationships (LSER). For this purpose, six azo dyes were used: tartrazine (E 102), ponceau 4R (E 124), azorubin (E 122), brilliant black (E 151), amaranth (E 123) and gelb orange S (E 110). Absorption spectra of dissolved azo dye have been recorded in the wavelength range of visible radiation, or from 380 to 760 nm, in eight solvent of different polarity. The choice of the solvent was limited due to the high polarity of the azo dye molecules themselves. The effect of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interaction are analysed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The linear correlation of the absorption maxima with parameters of Kamlet-Taft solvatochrome equation yielded satisfactory results.
AB  - Uticaj polarnosti rastvarača na apsorpcione spektre prehrambenih azo boja ispitivan je metodom linearne korelacije energije solvatacije (LSER). U ovu svrhu korišćeno je šest prehrambenih azo boja i to: tartrazin (E 102), ponceau 4R (E 124), azorubin (E 122), brilijant crna (E 151), amarant (E 123) i gelb oranž S (E 110). Apsorpcioni spektri rastvorenih azo boja određeni su u talasnom opsegu vidljivog zračenja, odnosno u opsegu od 380 do 760 nm, u osam rastvarača različite polarnosti. Polarnost samih boja je uticala na izbor malog broja polarnih rastvarača. Spektre ispitivanih azo boja karakteriše jedan apsorpcioni maksimum. Efekat polarnosti rastvarača i efakat vodoničnog vezivanja rastvarač-rastvorena supstanca ispitivan je primenom KamletTaftove solvatohromne jednačine. Linearna korelacija apsorbcionih maksimuma sa parametrima Kamlet-Taftove solvatohromne jednačine dala je zadovoljavajuće rezultate.
PB  - Inženjersko društvo za koroziju, Beograd
T2  - Zaštita materijala
T1  - Solvent influence on absorption spectra of food azo dyes
T1  - Uticaj rastvarača na apsorpcione spektre prehrambenih azo boja
EP  - 335
IS  - 4
SP  - 331
VL  - 60
DO  - 10.5937/zasmat1904331R
ER  - 

@article{
author = "Radivojević, Jelena and Ivanović, Evica and Popović-Djordjević, Jelena and Trišović, Nemanja and Banjac, Nebojša",
year = "2019",
abstract = "The solvent influence on absorption spectra of food azo dyes was examined by the method of Linear Solvation Energy Relationships (LSER). For this purpose, six azo dyes were used: tartrazine (E 102), ponceau 4R (E 124), azorubin (E 122), brilliant black (E 151), amaranth (E 123) and gelb orange S (E 110). Absorption spectra of dissolved azo dye have been recorded in the wavelength range of visible radiation, or from 380 to 760 nm, in eight solvent of different polarity. The choice of the solvent was limited due to the high polarity of the azo dye molecules themselves. The effect of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interaction are analysed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The linear correlation of the absorption maxima with parameters of Kamlet-Taft solvatochrome equation yielded satisfactory results., Uticaj polarnosti rastvarača na apsorpcione spektre prehrambenih azo boja ispitivan je metodom linearne korelacije energije solvatacije (LSER). U ovu svrhu korišćeno je šest prehrambenih azo boja i to: tartrazin (E 102), ponceau 4R (E 124), azorubin (E 122), brilijant crna (E 151), amarant (E 123) i gelb oranž S (E 110). Apsorpcioni spektri rastvorenih azo boja određeni su u talasnom opsegu vidljivog zračenja, odnosno u opsegu od 380 do 760 nm, u osam rastvarača različite polarnosti. Polarnost samih boja je uticala na izbor malog broja polarnih rastvarača. Spektre ispitivanih azo boja karakteriše jedan apsorpcioni maksimum. Efekat polarnosti rastvarača i efakat vodoničnog vezivanja rastvarač-rastvorena supstanca ispitivan je primenom KamletTaftove solvatohromne jednačine. Linearna korelacija apsorbcionih maksimuma sa parametrima Kamlet-Taftove solvatohromne jednačine dala je zadovoljavajuće rezultate.",
publisher = "Inženjersko društvo za koroziju, Beograd",
journal = "Zaštita materijala",
title = "Solvent influence on absorption spectra of food azo dyes, Uticaj rastvarača na apsorpcione spektre prehrambenih azo boja",
pages = "335-331",
number = "4",
volume = "60",
doi = "10.5937/zasmat1904331R"
}

Radivojević, J., Ivanović, E., Popović-Djordjević, J., Trišović, N.,& Banjac, N.. (2019). Solvent influence on absorption spectra of food azo dyes. in Zaštita materijala
Inženjersko društvo za koroziju, Beograd., 60(4), 331-335.
https://doi.org/10.5937/zasmat1904331R

Radivojević J, Ivanović E, Popović-Djordjević J, Trišović N, Banjac N. Solvent influence on absorption spectra of food azo dyes. in Zaštita materijala. 2019;60(4):331-335.
doi:10.5937/zasmat1904331R .

Radivojević, Jelena, Ivanović, Evica, Popović-Djordjević, Jelena, Trišović, Nemanja, Banjac, Nebojša, "Solvent influence on absorption spectra of food azo dyes" in Zaštita materijala, 60, no. 4 (2019):331-335,
https://doi.org/10.5937/zasmat1904331R . .

TY  - JOUR
AU  - Petković-Cvetković, Jelena
AU  - Božić, Bojan
AU  - Banjac, Nebojša
AU  - Ladarević, Jelena
AU  - Vitnik, Vesna
AU  - Vitnik, Željko J.
AU  - Valentić, Nataša
AU  - Ušćumlić, Gordana
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5071
AB  - Novel succinimide derivatives were synthesized from 3-methyl-3-phenylsuccinic acid and substituted anilines under solvent-free conditions by using microwave irradiation. All obtained compounds were characterized by ultraviolet (UV), Fourier-transform infrared (FT-IR), H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy as well as by elemental analysis. The influence of the substituent electronic effects on spectroscopic data was analyzed by applying the Hammett equation. Moreover, a detailed interpretation and comparison of experimentally obtained and theoretically calculated FT-IR, UV and NMR spectra was performed. Density functional theory (DFT) calculated data of the investigated succinimides were obtained and analyzed in order to determine their structural, spectroscopic and electronic properties. Furthermore, ADMET factor profiling and in-silico prediction of potential biological activities of novel succinimide derivatives have been performed.
PB  - Savez hemijskih inženjera, Beograd
T2  - HEMIJSKA INDUSTRIJA
T1  - Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents
EP  - 137
IS  - 2
SP  - 125
VL  - 73
DO  - 10.2298/HEMIND190214011P
ER  - 

@article{
author = "Petković-Cvetković, Jelena and Božić, Bojan and Banjac, Nebojša and Ladarević, Jelena and Vitnik, Vesna and Vitnik, Željko J. and Valentić, Nataša and Ušćumlić, Gordana",
year = "2019",
abstract = "Novel succinimide derivatives were synthesized from 3-methyl-3-phenylsuccinic acid and substituted anilines under solvent-free conditions by using microwave irradiation. All obtained compounds were characterized by ultraviolet (UV), Fourier-transform infrared (FT-IR), H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy as well as by elemental analysis. The influence of the substituent electronic effects on spectroscopic data was analyzed by applying the Hammett equation. Moreover, a detailed interpretation and comparison of experimentally obtained and theoretically calculated FT-IR, UV and NMR spectra was performed. Density functional theory (DFT) calculated data of the investigated succinimides were obtained and analyzed in order to determine their structural, spectroscopic and electronic properties. Furthermore, ADMET factor profiling and in-silico prediction of potential biological activities of novel succinimide derivatives have been performed.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "HEMIJSKA INDUSTRIJA",
title = "Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents",
pages = "137-125",
number = "2",
volume = "73",
doi = "10.2298/HEMIND190214011P"
}

Petković-Cvetković, J., Božić, B., Banjac, N., Ladarević, J., Vitnik, V., Vitnik, Ž. J., Valentić, N.,& Ušćumlić, G.. (2019). Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents. in HEMIJSKA INDUSTRIJA
Savez hemijskih inženjera, Beograd., 73(2), 125-137.
https://doi.org/10.2298/HEMIND190214011P

Petković-Cvetković J, Božić B, Banjac N, Ladarević J, Vitnik V, Vitnik ŽJ, Valentić N, Ušćumlić G. Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents. in HEMIJSKA INDUSTRIJA. 2019;73(2):125-137.
doi:10.2298/HEMIND190214011P .

