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Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels

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2016
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Authors
Novaković, Radmila
Radunović, Nebojša
Rajković, Jovana
Djokić, Vladimir
Petrović, Aleksandar
Ivković, Branka
Ćupić, Vitomir
Kanjuh, Vladimir
Helmut, Heinlev
Gojković-Bukarica, Ljiljana
Article (Published version)
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Abstract
Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol ind...uced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.

Keywords:
resveratrrol / uterus / inwardly recifying potassium channels / Kir
Source:
Veterinarski glasnik, 2016, 70, 3-4, 121-129
Publisher:
  • Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Funding / projects:
  • Development of new technology for production of red wine and diatery supplements reach with polyphenols with cardioprotective effects (RS-31020)

DOI: 10.2298/VETGL1604121N

ISSN: 0350-2457

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URI
http://aspace.agrif.bg.ac.rs/handle/123456789/4292
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  • Radovi istraživača / Researchers’ publications
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Poljoprivredni fakultet

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