Prikaz osnovnih podataka o dokumentu

dc.creatorPopović-Djordjević, Jelena
dc.creatorQuispe, Cristina
dc.creatorGiordo, Roberta
dc.creatorKostić, Aleksandar
dc.creatorKatanić Stanković, Jelena S.
dc.creatorTsouh Fokoue, Patrick Valere
dc.creatorCarbone, Katya
dc.creatorMartorell, Miquel
dc.creatorKumar, Manoj
dc.creatorPintus, Gianfranco
dc.creatorSharifi-Rad, Javad
dc.creatorDocea, Anca Oana
dc.creatorCalina, Daniela
dc.date.accessioned2022-03-18T08:10:18Z
dc.date.available2022-03-18T08:10:18Z
dc.date.issued2022
dc.identifier.issn0223-5234
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/6044
dc.description.abstractThe human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.sr
dc.language.isoensr
dc.publisherElsevier Masson s.r.l.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200378/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceEuropean Journal of Medicinal Chemistrysr
dc.subjectAnti-HIV agentssr
dc.subjectAntiretroviral therapysr
dc.subjectBotanical moleculessr
dc.subjectHIVsr
dc.subjectNatural productssr
dc.titleNatural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugssr
dc.typearticlesr
dc.rights.licenseARRsr
dc.citation.rankaM21
dc.citation.spage114217
dc.citation.volume233
dc.identifier.doi10.1016/j.ejmech.2022.114217
dc.identifier.scopus2-s2.0-85125775750
dc.type.versionpublishedVersionsr


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