Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers
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2017
Authors
Grković, MirjanaStojanović, Dušica B.
Pavlović, Vladimir

Rajilić-Stojanović, Mirjana

Bjelović, Milos
Uskoković, Petar S.
Article (Published version)

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In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.
Keywords:
Polymer-matrix composites (PMCs) / Nano-structures / Mechanical properties / Thermal propertiesSource:
Composites Part B-Engineering, 2017, 121, 58-67Publisher:
- Elsevier Sci Ltd, Oxford
Funding / projects:
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
- Predefined functional properties polymer composite materials processes and equipment development (RS-34011)
DOI: 10.1016/j.compositesb.2017.03.024
ISSN: 1359-8368
WoS: 000407413000005
Scopus: 2-s2.0-85016081941
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Poljoprivredni fakultetTY - JOUR AU - Grković, Mirjana AU - Stojanović, Dušica B. AU - Pavlović, Vladimir AU - Rajilić-Stojanović, Mirjana AU - Bjelović, Milos AU - Uskoković, Petar S. PY - 2017 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4459 AB - In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering. PB - Elsevier Sci Ltd, Oxford T2 - Composites Part B-Engineering T1 - Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers EP - 67 SP - 58 VL - 121 DO - 10.1016/j.compositesb.2017.03.024 ER -
@article{ author = "Grković, Mirjana and Stojanović, Dušica B. and Pavlović, Vladimir and Rajilić-Stojanović, Mirjana and Bjelović, Milos and Uskoković, Petar S.", year = "2017", abstract = "In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Composites Part B-Engineering", title = "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers", pages = "67-58", volume = "121", doi = "10.1016/j.compositesb.2017.03.024" }
Grković, M., Stojanović, D. B., Pavlović, V., Rajilić-Stojanović, M., Bjelović, M.,& Uskoković, P. S.. (2017). Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering Elsevier Sci Ltd, Oxford., 121, 58-67. https://doi.org/10.1016/j.compositesb.2017.03.024
Grković M, Stojanović DB, Pavlović V, Rajilić-Stojanović M, Bjelović M, Uskoković PS. Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering. 2017;121:58-67. doi:10.1016/j.compositesb.2017.03.024 .
Grković, Mirjana, Stojanović, Dušica B., Pavlović, Vladimir, Rajilić-Stojanović, Mirjana, Bjelović, Milos, Uskoković, Petar S., "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers" in Composites Part B-Engineering, 121 (2017):58-67, https://doi.org/10.1016/j.compositesb.2017.03.024 . .