Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres
Samo za registrovane korisnike
2021
Autori
Araškov, Jovana B.Nikolić, Milan
Armaković, Stevan
Armaković, Sanja

Rodić, Marko
Vušnjevac, Aleksandar
Padrón, José M.
Todorović, Tamara R.

Filipović, Nenad R.

Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays.
Ključne reči:
Antioxidant activity / Antiproliferative activity / DFT / Drug likeness parameters / Hydrazonyl‒thiazoles / Single crystal X-ray analysisIzvor:
Journal of Molecular Structure, 2021, 1240, 130512-Izdavač:
- Elsevier B.V.
Finansiranje / projekti:
- Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 200168 (Univerzitet u Beogradu, Hemijski fakultet) (RS-200168)
- Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 200288 (Inovacioni centar Hemijskog fakulteta u Beogradu doo) (RS-200288)
DOI: 10.1016/j.molstruc.2021.130512
ISSN: 0022-2860
WoS: 000664244900012
Scopus: 2-s2.0-85105531083
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Araškov, Jovana B. AU - Nikolić, Milan AU - Armaković, Stevan AU - Armaković, Sanja AU - Rodić, Marko AU - Vušnjevac, Aleksandar AU - Padrón, José M. AU - Todorović, Tamara R. AU - Filipović, Nenad R. PY - 2021 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5849 AB - To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays. PB - Elsevier B.V. T2 - Journal of Molecular Structure T1 - Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres SP - 130512 VL - 1240 DO - 10.1016/j.molstruc.2021.130512 ER -
@article{ author = "Araškov, Jovana B. and Nikolić, Milan and Armaković, Stevan and Armaković, Sanja and Rodić, Marko and Vušnjevac, Aleksandar and Padrón, José M. and Todorović, Tamara R. and Filipović, Nenad R.", year = "2021", abstract = "To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays.", publisher = "Elsevier B.V.", journal = "Journal of Molecular Structure", title = "Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres", pages = "130512", volume = "1240", doi = "10.1016/j.molstruc.2021.130512" }
Araškov, J. B., Nikolić, M., Armaković, S., Armaković, S., Rodić, M., Vušnjevac, A., Padrón, J. M., Todorović, T. R.,& Filipović, N. R.. (2021). Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres. in Journal of Molecular Structure Elsevier B.V.., 1240, 130512. https://doi.org/10.1016/j.molstruc.2021.130512
Araškov JB, Nikolić M, Armaković S, Armaković S, Rodić M, Vušnjevac A, Padrón JM, Todorović TR, Filipović NR. Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres. in Journal of Molecular Structure. 2021;1240:130512. doi:10.1016/j.molstruc.2021.130512 .
Araškov, Jovana B., Nikolić, Milan, Armaković, Stevan, Armaković, Sanja, Rodić, Marko, Vušnjevac, Aleksandar, Padrón, José M., Todorović, Tamara R., Filipović, Nenad R., "Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres" in Journal of Molecular Structure, 1240 (2021):130512, https://doi.org/10.1016/j.molstruc.2021.130512 . .