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dc.creatorMarković, Zoran M.
dc.creatorJovanović, Svetlana P.
dc.creatorMasković, Pavle Z.
dc.creatorMojsin, Marija M.
dc.creatorStevanović, Milena J.
dc.creatorDanko, Martin
dc.creatorMicusik, Matej
dc.creatorJovanović, Dragana J.
dc.creatorKleinova, Angela
dc.creatorSpitalsky, Zdeno
dc.creatorPavlović, Vladimir
dc.creatorTodorović-Marković, Biljana
dc.date.accessioned2020-12-17T22:34:20Z
dc.date.available2020-12-17T22:34:20Z
dc.date.issued2019
dc.identifier.issn1011-1344
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/5003
dc.description.abstractPhotoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.en
dc.publisherElsevier Science Sa, Lausanne
dc.relationVEGAVedecka grantova agentura MSVVaS SR a SAV (VEGA) [2/0093/16]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172003/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173051/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Photochemistry and Photobiology B-Biology
dc.subjectGraphene oxideen
dc.subjectGraphene quantum dotsen
dc.subjectCarbon quantum dotsen
dc.subjectReactive oxygen speciesen
dc.titleGraphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell linesen
dc.typearticle
dc.rights.licenseARR
dc.citation.other200: -
dc.citation.rankM21
dc.citation.volume200
dc.identifier.doi10.1016/j.jphotobiol.2019.111647
dc.identifier.scopus2-s2.0-85073508959
dc.identifier.pmid31648133
dc.identifier.wos000499768400002
dc.type.versionpublishedVersion


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Приказ основних података о документу