In vitro evaluation of the controlled release of antibiotics from liposomes
In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma
Апстракт
Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.
Кључне речи:
Controlled release / Diffusion / Liposomes / Membrane module / ModelingИзвор:
Chemical Industry and Chemical Engineering Quarterly / CICEQ, 2003, 9, 4, 589-595Издавач:
- Savez hemijskih inženjera, Beograd
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Boltić, Z. AU - Petkovska, Menka AU - Obradović, B. AU - Nedović, Viktor AU - Bugarski, Branko PY - 2003 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/523 AB - Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components. PB - Savez hemijskih inženjera, Beograd T2 - Chemical Industry and Chemical Engineering Quarterly / CICEQ T1 - In vitro evaluation of the controlled release of antibiotics from liposomes T1 - In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma EP - 595 IS - 4 SP - 589 VL - 9 UR - https://hdl.handle.net/21.15107/rcub_agrospace_523 ER -
@article{ author = "Boltić, Z. and Petkovska, Menka and Obradović, B. and Nedović, Viktor and Bugarski, Branko", year = "2003", abstract = "Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.", publisher = "Savez hemijskih inženjera, Beograd", journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ", title = "In vitro evaluation of the controlled release of antibiotics from liposomes, In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma", pages = "595-589", number = "4", volume = "9", url = "https://hdl.handle.net/21.15107/rcub_agrospace_523" }
Boltić, Z., Petkovska, M., Obradović, B., Nedović, V.,& Bugarski, B.. (2003). In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry and Chemical Engineering Quarterly / CICEQ Savez hemijskih inženjera, Beograd., 9(4), 589-595. https://hdl.handle.net/21.15107/rcub_agrospace_523
Boltić Z, Petkovska M, Obradović B, Nedović V, Bugarski B. In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2003;9(4):589-595. https://hdl.handle.net/21.15107/rcub_agrospace_523 .
Boltić, Z., Petkovska, Menka, Obradović, B., Nedović, Viktor, Bugarski, Branko, "In vitro evaluation of the controlled release of antibiotics from liposomes" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 9, no. 4 (2003):589-595, https://hdl.handle.net/21.15107/rcub_agrospace_523 .