Computational and experimental model of transdermal iontophorethic drug delivery system
Abstract
The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst-Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools... for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery.
Keywords:
Iontophoresis / Drug delivery / Dexamethasone sodium phosphate / Finite element methodSource:
International Journal of Pharmaceutics, 2017, 533, 2, 383-388Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- ELCODE project from Tecnalia
- Application of biomedical engineering for preclinical and clinical practice (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41007)
- Multiscale Methods and Their Applicatios in Nanomedicine (RS-MESTD-Basic Research (BR or ON)-174028)
DOI: 10.1016/j.ijpharm.2017.05.066
ISSN: 0378-5173
PubMed: 28576549
WoS: 000414188500009
Scopus: 2-s2.0-85020217441
Collections
Institution/Community
Poljoprivredni fakultetTY - CONF AU - Filipović, Nenad AU - Saveljić, Igor AU - Rac, Vladislav AU - Graells, Beatriz Olalde AU - Bijelić, Goran PY - 2017 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4451 AB - The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst-Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery. PB - Elsevier Science Bv, Amsterdam C3 - International Journal of Pharmaceutics T1 - Computational and experimental model of transdermal iontophorethic drug delivery system EP - 388 IS - 2 SP - 383 VL - 533 DO - 10.1016/j.ijpharm.2017.05.066 ER -
@conference{ author = "Filipović, Nenad and Saveljić, Igor and Rac, Vladislav and Graells, Beatriz Olalde and Bijelić, Goran", year = "2017", abstract = "The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst-Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery.", publisher = "Elsevier Science Bv, Amsterdam", journal = "International Journal of Pharmaceutics", title = "Computational and experimental model of transdermal iontophorethic drug delivery system", pages = "388-383", number = "2", volume = "533", doi = "10.1016/j.ijpharm.2017.05.066" }
Filipović, N., Saveljić, I., Rac, V., Graells, B. O.,& Bijelić, G.. (2017). Computational and experimental model of transdermal iontophorethic drug delivery system. in International Journal of Pharmaceutics Elsevier Science Bv, Amsterdam., 533(2), 383-388. https://doi.org/10.1016/j.ijpharm.2017.05.066
Filipović N, Saveljić I, Rac V, Graells BO, Bijelić G. Computational and experimental model of transdermal iontophorethic drug delivery system. in International Journal of Pharmaceutics. 2017;533(2):383-388. doi:10.1016/j.ijpharm.2017.05.066 .
Filipović, Nenad, Saveljić, Igor, Rac, Vladislav, Graells, Beatriz Olalde, Bijelić, Goran, "Computational and experimental model of transdermal iontophorethic drug delivery system" in International Journal of Pharmaceutics, 533, no. 2 (2017):383-388, https://doi.org/10.1016/j.ijpharm.2017.05.066 . .