Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines
Samo za registrovane korisnike
2019
Autori
Marković, Zoran M.Jovanović, Svetlana P.
Masković, Pavle Z.
Mojsin, Marija M.
Stevanović, Milena J.
Danko, Martin
Micusik, Matej
Jovanović, Dragana J.
Kleinova, Angela
Spitalsky, Zdeno
Pavlović, Vladimir
Todorović-Marković, Biljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light i...rradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.
Ključne reči:
Graphene oxide / Graphene quantum dots / Carbon quantum dots / Reactive oxygen speciesIzvor:
Journal of Photochemistry and Photobiology B-Biology, 2019, 200Izdavač:
- Elsevier Science Sa, Lausanne
Finansiranje / projekti:
- VEGAVedecka grantova agentura MSVVaS SR a SAV (VEGA) [2/0093/16]
- Tanki slojevi jednoslojnih ugljeničnih nanotuba i grafena za primenu u elektronici (RS-172003)
- Proučavanje signalnih puteva i epigenetičkih mehanizama uključenih u kontrolu ekspresije humanih SOX gena: dalje rasvetljavanje njihove uloge u određivanju sudbine i diferencijaciji ćelija (RS-173051)
DOI: 10.1016/j.jphotobiol.2019.111647
ISSN: 1011-1344
PubMed: 31648133
WoS: 000499768400002
Scopus: 2-s2.0-85073508959
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Marković, Zoran M. AU - Jovanović, Svetlana P. AU - Masković, Pavle Z. AU - Mojsin, Marija M. AU - Stevanović, Milena J. AU - Danko, Martin AU - Micusik, Matej AU - Jovanović, Dragana J. AU - Kleinova, Angela AU - Spitalsky, Zdeno AU - Pavlović, Vladimir AU - Todorović-Marković, Biljana PY - 2019 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5003 AB - Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much. PB - Elsevier Science Sa, Lausanne T2 - Journal of Photochemistry and Photobiology B-Biology T1 - Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines VL - 200 DO - 10.1016/j.jphotobiol.2019.111647 ER -
@article{ author = "Marković, Zoran M. and Jovanović, Svetlana P. and Masković, Pavle Z. and Mojsin, Marija M. and Stevanović, Milena J. and Danko, Martin and Micusik, Matej and Jovanović, Dragana J. and Kleinova, Angela and Spitalsky, Zdeno and Pavlović, Vladimir and Todorović-Marković, Biljana", year = "2019", abstract = "Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.", publisher = "Elsevier Science Sa, Lausanne", journal = "Journal of Photochemistry and Photobiology B-Biology", title = "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines", volume = "200", doi = "10.1016/j.jphotobiol.2019.111647" }
Marković, Z. M., Jovanović, S. P., Masković, P. Z., Mojsin, M. M., Stevanović, M. J., Danko, M., Micusik, M., Jovanović, D. J., Kleinova, A., Spitalsky, Z., Pavlović, V.,& Todorović-Marković, B.. (2019). Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B-Biology Elsevier Science Sa, Lausanne., 200. https://doi.org/10.1016/j.jphotobiol.2019.111647
Marković ZM, Jovanović SP, Masković PZ, Mojsin MM, Stevanović MJ, Danko M, Micusik M, Jovanović DJ, Kleinova A, Spitalsky Z, Pavlović V, Todorović-Marković B. Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B-Biology. 2019;200. doi:10.1016/j.jphotobiol.2019.111647 .
Marković, Zoran M., Jovanović, Svetlana P., Masković, Pavle Z., Mojsin, Marija M., Stevanović, Milena J., Danko, Martin, Micusik, Matej, Jovanović, Dragana J., Kleinova, Angela, Spitalsky, Zdeno, Pavlović, Vladimir, Todorović-Marković, Biljana, "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines" in Journal of Photochemistry and Photobiology B-Biology, 200 (2019), https://doi.org/10.1016/j.jphotobiol.2019.111647 . .