The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical app...lications.
TY - JOUR
AU - Vlaisavljević, Sanja
AU - Jelaca, Sanja
AU - Zengin, Gokhan
AU - Mimica-Dukić, Neda
AU - Berezni, Sanja
AU - Miljić, Milorad
AU - Dajić-Stevanović, Zora
PY - 2019
UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5000
AB - The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.
PB - Royal Soc Chemistry, Cambridge
T2 - RSC Advances
T1 - Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties
EP - 37483
IS - 64
SP - 37474
VL - 9
DO - 10.1039/c9ra08231j
ER -
@article{
author = "Vlaisavljević, Sanja and Jelaca, Sanja and Zengin, Gokhan and Mimica-Dukić, Neda and Berezni, Sanja and Miljić, Milorad and Dajić-Stevanović, Zora",
year = "2019",
abstract = "The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from Southeast Serbia (central Balkan) which was traditionally used to alleviate and treat many diseases. Bioactive compounds were characterized by LC-MS/MS technique and biological properties were evaluated using antioxidant, enzyme inhibitory and cytotoxic assays. Twenty-six phenolic compounds were quantified in methanolic, ethanolic, ethyl acetate and water extracts, whereas the highest yields were found in ethyl-acetate (EA) extract (gallic acid, caffeic acid, catchin, quercetin). This extract has also shown the greatest antioxidant, anticancer and inhibitory enzyme activities which were demonstrated for the first time in this study. The obtained results indicated that Alchemilla vulgaris from South Serbia possesses high potential for pharmaceutical applications.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties",
pages = "37483-37474",
number = "64",
volume = "9",
doi = "10.1039/c9ra08231j"
}
Vlaisavljević, S., Jelaca, S., Zengin, G., Mimica-Dukić, N., Berezni, S., Miljić, M.,& Dajić-Stevanović, Z.. (2019). Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances
Royal Soc Chemistry, Cambridge., 9(64), 37474-37483.
https://doi.org/10.1039/c9ra08231j
Vlaisavljević S, Jelaca S, Zengin G, Mimica-Dukić N, Berezni S, Miljić M, Dajić-Stevanović Z. Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties. in RSC Advances. 2019;9(64):37474-37483.
doi:10.1039/c9ra08231j .
Vlaisavljević, Sanja, Jelaca, Sanja, Zengin, Gokhan, Mimica-Dukić, Neda, Berezni, Sanja, Miljić, Milorad, Dajić-Stevanović, Zora, "Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties" in RSC Advances, 9, no. 64 (2019):37474-37483,
https://doi.org/10.1039/c9ra08231j . .