Petković-Cvetković, Jelena, Božić, Bojan, Banjac, Nebojša, Ladarević, Jelena, Vitnik, Vesna, Vitnik, Željko J., Valentić, Nataša, Ušćumlić, Gordana, "Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents" in HEMIJSKA INDUSTRIJA, 73, no. 2 (2019):125-137,
https://doi.org/10.2298/HEMIND190214011P . .

TY  - JOUR
AU  - Petković-Cvetković, Jelena
AU  - Božić, Bojan D.
AU  - Banjac, Nebojša
AU  - Petrović, Jovana
AU  - Soković, Marina
AU  - Vitnik, Vesna
AU  - Vitnik, Željko J.
AU  - Ušćumlić, Gordana
AU  - Valentić, Nataša
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5038
AB  - In the present study, twelve new 1-aryl-3-ethyl-3-methylpyrrolidine-2,5-diones were synthesized and their structures were characterized by FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis. In the final step of synthetic rout, condensation between corresponding succinic acid and substituted anilines has been improved using the microwave irradiation. Significantly higher yields compared to conventional condensation have been observed. The preliminary biological results indicated that some of the synthesized compounds showed promising in vitro antifungal activities towards several test fungi. 1-(4-Bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8) exhibited significant in vitro inhibitory activities against broad spectra of fungus, and on the basis of obtained data, the investigated bromo derivative has to be observed as novel potential fungicide. The density functional theory (DFT) calculations have been performed in order to study the structure-activity relationship (SAR) of the investigated molecules. In order to prediction of the chemical activity of the molecule, the molecular electrostatic potential (MEP) map was analyzed for the optimized geometry of 1-phenyl-3-ethyl-3-methylpyrrolidine-2,5-dione (4) and 1-(4-bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8).
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Molecular Structure
T1  - Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives
EP  - 156
SP  - 148
VL  - 1181
DO  - 10.1016/j.molstruc.2018.12.083
ER  - 

@article{
author = "Petković-Cvetković, Jelena and Božić, Bojan D. and Banjac, Nebojša and Petrović, Jovana and Soković, Marina and Vitnik, Vesna and Vitnik, Željko J. and Ušćumlić, Gordana and Valentić, Nataša",
year = "2019",
abstract = "In the present study, twelve new 1-aryl-3-ethyl-3-methylpyrrolidine-2,5-diones were synthesized and their structures were characterized by FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis. In the final step of synthetic rout, condensation between corresponding succinic acid and substituted anilines has been improved using the microwave irradiation. Significantly higher yields compared to conventional condensation have been observed. The preliminary biological results indicated that some of the synthesized compounds showed promising in vitro antifungal activities towards several test fungi. 1-(4-Bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8) exhibited significant in vitro inhibitory activities against broad spectra of fungus, and on the basis of obtained data, the investigated bromo derivative has to be observed as novel potential fungicide. The density functional theory (DFT) calculations have been performed in order to study the structure-activity relationship (SAR) of the investigated molecules. In order to prediction of the chemical activity of the molecule, the molecular electrostatic potential (MEP) map was analyzed for the optimized geometry of 1-phenyl-3-ethyl-3-methylpyrrolidine-2,5-dione (4) and 1-(4-bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8).",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Molecular Structure",
title = "Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives",
pages = "156-148",
volume = "1181",
doi = "10.1016/j.molstruc.2018.12.083"
}

Petković-Cvetković, J., Božić, B. D., Banjac, N., Petrović, J., Soković, M., Vitnik, V., Vitnik, Ž. J., Ušćumlić, G.,& Valentić, N.. (2019). Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives. in Journal of Molecular Structure
Elsevier Science Bv, Amsterdam., 1181, 148-156.
https://doi.org/10.1016/j.molstruc.2018.12.083

Petković-Cvetković J, Božić BD, Banjac N, Petrović J, Soković M, Vitnik V, Vitnik ŽJ, Ušćumlić G, Valentić N. Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives. in Journal of Molecular Structure. 2019;1181:148-156.
doi:10.1016/j.molstruc.2018.12.083 .

Petković-Cvetković, Jelena, Božić, Bojan D., Banjac, Nebojša, Petrović, Jovana, Soković, Marina, Vitnik, Vesna, Vitnik, Željko J., Ušćumlić, Gordana, Valentić, Nataša, "Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives" in Journal of Molecular Structure, 1181 (2019):148-156,
https://doi.org/10.1016/j.molstruc.2018.12.083 . .

TY  - JOUR
AU  - Božić, Bojan
AU  - Lović, Jelena
AU  - Banjac, Nebojša
AU  - Vitnik, Željko J.
AU  - Vitnik, Vesna
AU  - Mijin, Dukin
AU  - Ušćumlić, Gordana
AU  - Avramov-Ivić, Milka L.
PY  - 2018
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4765
AB  - A series of succinimide derivatives were studied using the cyclic and square wave voltammetry. Density function theory was used in order to determinate which of the structural parameters influence the electrochemical activity. The quantum chemical calculations of the investigated succinimides were linked with the experimental electrochemical data and used to propose the oxidation mechanism. The most active among studied succinimides is 1,3-diphenylsuccinimide. The results obtained from the cyclic and square wave voltammetry and quantum chemical calculations indicate that the investigated compounds undergo oxidation by irreversible, diffusion controlled process including transfer of 1e(-) and 1 proton. The voltammetric and DFT results signify that the mechanism of electrochemical oxidation of all compounds involve the conversion of carbonyl-methyne-phenyl segment or methylene group in free radical. This conversion proceeds by the loss of one proton one electron process.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Voltammetric and Quantum Investigation of Selected Succinimides
EP  - 4297
IS  - 5
SP  - 4285
VL  - 13
DO  - 10.20964/2018.05.54
ER  - 

@article{
author = "Božić, Bojan and Lović, Jelena and Banjac, Nebojša and Vitnik, Željko J. and Vitnik, Vesna and Mijin, Dukin and Ušćumlić, Gordana and Avramov-Ivić, Milka L.",
year = "2018",
abstract = "A series of succinimide derivatives were studied using the cyclic and square wave voltammetry. Density function theory was used in order to determinate which of the structural parameters influence the electrochemical activity. The quantum chemical calculations of the investigated succinimides were linked with the experimental electrochemical data and used to propose the oxidation mechanism. The most active among studied succinimides is 1,3-diphenylsuccinimide. The results obtained from the cyclic and square wave voltammetry and quantum chemical calculations indicate that the investigated compounds undergo oxidation by irreversible, diffusion controlled process including transfer of 1e(-) and 1 proton. The voltammetric and DFT results signify that the mechanism of electrochemical oxidation of all compounds involve the conversion of carbonyl-methyne-phenyl segment or methylene group in free radical. This conversion proceeds by the loss of one proton one electron process.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Voltammetric and Quantum Investigation of Selected Succinimides",
pages = "4297-4285",
number = "5",
volume = "13",
doi = "10.20964/2018.05.54"
}

Božić, B., Lović, J., Banjac, N., Vitnik, Ž. J., Vitnik, V., Mijin, D., Ušćumlić, G.,& Avramov-Ivić, M. L.. (2018). Voltammetric and Quantum Investigation of Selected Succinimides. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 13(5), 4285-4297.
https://doi.org/10.20964/2018.05.54

Božić B, Lović J, Banjac N, Vitnik ŽJ, Vitnik V, Mijin D, Ušćumlić G, Avramov-Ivić ML. Voltammetric and Quantum Investigation of Selected Succinimides. in International Journal of Electrochemical Science. 2018;13(5):4285-4297.
doi:10.20964/2018.05.54 .

