Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters
Само за регистроване кориснике
2022
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Even though platinum(II/IV) complexes are found to be very active as anticancer agents, they have many well-known limitations. These drawbacks reflect through severe side-effects due to damaging healthy tissue and resistance. Exploring non-platinum metal complexes emerged as essential since they might exhibit different mechanism of action as well as reduced side effects, than platinum(II)-based ones. In this review, the progress in the field of anticancer chemistry of palladium(II)-based complexes will be given highlighting the close relationship between their structural preferences and cytotoxic ability. Activity and structure of a significant number of palladium complexes described in literature will be conjoint, and probable in vivo mechanism of palladium(II) species discussed. It is shown that bidentate chelating amines (e.g. (S,S)-R2edda-type ligands; R2edda = O,O’-dialkyl-ethylenediamine-N,N’-diacete esters) as ligands could play a crucial role in the stability of complexes and t...heir ability to express biological activity. Complexes with general formulae [PdCl2{(S,S)-R2edda-type}], demonstrate good to moderate antiproliferative activity versus various cancer cell lines with emphasizing of O,O’-dipropyl-(S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoate, [PdCl2(S,S)-(n-Pr)2eddl] (most powerful against chronic lymphocytic leukemia cells, CLL). Structural features and diastereoisomers arising from nitrogen coordination in square-planar palladium(II) complexes with bidentate κ2N,N’ or tridentate κ2N,N’κO, ligands will be summarized and discussed. In vitro cytotoxicity of these complexes on a number of tumor cell lines will give an insight in structure–activity relationships which may lead to the divergence from platinum based drugs. Additionally, an overview of antimicrobial activity is presented.
Кључне речи:
Anticancer drugs / Biological activity / Metal complexes / Palladium(II) complexes / R2edda-type ligandsИзвор:
Inorganica Chimica Acta, 2022, 534, 120797-Издавач:
- Elsevier B.V.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200116 (Универзитет у Београду, Пољопривредни факултет) (RS-200116)
DOI: 10.1016/j.ica.2022.120797
ISSN: 0020-1693
WoS: 00078028160000
Scopus: 2-s2.0-85123292163
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Zmejkovski, Bojana B. AU - Pantelić, Nebojša Đ. AU - Kaluđerović, Goran N. PY - 2022 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/6006 AB - Even though platinum(II/IV) complexes are found to be very active as anticancer agents, they have many well-known limitations. These drawbacks reflect through severe side-effects due to damaging healthy tissue and resistance. Exploring non-platinum metal complexes emerged as essential since they might exhibit different mechanism of action as well as reduced side effects, than platinum(II)-based ones. In this review, the progress in the field of anticancer chemistry of palladium(II)-based complexes will be given highlighting the close relationship between their structural preferences and cytotoxic ability. Activity and structure of a significant number of palladium complexes described in literature will be conjoint, and probable in vivo mechanism of palladium(II) species discussed. It is shown that bidentate chelating amines (e.g. (S,S)-R2edda-type ligands; R2edda = O,O’-dialkyl-ethylenediamine-N,N’-diacete esters) as ligands could play a crucial role in the stability of complexes and their ability to express biological activity. Complexes with general formulae [PdCl2{(S,S)-R2edda-type}], demonstrate good to moderate antiproliferative activity versus various cancer cell lines with emphasizing of O,O’-dipropyl-(S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoate, [PdCl2(S,S)-(n-Pr)2eddl] (most powerful against chronic lymphocytic leukemia cells, CLL). Structural features and diastereoisomers arising from nitrogen coordination in square-planar palladium(II) complexes with bidentate κ2N,N’ or tridentate κ2N,N’κO, ligands will be summarized and discussed. In vitro cytotoxicity of these complexes on a number of tumor cell lines will give an insight in structure–activity relationships which may lead to the divergence from platinum based drugs. Additionally, an overview of antimicrobial activity is presented. PB - Elsevier B.V. T2 - Inorganica Chimica Acta T1 - Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters SP - 120797 VL - 534 DO - 10.1016/j.ica.2022.120797 ER -
@article{ author = "Zmejkovski, Bojana B. and Pantelić, Nebojša Đ. and Kaluđerović, Goran N.", year = "2022", abstract = "Even though platinum(II/IV) complexes are found to be very active as anticancer agents, they have many well-known limitations. These drawbacks reflect through severe side-effects due to damaging healthy tissue and resistance. Exploring non-platinum metal complexes emerged as essential since they might exhibit different mechanism of action as well as reduced side effects, than platinum(II)-based ones. In this review, the progress in the field of anticancer chemistry of palladium(II)-based complexes will be given highlighting the close relationship between their structural preferences and cytotoxic ability. Activity and structure of a significant number of palladium complexes described in literature will be conjoint, and probable in vivo mechanism of palladium(II) species discussed. It is shown that bidentate chelating amines (e.g. (S,S)-R2edda-type ligands; R2edda = O,O’-dialkyl-ethylenediamine-N,N’-diacete esters) as ligands could play a crucial role in the stability of complexes and their ability to express biological activity. Complexes with general formulae [PdCl2{(S,S)-R2edda-type}], demonstrate good to moderate antiproliferative activity versus various cancer cell lines with emphasizing of O,O’-dipropyl-(S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoate, [PdCl2(S,S)-(n-Pr)2eddl] (most powerful against chronic lymphocytic leukemia cells, CLL). Structural features and diastereoisomers arising from nitrogen coordination in square-planar palladium(II) complexes with bidentate κ2N,N’ or tridentate κ2N,N’κO, ligands will be summarized and discussed. In vitro cytotoxicity of these complexes on a number of tumor cell lines will give an insight in structure–activity relationships which may lead to the divergence from platinum based drugs. Additionally, an overview of antimicrobial activity is presented.", publisher = "Elsevier B.V.", journal = "Inorganica Chimica Acta", title = "Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters", pages = "120797", volume = "534", doi = "10.1016/j.ica.2022.120797" }
Zmejkovski, B. B., Pantelić, N. Đ.,& Kaluđerović, G. N.. (2022). Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters. in Inorganica Chimica Acta Elsevier B.V.., 534, 120797. https://doi.org/10.1016/j.ica.2022.120797
Zmejkovski BB, Pantelić NĐ, Kaluđerović GN. Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters. in Inorganica Chimica Acta. 2022;534:120797. doi:10.1016/j.ica.2022.120797 .
Zmejkovski, Bojana B., Pantelić, Nebojša Đ., Kaluđerović, Goran N., "Palladium(II) complexes: Structure, development and cytotoxicity from cisplatin analogues to chelating ligands with N stereocenters" in Inorganica Chimica Acta, 534 (2022):120797, https://doi.org/10.1016/j.ica.2022.120797 . .