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dc.creatorWan-Mohtar, Wan Abd Al Qadr Imad
dc.creatorViegelmann, Christina
dc.creatorKlaus, Anita
dc.creatorLim, Sarina Abdul Halim
dc.date.accessioned2020-12-17T21:56:05Z
dc.date.available2020-12-17T21:56:05Z
dc.date.issued2017
dc.identifier.issn1226-7708
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/4379
dc.description.abstractUnderutilized mycelium of Ganoderma lucidum BCCM 31549 has been a significant source of a glucan sulfate (GS) possessing therapeutic activities. GS have been evaluated for their antifungaldemelanizing properties and nitrite oxide production from stimulated RAW264.7 macrophages. GS exhibited antifungal activity against Aspergillus niger A60 with a minimum inhibitory concentration of 60 mg/mL and a minimum fungicidal concentration of 100 mg/mL. At 60mg/mL (sublethal) and 30mg/mL (subinhibitory) doses of GS, the mycelium of A. niger A60 was successfully demelanized with a conidiophore head and black pigment reduction. Additionally, GS successfully stimulated RAW264.7 macrophage cells at a concentration of 500 mu g/mL to produce 0.45 mu M of nitric oxide. The GS-stimulated RAW264.7 macrophages were morphologically similar to those treated with lipopolysaccharide. The results highlight a novel bifunctional property of mycelial GS from G. lucidum.en
dc.publisherKorean Society Food Science & Technology-Kosfost, Seoul
dc.relationMajlis Amanah Rakyat Malaysia
dc.rightsopenAccess
dc.sourceFood Science and Biotechnology
dc.subjectantifungal activityen
dc.subjectdemelanizationen
dc.subjectGanoderma lucidumen
dc.subjectglucan sulfateen
dc.subjectnitric oxide productionen
dc.titleAntifungal-demelanizing properties and RAW264.7 macrophages stimulation of glucan sulfate from the mycelium of the mushroom Ganoderma lucidumen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage165
dc.citation.issue1
dc.citation.other26(1): 159-165
dc.citation.rankM23
dc.citation.spage159
dc.citation.volume26
dc.identifier.doi10.1007/s10068-017-0021-6
dc.identifier.fulltexthttp://aspace.agrif.bg.ac.rs/bitstream/id/2923/4376.pdf
dc.identifier.scopus2-s2.0-85014896461
dc.identifier.pmid30263523
dc.identifier.wos000396268200021
dc.type.versionpublishedVersion


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