Božić, Bojan, Lović, Jelena, Banjac, Nebojša, Vitnik, Željko J., Vitnik, Vesna, Mijin, Dukin, Ušćumlić, Gordana, Avramov-Ivić, Milka L., "Voltammetric and Quantum Investigation of Selected Succinimides" in International Journal of Electrochemical Science, 13, no. 5 (2018):4285-4297,
https://doi.org/10.20964/2018.05.54 . .

TY  - JOUR
AU  - Banjac, Nebojša
AU  - Božić, Bojan D.
AU  - Mirković, Jelena M.
AU  - Vitnik, Vesna
AU  - Vitnik, Željko J.
AU  - Valentić, Nataša
AU  - Ušćumlić, Gordana
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4375
AB  - A series of ten 1-aryl-3-methylsuccinimides was synthesized and their solvatochromic properties were studied in a set of fifteen binary solvent mixtures. The solute-solvent interactions were analyzed on the basis of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The electronic effect of the substituents on the UV-Vis absorption and NMR spectra was analyzed using the simple Hammett equation. Moreover, the B3LYP, CAM-B3LYP, and M06-2X functionals using the 6-311G(d,p) basic set have been assessed in light of the position of experimental absorption maxima obtained for these compounds. The integration grid effects have also been evaluated. An interpretation of the substituent-effect transmission through the molecular skeleton and the nature of the HOMO and LUMO orbitals based on quantum-chemical calculations is given. The values of partial atomic charges from the atomic polar tenzors (APT), natural population analysis (NBO), and charges fit to the electrostatic potential using the B3LYP, CAM-B3LYP, and M06-2X methods are produced and correlated with different experimental properties. In order to estimate the chemical activity of the molecule, the molecular electrostatic potential (MEP) surface map is calculated for the optimized geometry of 1-phenyl-3-methylsuccinimide.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Molecular Structure
T1  - Experimental and theoretical study on the structure-property relationship of novel 1-aryl-3-methylsuccinimides
EP  - 282
SP  - 271
VL  - 1129
DO  - 10.1016/j.molstruc.2016.09.086
ER  - 

@article{
author = "Banjac, Nebojša and Božić, Bojan D. and Mirković, Jelena M. and Vitnik, Vesna and Vitnik, Željko J. and Valentić, Nataša and Ušćumlić, Gordana",
year = "2017",
abstract = "A series of ten 1-aryl-3-methylsuccinimides was synthesized and their solvatochromic properties were studied in a set of fifteen binary solvent mixtures. The solute-solvent interactions were analyzed on the basis of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The electronic effect of the substituents on the UV-Vis absorption and NMR spectra was analyzed using the simple Hammett equation. Moreover, the B3LYP, CAM-B3LYP, and M06-2X functionals using the 6-311G(d,p) basic set have been assessed in light of the position of experimental absorption maxima obtained for these compounds. The integration grid effects have also been evaluated. An interpretation of the substituent-effect transmission through the molecular skeleton and the nature of the HOMO and LUMO orbitals based on quantum-chemical calculations is given. The values of partial atomic charges from the atomic polar tenzors (APT), natural population analysis (NBO), and charges fit to the electrostatic potential using the B3LYP, CAM-B3LYP, and M06-2X methods are produced and correlated with different experimental properties. In order to estimate the chemical activity of the molecule, the molecular electrostatic potential (MEP) surface map is calculated for the optimized geometry of 1-phenyl-3-methylsuccinimide.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Molecular Structure",
title = "Experimental and theoretical study on the structure-property relationship of novel 1-aryl-3-methylsuccinimides",
pages = "282-271",
volume = "1129",
doi = "10.1016/j.molstruc.2016.09.086"
}

Banjac, N., Božić, B. D., Mirković, J. M., Vitnik, V., Vitnik, Ž. J., Valentić, N.,& Ušćumlić, G.. (2017). Experimental and theoretical study on the structure-property relationship of novel 1-aryl-3-methylsuccinimides. in Journal of Molecular Structure
Elsevier Science Bv, Amsterdam., 1129, 271-282.
https://doi.org/10.1016/j.molstruc.2016.09.086

Banjac N, Božić BD, Mirković JM, Vitnik V, Vitnik ŽJ, Valentić N, Ušćumlić G. Experimental and theoretical study on the structure-property relationship of novel 1-aryl-3-methylsuccinimides. in Journal of Molecular Structure. 2017;1129:271-282.
doi:10.1016/j.molstruc.2016.09.086 .

Banjac, Nebojša, Božić, Bojan D., Mirković, Jelena M., Vitnik, Vesna, Vitnik, Željko J., Valentić, Nataša, Ušćumlić, Gordana, "Experimental and theoretical study on the structure-property relationship of novel 1-aryl-3-methylsuccinimides" in Journal of Molecular Structure, 1129 (2017):271-282,
https://doi.org/10.1016/j.molstruc.2016.09.086 . .

TY  - JOUR
AU  - Milošević, Nataša P.
AU  - Kojić, Vesna
AU  - Curcić, Jelena
AU  - Jakimov, Dimitar
AU  - Milić, Nataša
AU  - Banjac, Nebojša
AU  - Ušćumlić, Gordana
AU  - Kaliszan, Roman
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4397
AB  - Design of a new drug entity is usually preceded by analysis of quantitative structure activity (properties) relationships, QSA(P)R. Six newly synthesized succinimide derivatives have been determined for (i) in silico physico-chemical descriptors, pharmacokinetic and toxicity predictors, (ii) in vitro biological activity on four different carcinoma cell lines and on normal fetal lung cells and (iii) lipophilicity on liquid chromatography. All compounds observed were predicted for good permeability and solubility, good oral absorption rate and moderate volume of distribution as well as for modest blood brain permeation, followed by acceptable observed toxicity. In silico determined lipophilicity, permeability through jejunum and aqueous solubility were correlated with experimentally obtained lipophilic constants (by use of high pressure liquid chromatography) and linear correlations were obtained. Absorption rate and volume of distribution were predicted by chromatographic lipophilicity measurements while permeation through blood bran barrier was predicted dominantly by molecular size defined with molecular weight. Five compounds have demonstrated antiproliferative activity toward cervix carcinoma HeLa cell lines; three were cytotoxic against breast carcinoma MCF-7 cells, while one inhibited proliferation of colon carcinoma HT 29 cell lines. Only one compound was cytotoxic toward normal cell lines, while other compounds were proven as safe. Antiproliferative potential against HeLa cells was described as exponential function of lipophilicity. Based on obtained results, lead compounds were selected.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Evaluation of in silico pharmacokinetic properties and in vitro cytotoxic activity of selected newly synthesized N-succinimide derivatives
EP  - 257
SP  - 252
VL  - 137
DO  - 10.1016/j.jpba.2017.01.042
ER  - 

