Structural, antioxidant, antiproliferative and in‒silico study of pyridine-based hydrazonyl‒selenazoles and their sulphur isosteres
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2021
Authors
Araškov, Jovana B.Nikolić, Milan
Armaković, Stevan
Armaković, Sanja

Rodić, Marko
Vušnjevac, Aleksandar
Padrón, José M.
Todorović, Tamara R.

Filipović, Nenad R.

Article (Published version)

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Show full item recordAbstract
To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1,3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. In-silico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays.
Keywords:
Antioxidant activity / Antiproliferative activity / DFT / Drug likeness parameters / Hydrazonyl‒thiazoles / Single crystal X-ray analysisSource:
Journal of Molecular Structure, 2021, 1240, 130512-Publisher:
- Elsevier B.V.
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200288 (Innovation Center of the Faculty of Chemistry) (RS-200288)
DOI: 10.1016/j.molstruc.2021.130512
ISSN: 0022-2860