Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres
Само за регистроване кориснике
2021
Аутори
Araškov, Jovana B.Nikolić, Milan
Armaković, Stevan
Armaković, Sanja
![](/themes/MirageAGROSPACE/images/orcid.png)
Rodić, Marko
Vušnjevac, Aleksandar
Padrón, José M.
Todorović, Tamara R.
![](/themes/MirageAGROSPACE/images/orcid.png)
Filipović, Nenad R.
![](/themes/MirageAGROSPACE/images/orcid.png)
Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays.
Кључне речи:
Antioxidant activity / Antiproliferative activity / DFT / Drug likeness parameters / Hydrazonyl‒thiazoles / Single crystal X-ray analysisИзвор:
Journal of Molecular Structure, 2021, 1240, 130512-Издавач:
- Elsevier B.V.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
DOI: 10.1016/j.molstruc.2021.130512
ISSN: 0022-2860
WoS: 000664244900012
Scopus: 2-s2.0-85105531083
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Araškov, Jovana B. AU - Nikolić, Milan AU - Armaković, Stevan AU - Armaković, Sanja AU - Rodić, Marko AU - Vušnjevac, Aleksandar AU - Padrón, José M. AU - Todorović, Tamara R. AU - Filipović, Nenad R. PY - 2021 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5849 AB - To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays. PB - Elsevier B.V. T2 - Journal of Molecular Structure T1 - Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres SP - 130512 VL - 1240 DO - 10.1016/j.molstruc.2021.130512 ER -
@article{ author = "Araškov, Jovana B. and Nikolić, Milan and Armaković, Stevan and Armaković, Sanja and Rodić, Marko and Vušnjevac, Aleksandar and Padrón, José M. and Todorović, Tamara R. and Filipović, Nenad R.", year = "2021", abstract = "To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays.", publisher = "Elsevier B.V.", journal = "Journal of Molecular Structure", title = "Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres", pages = "130512", volume = "1240", doi = "10.1016/j.molstruc.2021.130512" }
Araškov, J. B., Nikolić, M., Armaković, S., Armaković, S., Rodić, M., Vušnjevac, A., Padrón, J. M., Todorović, T. R.,& Filipović, N. R.. (2021). Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres. in Journal of Molecular Structure Elsevier B.V.., 1240, 130512. https://doi.org/10.1016/j.molstruc.2021.130512
Araškov JB, Nikolić M, Armaković S, Armaković S, Rodić M, Vušnjevac A, Padrón JM, Todorović TR, Filipović NR. Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres. in Journal of Molecular Structure. 2021;1240:130512. doi:10.1016/j.molstruc.2021.130512 .
Araškov, Jovana B., Nikolić, Milan, Armaković, Stevan, Armaković, Sanja, Rodić, Marko, Vušnjevac, Aleksandar, Padrón, José M., Todorović, Tamara R., Filipović, Nenad R., "Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres" in Journal of Molecular Structure, 1240 (2021):130512, https://doi.org/10.1016/j.molstruc.2021.130512 . .