@article{
author = "Milošević, Nataša P. and Kojić, Vesna and Curcić, Jelena and Jakimov, Dimitar and Milić, Nataša and Banjac, Nebojša and Ušćumlić, Gordana and Kaliszan, Roman",
year = "2017",
abstract = "Design of a new drug entity is usually preceded by analysis of quantitative structure activity (properties) relationships, QSA(P)R. Six newly synthesized succinimide derivatives have been determined for (i) in silico physico-chemical descriptors, pharmacokinetic and toxicity predictors, (ii) in vitro biological activity on four different carcinoma cell lines and on normal fetal lung cells and (iii) lipophilicity on liquid chromatography. All compounds observed were predicted for good permeability and solubility, good oral absorption rate and moderate volume of distribution as well as for modest blood brain permeation, followed by acceptable observed toxicity. In silico determined lipophilicity, permeability through jejunum and aqueous solubility were correlated with experimentally obtained lipophilic constants (by use of high pressure liquid chromatography) and linear correlations were obtained. Absorption rate and volume of distribution were predicted by chromatographic lipophilicity measurements while permeation through blood bran barrier was predicted dominantly by molecular size defined with molecular weight. Five compounds have demonstrated antiproliferative activity toward cervix carcinoma HeLa cell lines; three were cytotoxic against breast carcinoma MCF-7 cells, while one inhibited proliferation of colon carcinoma HT 29 cell lines. Only one compound was cytotoxic toward normal cell lines, while other compounds were proven as safe. Antiproliferative potential against HeLa cells was described as exponential function of lipophilicity. Based on obtained results, lead compounds were selected.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Evaluation of in silico pharmacokinetic properties and in vitro cytotoxic activity of selected newly synthesized N-succinimide derivatives",
pages = "257-252",
volume = "137",
doi = "10.1016/j.jpba.2017.01.042"
}

Milošević, N. P., Kojić, V., Curcić, J., Jakimov, D., Milić, N., Banjac, N., Ušćumlić, G.,& Kaliszan, R.. (2017). Evaluation of in silico pharmacokinetic properties and in vitro cytotoxic activity of selected newly synthesized N-succinimide derivatives. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science Bv, Amsterdam., 137, 252-257.
https://doi.org/10.1016/j.jpba.2017.01.042

Milošević NP, Kojić V, Curcić J, Jakimov D, Milić N, Banjac N, Ušćumlić G, Kaliszan R. Evaluation of in silico pharmacokinetic properties and in vitro cytotoxic activity of selected newly synthesized N-succinimide derivatives. in Journal of Pharmaceutical and Biomedical Analysis. 2017;137:252-257.
doi:10.1016/j.jpba.2017.01.042 .

Milošević, Nataša P., Kojić, Vesna, Curcić, Jelena, Jakimov, Dimitar, Milić, Nataša, Banjac, Nebojša, Ušćumlić, Gordana, Kaliszan, Roman, "Evaluation of in silico pharmacokinetic properties and in vitro cytotoxic activity of selected newly synthesized N-succinimide derivatives" in Journal of Pharmaceutical and Biomedical Analysis, 137 (2017):252-257,
https://doi.org/10.1016/j.jpba.2017.01.042 . .

TY  - JOUR
AU  - Perisić-Janjić, Nada
AU  - Kaliszan, Roman
AU  - Milošević, Nataša
AU  - Ušćumlić, Gordana
AU  - Banjac, Nebojša
PY  - 2013
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3313
AB  - Reversed-phase thin-layer chromatographic (RP TLC) retention coefficients for a newly designed series of N-phenyl-3-methyl succinimide derivatives, of a rationally expected anticonvusant activity, were determined as parameters of their lipophilicity. Basic pharmacokinetic descriptors of the agents were calculated in silico with the use of the established medicinal chemistry/drug design software. Highly significant, predictive relationships were found between the chromatographic retention constants and the bioactivity descriptors, which are assumed to account for drug absorption, distribution, elimination and toxicity (ADMETox) in humans. Among the agents investigated, the compounds with halogen substituent (Compounds nos. 9-13 in Fig. 1), were identified as the best drug candidates, because of their predicted proper pharmacokinetics, and have been selected for further research and development studies on new antiepileptic drugs. At the same time, among the congeners studied these can be indicated, which should not be rationally subjected to bioactivity tests.
PB  - Elsevier, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Chromatographic retention parameters in correlation analysis with in silico biological descriptors of a novel series of N-phenyl-3-methyl succinimide derivatives
EP  - 73
SP  - 65
VL  - 72
DO  - 10.1016/j.jpba.2012.09.006
ER  - 

@article{
author = "Perisić-Janjić, Nada and Kaliszan, Roman and Milošević, Nataša and Ušćumlić, Gordana and Banjac, Nebojša",
year = "2013",
abstract = "Reversed-phase thin-layer chromatographic (RP TLC) retention coefficients for a newly designed series of N-phenyl-3-methyl succinimide derivatives, of a rationally expected anticonvusant activity, were determined as parameters of their lipophilicity. Basic pharmacokinetic descriptors of the agents were calculated in silico with the use of the established medicinal chemistry/drug design software. Highly significant, predictive relationships were found between the chromatographic retention constants and the bioactivity descriptors, which are assumed to account for drug absorption, distribution, elimination and toxicity (ADMETox) in humans. Among the agents investigated, the compounds with halogen substituent (Compounds nos. 9-13 in Fig. 1), were identified as the best drug candidates, because of their predicted proper pharmacokinetics, and have been selected for further research and development studies on new antiepileptic drugs. At the same time, among the congeners studied these can be indicated, which should not be rationally subjected to bioactivity tests.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Chromatographic retention parameters in correlation analysis with in silico biological descriptors of a novel series of N-phenyl-3-methyl succinimide derivatives",
pages = "73-65",
volume = "72",
doi = "10.1016/j.jpba.2012.09.006"
}

Perisić-Janjić, N., Kaliszan, R., Milošević, N., Ušćumlić, G.,& Banjac, N.. (2013). Chromatographic retention parameters in correlation analysis with in silico biological descriptors of a novel series of N-phenyl-3-methyl succinimide derivatives. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier, Amsterdam., 72, 65-73.
https://doi.org/10.1016/j.jpba.2012.09.006

Perisić-Janjić N, Kaliszan R, Milošević N, Ušćumlić G, Banjac N. Chromatographic retention parameters in correlation analysis with in silico biological descriptors of a novel series of N-phenyl-3-methyl succinimide derivatives. in Journal of Pharmaceutical and Biomedical Analysis. 2013;72:65-73.
doi:10.1016/j.jpba.2012.09.006 .

Perisić-Janjić, Nada, Kaliszan, Roman, Milošević, Nataša, Ušćumlić, Gordana, Banjac, Nebojša, "Chromatographic retention parameters in correlation analysis with in silico biological descriptors of a novel series of N-phenyl-3-methyl succinimide derivatives" in Journal of Pharmaceutical and Biomedical Analysis, 72 (2013):65-73,
https://doi.org/10.1016/j.jpba.2012.09.006 . .

