Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts
Аутори
Sknepnek, Aleksandra
Tomić, Sergej
Miletić, Dunja

Lević, Steva

Čolić, Miodrag
Nedović, Viktor

Nikšić, Miomir

Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
Medicinal mushrooms, Coriolus versicolor and Lentinus edodes are extremely attractive as nutraceuticals. Here we used fruiting bodies to prepare novel kombucha beverage. Microbiological, physicochemical and chemical properties were monitored for eleven days, while the immunological properties of kombucha polysaccharide extracts were determined in peripheral blood mononuclear cell (PBMC) cultures. FTIR analysis of polysaccharide extracts showed dominant presence of polysaccharides, in addition to phenols, lipids and proteins. C. versicolor kombucha extract displayed more complex polysaccharides, and a higher content of total polysaccharides, phenols and flavonoids compared to L. edodes kombucha extract. The extracts were not cytotoxic for PBMC in vitro up to 500 µg/ml, while immunomodulatory effects depended on their chemical compositions. The most prominent effect was on the reduction of Th2 cytokines and IL-10 in PBMC cultures. Based on these results, novel kombucha products could be ...recommended as functional beverages or nutraceuticals with potentially beneficial immunomodulatory effects in allergies.
Кључне речи:
Cytokines / Immunomodulation / Kombucha / Medicinal mushroomsИзвор:
Food Chemistry, 2021, 342, 128344-Издавач:
- Elsevier
Финансирање / пројекти:
- info:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS/ (RS-200116)
- Примена функционализованих угљеничних наноцеви и наночестица злата за припрему дендритских ћелија у терапији тумора (RS-175102)
Напомена:
- This is the peer-reviewed version of the article: Sknepnek, A.; Tomić, S.; Miletić, D.; Lević, S.; Čolić, M.; Nedović, V.; Nikšić, M. Fermentation Characteristics of Novel Coriolus Versicolor and Lentinus Edodes Kombucha Beverages and Immunomodulatory Potential of Their Polysaccharide Extracts. Food Chemistry 2021, 342, 128344. https://doi.org/10.1016/j.foodchem.2020.128344.
- Supplementary material: http://aspace.agrif.bg.ac.rs/handle/123456789/5996
Повезане информације:
- Друга верзија
http://aspace.agrif.bg.ac.rs/handle/123456789/5771 - Друга верзија
https://doi.org/10.1016/j.foodchem.2020.128344 - Повезани садржај
http://aspace.agrif.bg.ac.rs/handle/123456789/5996
DOI: 10.1016/j.foodchem.2020.128344
ISSN: 0308-8146
WoS: 000617936400015
Scopus: 2-s2.0-85094559035
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Sknepnek, Aleksandra AU - Tomić, Sergej AU - Miletić, Dunja AU - Lević, Steva AU - Čolić, Miodrag AU - Nedović, Viktor AU - Nikšić, Miomir PY - 2021 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5772 AB - Medicinal mushrooms, Coriolus versicolor and Lentinus edodes are extremely attractive as nutraceuticals. Here we used fruiting bodies to prepare novel kombucha beverage. Microbiological, physicochemical and chemical properties were monitored for eleven days, while the immunological properties of kombucha polysaccharide extracts were determined in peripheral blood mononuclear cell (PBMC) cultures. FTIR analysis of polysaccharide extracts showed dominant presence of polysaccharides, in addition to phenols, lipids and proteins. C. versicolor kombucha extract displayed more complex polysaccharides, and a higher content of total polysaccharides, phenols and flavonoids compared to L. edodes kombucha extract. The extracts were not cytotoxic for PBMC in vitro up to 500 µg/ml, while immunomodulatory effects depended on their chemical compositions. The most prominent effect was on the reduction of Th2 cytokines and IL-10 in PBMC cultures. Based on these results, novel kombucha products could be recommended as functional beverages or nutraceuticals with potentially beneficial immunomodulatory effects in allergies. PB - Elsevier T2 - Food Chemistry T1 - Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts SP - 128344 VL - 342 DO - 10.1016/j.foodchem.2020.128344 ER -
@article{ author = "Sknepnek, Aleksandra and Tomić, Sergej and Miletić, Dunja and Lević, Steva and Čolić, Miodrag and Nedović, Viktor and Nikšić, Miomir", year = "2021", abstract = "Medicinal mushrooms, Coriolus versicolor and Lentinus edodes are extremely attractive as nutraceuticals. Here we used fruiting bodies to prepare novel kombucha beverage. Microbiological, physicochemical and chemical properties were monitored for eleven days, while the immunological properties of kombucha polysaccharide extracts were determined in peripheral blood mononuclear cell (PBMC) cultures. FTIR analysis of polysaccharide extracts showed dominant presence of polysaccharides, in addition to phenols, lipids and proteins. C. versicolor kombucha extract displayed more complex polysaccharides, and a higher content of total polysaccharides, phenols and flavonoids compared to L. edodes kombucha extract. The extracts were not cytotoxic for PBMC in vitro up to 500 µg/ml, while immunomodulatory effects depended on their chemical compositions. The most prominent effect was on the reduction of Th2 cytokines and IL-10 in PBMC cultures. Based on these results, novel kombucha products could be recommended as functional beverages or nutraceuticals with potentially beneficial immunomodulatory effects in allergies.", publisher = "Elsevier", journal = "Food Chemistry", title = "Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts", pages = "128344", volume = "342", doi = "10.1016/j.foodchem.2020.128344" }
Sknepnek, A., Tomić, S., Miletić, D., Lević, S., Čolić, M., Nedović, V.,& Nikšić, M.. (2021). Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts. in Food Chemistry Elsevier., 342, 128344. https://doi.org/10.1016/j.foodchem.2020.128344
Sknepnek A, Tomić S, Miletić D, Lević S, Čolić M, Nedović V, Nikšić M. Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts. in Food Chemistry. 2021;342:128344. doi:10.1016/j.foodchem.2020.128344 .
Sknepnek, Aleksandra, Tomić, Sergej, Miletić, Dunja, Lević, Steva, Čolić, Miodrag, Nedović, Viktor, Nikšić, Miomir, "Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts" in Food Chemistry, 342 (2021):128344, https://doi.org/10.1016/j.foodchem.2020.128344 . .