Synthesis, antioxidant and antimicrobial activity of carbohydrazones
2017
Authors
Božić, Aleksandra R.Filipović, Nenad
Novaković, Irena
Bjelogrlić, Snežana
Nikolić, Jasmina B.
Drmanić, Sasa Z.
Marinković, Aleksandar D.
Article (Published version)
Metadata
Show full item recordAbstract
Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide-water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone.
Keywords:
carbohydrazones / antibacterial / antifungal / antioxidant activity / isomersSource:
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2017, 82, 5, 495-508Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-MESTD-Basic Research (BR or ON)-172013)
DOI: 10.2298/JSC161220045B
ISSN: 0352-5139
WoS: 000408085400003
Scopus: 2-s2.0-85021727647
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Poljoprivredni fakultetTY - JOUR AU - Božić, Aleksandra R. AU - Filipović, Nenad AU - Novaković, Irena AU - Bjelogrlić, Snežana AU - Nikolić, Jasmina B. AU - Drmanić, Sasa Z. AU - Marinković, Aleksandar D. PY - 2017 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4456 AB - Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide-water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone. PB - Srpsko hemijsko društvo, Beograd T2 - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY T1 - Synthesis, antioxidant and antimicrobial activity of carbohydrazones EP - 508 IS - 5 SP - 495 VL - 82 DO - 10.2298/JSC161220045B ER -
@article{ author = "Božić, Aleksandra R. and Filipović, Nenad and Novaković, Irena and Bjelogrlić, Snežana and Nikolić, Jasmina B. and Drmanić, Sasa Z. and Marinković, Aleksandar D.", year = "2017", abstract = "Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide-water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY", title = "Synthesis, antioxidant and antimicrobial activity of carbohydrazones", pages = "508-495", number = "5", volume = "82", doi = "10.2298/JSC161220045B" }
Božić, A. R., Filipović, N., Novaković, I., Bjelogrlić, S., Nikolić, J. B., Drmanić, S. Z.,& Marinković, A. D.. (2017). Synthesis, antioxidant and antimicrobial activity of carbohydrazones. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY Srpsko hemijsko društvo, Beograd., 82(5), 495-508. https://doi.org/10.2298/JSC161220045B
Božić AR, Filipović N, Novaković I, Bjelogrlić S, Nikolić JB, Drmanić SZ, Marinković AD. Synthesis, antioxidant and antimicrobial activity of carbohydrazones. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2017;82(5):495-508. doi:10.2298/JSC161220045B .
Božić, Aleksandra R., Filipović, Nenad, Novaković, Irena, Bjelogrlić, Snežana, Nikolić, Jasmina B., Drmanić, Sasa Z., Marinković, Aleksandar D., "Synthesis, antioxidant and antimicrobial activity of carbohydrazones" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 82, no. 5 (2017):495-508, https://doi.org/10.2298/JSC161220045B . .