Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment.
TY - JOUR
AU - Zmejkoski, Danica Z.
AU - Marković, Zoran M.
AU - Budimir, Milica D.
AU - Zdravković, Nemanja M.
AU - Trišić, Dijana D.
AU - Bugarova, Nikol
AU - Danko, Martin
AU - Kozyrovska, Natalia O.
AU - Špitalský, Zdeno
AU - Kleinova, Angela
AU - Kuzman, Sanja B.
AU - Pavlović, Vladimir
AU - Todorović Marković, Biljana M.
PY - 2021
UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5810
AB - Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment.
PB - Elsevier Ltd
T2 - Materials Science & Engineering C
T1 - Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment
SP - 111925
VL - 122
DO - 10.1016/j.msec.2021.111925
ER -
@article{
author = "Zmejkoski, Danica Z. and Marković, Zoran M. and Budimir, Milica D. and Zdravković, Nemanja M. and Trišić, Dijana D. and Bugarova, Nikol and Danko, Martin and Kozyrovska, Natalia O. and Špitalský, Zdeno and Kleinova, Angela and Kuzman, Sanja B. and Pavlović, Vladimir and Todorović Marković, Biljana M.",
year = "2021",
abstract = "Bacterial infection and their resistance to known antibiotics delays wound healing. In this study, nanochitosan dots (nChiD) produced by gamma irradiation have been encapsulated in bacterial cellulose (BC) polymer matrix to study the antibacterial potentials of these nanocomposites and their possible usage in wound healing treatment (scratch assay). Detailed analyses show that nChiDs have disc-like shape and average diameter in the range of 40 to 60 nm depending of the applied dose. All nChiDs as well as BC-nChiD nanocomposites emit green photoluminescence independently on the excitation wavelengths. The new designed nanocomposites do not have a cytotoxic effect; antioxidant analysis shows their moderate radical scavenging activity whereas antibacterial properties show significant growth inhibition of strains mostly found in difficult-to-heal wounds. The obtained results confirm that new designed BC-nChiD nanocomposites might be potential agent in wound healing treatment.",
publisher = "Elsevier Ltd",
journal = "Materials Science & Engineering C",
title = "Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment",
pages = "111925",
volume = "122",
doi = "10.1016/j.msec.2021.111925"
}
Zmejkoski, D. Z., Marković, Z. M., Budimir, M. D., Zdravković, N. M., Trišić, D. D., Bugarova, N., Danko, M., Kozyrovska, N. O., Špitalský, Z., Kleinova, A., Kuzman, S. B., Pavlović, V.,& Todorović Marković, B. M.. (2021). Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment. in Materials Science & Engineering C
Elsevier Ltd., 122, 111925.
https://doi.org/10.1016/j.msec.2021.111925
Zmejkoski DZ, Marković ZM, Budimir MD, Zdravković NM, Trišić DD, Bugarova N, Danko M, Kozyrovska NO, Špitalský Z, Kleinova A, Kuzman SB, Pavlović V, Todorović Marković BM. Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment. in Materials Science & Engineering C. 2021;122:111925.
doi:10.1016/j.msec.2021.111925 .
Zmejkoski, Danica Z., Marković, Zoran M., Budimir, Milica D., Zdravković, Nemanja M., Trišić, Dijana D., Bugarova, Nikol, Danko, Martin, Kozyrovska, Natalia O., Špitalský, Zdeno, Kleinova, Angela, Kuzman, Sanja B., Pavlović, Vladimir, Todorović Marković, Biljana M., "Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment" in Materials Science & Engineering C, 122 (2021):111925,
https://doi.org/10.1016/j.msec.2021.111925 . .