TY  - JOUR
AU  - Demin, Mirjana
AU  - Vučelić-Radović, Biljana
AU  - Banjac, Nebojša
AU  - Tipsina, Nikolaevna Neli
AU  - Milovanović, Mirjana M.
PY  - 2013
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3227
AB  - The aim of this work was to compare the nutritional characteristics of wheat bread with those of bread produced of wheat flour supplemented with quinoa and buckwheat seeds. Bread making properties of these blends were analyzed in order to investigate their ability to make molded bread. Quinoa (Chenopodium quinoa Will.) and buckwheat seeds were grown in the vicinity of Belgrade, Serbia. The addition of pseudo cereal seeds (at levels of 30 and 40%) and a selected technological process, which included hydrothermal preparation of supplements, resulted in a valuable effect on the nutritive value of the breads. In comparison with the wheat bread that was used as the control sample, a protein increase of 2% and the increase of crude fiber content at around 0.5% in 30% supplemented breads were registered. Furthermore, the incorporation of both seeds mixture at a 40% level increased the content of protein by 2.5% and fiber content by 0.4%. In regard to the starch, fat, and ash contents there were no major differences. The investigated breads were nutritionally superior to the wheat bread. Chemical composition of the selected seeds was also investigated. The results showed that the blends containing either 30 or 40% of selected seeds expressed high potential for the production of molded breads as new baking products with enhanced nutritional composition. The applied technological procedure was modified in such way that for all blended combination of supplements it changed the rheological properties of the dough. Furthermore, it resulted in a good volume of breads with excellent sensory properties of aroma-odor and taste.
AB  - Kvinoja (Chenopodium quinoa Will.) jeste ratarska biljka poreklom iz andskih država Južne Amerike. Na području Srbije ova biljka dosad nije gajena. Agrotehnika kvinoje je zasnovana na principu organske poljoprivredne proizvodnje i primenjuje se u Danskoj i Makedoniji. Predmet proučavanja bila je danska sorta KVL 37, i domaća sorta heljde, koje su gajene na lokalitetu Stara Pazova. U ovom radu prikazan je hemijski sastav prečišćenih semena kvinoje i heljde koja su korišćena za proizvodnju hleba. Određene su nutritivne vrednosti pšeničnog hleba sa dodatkom semena pseudocerealija, kvinoje i heljde, u količini od 30 i 40% i upoređene su sa kontrolnim pšeničnim hlebom. Analizirane su tehnološke i pecivne osobine mešavina ovih semena i pšeničnog brašna, kao i mogućnost njihove primene u proizvodnji hleba u kalupu. Tehnološki proces je modifikovan uvoćenjem hidrotermičkog tretmana semena. Hleb sa dodatkom 30% semena pseudocerealija je sadržao 2% više proteina, oko 0,5% više sirovih vlakana, dok je dodatak 40% semena hlebu povećao sadržaj proteina za 2,5% a vlakana za oko 0,4%. U pogledu sadržaja skroba, ulja i pepela nije bilo većih promena. Pokazano je da su se sve ispitivane mešavine pšeničnog brašna i semena pseudocerealija pokazale pogodnim za proizvodnju ukalupljenog hleba, povećane nutritivne vrednosti. Primenjeni tehnološki postupak je uticao na reološke osobine testa. Dobijeni hlebovi su imali dobru specifičnu zapreminu i odlične senzorne osobine.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Buckwheat and quinoa seeds as supplements in wheat bread production
T1  - Proizvodnja pšeničnog hleba sa dodatkom semena kvinoje i heljde
EP  - 121
IS  - 1
SP  - 115
VL  - 67
DO  - 10.2298/HEMIND120314048D
ER  - 

@article{
author = "Demin, Mirjana and Vučelić-Radović, Biljana and Banjac, Nebojša and Tipsina, Nikolaevna Neli and Milovanović, Mirjana M.",
year = "2013",
abstract = "The aim of this work was to compare the nutritional characteristics of wheat bread with those of bread produced of wheat flour supplemented with quinoa and buckwheat seeds. Bread making properties of these blends were analyzed in order to investigate their ability to make molded bread. Quinoa (Chenopodium quinoa Will.) and buckwheat seeds were grown in the vicinity of Belgrade, Serbia. The addition of pseudo cereal seeds (at levels of 30 and 40%) and a selected technological process, which included hydrothermal preparation of supplements, resulted in a valuable effect on the nutritive value of the breads. In comparison with the wheat bread that was used as the control sample, a protein increase of 2% and the increase of crude fiber content at around 0.5% in 30% supplemented breads were registered. Furthermore, the incorporation of both seeds mixture at a 40% level increased the content of protein by 2.5% and fiber content by 0.4%. In regard to the starch, fat, and ash contents there were no major differences. The investigated breads were nutritionally superior to the wheat bread. Chemical composition of the selected seeds was also investigated. The results showed that the blends containing either 30 or 40% of selected seeds expressed high potential for the production of molded breads as new baking products with enhanced nutritional composition. The applied technological procedure was modified in such way that for all blended combination of supplements it changed the rheological properties of the dough. Furthermore, it resulted in a good volume of breads with excellent sensory properties of aroma-odor and taste., Kvinoja (Chenopodium quinoa Will.) jeste ratarska biljka poreklom iz andskih država Južne Amerike. Na području Srbije ova biljka dosad nije gajena. Agrotehnika kvinoje je zasnovana na principu organske poljoprivredne proizvodnje i primenjuje se u Danskoj i Makedoniji. Predmet proučavanja bila je danska sorta KVL 37, i domaća sorta heljde, koje su gajene na lokalitetu Stara Pazova. U ovom radu prikazan je hemijski sastav prečišćenih semena kvinoje i heljde koja su korišćena za proizvodnju hleba. Određene su nutritivne vrednosti pšeničnog hleba sa dodatkom semena pseudocerealija, kvinoje i heljde, u količini od 30 i 40% i upoređene su sa kontrolnim pšeničnim hlebom. Analizirane su tehnološke i pecivne osobine mešavina ovih semena i pšeničnog brašna, kao i mogućnost njihove primene u proizvodnji hleba u kalupu. Tehnološki proces je modifikovan uvoćenjem hidrotermičkog tretmana semena. Hleb sa dodatkom 30% semena pseudocerealija je sadržao 2% više proteina, oko 0,5% više sirovih vlakana, dok je dodatak 40% semena hlebu povećao sadržaj proteina za 2,5% a vlakana za oko 0,4%. U pogledu sadržaja skroba, ulja i pepela nije bilo većih promena. Pokazano je da su se sve ispitivane mešavine pšeničnog brašna i semena pseudocerealija pokazale pogodnim za proizvodnju ukalupljenog hleba, povećane nutritivne vrednosti. Primenjeni tehnološki postupak je uticao na reološke osobine testa. Dobijeni hlebovi su imali dobru specifičnu zapreminu i odlične senzorne osobine.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Buckwheat and quinoa seeds as supplements in wheat bread production, Proizvodnja pšeničnog hleba sa dodatkom semena kvinoje i heljde",
pages = "121-115",
number = "1",
volume = "67",
doi = "10.2298/HEMIND120314048D"
}

Demin, M., Vučelić-Radović, B., Banjac, N., Tipsina, N. N.,& Milovanović, M. M.. (2013). Buckwheat and quinoa seeds as supplements in wheat bread production. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 67(1), 115-121.
https://doi.org/10.2298/HEMIND120314048D

Demin M, Vučelić-Radović B, Banjac N, Tipsina NN, Milovanović MM. Buckwheat and quinoa seeds as supplements in wheat bread production. in Hemijska industrija. 2013;67(1):115-121.
doi:10.2298/HEMIND120314048D .

Demin, Mirjana, Vučelić-Radović, Biljana, Banjac, Nebojša, Tipsina, Nikolaevna Neli, Milovanović, Mirjana M., "Buckwheat and quinoa seeds as supplements in wheat bread production" in Hemijska industrija, 67, no. 1 (2013):115-121,
https://doi.org/10.2298/HEMIND120314048D . .

