Risk assessment of dietary exposure to aflatoxin B1 in Serbia
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2021
Authors
Udovički, Božidar
Tomić, Nikola

Spirović Trifunović, Bojana
Despotović, Saša

Jovanović, Jelena
Jacxsens, Liesbeth
Rajković, Andreja

Article (Published version)

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Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative. A total of 463 samples of products susceptible to contamination with AFB1 and commonly consumed in Serbia were collected and analyzed. Consumption surveys were performed using a food frequency questionnaire (FFQ) and 24-h recall-based method. Monte Carlo simulation of 100,000 iterations was performed to estimate the intake of AFB1 through each food category, while a simple distribution approach was performed to estimate overall exposure of tested population groups. Risk characterization was performed by calculation of the Margin of Exposure (MOE) and by calculation of the number of possible hepatocellular carcinoma (HCC) cases. The highest exposure was observed in children with the mean overall estimated daily intake (EDI) in the ra...nge of 0.79–1.10 and 1.20–1.66 ng kg−1 bw day−1, followed by adolescents 0.56–0.81 and 0.94–1.32 ng kg−1 bw day−1, adult females 0.52–0.72 and 0.56–0.76 ng kg−1 bw day−1 and adult males with the mean overall EDI in the range of 0.39–0.56 and 0.47–0.66 ng kg−1 bw day−1 depending on consumption survey method and for the lower (LB) and upper bound (UB) scenario. MOE values that resulted from the mean values of the overall EDI of AFB1 were low, indicating high concern for all population groups. Based on obtained mean values of the overall EDI higher estimates of possible HCC cases caused by exposure to AFB1 were in the range of 0.01–0.02 cases/year/105 individuals, depending on the population group.
Keywords:
ELISA / HCC risk / LC/MS-MS / MOE / Monte Carlo simulationSource:
Food and Chemical Toxicology, 2021, 151, 112116-Publisher:
- Elsevier Ltd
Funding / projects:
- Integrated and innovative key actions for mycotoxin management in the food and feed chain (EU-678781)
Note:
- Supplemenatry material: http://aspace.agrif.bg.ac.rs/handle/123456789/5998
Related info:
- Referenced by
http://aspace.agrif.bg.ac.rs/handle/123456789/5998
DOI: 10.1016/j.fct.2021.112116
ISSN: 0278-6915
WoS: 000642485100018
Scopus: 2-s2.0-85102632891
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Poljoprivredni fakultetTY - JOUR AU - Udovički, Božidar AU - Tomić, Nikola AU - Spirović Trifunović, Bojana AU - Despotović, Saša AU - Jovanović, Jelena AU - Jacxsens, Liesbeth AU - Rajković, Andreja PY - 2021 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5826 AB - Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative. A total of 463 samples of products susceptible to contamination with AFB1 and commonly consumed in Serbia were collected and analyzed. Consumption surveys were performed using a food frequency questionnaire (FFQ) and 24-h recall-based method. Monte Carlo simulation of 100,000 iterations was performed to estimate the intake of AFB1 through each food category, while a simple distribution approach was performed to estimate overall exposure of tested population groups. Risk characterization was performed by calculation of the Margin of Exposure (MOE) and by calculation of the number of possible hepatocellular carcinoma (HCC) cases. The highest exposure was observed in children with the mean overall estimated daily intake (EDI) in the range of 0.79–1.10 and 1.20–1.66 ng kg−1 bw day−1, followed by adolescents 0.56–0.81 and 0.94–1.32 ng kg−1 bw day−1, adult females 0.52–0.72 and 0.56–0.76 ng kg−1 bw day−1 and adult males with the mean overall EDI in the range of 0.39–0.56 and 0.47–0.66 ng kg−1 bw day−1 depending on consumption survey method and for the lower (LB) and upper bound (UB) scenario. MOE values that resulted from the mean values of the overall EDI of AFB1 were low, indicating high concern for all population groups. Based on obtained mean values of the overall EDI higher estimates of possible HCC cases caused by exposure to AFB1 were in the range of 0.01–0.02 cases/year/105 individuals, depending on the population group. PB - Elsevier Ltd T2 - Food and Chemical Toxicology T1 - Risk assessment of dietary exposure to aflatoxin B1 in Serbia SP - 112116 VL - 151 DO - 10.1016/j.fct.2021.112116 ER -
@article{ author = "Udovički, Božidar and Tomić, Nikola and Spirović Trifunović, Bojana and Despotović, Saša and Jovanović, Jelena and Jacxsens, Liesbeth and Rajković, Andreja", year = "2021", abstract = "Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative. A total of 463 samples of products susceptible to contamination with AFB1 and commonly consumed in Serbia were collected and analyzed. Consumption surveys were performed using a food frequency questionnaire (FFQ) and 24-h recall-based method. Monte Carlo simulation of 100,000 iterations was performed to estimate the intake of AFB1 through each food category, while a simple distribution approach was performed to estimate overall exposure of tested population groups. Risk characterization was performed by calculation of the Margin of Exposure (MOE) and by calculation of the number of possible hepatocellular carcinoma (HCC) cases. The highest exposure was observed in children with the mean overall estimated daily intake (EDI) in the range of 0.79–1.10 and 1.20–1.66 ng kg−1 bw day−1, followed by adolescents 0.56–0.81 and 0.94–1.32 ng kg−1 bw day−1, adult females 0.52–0.72 and 0.56–0.76 ng kg−1 bw day−1 and adult males with the mean overall EDI in the range of 0.39–0.56 and 0.47–0.66 ng kg−1 bw day−1 depending on consumption survey method and for the lower (LB) and upper bound (UB) scenario. MOE values that resulted from the mean values of the overall EDI of AFB1 were low, indicating high concern for all population groups. Based on obtained mean values of the overall EDI higher estimates of possible HCC cases caused by exposure to AFB1 were in the range of 0.01–0.02 cases/year/105 individuals, depending on the population group.", publisher = "Elsevier Ltd", journal = "Food and Chemical Toxicology", title = "Risk assessment of dietary exposure to aflatoxin B1 in Serbia", pages = "112116", volume = "151", doi = "10.1016/j.fct.2021.112116" }
Udovički, B., Tomić, N., Spirović Trifunović, B., Despotović, S., Jovanović, J., Jacxsens, L.,& Rajković, A.. (2021). Risk assessment of dietary exposure to aflatoxin B1 in Serbia. in Food and Chemical Toxicology Elsevier Ltd., 151, 112116. https://doi.org/10.1016/j.fct.2021.112116
Udovički B, Tomić N, Spirović Trifunović B, Despotović S, Jovanović J, Jacxsens L, Rajković A. Risk assessment of dietary exposure to aflatoxin B1 in Serbia. in Food and Chemical Toxicology. 2021;151:112116. doi:10.1016/j.fct.2021.112116 .
Udovički, Božidar, Tomić, Nikola, Spirović Trifunović, Bojana, Despotović, Saša, Jovanović, Jelena, Jacxsens, Liesbeth, Rajković, Andreja, "Risk assessment of dietary exposure to aflatoxin B1 in Serbia" in Food and Chemical Toxicology, 151 (2021):112116, https://doi.org/10.1016/j.fct.2021.112116 . .