Prikaz osnovnih podataka o dokumentu
Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters
dc.creator | Zmejkovski, Bojana B. | |
dc.creator | Pantelić, Nebojša Đ. | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2022-03-09T11:31:17Z | |
dc.date.available | 2022-03-09T11:31:17Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0020-1693 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/6006 | |
dc.description.abstract | Even though platinum(II/IV) complexes are found to be very active as anticancer agents, they have many well-known limitations. These drawbacks reflect through severe side-effects due to damaging healthy tissue and resistance. Exploring non-platinum metal complexes emerged as essential since they might exhibit different mechanism of action as well as reduced side effects, than platinum(II)-based ones. In this review, the progress in the field of anticancer chemistry of palladium(II)-based complexes will be given highlighting the close relationship between their structural preferences and cytotoxic ability. Activity and structure of a significant number of palladium complexes described in literature will be conjoint, and probable in vivo mechanism of palladium(II) species discussed. It is shown that bidentate chelating amines (e.g. (S,S)-R2edda-type ligands; R2edda = O,O’-dialkyl-ethylenediamine-N,N’-diacete esters) as ligands could play a crucial role in the stability of complexes and their ability to express biological activity. Complexes with general formulae [PdCl2{(S,S)-R2edda-type}], demonstrate good to moderate antiproliferative activity versus various cancer cell lines with emphasizing of O,O’-dipropyl-(S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoate, [PdCl2(S,S)-(n-Pr)2eddl] (most powerful against chronic lymphocytic leukemia cells, CLL). Structural features and diastereoisomers arising from nitrogen coordination in square-planar palladium(II) complexes with bidentate κ2N,N’ or tridentate κ2N,N’κO, ligands will be summarized and discussed. In vitro cytotoxicity of these complexes on a number of tumor cell lines will give an insight in structure–activity relationships which may lead to the divergence from platinum based drugs. Additionally, an overview of antimicrobial activity is presented. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier B.V. | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Inorganica Chimica Acta | sr |
dc.subject | Anticancer drugs | sr |
dc.subject | Biological activity | sr |
dc.subject | Metal complexes | sr |
dc.subject | Palladium(II) complexes | sr |
dc.subject | R2edda-type ligands | sr |
dc.title | Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.rank | M22 | |
dc.citation.spage | 120797 | |
dc.citation.volume | 534 | |
dc.identifier.doi | 10.1016/j.ica.2022.120797 | |
dc.identifier.scopus | 2-s2.0-85123292163 | |
dc.identifier.wos | 00078028160000 | |
dc.type.version | publishedVersion | sr |