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Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

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2022
Authors
Popović-Djordjević, Jelena
Quispe, Cristina
Giordo, Roberta
Kostić, Aleksandar
Katanić Stanković, Jelena S.
Tsouh Fokoue, Patrick Valere
Carbone, Katya
Martorell, Miquel
Kumar, Manoj
Pintus, Gianfranco
Sharifi-Rad, Javad
Docea, Anca Oana
Calina, Daniela
article (publishedVersion)
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Abstract
The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy (HAART) is the standard HIV-treatment regimen that usually comprises a combination of three or more antiretroviral drugs. HIV reverse transcriptase inhibitors are the main HAART target, which involves the use of both nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, compounds affecting other aspects of HIV replication, such as virus entry and fusion or important viral enzymes, such as integrases and proteases, have also been developed. Natural compounds from different sources, like plants, microbial and marine organisms, showed promising anti-HIV activities to the point of establishing the basis for developing new drugs. Indeed, natural compounds-based therapies have the potential to become more efficient than conventional HAART, with less or... no side effects. This review aims to gather and discuss the current information about the anti-HIV activity of natural and synthetic compounds, their history and mechanism of action as well as the role of plants and their bioactive compounds as a source of new anti-HIV drugs.

Keywords:
Anti-HIV agents / Antiretroviral therapy / Botanical molecules / HIV / Natural products
Source:
European Journal of Medicinal Chemistry, 2022, 233, 114217-
Publisher:
  • Elsevier Masson s.r.l.
Funding / projects:
  • info:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS// (RS-200116)
  • info:eu-repo/grantAgreement/MESTD/inst-2020/200378/RS// (RS-200378)

DOI: 10.1016/j.ejmech.2022.114217

ISSN: 0223-5234

Scopus: 2-s2.0-85125775750
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URI
http://aspace.agrif.bg.ac.rs/handle/123456789/6044
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  • Radovi istraživača / Researchers’ publications
Institution/Community
Poljoprivredni fakultet

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