TY  - THES
AU  - Banjac, Nebojša
PY  - 2013
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/17
AB  - In order to investigate solvent effects and molecular structure on the activity of N-phenylsuccinimide, derivatives three series of corresponding compounds have been synthesized. The first series represents N-(3- and 4- substituted phenyl)-2-methylsuccinimides, with substituents: hydrogen, metoxy, methyl, hydroxy, chlor, brom, acetyl, iod, carboxy and nitro group. The second compound consists of N-(3- and 4- substituted phenyl)-2-phenylsuccinimides, in reference to his with different substituents in 3- and 4- position of phenyl nucleus. The substituents are: hydrogen, methyl, metoxy, chlor, brom, nitro, hydroxy and acetyl group. The third series consists of N-(3- and 4- substituted phenyl)-2,2-diphenylsuccinimide with different substituents in 3- and 4- position of phenyl nucleus. The substituents are: hydrogen, methyl, metoxy, nitro, hydroxy, cyano, fluor, chlor, brom, iod and acetyl group. All the succinimides have been synthesized according to procedure given in the literature or their modification. The purity of the obtained compounds have been confirmed by the determining melting points and recording the UV, FTIR, 1HNMR and 13CNMR spectra. Solvent effects on the activity of investigated succinimides have been interpret on the basis of UV absorption maximum in different solvents. Protic solvents having higher polarity cause hypsochromic effect. Contrary, aprotic solvents shifted absorption maximums to the higher wavelengths and batochromic effect occurs. The quantitative assessment of solvent effects on the absorption maximums of the investigated molecules was carried out by the means of linear solvatochromic energy relationship, using Kamlet-Taft equation...
AB  - U okviru proučavanja uticaja strukture na antikonvulzivnu aktivnost sukcinimida u ovom radu su sintetisane tri različite serije novih potencijalno farmakološki aktivnih derivata sukcinimida. Osnovni cilj istraživanja je uspostavljanje novog modela za procenu farmakološke aktivnosti sukcinimida primenom linearne korelacije solvatohromnih energija na apsorpcione maksimume proučavanih molekula u različitim rastvaračima. Prvu seriju sintetisanih molekula čine N-(3- i 4- supstituisani fenil)-2-fenilsukcinimidi (A) sa različitim supstituentima u položajima tri i četiri fenilnog jezgra. Supstituenti su: vodonik, metil, metoksi, hlor, brom, nitro, hidroksi i acetil grupa. Drugu seriju jedinjenja predstavljaju N-(3- i 4- supstituisani fenil)-2,2-difenil-sukcinimidi (B), sa različitim supstituentima u položajima tri i četiri fenilnog jezgra. Supstituenti su: vodonik, metil, metoksi, nitro, hidroksi, cijano, fluor, hlor, brom, jod i acetil grupa. Treću grupu jedinjenja predstavljaju N-(3- i 4- supstituisani fenil)-2-metilsukcinimidi (C) sa različitim supstituentima u položajima tri i četiri fenilnog jezgra. Supstituenti su: vodonik, metoksi, metil, hidroksi, hlor, brom, acetil, jod, karboksi i nitro grupa. Sinteze gore pomenutih molekula su izvedene na osnovu postupaka navedenih u literaturi, odnosno njihovih neznatnih modifikacija. Karakterizacija i identifikacija sintetisanih jedinjenja izvršena je određivanjem temperature topljenja i snimanjem UV, FTIR, 1H NMR, 13C NMR spektara. UV apsorpcioni maksimumi navedenih molekula određeni su u 15 rastvarača različitih polarnosti, u opsegu talasnih dužina 200-400 nm. Koncentracije rastvora su iznosile 10-4 mol/dm3. Povećanje polarnosti protičnih rastvarača izaziva pomeranje apsorpcionih maksimuma ka manjim talasnim dužinama, odnosno javlja se hipsohromni efekat. Kod aprotičnih rastvarača javlja se suprotan efekat, odnosno dolazi do pomeranja apsorpcionih maksimuma ka većim talasnim dužinama i pojave batohromnog efekta. Kvantitativna procena efekta rastvarača na apsorpcione maksimume izvršena je metodom linearne korelacije solvatohromnih energija, odnosno korelacije UV apsorpcionih maksimuma Kamlet-Taftovom (Kamlet-Taft) jednačinom...
PB  - Univerzitet u Beogradu, Tehnološko-metalurški fakultet
T1  - Synthesis, structure and solvatochromism of potentially pharmacologically active derivates of succinimides
T1  - Sinteza, struktura i solvatohromizam potencijalno farmakološki aktivnih derivata sukcinimida
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2926
ER  - 

@phdthesis{
author = "Banjac, Nebojša",
year = "2013",
abstract = "In order to investigate solvent effects and molecular structure on the activity of N-phenylsuccinimide, derivatives three series of corresponding compounds have been synthesized. The first series represents N-(3- and 4- substituted phenyl)-2-methylsuccinimides, with substituents: hydrogen, metoxy, methyl, hydroxy, chlor, brom, acetyl, iod, carboxy and nitro group. The second compound consists of N-(3- and 4- substituted phenyl)-2-phenylsuccinimides, in reference to his with different substituents in 3- and 4- position of phenyl nucleus. The substituents are: hydrogen, methyl, metoxy, chlor, brom, nitro, hydroxy and acetyl group. The third series consists of N-(3- and 4- substituted phenyl)-2,2-diphenylsuccinimide with different substituents in 3- and 4- position of phenyl nucleus. The substituents are: hydrogen, methyl, metoxy, nitro, hydroxy, cyano, fluor, chlor, brom, iod and acetyl group. All the succinimides have been synthesized according to procedure given in the literature or their modification. The purity of the obtained compounds have been confirmed by the determining melting points and recording the UV, FTIR, 1HNMR and 13CNMR spectra. Solvent effects on the activity of investigated succinimides have been interpret on the basis of UV absorption maximum in different solvents. Protic solvents having higher polarity cause hypsochromic effect. Contrary, aprotic solvents shifted absorption maximums to the higher wavelengths and batochromic effect occurs. The quantitative assessment of solvent effects on the absorption maximums of the investigated molecules was carried out by the means of linear solvatochromic energy relationship, using Kamlet-Taft equation..., U okviru proučavanja uticaja strukture na antikonvulzivnu aktivnost sukcinimida u ovom radu su sintetisane tri različite serije novih potencijalno farmakološki aktivnih derivata sukcinimida. Osnovni cilj istraživanja je uspostavljanje novog modela za procenu farmakološke aktivnosti sukcinimida primenom linearne korelacije solvatohromnih energija na apsorpcione maksimume proučavanih molekula u različitim rastvaračima. Prvu seriju sintetisanih molekula čine N-(3- i 4- supstituisani fenil)-2-fenilsukcinimidi (A) sa različitim supstituentima u položajima tri i četiri fenilnog jezgra. Supstituenti su: vodonik, metil, metoksi, hlor, brom, nitro, hidroksi i acetil grupa. Drugu seriju jedinjenja predstavljaju N-(3- i 4- supstituisani fenil)-2,2-difenil-sukcinimidi (B), sa različitim supstituentima u položajima tri i četiri fenilnog jezgra. Supstituenti su: vodonik, metil, metoksi, nitro, hidroksi, cijano, fluor, hlor, brom, jod i acetil grupa. Treću grupu jedinjenja predstavljaju N-(3- i 4- supstituisani fenil)-2-metilsukcinimidi (C) sa različitim supstituentima u položajima tri i četiri fenilnog jezgra. Supstituenti su: vodonik, metoksi, metil, hidroksi, hlor, brom, acetil, jod, karboksi i nitro grupa. Sinteze gore pomenutih molekula su izvedene na osnovu postupaka navedenih u literaturi, odnosno njihovih neznatnih modifikacija. Karakterizacija i identifikacija sintetisanih jedinjenja izvršena je određivanjem temperature topljenja i snimanjem UV, FTIR, 1H NMR, 13C NMR spektara. UV apsorpcioni maksimumi navedenih molekula određeni su u 15 rastvarača različitih polarnosti, u opsegu talasnih dužina 200-400 nm. Koncentracije rastvora su iznosile 10-4 mol/dm3. Povećanje polarnosti protičnih rastvarača izaziva pomeranje apsorpcionih maksimuma ka manjim talasnim dužinama, odnosno javlja se hipsohromni efekat. Kod aprotičnih rastvarača javlja se suprotan efekat, odnosno dolazi do pomeranja apsorpcionih maksimuma ka većim talasnim dužinama i pojave batohromnog efekta. Kvantitativna procena efekta rastvarača na apsorpcione maksimume izvršena je metodom linearne korelacije solvatohromnih energija, odnosno korelacije UV apsorpcionih maksimuma Kamlet-Taftovom (Kamlet-Taft) jednačinom...",
publisher = "Univerzitet u Beogradu, Tehnološko-metalurški fakultet",
title = "Synthesis, structure and solvatochromism of potentially pharmacologically active derivates of succinimides, Sinteza, struktura i solvatohromizam potencijalno farmakološki aktivnih derivata sukcinimida",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2926"
}

Banjac, N.. (2013). Synthesis, structure and solvatochromism of potentially pharmacologically active derivates of succinimides. 
Univerzitet u Beogradu, Tehnološko-metalurški fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_2926

Banjac N. Synthesis, structure and solvatochromism of potentially pharmacologically active derivates of succinimides. 2013;.
https://hdl.handle.net/21.15107/rcub_nardus_2926 .

