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Potential use of deodorised water extracts: polyphenol-rich extract of Thymus pannonicus All. as a chemopreventive agent

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2018
4737.pdf (1.182Mb)
Authors
Cebović, Tatjana
Arsenijević, Jelena
Drobac, Milica
Zivković, Jelena
Šoštarić, Ivan
Maksimović, Zoran
Article (Published version)
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Abstract
Deodorised water extracts of aromatic plants are obtained as by-products of essential oil isolation and usually discarded as waste. However, phytochemical composition of these extracts encourages their further utilization as food additives or functional food ingredients. In this study we investigated phytochemical composition, antioxidant and in vivo antiproliferative activity of deodorised water extract of Thymus pannonicus All. (DWE). HPLC analysis revealed rosmarinic acid (RA) (71.11 +/- 1.54 mg/g) as the most abundant constituent of the extract, followed by salvianolic acid H (14.83 +/- 0.79 mg/g, calculated as RA). DWE exhibited pronounced antioxidant activity in vitro, in FRAP and DPPH tests (FRAP value: 7.41 mmol Fe/g and SC50: 3.80 mu g/g, respectively). Using the model of Ehrlich carcinoma cells in mice that were treated with DWE prior, at the time, and after tumour cells implantation, the tumour growth suppression and redox status of malignant cells (i.e., activities of antio...xidant enzymes, level of glutathione and intensity of lipid peroxidation) were followed. DWE applied as pretreatment caused disturbance of antioxidant equilibrium as well as apoptosis/necrosis of up to 90% EAC cells. Results obtained in the present study revealed chemopreventive potential and possibility of T. pannonicus DWE usage. High content of RA and other phenolic compounds explains, at least in part, the observed effects.

Keywords:
Thyme / Water extract / Antioxidant / Prooxidant / Cytotoxicity / HPLC
Source:
Journal of Food Science and Technology-Mysore, 2018, 55, 2, 560-567
Publisher:
  • Springer India, New Delhi
Funding / projects:
  • Morphological, chemical, pharmacological and agronomic characterization of the Pannonian Thyme (Thymus pannonicus All., Lamiaceae), with the purpose of sustainable production in intensive cropping system (RS-31089)
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1007/s13197-017-2965-1

ISSN: 0022-1155

PubMed: 29391620

WoS: 000423388600013

Scopus: 2-s2.0-85035798705
[ Google Scholar ]
URI
http://aspace.agrif.bg.ac.rs/handle/123456789/4740
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  • Radovi istraživača / Researchers’ publications
Institution/Community
Poljoprivredni fakultet

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