Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts
Authors
Sknepnek, Aleksandra
Tomić, Sergej
Miletić, Dunja

Lević, Steva

Čolić, Miodrag
Nedović, Viktor

Nikšić, Miomir

Article (Accepted Version)
Metadata
Show full item recordAbstract
Medicinal mushrooms, Coriolus versicolor and Lentinus edodes are extremely attractive as nutraceuticals. Here we used fruiting bodies to prepare novel kombucha beverage. Microbiological, physicochemical and chemical properties were monitored for eleven days, while the immunological properties of kombucha polysaccharide extracts were determined in peripheral blood mononuclear cell (PBMC) cultures. FTIR analysis of polysaccharide extracts showed dominant presence of polysaccharides, in addition to phenols, lipids and proteins. C. versicolor kombucha extract displayed more complex polysaccharides, and a higher content of total polysaccharides, phenols and flavonoids compared to L. edodes kombucha extract. The extracts were not cytotoxic for PBMC in vitro up to 500 µg/ml, while immunomodulatory effects depended on their chemical compositions. The most prominent effect was on the reduction of Th2 cytokines and IL-10 in PBMC cultures. Based on these results, novel kombucha products could be ...recommended as functional beverages or nutraceuticals with potentially beneficial immunomodulatory effects in allergies.
Keywords:
Cytokines / Immunomodulation / Kombucha / Medicinal mushroomsSource:
Food Chemistry, 2021, 342, 128344-Publisher:
- Elsevier
Funding / projects:
- info:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS/ (RS-200116)
- Application of functionalyzed carbon nanotubes and gold nanoparticles for preparation of dendritic cells for tumor therapy (RS-175102)
Note:
- This is the peer-reviewed version of the article: Sknepnek, A.; Tomić, S.; Miletić, D.; Lević, S.; Čolić, M.; Nedović, V.; Nikšić, M. Fermentation Characteristics of Novel Coriolus Versicolor and Lentinus Edodes Kombucha Beverages and Immunomodulatory Potential of Their Polysaccharide Extracts. Food Chemistry 2021, 342, 128344. https://doi.org/10.1016/j.foodchem.2020.128344.
- Supplementary material: http://aspace.agrif.bg.ac.rs/handle/123456789/5996
Related info:
- Version of
http://aspace.agrif.bg.ac.rs/handle/123456789/5771 - Version of
https://doi.org/10.1016/j.foodchem.2020.128344 - Referenced by
http://aspace.agrif.bg.ac.rs/handle/123456789/5996
DOI: 10.1016/j.foodchem.2020.128344
ISSN: 0308-8146