Banjac, Nebojša, "Synthesis, structure and solvatochromism of potentially pharmacologically active derivates of succinimides" (2013),
https://hdl.handle.net/21.15107/rcub_nardus_2926 .

TY  - CONF
AU  - Demin, Mirjana
AU  - Milovanović, M.M.
AU  - Stikić, Radmila
AU  - Banjac, Nebojša
AU  - Rabrenović, Biljana
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2436
AB  - The objective of this work was to compare the nutritional characteristics of wheat bread and the bread produced of wheat flour, with seeds of quinoa, buckwheat and flaxseed as supplements. Bread making properties of these blends were analyzed in order to provide their ability to make molded bread. Quinoa seeds (Chenopodium quinoa Will.) were produced in the vicinity of Belgrade, and the other seeds were collected from the local market. The addition of seeds of cereals and a selected technological process, which include hydrothermal preparation of supplements, possessed a remarkable effect on nutritive value of bread. Moisture, protein, lipid, dietary fiber, ash and starch content of breads were determined. The quinoa proteins are rich in amino acids like lysine and methionine, which are deficient in cereals, and in combination with other cereals might easily replace meat and more ecological food habits. The other ingredients, flax were primarily used as a complement for the polyunsaturated fatty acids, and the buckwheat for increasing protein content. Sensory properties, appearance, crust texture, crumb texture, aroma-odor of crust and crumb and aroma-taste of crust and crumb were also appraised. Sensory characteristics of evaluated bread were excellent with an increase in specific volume of 2%.
PB  - 6th International Congress and the 8th Croatian Congress of Cereal Technologists, FLOUR-BREAD 2011
C3  - Proceedings of 6th International Congress FLOUR-BREAD 2011 - 8th Croatian Congress of Cereal Technol
T1  - Quinoa, buckwheat and flaxseed ingredients in the wheat bread production with nutritional quality
EP  - 251
SP  - 245
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_2436
ER  - 

@conference{
author = "Demin, Mirjana and Milovanović, M.M. and Stikić, Radmila and Banjac, Nebojša and Rabrenović, Biljana",
year = "2011",
abstract = "The objective of this work was to compare the nutritional characteristics of wheat bread and the bread produced of wheat flour, with seeds of quinoa, buckwheat and flaxseed as supplements. Bread making properties of these blends were analyzed in order to provide their ability to make molded bread. Quinoa seeds (Chenopodium quinoa Will.) were produced in the vicinity of Belgrade, and the other seeds were collected from the local market. The addition of seeds of cereals and a selected technological process, which include hydrothermal preparation of supplements, possessed a remarkable effect on nutritive value of bread. Moisture, protein, lipid, dietary fiber, ash and starch content of breads were determined. The quinoa proteins are rich in amino acids like lysine and methionine, which are deficient in cereals, and in combination with other cereals might easily replace meat and more ecological food habits. The other ingredients, flax were primarily used as a complement for the polyunsaturated fatty acids, and the buckwheat for increasing protein content. Sensory properties, appearance, crust texture, crumb texture, aroma-odor of crust and crumb and aroma-taste of crust and crumb were also appraised. Sensory characteristics of evaluated bread were excellent with an increase in specific volume of 2%.",
publisher = "6th International Congress and the 8th Croatian Congress of Cereal Technologists, FLOUR-BREAD 2011",
journal = "Proceedings of 6th International Congress FLOUR-BREAD 2011 - 8th Croatian Congress of Cereal Technol",
title = "Quinoa, buckwheat and flaxseed ingredients in the wheat bread production with nutritional quality",
pages = "251-245",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_2436"
}

Demin, M., Milovanović, M.M., Stikić, R., Banjac, N.,& Rabrenović, B.. (2011). Quinoa, buckwheat and flaxseed ingredients in the wheat bread production with nutritional quality. in Proceedings of 6th International Congress FLOUR-BREAD 2011 - 8th Croatian Congress of Cereal Technol
6th International Congress and the 8th Croatian Congress of Cereal Technologists, FLOUR-BREAD 2011., 245-251.
https://hdl.handle.net/21.15107/rcub_agrospace_2436

Demin M, Milovanović M, Stikić R, Banjac N, Rabrenović B. Quinoa, buckwheat and flaxseed ingredients in the wheat bread production with nutritional quality. in Proceedings of 6th International Congress FLOUR-BREAD 2011 - 8th Croatian Congress of Cereal Technol. 2011;:245-251.
https://hdl.handle.net/21.15107/rcub_agrospace_2436 .

Demin, Mirjana, Milovanović, M.M., Stikić, Radmila, Banjac, Nebojša, Rabrenović, Biljana, "Quinoa, buckwheat and flaxseed ingredients in the wheat bread production with nutritional quality" in Proceedings of 6th International Congress FLOUR-BREAD 2011 - 8th Croatian Congress of Cereal Technol (2011):245-251,
https://hdl.handle.net/21.15107/rcub_agrospace_2436 .

TY  - JOUR
AU  - Banjac, Nebojša
AU  - Trišović, Nemanja
AU  - Valentić, Nataša
AU  - Ušćumlić, Gordana
AU  - Petrović, Slobodan
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2489
AB  - Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson's agents. This paper describes different ways of synthesis of succinimide derivatives, their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.
AB  - Sukcinimidi su ciklični imidi ćilibarne (sukcinske) kiseline, koji se primenjuju u medicini kao antikonvulzivi. Mogu se, takođe, koristiti u tretiranju drugih cerebralnih oboljenja, kao na primer tremora, Parkinsonove bolesti, itd. U ovom radu su prikazani postupci dobijanja sukcinimida, koji se upotrebljavaju u medicini, kao i njihova struktura i fizičke i hemijske osobine. Razmatran je uticaj strukture na antikonvulzivnu aktivnost različitih derivata sukcinimida sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Succinimides: Synthesis, properties and anticonvulsant activity
T1  - Sukcinimidi - dobijanje, svojstva i antikonvulzivna aktivnost
EP  - 453
IS  - 4
SP  - 439
VL  - 65
DO  - 10.2298/HEMIND110224030B
ER  - 

@article{
author = "Banjac, Nebojša and Trišović, Nemanja and Valentić, Nataša and Ušćumlić, Gordana and Petrović, Slobodan",
year = "2011",
abstract = "Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson's agents. This paper describes different ways of synthesis of succinimide derivatives, their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here., Sukcinimidi su ciklični imidi ćilibarne (sukcinske) kiseline, koji se primenjuju u medicini kao antikonvulzivi. Mogu se, takođe, koristiti u tretiranju drugih cerebralnih oboljenja, kao na primer tremora, Parkinsonove bolesti, itd. U ovom radu su prikazani postupci dobijanja sukcinimida, koji se upotrebljavaju u medicini, kao i njihova struktura i fizičke i hemijske osobine. Razmatran je uticaj strukture na antikonvulzivnu aktivnost različitih derivata sukcinimida sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Succinimides: Synthesis, properties and anticonvulsant activity, Sukcinimidi - dobijanje, svojstva i antikonvulzivna aktivnost",
pages = "453-439",
number = "4",
volume = "65",
doi = "10.2298/HEMIND110224030B"
}

Banjac, N., Trišović, N., Valentić, N., Ušćumlić, G.,& Petrović, S.. (2011). Succinimides: Synthesis, properties and anticonvulsant activity. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 65(4), 439-453.
https://doi.org/10.2298/HEMIND110224030B

Banjac N, Trišović N, Valentić N, Ušćumlić G, Petrović S. Succinimides: Synthesis, properties and anticonvulsant activity. in Hemijska industrija. 2011;65(4):439-453.
doi:10.2298/HEMIND110224030B .

Banjac, Nebojša, Trišović, Nemanja, Valentić, Nataša, Ušćumlić, Gordana, Petrović, Slobodan, "Succinimides: Synthesis, properties and anticonvulsant activity" in Hemijska industrija, 65, no. 4 (2011):439-453,
https://doi.org/10.2298/HEMIND110224030B . .

