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dc.creatorStanković, Jovana
dc.creatorGodjevac, Dejan
dc.creatorTešević, Vele
dc.creatorDajić-Stevanović, Zora
dc.creatorĆirić, Ana
dc.creatorSoković, Marina
dc.creatorNovaković, Miroslav
dc.date.accessioned2020-12-17T22:37:02Z
dc.date.available2020-12-17T22:37:02Z
dc.date.issued2019
dc.identifier.issn0163-3864
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/5049
dc.description.abstractA new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-beta-D-glucuronopyranosyl-(1 -> 2)-beta-D-glucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, beta-D-glucopyranosyl-3-O-(2-O-sulfo-beta-D-galactopyranosyl)-(1 -> 2)-alpha-L-arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, beta-D-glucopyranosyl-3-O-(2-O-sulfo-beta-D-galactopyranosyl)-(1 -> 2)-alpha-L-arabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and beta-D-glucopyranosyl-3-D-(beta-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3-O-beta-D-apiofuranosyl-(1 '''-> 2 '')-beta-D-glucopyranoside (5) and patuletin 3-O-5 '''-O-feruloyl-beta-D-apiofuranosyl-(1 '''-> 2 '')-beta-D-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31089/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Natural Products
dc.titleAntibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosaen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1495
dc.citation.issue6
dc.citation.other82(6): 1487-1495
dc.citation.rankM21
dc.citation.spage1487
dc.citation.volume82
dc.identifier.doi10.1021/acs.jnatprod.8b00970
dc.identifier.rcubconv_6625
dc.identifier.scopus2-s2.0-85067065776
dc.identifier.pmid31181926
dc.identifier.wos000473827300011
dc.type.versionpublishedVersion


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