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dc.creatorStikić, Radmila
dc.creatorMilincić, Danijel D.
dc.creatorKostić, Aleksandar
dc.creatorJovanović, Zorica
dc.creatorGašić, Uroš M.
dc.creatorTešić, Živoslav
dc.creatorDjordjević, Nataša Z.
dc.creatorSavić, Sladjana
dc.creatorCzekus, Borisz G.
dc.creatorPešić, Mirjana
dc.date.accessioned2020-12-17T22:56:15Z
dc.date.available2020-12-17T22:56:15Z
dc.date.issued2020
dc.identifier.issn0009-0352
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/5367
dc.description.abstractBACKGROUND: and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31005/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31006/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31069/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173024/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173041/RS//
dc.rightsrestrictedAccess
dc.sourceCereal Chemistry
dc.subjectantioxidant activityen
dc.subjectcolon canceren
dc.subjectcytotoxic activityen
dc.subjectflavonoidsen
dc.subjectphenolic acidsen
dc.subjectquinoa seeden
dc.titlePolyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivarsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage633
dc.citation.issue3
dc.citation.other97(3): 626-633
dc.citation.rankM22
dc.citation.spage626
dc.citation.volume97
dc.identifier.doi10.1002/cche.10278
dc.identifier.scopus2-s2.0-85082187869
dc.identifier.wos000521447000001
dc.type.versionpublishedVersion


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