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Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres
dc.creator | Araškov, Jovana B. | |
dc.creator | Nikolić, Milan | |
dc.creator | Armaković, Stevan | |
dc.creator | Armaković, Sanja | |
dc.creator | Rodić, Marko | |
dc.creator | Vušnjevac, Aleksandar | |
dc.creator | Padrón, José M. | |
dc.creator | Todorović, Tamara R. | |
dc.creator | Filipović, Nenad R. | |
dc.date.accessioned | 2021-05-25T10:59:14Z | |
dc.date.available | 2021-05-25T10:59:14Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0022-2860 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/5849 | |
dc.description.abstract | To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier B.V. | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200288/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Molecular Structure | sr |
dc.subject | Antioxidant activity | sr |
dc.subject | Antiproliferative activity | sr |
dc.subject | DFT | sr |
dc.subject | Drug likeness parameters | sr |
dc.subject | Hydrazonyl‒thiazoles | sr |
dc.subject | Single crystal X-ray analysis | sr |
dc.title | Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.rank | M22 | |
dc.citation.spage | 130512 | |
dc.citation.volume | 1240 | |
dc.identifier.doi | 10.1016/j.molstruc.2021.130512 | |
dc.identifier.scopus | 2-s2.0-85105531083 | |
dc.identifier.wos | 000664244900012 | |
dc.type.version | publishedVersion | sr |