Приказ основних података о документу

dc.creatorOsmokrović, Andrea
dc.creatorJancić, Ivan
dc.creatorVunduk, Jovana
dc.creatorPetrović, Predrag
dc.creatorMilenković, Marina
dc.creatorObradović, Bojana
dc.date.accessioned2020-12-17T22:21:25Z
dc.date.available2020-12-17T22:21:25Z
dc.date.issued2018
dc.identifier.issn0144-8617
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/4785
dc.description.abstractNew composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provide utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption.en
dc.publisherElsevier Sci Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS//
dc.rightsrestrictedAccess
dc.sourceCarbohydrate Polymers
dc.subjectAlginateen
dc.subjectActivated charcoalen
dc.subjectPovidone iodineen
dc.subjectAntibacterial activityen
dc.subjectWound dressingen
dc.titleAchieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agenten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage288
dc.citation.other196: 279-288
dc.citation.rankaM21
dc.citation.spage279
dc.citation.volume196
dc.identifier.doi10.1016/j.carbpol.2018.05.045
dc.identifier.scopus2-s2.0-85047260873
dc.identifier.pmid29891298
dc.identifier.wos000436571600032
dc.type.versionpublishedVersion


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Приказ основних података о документу