TY  - JOUR
AU  - Milovanović, Mirjana
AU  - Banjac, Nebojša
AU  - Vučelić-Radović, Biljana
PY  - 2009
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1895
AB  - Two plant species of the genus Anthriscus (A. sylvestris and A. cerefolium) and Laserpitium latifolium L. are described as a good source of new aroma constituents and phytosterols. These plants are the herbs widely distributed in Serbia and possess significant medicinal value. They are widely applied in traditional medicine, but they are not used as functional food or in food technology. Two well-known domestic aromatic plant species: Mentha piperita L. and Thymus vulgaris L. and the lesser known Alliaria officinalis Andrz. are described as a good sources of highly prized essential oils in several wild-growing herbs. They are traditionally used in cooking. Quinoa seeds considered as multipurpose agro-industrial crop and the seeds may be utilized for human food and in flour products and in animal feed stocks because of its high nutritive value. Furthermore, watermelon meal possesses good nutritional quality, which may be commercially used as a new feed in the human or in the cattle nutrition. Seed oils, from Rubus ideaus, Ribes nigrum and walnut are also presented. The chemical composition on the sterols and essential fatty acids content, of these seed oils are shown that some of them can be successfully used in human nutrition, under specific conditions. Finally, developing new cholesterol-reducing products, such as phytosterols and their esters, which are marked as cholesterol-reducing food ingredient as well as the information on its incorporation into foods, are also included.
AB  - Opisane su dve biljne vrste roda Anthriscus (A. sylvestris and A. cerefolium) i biljka Laserpitium latifolium L. kao novi izvori specifičnih aroma i fitosterola. Ove lekovite biljke poseduju medicinske vrednosti i veoma su rasprostranjene u flori Srbije. Koriste se u tradicionalnoj medicini, ali ne i kao aditivi u hrani. Dalje, dve dobro poznate biljke Mentha piperita L. (nana) i Thymus vulgaris L. (majčina dušica), kao i manje poznata Alliaria officinalis Andrz. su prikazane kao izvori visoko cenjenih esencijalnih ulja, u nekoliko domaćih divljih sorti. Ove biljke se koriste u kulinarstvu. Seme kvinoje, predstavlja mnogostruko vrednu agrokulturu, poseduje visoke nutritivne vrednosti, a koristi se kao brašno u humanoj ishrani i kao stočna hrana. Potom, seme lubenice, kao sačma, poseduje dobre nutritvne kvalitete, pa se preporučuje kao nova hrana u humanoj i stočnoj ishrani. Prikazan je sastav retkih biljnih ulja semena maline, crne borovnice i oraha, odredjen je sadržaj sterola i esencijalnih masnih kiselina, kao i uslovi za njihovu primenu u kulinarstvu. Prikazani su zdravstveni efekti prisustva fitosterola u hrani, jer smanjuju nivo slabo rastvornog holesterola, pa se smanjenje rizik od kardiovaskularnih obolenja. Na kraju, dat je i nutritivni značaj i potrebe za dnevnim unosima namirnica bogatih u sadržaju biljnih sterola.
PB  - Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd
T2  - Journal of Agricultural Sciences (Belgrade)
T1  - Functional food: Rare herbs, seeds and vegetable oils as sources of flavors and phytosterols
T1  - Aditivi u hrani - seme, biljna ulja i retke lekovite biljke kao izvori fitosterola i aroma
EP  - 94
IS  - 1
SP  - 81
VL  - 54
DO  - 10.2298/JAS0901081M
ER  - 

@article{
author = "Milovanović, Mirjana and Banjac, Nebojša and Vučelić-Radović, Biljana",
year = "2009",
abstract = "Two plant species of the genus Anthriscus (A. sylvestris and A. cerefolium) and Laserpitium latifolium L. are described as a good source of new aroma constituents and phytosterols. These plants are the herbs widely distributed in Serbia and possess significant medicinal value. They are widely applied in traditional medicine, but they are not used as functional food or in food technology. Two well-known domestic aromatic plant species: Mentha piperita L. and Thymus vulgaris L. and the lesser known Alliaria officinalis Andrz. are described as a good sources of highly prized essential oils in several wild-growing herbs. They are traditionally used in cooking. Quinoa seeds considered as multipurpose agro-industrial crop and the seeds may be utilized for human food and in flour products and in animal feed stocks because of its high nutritive value. Furthermore, watermelon meal possesses good nutritional quality, which may be commercially used as a new feed in the human or in the cattle nutrition. Seed oils, from Rubus ideaus, Ribes nigrum and walnut are also presented. The chemical composition on the sterols and essential fatty acids content, of these seed oils are shown that some of them can be successfully used in human nutrition, under specific conditions. Finally, developing new cholesterol-reducing products, such as phytosterols and their esters, which are marked as cholesterol-reducing food ingredient as well as the information on its incorporation into foods, are also included., Opisane su dve biljne vrste roda Anthriscus (A. sylvestris and A. cerefolium) i biljka Laserpitium latifolium L. kao novi izvori specifičnih aroma i fitosterola. Ove lekovite biljke poseduju medicinske vrednosti i veoma su rasprostranjene u flori Srbije. Koriste se u tradicionalnoj medicini, ali ne i kao aditivi u hrani. Dalje, dve dobro poznate biljke Mentha piperita L. (nana) i Thymus vulgaris L. (majčina dušica), kao i manje poznata Alliaria officinalis Andrz. su prikazane kao izvori visoko cenjenih esencijalnih ulja, u nekoliko domaćih divljih sorti. Ove biljke se koriste u kulinarstvu. Seme kvinoje, predstavlja mnogostruko vrednu agrokulturu, poseduje visoke nutritivne vrednosti, a koristi se kao brašno u humanoj ishrani i kao stočna hrana. Potom, seme lubenice, kao sačma, poseduje dobre nutritvne kvalitete, pa se preporučuje kao nova hrana u humanoj i stočnoj ishrani. Prikazan je sastav retkih biljnih ulja semena maline, crne borovnice i oraha, odredjen je sadržaj sterola i esencijalnih masnih kiselina, kao i uslovi za njihovu primenu u kulinarstvu. Prikazani su zdravstveni efekti prisustva fitosterola u hrani, jer smanjuju nivo slabo rastvornog holesterola, pa se smanjenje rizik od kardiovaskularnih obolenja. Na kraju, dat je i nutritivni značaj i potrebe za dnevnim unosima namirnica bogatih u sadržaju biljnih sterola.",
publisher = "Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd",
journal = "Journal of Agricultural Sciences (Belgrade)",
title = "Functional food: Rare herbs, seeds and vegetable oils as sources of flavors and phytosterols, Aditivi u hrani - seme, biljna ulja i retke lekovite biljke kao izvori fitosterola i aroma",
pages = "94-81",
number = "1",
volume = "54",
doi = "10.2298/JAS0901081M"
}

Milovanović, M., Banjac, N.,& Vučelić-Radović, B.. (2009). Functional food: Rare herbs, seeds and vegetable oils as sources of flavors and phytosterols. in Journal of Agricultural Sciences (Belgrade)
Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd., 54(1), 81-94.
https://doi.org/10.2298/JAS0901081M

Milovanović M, Banjac N, Vučelić-Radović B. Functional food: Rare herbs, seeds and vegetable oils as sources of flavors and phytosterols. in Journal of Agricultural Sciences (Belgrade). 2009;54(1):81-94.
doi:10.2298/JAS0901081M .

Milovanović, Mirjana, Banjac, Nebojša, Vučelić-Radović, Biljana, "Functional food: Rare herbs, seeds and vegetable oils as sources of flavors and phytosterols" in Journal of Agricultural Sciences (Belgrade), 54, no. 1 (2009):81-94,
https://doi.org/10.2298/JAS0901081M . .