Immobilization of Chaga extract in alginate beads for modified release: simplicity meets efficiency

2019
Authors
Petrović, PredragIvanović, Katarina
Octrue, Charly
Tumara, Mica
Jovanović, Aleksandra
Vunduk, Jovana

Nikšić, Miomir

Pjanović, Rada
Bugarski, Branko

Klaus, Anita

Article (Published version)
Metadata
Show full item recordAbstract
Chaga (Inonotus obliquus) is a parasitic fungus, which has been used in traditional medicine in Russia and other northern European countries in the treatment of cancer, gastrointestinal andliver diseases. It has been a subject of intensive researchrecently, confirming many of its health-beneficial effects. In order to obtain a product that would allow modified and prolonged release of the Chaga's active metabolites, hot water Chaga extract was immobilized using calcium - alginate. The extract, which was predominantly composed of carbohydrates (57 %), also contained a relatively high amount of antioxidants/phenolic compounds (130 mg gallic acid equivalents per g of dry extract) and exhibited pronounced radical scavenging activity. It showed significant antibacterial activity as well, inhibiting growth of tested bacterial strains at concentrations of 1.25-20 mg/mL. Entrapment efficiency was about 80 %, and the extract-alginate system showed pH-dependant extract release; there was negligi...ble release at pH 1.75 (gastric pH), and the release gradually increased with the increase in pH, reaching similar to 43 % of immobilized extract at pH 8.5 after 90 min. Such a product could be used as a dietary supplement, adjuvant in therapy of gastrointestinal diseases or as a food additive.
Keywords:
mushrooms / natural product / antioxidant / antimicrobial / encapsulationSource:
HEMIJSKA INDUSTRIJA, 2019, 73, 5, 325-335Publisher:
- Savez hemijskih inženjera, Beograd
Funding / projects:
DOI: 10.2298/HEMIND190819028P
ISSN: 0367-598X