Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts
2017
Authors
Veljović, SonjaVeljović, Mile
Nikićević, Ninoslav
Despotović, Saša
Radulović, Siniša
Nikšić, Miomir
Filipović, Lana
Article (Published version)
Metadata
Show full item recordAbstract
The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, alpha- and beta-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1.875-3.222 mu g/g) and naringenin (1.235-2.856 mu g/g). The ethanol extracts exhibited noteworthy antioxidant activity, but the significant amount of phenolic compounds was strongly linked to polysaccharides, and hence reduced their antioxidant capacity. The results of the antiproliferative activity in vitro showed that the analyzed extracts were the most effective against HeLa cells. Significant correlations were observed between the antipro...liferative effect and the TPC/glucan content of extracts.
Keywords:
Ganoderma lucidum / Ethanol extracts / Phenolic compounds / Glucans / Antioxidant capacity / Antiproliferative activitySource:
Journal of Food Science and Technology-Mysore, 2017, 54, 5, 1312-1320Publisher:
- Springer India, New Delhi
Funding / projects:
- Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41026)
DOI: 10.1007/s13197-017-2559-y
ISSN: 0022-1155
PubMed: 28416882
WoS: 000401448300030
Scopus: 2-s2.0-85014738986
Collections
Institution/Community
Poljoprivredni fakultetTY - JOUR AU - Veljović, Sonja AU - Veljović, Mile AU - Nikićević, Ninoslav AU - Despotović, Saša AU - Radulović, Siniša AU - Nikšić, Miomir AU - Filipović, Lana PY - 2017 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4355 AB - The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, alpha- and beta-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1.875-3.222 mu g/g) and naringenin (1.235-2.856 mu g/g). The ethanol extracts exhibited noteworthy antioxidant activity, but the significant amount of phenolic compounds was strongly linked to polysaccharides, and hence reduced their antioxidant capacity. The results of the antiproliferative activity in vitro showed that the analyzed extracts were the most effective against HeLa cells. Significant correlations were observed between the antiproliferative effect and the TPC/glucan content of extracts. PB - Springer India, New Delhi T2 - Journal of Food Science and Technology-Mysore T1 - Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts EP - 1320 IS - 5 SP - 1312 VL - 54 DO - 10.1007/s13197-017-2559-y ER -
@article{ author = "Veljović, Sonja and Veljović, Mile and Nikićević, Ninoslav and Despotović, Saša and Radulović, Siniša and Nikšić, Miomir and Filipović, Lana", year = "2017", abstract = "The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, alpha- and beta-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1.875-3.222 mu g/g) and naringenin (1.235-2.856 mu g/g). The ethanol extracts exhibited noteworthy antioxidant activity, but the significant amount of phenolic compounds was strongly linked to polysaccharides, and hence reduced their antioxidant capacity. The results of the antiproliferative activity in vitro showed that the analyzed extracts were the most effective against HeLa cells. Significant correlations were observed between the antiproliferative effect and the TPC/glucan content of extracts.", publisher = "Springer India, New Delhi", journal = "Journal of Food Science and Technology-Mysore", title = "Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts", pages = "1320-1312", number = "5", volume = "54", doi = "10.1007/s13197-017-2559-y" }
Veljović, S., Veljović, M., Nikićević, N., Despotović, S., Radulović, S., Nikšić, M.,& Filipović, L.. (2017). Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts. in Journal of Food Science and Technology-Mysore Springer India, New Delhi., 54(5), 1312-1320. https://doi.org/10.1007/s13197-017-2559-y
Veljović S, Veljović M, Nikićević N, Despotović S, Radulović S, Nikšić M, Filipović L. Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts. in Journal of Food Science and Technology-Mysore. 2017;54(5):1312-1320. doi:10.1007/s13197-017-2559-y .
Veljović, Sonja, Veljović, Mile, Nikićević, Ninoslav, Despotović, Saša, Radulović, Siniša, Nikšić, Miomir, Filipović, Lana, "Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts" in Journal of Food Science and Technology-Mysore, 54, no. 5 (2017):1312-1320, https://doi.org/10.1007/s13197-017-2559-y . .