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dc.creatorZmejkovski, Bojana B.
dc.creatorPantelić, Nebojša Đ.
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2022-03-09T11:31:17Z
dc.date.available2022-03-09T11:31:17Z
dc.date.issued2022
dc.identifier.issn0020-1693
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/6006
dc.description.abstractEven though platinum(II/IV) complexes are found to be very active as anticancer agents, they have many well-known limitations. These drawbacks reflect through severe side-effects due to damaging healthy tissue and resistance. Exploring non-platinum metal complexes emerged as essential since they might exhibit different mechanism of action as well as reduced side effects, than platinum(II)-based ones. In this review, the progress in the field of anticancer chemistry of palladium(II)-based complexes will be given highlighting the close relationship between their structural preferences and cytotoxic ability. Activity and structure of a significant number of palladium complexes described in literature will be conjoint, and probable in vivo mechanism of palladium(II) species discussed. It is shown that bidentate chelating amines (e.g. (S,S)-R2edda-type ligands; R2edda = O,O’-dialkyl-ethylenediamine-N,N’-diacete esters) as ligands could play a crucial role in the stability of complexes and their ability to express biological activity. Complexes with general formulae [PdCl2{(S,S)-R2edda-type}], demonstrate good to moderate antiproliferative activity versus various cancer cell lines with emphasizing of O,O’-dipropyl-(S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoate, [PdCl2(S,S)-(n-Pr)2eddl] (most powerful against chronic lymphocytic leukemia cells, CLL). Structural features and diastereoisomers arising from nitrogen coordination in square-planar palladium(II) complexes with bidentate κ2N,N’ or tridentate κ2N,N’κO, ligands will be summarized and discussed. In vitro cytotoxicity of these complexes on a number of tumor cell lines will give an insight in structure–activity relationships which may lead to the divergence from platinum based drugs. Additionally, an overview of antimicrobial activity is presented.sr
dc.language.isoensr
dc.publisherElsevier B.V.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceInorganica Chimica Actasr
dc.subjectAnticancer drugssr
dc.subjectBiological activitysr
dc.subjectMetal complexessr
dc.subjectPalladium(II) complexessr
dc.subjectR2edda-type ligandssr
dc.titlePalladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenterssr
dc.typearticlesr
dc.rights.licenseARRsr
dc.citation.rankM22~
dc.citation.spage120797
dc.citation.volume534
dc.identifier.doi10.1016/j.ica.2022.120797
dc.identifier.scopus2-s2.0-85123292163
dc.identifier.wos00078028160000
dc.type.versionpublishedVersionsr


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