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dc.creatorMilincić, Danijel D.
dc.creatorVojinović, Uroš
dc.creatorKostić, Aleksandar
dc.creatorPešić, Mirjana
dc.creatorŠpirović-Trifunović, Bojana
dc.creatorBrkić, Dragica
dc.creatorStević, Milan
dc.creatorKojić, Milan
dc.creatorStanisavljević, Nemanja S.
dc.date.accessioned2020-12-17T22:56:30Z
dc.date.available2020-12-17T22:56:30Z
dc.date.issued2020
dc.identifier.issn0045-6535
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/5371
dc.description.abstractThe aim of this study was to investigate the bioaccessibility of pesticide residues in blueberries (com-mercial and sample from controlled field trial) from Serbia, involving the presence of a complex food matrix and to assess the potential risk to human health. The presence of nine active substances (azox-ystrobin, boscalid, fludioxonil, cyprodinil, pyrimethanil, pyridaben, pyriproxyfen, acetamiprid and thia-metoxam) in initial blueberry samples was determined in concentration range from 5.15 mu g/kg for thiametoxam to 187 mu g/kg for azoxystrobin. Clothianidin, metabolite of thiametoxam, was not detected in any blueberry sample. However, after in vitro digestion, the content of initially detected pesticides residues was significantly decreased or it was below limit of quantification resulting in the total bio-accessibility of about 15%. Azoxystrobin, pyrimethanil and fludioxonil was quantified in digestive juice at concentrations which were about 81%, 37% and 10% less than the inital concentration, respectively. The presence of food matrix during digestion of blueberries even more severely reduced concentration of pesticide residues (total bioaccessibility was about 7%) compared to digestion without the food matrix. Only azoxystrobin was quantified after digestion with food matrix in concentration of 27 mu g/kg in sample from controlled field trial and detected in two commercial samples but below the limit of quantification. Furthermore, chronic risk assessment indicated that risk is acceptable for the health of different human subpopulation groups. The current study on pesticides residues, most commonly applied on blueberries, provides for the first time an insight into their bioaccessibility under conditions that mimic physiological environment of human digestive tract.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173019/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46008/RS//
dc.rightsrestrictedAccess
dc.sourceChemosphere
dc.subjectIn vitro digestionen
dc.subjectBlueberryen
dc.subjectPesticide residuesen
dc.subjectFood matrixen
dc.subjectRisk assessmenten
dc.titleIn vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrixen
dc.typearticle
dc.rights.licenseARR
dc.citation.other252: -
dc.citation.rankM21
dc.citation.volume252
dc.identifier.doi10.1016/j.chemosphere.2020.126568
dc.identifier.rcubconv_6856
dc.identifier.scopus2-s2.0-85082190379
dc.identifier.pmid32220723
dc.identifier.wos000534377000077
dc.type.versionpublishedVersion


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