(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines
2017
Authors
Todorović, Tamara R.Vukasinović, Jelena
Portalone, Gustavo
Suleiman, Sherif
Gligorijević, Nevenka
Bjelogrlić, Snežana
Jovanović, Katarina
Radulović, Siniša
Andjelković, Katarina
Cassar, Analisse
Filipović, Nenad
Schembri-Wismayer, Pierre
Article (Published version)
Metadata
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Cobalt complexes with semi-and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it ...was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin.
Source:
Medchemcomm, 2017, 8, 1, 103-111Publisher:
- Royal Soc Chemistry, Cambridge
Funding / projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
DOI: 10.1039/c6md00501b
ISSN: 2040-2503
PubMed: 30108695
WoS: 000394945200009
Scopus: 2-s2.0-85010739298
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Poljoprivredni fakultetTY - JOUR AU - Todorović, Tamara R. AU - Vukasinović, Jelena AU - Portalone, Gustavo AU - Suleiman, Sherif AU - Gligorijević, Nevenka AU - Bjelogrlić, Snežana AU - Jovanović, Katarina AU - Radulović, Siniša AU - Andjelković, Katarina AU - Cassar, Analisse AU - Filipović, Nenad AU - Schembri-Wismayer, Pierre PY - 2017 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4388 AB - Cobalt complexes with semi-and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin. PB - Royal Soc Chemistry, Cambridge T2 - Medchemcomm T1 - (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines EP - 111 IS - 1 SP - 103 VL - 8 DO - 10.1039/c6md00501b ER -
@article{ author = "Todorović, Tamara R. and Vukasinović, Jelena and Portalone, Gustavo and Suleiman, Sherif and Gligorijević, Nevenka and Bjelogrlić, Snežana and Jovanović, Katarina and Radulović, Siniša and Andjelković, Katarina and Cassar, Analisse and Filipović, Nenad and Schembri-Wismayer, Pierre", year = "2017", abstract = "Cobalt complexes with semi-and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Medchemcomm", title = "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines", pages = "111-103", number = "1", volume = "8", doi = "10.1039/c6md00501b" }
Todorović, T. R., Vukasinović, J., Portalone, G., Suleiman, S., Gligorijević, N., Bjelogrlić, S., Jovanović, K., Radulović, S., Andjelković, K., Cassar, A., Filipović, N.,& Schembri-Wismayer, P.. (2017). (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in Medchemcomm Royal Soc Chemistry, Cambridge., 8(1), 103-111. https://doi.org/10.1039/c6md00501b
Todorović TR, Vukasinović J, Portalone G, Suleiman S, Gligorijević N, Bjelogrlić S, Jovanović K, Radulović S, Andjelković K, Cassar A, Filipović N, Schembri-Wismayer P. (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in Medchemcomm. 2017;8(1):103-111. doi:10.1039/c6md00501b .
Todorović, Tamara R., Vukasinović, Jelena, Portalone, Gustavo, Suleiman, Sherif, Gligorijević, Nevenka, Bjelogrlić, Snežana, Jovanović, Katarina, Radulović, Siniša, Andjelković, Katarina, Cassar, Analisse, Filipović, Nenad, Schembri-Wismayer, Pierre, "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines" in Medchemcomm, 8, no. 1 (2017):103-111, https://doi.org/10.1039/c6md00501b . .