Exposure Assessment and Risk Characterization of Aflatoxin M1 Intake through Consumption of Milk and Yoghurt by Student Population in Serbia and Greece
Апстракт
The objective of this research was to perform an exposure assessment of aflatoxin M1 (AFM1) intake through the consumption of milk and yoghurt by the student population in Serbia and Greece. A food consumption survey of milk and yoghurt was performed during the first half of 2018 in the two countries with at least 500 interviewees (aged between 18 and 27 years) per country, covering their dietary habits and body weight based on one-day and seven-day recall methods. Values for the concentration of AFM1 were extracted from published research. Finally, a Monte Carlo analysis of 100,000 iterations was performed to estimate the intake of AFM1 from the consumption of the two dairy products. Results revealed that the estimated average exposure of students to AFM1 was in the range of 1.238-2.674 ng kg(-1) bw day(-1) for Serbia, and 0.350-0.499 ng kg(-1) bw day(-1) for Greece, depending on the dietary recall method employed. High estimations for hepatocellular carcinoma (HCC) cases/year/10(5) i...ndividuals, depending on the prevalence of Hepatitis B virus surface antigen positive individuals (HBsAg+), were 0.0036-0.0047 and 0.0007-0.0009 for Serbia and Greece, respectively. Presented Margin of Exposure (MOE) and Hazard Index (HI) values indicate increased risk from exposure to AFM1, particularly in Serbia.
Кључне речи:
milk / aflatoxin M1 / exposure assessment / risk characterization / Monte Carlo / HCC / MOEИзвор:
Toxins, 2019, 11, 4Издавач:
- MDPI, BASEL
Финансирање / пројекти:
- Одабране биолошке опасности за безбедност/квалитет хране анималног порекла и контролне мере од фарме до потрошача (RS-MESTD-Technological Development (TD or TR)-31034)
DOI: 10.3390/toxins11040205
ISSN: 2072-6651
PubMed: 30959754
WoS: 000467299600023
Scopus: 2-s2.0-85064542393
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Udovički, Božidar AU - Đekić, Ilija AU - Kalogianni, Eleni P. AU - Rajković, Andreja PY - 2019 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5056 AB - The objective of this research was to perform an exposure assessment of aflatoxin M1 (AFM1) intake through the consumption of milk and yoghurt by the student population in Serbia and Greece. A food consumption survey of milk and yoghurt was performed during the first half of 2018 in the two countries with at least 500 interviewees (aged between 18 and 27 years) per country, covering their dietary habits and body weight based on one-day and seven-day recall methods. Values for the concentration of AFM1 were extracted from published research. Finally, a Monte Carlo analysis of 100,000 iterations was performed to estimate the intake of AFM1 from the consumption of the two dairy products. Results revealed that the estimated average exposure of students to AFM1 was in the range of 1.238-2.674 ng kg(-1) bw day(-1) for Serbia, and 0.350-0.499 ng kg(-1) bw day(-1) for Greece, depending on the dietary recall method employed. High estimations for hepatocellular carcinoma (HCC) cases/year/10(5) individuals, depending on the prevalence of Hepatitis B virus surface antigen positive individuals (HBsAg+), were 0.0036-0.0047 and 0.0007-0.0009 for Serbia and Greece, respectively. Presented Margin of Exposure (MOE) and Hazard Index (HI) values indicate increased risk from exposure to AFM1, particularly in Serbia. PB - MDPI, BASEL T2 - Toxins T1 - Exposure Assessment and Risk Characterization of Aflatoxin M1 Intake through Consumption of Milk and Yoghurt by Student Population in Serbia and Greece IS - 4 VL - 11 DO - 10.3390/toxins11040205 ER -
@article{ author = "Udovički, Božidar and Đekić, Ilija and Kalogianni, Eleni P. and Rajković, Andreja", year = "2019", abstract = "The objective of this research was to perform an exposure assessment of aflatoxin M1 (AFM1) intake through the consumption of milk and yoghurt by the student population in Serbia and Greece. A food consumption survey of milk and yoghurt was performed during the first half of 2018 in the two countries with at least 500 interviewees (aged between 18 and 27 years) per country, covering their dietary habits and body weight based on one-day and seven-day recall methods. Values for the concentration of AFM1 were extracted from published research. Finally, a Monte Carlo analysis of 100,000 iterations was performed to estimate the intake of AFM1 from the consumption of the two dairy products. Results revealed that the estimated average exposure of students to AFM1 was in the range of 1.238-2.674 ng kg(-1) bw day(-1) for Serbia, and 0.350-0.499 ng kg(-1) bw day(-1) for Greece, depending on the dietary recall method employed. High estimations for hepatocellular carcinoma (HCC) cases/year/10(5) individuals, depending on the prevalence of Hepatitis B virus surface antigen positive individuals (HBsAg+), were 0.0036-0.0047 and 0.0007-0.0009 for Serbia and Greece, respectively. Presented Margin of Exposure (MOE) and Hazard Index (HI) values indicate increased risk from exposure to AFM1, particularly in Serbia.", publisher = "MDPI, BASEL", journal = "Toxins", title = "Exposure Assessment and Risk Characterization of Aflatoxin M1 Intake through Consumption of Milk and Yoghurt by Student Population in Serbia and Greece", number = "4", volume = "11", doi = "10.3390/toxins11040205" }
Udovički, B., Đekić, I., Kalogianni, E. P.,& Rajković, A.. (2019). Exposure Assessment and Risk Characterization of Aflatoxin M1 Intake through Consumption of Milk and Yoghurt by Student Population in Serbia and Greece. in Toxins MDPI, BASEL., 11(4). https://doi.org/10.3390/toxins11040205
Udovički B, Đekić I, Kalogianni EP, Rajković A. Exposure Assessment and Risk Characterization of Aflatoxin M1 Intake through Consumption of Milk and Yoghurt by Student Population in Serbia and Greece. in Toxins. 2019;11(4). doi:10.3390/toxins11040205 .
Udovički, Božidar, Đekić, Ilija, Kalogianni, Eleni P., Rajković, Andreja, "Exposure Assessment and Risk Characterization of Aflatoxin M1 Intake through Consumption of Milk and Yoghurt by Student Population in Serbia and Greece" in Toxins, 11, no. 4 (2019), https://doi.org/10.3390/toxins11040205 . .